PittsburghV1, Ncbi, Checkpoint, bibRecord, 002571

Induced regulatory T cells in inhibitory microenvironments created by cancer

Identifieur interne : 002571 ( Ncbi/Checkpoint ); précédent : 002570; suivant : 002572

Induced regulatory T cells in inhibitory microenvironments created by cancer

Auteurs : Theresa L. Whiteside

Source :

Expert opinion on biological therapy [ 1471-2598 ] ; 2014.

RBID : PMC:4367126

Descripteurs français

KwdFr :
- Humains, Immunothérapie (), Lymphocytes T régulateurs (immunologie), Microenvironnement tumoral (immunologie), Tolérance immunitaire, Tumeurs (), Tumeurs (immunologie), Échappement de la tumeur à la surveillance immunitaire (immunologie).
MESH :
- immunologie : Lymphocytes T régulateurs, Microenvironnement tumoral, Tumeurs, Échappement de la tumeur à la surveillance immunitaire.
- Humains, Immunothérapie, Tolérance immunitaire, Tumeurs.

English descriptors

KwdEn :
- Humans, Immune Tolerance, Immunotherapy (methods), Neoplasms (immunology), Neoplasms (therapy), T-Lymphocytes, Regulatory (immunology), Tumor Escape (immunology), Tumor Microenvironment (immunology).
MESH :
- immunology : Neoplasms, T-Lymphocytes, Regulatory, Tumor Escape, Tumor Microenvironment.
- methods : Immunotherapy.
- therapy : Neoplasms.
- Humans, Immune Tolerance.

Abstract

Introduction

Regulatory T cells (Tregs) accumulating in the peripheral circulation and tumor sites of patients contribute to tumor escape from the host immune system. Tregs encompass subsets of immune cells with distinct phenotypic and functional properties. Whereas natural (n) or thymic-derived (t) Tregs regulate responses to self-antigens, inducible (i) or peripheral (p) Tregs generated and expanded in regulatory microenvironments control immune responses to a broad variety of antigens.

Areas covered

Tregs accumulating in the tumor microenvironment (TME) are contextually regulated. They acquire phenotypic and functional attributes imposed by the inhibitory molecular pathways operating in situ. Several molecular pathways active in human cancer are reviewed. The pathways may differ from one tumor to another, and environmentally induced Tregs may be functionally distinct. Potential therapeutic strategies for selective silencing of iTregs are considered in the light of the newly acquired understanding of their phenotypic and functional diversity.

Expert opinion

Human Tregs accumulating in cancer comprise ‘bad’ subsets, which inhibit antitumor immunity, and ‘good’ anti-inflammatory subsets, which maintain tolerance to self and benefit the host. Future therapeutic strategies targeting Tregs will need to discriminate between these Treg subsets and will need to consider reprogramming strategies instead of Treg elimination. Re-establishment of effective antitumor immune responses in cancer patients without disturbing a normal homeostatic T-cell balance will greatly benefit from insights into inhibitory pathways engaged by human tumors.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367126

DOI: 10.1517/14712598.2014.927432
PubMed: 24934899
PubMed Central: 4367126

Affiliations:

Links to Exploration step

PMC:4367126

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Introduction</title>
<p id="P1">Regulatory T cells (Tregs) accumulating in the peripheral circulation and tumor sites of patients contribute to tumor escape from the host immune system. Tregs encompass subsets of immune cells with distinct phenotypic and functional properties. Whereas natural (n) or thymic-derived (t) Tregs regulate responses to self-antigens, inducible (i) or peripheral (p) Tregs generated and expanded in regulatory microenvironments control immune responses to a broad variety of antigens.</p>
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<sec id="S2"><title>Areas covered</title>
<p id="P2">Tregs accumulating in the tumor microenvironment (TME) are contextually regulated. They acquire phenotypic and functional attributes imposed by the inhibitory molecular pathways operating <italic>in situ.</italic>
 Several molecular pathways active in human cancer are reviewed. The pathways may differ from one tumor to another, and environmentally induced Tregs may be functionally distinct. Potential therapeutic strategies for selective silencing of iTregs are considered in the light of the newly acquired understanding of their phenotypic and functional diversity.</p>
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<sec id="S3"><title>Expert opinion</title>
<p id="P3">Human Tregs accumulating in cancer comprise ‘bad’ subsets, which inhibit antitumor immunity, and ‘good’ anti-inflammatory subsets, which maintain tolerance to self and benefit the host. Future therapeutic strategies targeting Tregs will need to discriminate between these Treg subsets and will need to consider reprogramming strategies instead of Treg elimination. Re-establishment of effective antitumor immune responses in cancer patients without disturbing a normal homeostatic T-cell balance will greatly benefit from insights into inhibitory pathways engaged by human tumors.</p>
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Induced regulatory T cells in inhibitory microenvironments created by cancer

Induced regulatory T cells in inhibitory microenvironments created by cancer

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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