A Long-Term Intensive Lifestyle Intervention and Physical Function: the Look AHEAD Movement and Memory Study
Identifieur interne : 004138 ( Ncbi/Checkpoint ); précédent : 004137; suivant : 004139A Long-Term Intensive Lifestyle Intervention and Physical Function: the Look AHEAD Movement and Memory Study
Auteurs : Denise K. Houston [États-Unis] ; Xiaoyan Leng [États-Unis] ; George A. Bray ; Andrea L. Hergenroeder [États-Unis] ; James O. Hill [États-Unis] ; John M. Jakicic [États-Unis] ; Karen C. Johnson [États-Unis] ; Rebecca H. Neiberg [États-Unis] ; Anthony P. Marsh [États-Unis] ; W. Jack Rejeski [États-Unis] ; Stephen B. Kritchevsky [États-Unis]Source :
- Obesity (Silver Spring, Md.) [ 1930-7381 ] ; 2014.
Abstract
To assess the long-term effects of an intensive lifestyle intervention on physical function using a randomized post-test design in the Look AHEAD trial.
Overweight and obese (BMI ≥25 kg/m2) middle-aged and older adults (aged 45–76 years at enrollment) with type 2 diabetes (n=964) at four clinics in Look AHEAD, a trial evaluating an intensive lifestyle intervention (ILI) designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including an expanded short physical performance battery (SPPBexp), 20-m and 400-m walk, and grip and knee extensor strength 8 years post-randomization, during the trial’s weight maintenance phase.
Eight years post-randomization, individuals randomized to ILI had better SPPBexp scores (adjusted mean (SE) difference: 0.055 (0.022), p=0.01) and faster 20-m and 400-m walk speeds (0.032 (0.012) m/sec, p=0.01, and 0.025 (0.011) m/sec, p=0.02, respectively) compared to those randomized to DSE. Achieved weight loss greatly attenuated the group differences in physical function and the intervention effect was no longer significant.
An intensive lifestyle intervention has long-term benefits for mobility function in overweight and obese middle-aged and older individuals with type 2 diabetes.
Url:
DOI: 10.1002/oby.20944
PubMed: 25452229
PubMed Central: 4276480
Affiliations:
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Jack Rejeski</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Health and Exercise Science, Wake Forest University, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Winston-Salem</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25452229</idno><idno type="pmc">4276480</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276480</idno><idno type="RBID">PMC:4276480</idno><idno type="doi">10.1002/oby.20944</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001E54</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E54</idno><idno type="wicri:Area/Pmc/Curation">001E28</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001E28</idno><idno type="wicri:Area/Pmc/Checkpoint">001E61</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001E61</idno><idno type="wicri:Area/Ncbi/Merge">004138</idno><idno type="wicri:Area/Ncbi/Curation">004138</idno><idno type="wicri:Area/Ncbi/Checkpoint">004138</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Long-Term Intensive Lifestyle Intervention and Physical Function: the Look AHEAD Movement and Memory Study</title><author><name sortKey="Houston, Denise K" sort="Houston, Denise K" uniqKey="Houston D" first="Denise K." last="Houston">Denise K. Houston</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Leng, Xiaoyan" sort="Leng, Xiaoyan" uniqKey="Leng X" first="Xiaoyan" last="Leng">Xiaoyan Leng</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Bray, George A" sort="Bray, George A" uniqKey="Bray G" first="George A." last="Bray">George A. Bray</name><affiliation><nlm:aff id="A3">Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, 70808</nlm:aff><wicri:noCountry code="subfield">70808</wicri:noCountry></affiliation></author><author><name sortKey="Hergenroeder, Andrea L" sort="Hergenroeder, Andrea L" uniqKey="Hergenroeder A" first="Andrea L." last="Hergenroeder">Andrea L. Hergenroeder</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA 15203</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Physical Therapy, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Hill, James O" sort="Hill, James O" uniqKey="Hill J" first="James O." last="Hill">James O. Hill</name><affiliation wicri:level="2"><nlm:aff id="A5">University of Colorado Denver School of Medicine, Aurora, CO 80010</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>University of Colorado Denver School of Medicine, Aurora</wicri:cityArea></affiliation></author><author><name sortKey="Jakicic, John M" sort="Jakicic, John M" uniqKey="Jakicic J" first="John M." last="Jakicic">John M. Jakicic</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh, PA 15203</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Johnson, Karen C" sort="Johnson, Karen C" uniqKey="Johnson K" first="Karen C." last="Johnson">Karen C. Johnson</name><affiliation wicri:level="2"><nlm:aff id="A7">Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN 38105</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Neiberg, Rebecca H" sort="Neiberg, Rebecca H" uniqKey="Neiberg R" first="Rebecca H." last="Neiberg">Rebecca H. Neiberg</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Marsh, Anthony P" sort="Marsh, Anthony P" uniqKey="Marsh A" first="Anthony P." last="Marsh">Anthony P. Marsh</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Health and Exercise Science, Wake Forest University, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Rejeski, W Jack" sort="Rejeski, W Jack" uniqKey="Rejeski W" first="W. Jack" last="Rejeski">W. Jack Rejeski</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Health and Exercise Science, Wake Forest University, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Winston-Salem</wicri:cityArea></affiliation></author></analytic><series><title level="j">Obesity (Silver Spring, Md.)</title><idno type="ISSN">1930-7381</idno><idno type="eISSN">1930-739X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>OBJECTIVE</title><p id="P1">To assess the long-term effects of an intensive lifestyle intervention on physical function using a randomized post-test design in the Look AHEAD trial.</p></sec><sec id="S2"><title>METHODS</title><p id="P2">Overweight and obese (BMI ≥25 kg/m<sup>2</sup>) middle-aged and older adults (aged 45–76 years at enrollment) with type 2 diabetes (n=964) at four clinics in Look AHEAD, a trial evaluating an intensive lifestyle intervention (ILI) designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including an expanded short physical performance battery (SPPB<sub>exp</sub>), 20-m and 400-m walk, and grip and knee extensor strength 8 years post-randomization, during the trial’s weight maintenance phase.</p></sec><sec id="S3"><title>RESULTS</title><p id="P3">Eight years post-randomization, individuals randomized to ILI had better SPPB<sub>exp</sub> scores (adjusted mean (SE) difference: 0.055 (0.022), p=0.01) and faster 20-m and 400-m walk speeds (0.032 (0.012) m/sec, p=0.01, and 0.025 (0.011) m/sec, p=0.02, respectively) compared to those randomized to DSE. Achieved weight loss greatly attenuated the group differences in physical function and the intervention effect was no longer significant.</p></sec><sec id="S4"><title>CONCLUSIONS</title><p id="P4">An intensive lifestyle intervention has long-term benefits for mobility function in overweight and obese middle-aged and older individuals with type 2 diabetes.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Guralnik, Jm" uniqKey="Guralnik J">JM Guralnik</name></author><author><name sortKey="Fried, Lp" uniqKey="Fried L">LP Fried</name></author><author><name sortKey="Salive, Me" uniqKey="Salive M">ME Salive</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fried, Lp" uniqKey="Fried L">LP Fried</name></author><author><name sortKey="Guralnik, Jm" uniqKey="Guralnik J">JM Guralnik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vincent, Hk" uniqKey="Vincent H">HK 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Woodman</name></author><author><name sortKey="Studenski, Sa" uniqKey="Studenski S">SA Studenski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Studenski, S" uniqKey="Studenski S">S Studenski</name></author><author><name sortKey="Perera, S" uniqKey="Perera S">S Perera</name></author><author><name sortKey="Patel, K" uniqKey="Patel K">K Patel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sorensen, Ti" uniqKey="Sorensen T">TI Sorensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rolland, Y" uniqKey="Rolland Y">Y Rolland</name></author><author><name sortKey="Kim, Mj" uniqKey="Kim M">MJ Kim</name></author><author><name sortKey="Gammack, Jk" uniqKey="Gammack J">JK Gammack</name></author><author><name sortKey="Wilson, Mm" uniqKey="Wilson M">MM Wilson</name></author><author><name sortKey="Thomas, Dr" uniqKey="Thomas D">DR Thomas</name></author><author><name sortKey="Morley, Je" 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Nicklas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marsh, Ap" uniqKey="Marsh A">AP Marsh</name></author><author><name sortKey="Shea, Mk" uniqKey="Shea M">MK Shea</name></author><author><name sortKey="Vance Locke, Rm" uniqKey="Vance Locke R">RM Vance Locke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goodpaster, Bh" uniqKey="Goodpaster B">BH Goodpaster</name></author><author><name sortKey="Park, Sw" uniqKey="Park S">SW Park</name></author><author><name sortKey="Harris, Tb" uniqKey="Harris T">TB Harris</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Colorado</li><li>Pennsylvanie</li><li>Tennessee</li></region></list><tree><noCountry><name sortKey="Bray, George A" sort="Bray, George A" uniqKey="Bray G" first="George A." last="Bray">George A. Bray</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Houston, Denise K" sort="Houston, Denise K" uniqKey="Houston D" first="Denise K." last="Houston">Denise K. Houston</name></region><name sortKey="Hergenroeder, Andrea L" sort="Hergenroeder, Andrea L" uniqKey="Hergenroeder A" first="Andrea L." last="Hergenroeder">Andrea L. Hergenroeder</name><name sortKey="Hill, James O" sort="Hill, James O" uniqKey="Hill J" first="James O." last="Hill">James O. Hill</name><name sortKey="Jakicic, John M" sort="Jakicic, John M" uniqKey="Jakicic J" first="John M." last="Jakicic">John M. Jakicic</name><name sortKey="Johnson, Karen C" sort="Johnson, Karen C" uniqKey="Johnson K" first="Karen C." last="Johnson">Karen C. Johnson</name><name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name><name sortKey="Leng, Xiaoyan" sort="Leng, Xiaoyan" uniqKey="Leng X" first="Xiaoyan" last="Leng">Xiaoyan Leng</name><name sortKey="Marsh, Anthony P" sort="Marsh, Anthony P" uniqKey="Marsh A" first="Anthony P." last="Marsh">Anthony P. Marsh</name><name sortKey="Neiberg, Rebecca H" sort="Neiberg, Rebecca H" uniqKey="Neiberg R" first="Rebecca H." last="Neiberg">Rebecca H. Neiberg</name><name sortKey="Rejeski, W Jack" sort="Rejeski, W Jack" uniqKey="Rejeski W" first="W. Jack" last="Rejeski">W. Jack Rejeski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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