HYPERTENSION AND OBESITY AND THE RISK OF KIDNEY CANCER IN TWO LARGE COHORTS OF US MEN AND WOMEN
Identifieur interne : 001634 ( Ncbi/Checkpoint ); précédent : 001633; suivant : 001635HYPERTENSION AND OBESITY AND THE RISK OF KIDNEY CANCER IN TWO LARGE COHORTS OF US MEN AND WOMEN
Auteurs : Kristen M. Sanfilippo ; Kathleen M. Mctigue [États-Unis] ; Christian J. Fidler [États-Unis] ; James D. Neaton [États-Unis] ; Yuefang Chang [États-Unis] ; Linda F. Fried [États-Unis] ; Simin Liu [États-Unis] ; Lewis H. Kuller [États-Unis]Source :
- Hypertension [ 0194-911X ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Comorbidité, Facteurs de risque, Femelle, Humains, Hypertension artérielle (), Hypertension artérielle (physiopathologie), Hypertension artérielle (épidémiologie), Incidence, Indice de masse corporelle, Modèles de hasards proportionnels, Mâle, Obésité (), Obésité (physiopathologie), Obésité (épidémiologie), Pression sanguine (physiologie), Taux de survie, Tumeurs du rein (mortalité), Tumeurs du rein (épidémiologie), Valeur prédictive des tests, États-Unis d'Amérique, Études de cohortes, Études de suivi, Études longitudinales.
- MESH :
- mortalité : Tumeurs du rein.
- physiologie : Pression sanguine.
- physiopathologie : Hypertension artérielle, Obésité.
- épidémiologie : Hypertension artérielle, Obésité, Tumeurs du rein.
- Adulte, Adulte d'âge moyen, Comorbidité, Facteurs de risque, Femelle, Humains, Hypertension artérielle, Incidence, Indice de masse corporelle, Modèles de hasards proportionnels, Mâle, Obésité, Taux de survie, Valeur prédictive des tests, États-Unis d'Amérique, Études de cohortes, Études de suivi, Études longitudinales.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Adult, Blood Pressure (physiology), Body Mass Index, Cohort Studies, Comorbidity, Female, Follow-Up Studies, Humans, Hypertension (complications), Hypertension (epidemiology), Hypertension (physiopathology), Incidence, Kidney Neoplasms (epidemiology), Kidney Neoplasms (mortality), Longitudinal Studies, Male, Middle Aged, Obesity (complications), Obesity (epidemiology), Obesity (physiopathology), Predictive Value of Tests, Proportional Hazards Models, Risk Factors, Survival Rate, United States.
- MESH :
- geographic : United States.
- complications : Hypertension, Obesity.
- epidemiology : Hypertension, Kidney Neoplasms, Obesity.
- mortality : Kidney Neoplasms.
- physiology : Blood Pressure.
- physiopathology : Hypertension, Obesity.
- Adult, Body Mass Index, Cohort Studies, Comorbidity, Female, Follow-Up Studies, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Proportional Hazards Models, Risk Factors, Survival Rate.
Abstract
Kidney cancer incidence is increasing globally. Reasons for this rise are unclear, but could relate to obesity and hypertension. We analyzed longitudinal relationships between hypertension and obesity and kidney cancer incidence in 156,774 participants of the Women’s Health Initiative (WHI) clinical trials and observational studies over 10.8 years. In addition, we examined the impact of blood pressure (BP) on kidney cancer deaths over 25 years among the 353,340 men screened for the Multiple Risk Factor Intervention Trial (MRFIT). In the WHI, systolic SBP was categorized in 6 groups from <120 to >160 mmHg and body mass index (BMI) was categorized using standard criteria. In age-adjusted analyses, kidney cancer risk increased across SBP categories (p-value for trend <0.0001) and BMI categories (p-value for trend <0.0001). In adjusted Cox proportional hazards models, both SBP levels and BMI were predictors of kidney cancer. In the MRFIT sample, there were 906 deaths after an average of 25 years of follow-up attributed to kidney cancer amongst the 353,340 participants aged 35–57 years at screening. The risk of death from kidney cancer increased in a dose-response fashion with increasing SBP (HR=1.87 for SBP>160 versus <120 mmHg; 95% CI, 1.38–2.53). Risk was increased among cigarette smokers. Further research is needed to determine the pathophysiologic basis of relationships between both higher BP and the risk of kidney cancer, and whether specific drug therapies for hypertension can reduce kidney cancer risk.
Url:
DOI: 10.1161/HYPERTENSIONAHA.113.02953
PubMed: 24637660
PubMed Central: 4098147
Affiliations:
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PMC:4098147Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Kidney cancer incidence is increasing globally. Reasons for this rise are unclear, but could relate to obesity and hypertension. We analyzed longitudinal relationships between hypertension and obesity and kidney cancer incidence in 156,774 participants of the Women’s Health Initiative (WHI) clinical trials and observational studies over 10.8 years. In addition, we examined the impact of blood pressure (BP) on kidney cancer deaths over 25 years among the 353,340 men screened for the Multiple Risk Factor Intervention Trial (MRFIT). In the WHI, systolic SBP was categorized in 6 groups from <120 to >160 mmHg and body mass index (BMI) was categorized using standard criteria. In age-adjusted analyses, kidney cancer risk increased across SBP categories (p-value for trend <0.0001) and BMI categories (p-value for trend <0.0001). In adjusted Cox proportional hazards models, both SBP levels and BMI were predictors of kidney cancer. In the MRFIT sample, there were 906 deaths after an average of 25 years of follow-up attributed to kidney cancer amongst the 353,340 participants aged 35–57 years at screening. The risk of death from kidney cancer increased in a dose-response fashion with increasing SBP (HR=1.87 for SBP>160 versus <120 mmHg; 95% CI, 1.38–2.53). Risk was increased among cigarette smokers. Further research is needed to determine the pathophysiologic basis of relationships between both higher BP and the risk of kidney cancer, and whether specific drug therapies for hypertension can reduce kidney cancer risk.</p>
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<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Mctigue, Kathleen M" sort="Mctigue, Kathleen M" uniqKey="Mctigue K" first="Kathleen M." last="Mctigue">Kathleen M. Mctigue</name>
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<name sortKey="Fried, Linda F" sort="Fried, Linda F" uniqKey="Fried L" first="Linda F." last="Fried">Linda F. Fried</name>
<name sortKey="Fried, Linda F" sort="Fried, Linda F" uniqKey="Fried L" first="Linda F." last="Fried">Linda F. Fried</name>
<name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H." last="Kuller">Lewis H. Kuller</name>
<name sortKey="Liu, Simin" sort="Liu, Simin" uniqKey="Liu S" first="Simin" last="Liu">Simin Liu</name>
<name sortKey="Mctigue, Kathleen M" sort="Mctigue, Kathleen M" uniqKey="Mctigue K" first="Kathleen M." last="Mctigue">Kathleen M. Mctigue</name>
<name sortKey="Neaton, James D" sort="Neaton, James D" uniqKey="Neaton J" first="James D." last="Neaton">James D. Neaton</name>
</country>
</tree>
</affiliations>
</record>
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