PittsburghV1, Ncbi, Checkpoint, bibRecord, 003556

The Effects of Chronic Alcohol Self-Administration on Serotonin-1A Receptor Binding in Nonhuman Primates

Identifieur interne : 003556 ( Ncbi/Checkpoint ); précédent : 003555; suivant : 003557

The Effects of Chronic Alcohol Self-Administration on Serotonin-1A Receptor Binding in Nonhuman Primates

Auteurs : Ansel T. Hillmer ; Dustin W. Wooten ; Dana L. Tudorascu [États-Unis] ; Todd E. Barnhart ; Elizabeth O. Ahlers ; Leslie M. Resch ; Julie A. Larson ; Alexander K. Converse ; Colleen F. Moore ; Mary L. Schneider ; Bradley T. Christian

Source :

Drug and alcohol dependence [ 0376-8716 ] ; 2014.

RBID : PMC:4253864

Descripteurs français

KwdFr :
- Animaux, Autoadministration, Consommation d'alcool (métabolisme), Femelle, Liaison aux protéines (), Macaca mulatta, Mâle, Noyaux du raphé (), Noyaux du raphé (imagerie diagnostique), Noyaux du raphé (métabolisme), Récepteur de la sérotonine de type 5-HT1A (métabolisme), Tomographie par émission de positons (), Éthanol (administration et posologie).
MESH :
- administration et posologie : Éthanol.
- imagerie diagnostique : Noyaux du raphé.
- métabolisme : Consommation d'alcool, Noyaux du raphé, Récepteur de la sérotonine de type 5-HT1A.
- Animaux, Autoadministration, Femelle, Liaison aux protéines, Macaca mulatta, Mâle, Noyaux du raphé, Tomographie par émission de positons.

English descriptors

KwdEn :
- Alcohol Drinking (metabolism), Animals, Ethanol (administration & dosage), Female, Macaca mulatta, Male, Positron-Emission Tomography (methods), Protein Binding (drug effects), Raphe Nuclei (diagnostic imaging), Raphe Nuclei (drug effects), Raphe Nuclei (metabolism), Receptor, Serotonin, 5-HT1A (metabolism), Self Administration.
MESH :
- chemical , administration & dosage : Ethanol.
- diagnostic imaging : Raphe Nuclei.
- drug effects : Protein Binding, Raphe Nuclei.
- metabolism : Alcohol Drinking, Raphe Nuclei, Receptor, Serotonin, 5-HT1A.
- methods : Positron-Emission Tomography.
- Animals, Female, Macaca mulatta, Male, Self Administration.

Abstract

Background

Previous studies have found interrelationships between the serotonin system and alcohol self-administration. The goal of this work was to directly observe in vivo effects of chronic ethanol self-administration on serotonin 5-HT_1A receptor binding with [¹⁸F]mefway PET neuroimaging in rhesus monkeys. Subjects were first imaged alcohol-naïve and again during chronic ethanol self-administration to quantify changes in 5-HT_1A receptor binding.

Methods

Fourteen rhesus monkey subjects (10.7-12.8 years) underwent baseline [¹⁸F]mefway PET scans prior to alcohol exposure. Subjects then drank gradually increasing ethanol doses over four months as an induction period, immediately followed by at least nine months ad libidum ethanol access. A post [¹⁸F]mefway PET scan was acquired during the final three months of ad libidum ethanol self-administration. 5-HT_1A receptor binding was assayed with binding potential (BP_ND) using the cerebellum as a reference region. Changes in 5-HT_1A binding during chronic ethanol self-administration were examined. Relationships of binding metrics with daily ethanol self-administration were also assessed.

Results

Widespread increases in 5-HT_1A binding were observed during chronic ethanol self-administration, independent of the amount of ethanol consumed. A positive correlation between 5-HT_1A binding in the raphe nuclei and average daily ethanol self-administration was also observed, indicating that baseline 5-HT_1A binding in this region predicted drinking levels.

Conclusions

The increase in 5-HT_1A binding levels during chronic ethanol self-administration demonstrates an important modulation of the serotonin system due to chronic alcohol exposure. Furthermore, the correlation between 5-HT_1A binding in the raphe nuclei and daily ethanol self-administration indicates a relationship between the serotonin system and alcohol self-administration.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253864

DOI: 10.1016/j.drugalcdep.2014.08.015
PubMed: 25220896
PubMed Central: 4253864

Affiliations:

Links to Exploration step

PMC:4253864

Le document en format XML

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<affiliation><nlm:aff id="A2">Department of Medical Physics, University of Wisconsin, Madison</nlm:aff>
<wicri:noCountry code="subfield">Madison</wicri:noCountry>
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<affiliation><nlm:aff id="A9">Department of Psychiatry, University of Wisconsin, Madison</nlm:aff>
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<author><name sortKey="Ahlers, Elizabeth O" sort="Ahlers, Elizabeth O" uniqKey="Ahlers E" first="Elizabeth O." last="Ahlers">Elizabeth O. Ahlers</name>
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<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A6">Department of Kinesiology, University of Wisconsin, Madison</nlm:aff>
<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
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<author><name sortKey="Larson, Julie A" sort="Larson, Julie A" uniqKey="Larson J" first="Julie A." last="Larson">Julie A. Larson</name>
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<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A6">Department of Kinesiology, University of Wisconsin, Madison</nlm:aff>
<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
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<author><name sortKey="Converse, Alexander K" sort="Converse, Alexander K" uniqKey="Converse A" first="Alexander K." last="Converse">Alexander K. Converse</name>
<affiliation><nlm:aff id="A1">Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison</nlm:aff>
<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Moore, Colleen F" sort="Moore, Colleen F" uniqKey="Moore C" first="Colleen F." last="Moore">Colleen F. Moore</name>
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<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A8">Department of Psychology, Montana State University</nlm:aff>
<wicri:noCountry code="subfield">Montana State University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Schneider, Mary L" sort="Schneider, Mary L" uniqKey="Schneider M" first="Mary L." last="Schneider">Mary L. Schneider</name>
<affiliation><nlm:aff id="A5">Harlow Center for Biological Psychology, University of Wisconsin, Madison</nlm:aff>
<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A6">Department of Kinesiology, University of Wisconsin, Madison</nlm:aff>
<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A7">Department of Psychology, University of Wisconsin, Madison</nlm:aff>
<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Christian, Bradley T" sort="Christian, Bradley T" uniqKey="Christian B" first="Bradley T." last="Christian">Bradley T. Christian</name>
<affiliation><nlm:aff id="A1">Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison</nlm:aff>
<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Medical Physics, University of Wisconsin, Madison</nlm:aff>
<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A9">Department of Psychiatry, University of Wisconsin, Madison</nlm:aff>
<wicri:noCountry code="subfield">Madison</wicri:noCountry>
</affiliation>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcohol Drinking (metabolism)</term>
<term>Animals</term>
<term>Ethanol (administration & dosage)</term>
<term>Female</term>
<term>Macaca mulatta</term>
<term>Male</term>
<term>Positron-Emission Tomography (methods)</term>
<term>Protein Binding (drug effects)</term>
<term>Raphe Nuclei (diagnostic imaging)</term>
<term>Raphe Nuclei (drug effects)</term>
<term>Raphe Nuclei (metabolism)</term>
<term>Receptor, Serotonin, 5-HT1A (metabolism)</term>
<term>Self Administration</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Autoadministration</term>
<term>Consommation d'alcool (métabolisme)</term>
<term>Femelle</term>
<term>Liaison aux protéines ()</term>
<term>Macaca mulatta</term>
<term>Mâle</term>
<term>Noyaux du raphé ()</term>
<term>Noyaux du raphé (imagerie diagnostique)</term>
<term>Noyaux du raphé (métabolisme)</term>
<term>Récepteur de la sérotonine de type 5-HT1A (métabolisme)</term>
<term>Tomographie par émission de positons ()</term>
<term>Éthanol (administration et posologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Ethanol</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Éthanol</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Raphe Nuclei</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Protein Binding</term>
<term>Raphe Nuclei</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Noyaux du raphé</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alcohol Drinking</term>
<term>Raphe Nuclei</term>
<term>Receptor, Serotonin, 5-HT1A</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Consommation d'alcool</term>
<term>Noyaux du raphé</term>
<term>Récepteur de la sérotonine de type 5-HT1A</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Macaca mulatta</term>
<term>Male</term>
<term>Self Administration</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Autoadministration</term>
<term>Femelle</term>
<term>Liaison aux protéines</term>
<term>Macaca mulatta</term>
<term>Mâle</term>
<term>Noyaux du raphé</term>
<term>Tomographie par émission de positons</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Previous studies have found interrelationships between the serotonin system and alcohol self-administration. The goal of this work was to directly observe <italic>in vivo</italic>
 effects of chronic ethanol self-administration on serotonin 5-HT<sub>1A</sub>
 receptor binding with [<sup>18</sup>
F]mefway PET neuroimaging in rhesus monkeys. Subjects were first imaged alcohol-naïve and again during chronic ethanol self-administration to quantify changes in 5-HT<sub>1A</sub>
 receptor binding.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Fourteen rhesus monkey subjects (10.7-12.8 years) underwent baseline [<sup>18</sup>
F]mefway PET scans prior to alcohol exposure. Subjects then drank gradually increasing ethanol doses over four months as an induction period, immediately followed by at least nine months <italic>ad libidum</italic>
 ethanol access. A post [<sup>18</sup>
F]mefway PET scan was acquired during the final three months of <italic>ad libidum</italic>
 ethanol self-administration. 5-HT<sub>1A</sub>
 receptor binding was assayed with binding potential (<italic>BP<sub>ND</sub>
</italic>
) using the cerebellum as a reference region. Changes in 5-HT<sub>1A</sub>
 binding during chronic ethanol self-administration were examined. Relationships of binding metrics with daily ethanol self-administration were also assessed.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Widespread increases in 5-HT<sub>1A</sub>
 binding were observed during chronic ethanol self-administration, independent of the amount of ethanol consumed. A positive correlation between 5-HT<sub>1A</sub>
 binding in the raphe nuclei and average daily ethanol self-administration was also observed, indicating that baseline 5-HT<sub>1A</sub>
 binding in this region predicted drinking levels.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">The increase in 5-HT<sub>1A</sub>
 binding levels during chronic ethanol self-administration demonstrates an important modulation of the serotonin system due to chronic alcohol exposure. Furthermore, the correlation between 5-HT<sub>1A</sub>
 binding in the raphe nuclei and daily ethanol self-administration indicates a relationship between the serotonin system and alcohol self-administration.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
</region>
<settlement><li>Pittsburgh</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Ahlers, Elizabeth O" sort="Ahlers, Elizabeth O" uniqKey="Ahlers E" first="Elizabeth O." last="Ahlers">Elizabeth O. Ahlers</name>
<name sortKey="Barnhart, Todd E" sort="Barnhart, Todd E" uniqKey="Barnhart T" first="Todd E." last="Barnhart">Todd E. Barnhart</name>
<name sortKey="Christian, Bradley T" sort="Christian, Bradley T" uniqKey="Christian B" first="Bradley T." last="Christian">Bradley T. Christian</name>
<name sortKey="Converse, Alexander K" sort="Converse, Alexander K" uniqKey="Converse A" first="Alexander K." last="Converse">Alexander K. Converse</name>
<name sortKey="Hillmer, Ansel T" sort="Hillmer, Ansel T" uniqKey="Hillmer A" first="Ansel T." last="Hillmer">Ansel T. Hillmer</name>
<name sortKey="Larson, Julie A" sort="Larson, Julie A" uniqKey="Larson J" first="Julie A." last="Larson">Julie A. Larson</name>
<name sortKey="Moore, Colleen F" sort="Moore, Colleen F" uniqKey="Moore C" first="Colleen F." last="Moore">Colleen F. Moore</name>
<name sortKey="Resch, Leslie M" sort="Resch, Leslie M" uniqKey="Resch L" first="Leslie M." last="Resch">Leslie M. Resch</name>
<name sortKey="Schneider, Mary L" sort="Schneider, Mary L" uniqKey="Schneider M" first="Mary L." last="Schneider">Mary L. Schneider</name>
<name sortKey="Wooten, Dustin W" sort="Wooten, Dustin W" uniqKey="Wooten D" first="Dustin W." last="Wooten">Dustin W. Wooten</name>
</noCountry>
<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Tudorascu, Dana L" sort="Tudorascu, Dana L" uniqKey="Tudorascu D" first="Dana L." last="Tudorascu">Dana L. Tudorascu</name>
</region>
<name sortKey="Tudorascu, Dana L" sort="Tudorascu, Dana L" uniqKey="Tudorascu D" first="Dana L." last="Tudorascu">Dana L. Tudorascu</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Ncbi/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003556 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 003556 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Ncbi
   |étape=   Checkpoint
   |type=    RBID
   |clé=     PMC:4253864
   |texte=   The Effects of Chronic Alcohol Self-Administration on Serotonin-1A Receptor Binding in Nonhuman Primates
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i   -Sk "pubmed:25220896" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a PittsburghV1

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

Serveur d'exploration sur Pittsburgh

The Effects of Chronic Alcohol Self-Administration on Serotonin-1A Receptor Binding in Nonhuman Primates

The Effects of Chronic Alcohol Self-Administration on Serotonin-1A Receptor Binding in Nonhuman Primates

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.