Trophic factors in the pathogenesis and therapy for retinal degenerative diseases.
Identifieur interne : 00D613 ( Main/Merge ); précédent : 00D612; suivant : 00D614Trophic factors in the pathogenesis and therapy for retinal degenerative diseases.
Auteurs : Anton M. Kolomeyer [États-Unis] ; Marco A. Zarbin [États-Unis]Source :
- Survey of ophthalmology [ 1879-3304 ]
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Cellules photoréceptrices de vertébré, Protéines et peptides de signalisation intercellulaire, Transduction du signal.
- physiopathologie : Dégénérescence de la rétine.
- Animaux, Lapins, Modèles animaux de maladie humaine, Rats, Souris, Suidae.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Intercellular Signaling Peptides and Proteins.
- physiology : Photoreceptor Cells, Vertebrate, Signal Transduction.
- physiopathology : Retinal Degeneration.
- Animals, Disease Models, Animal, Mice, Rabbits, Rats, Swine.
Abstract
Trophic factors are endogenously secreted proteins that act in an autocrine and/or paracrine fashion to affect vital cellular processes such as proliferation, differentiation, and regeneration, thereby maintaining overall cell homeostasis. In the eye, the major contributors of these molecules are the retinal pigment epithelial (RPE) and Müller cells. The primary paracrine targets of these secreted proteins include the photoreceptors and choriocapillaris. Retinal degenerative diseases such as age-related macular degeneration and retinitis pigmentosa are characterized by aberrant function and/or eventual death of RPE cells, photoreceptors, choriocapillaris, and other retinal cells. We discuss results of in vitro and in vivo animal studies in which candidate trophic factors, either singly or in combination, were used in an attempt to ameliorate photoreceptor and/or retinal degeneration. We also examine current trophic factor therapies as they relate to the treatment of retinal degenerative diseases in clinical studies.
DOI: 10.1016/j.survophthal.2013.09.004
PubMed: 24417953
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Zarbin</name><affiliation wicri:level="2"><nlm:affiliation>The Institute of Ophthalmology and Visual Science, New Jersey Medical School, Rutgers University, Newark, New Jersey. Electronic address: zarbin@njms.rutgers.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>The Institute of Ophthalmology and Visual Science, New Jersey Medical School, Rutgers University, Newark</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2014 Mar-Apr</MedlineDate></PubDate></date><idno type="RBID">pubmed:24417953</idno><idno type="pmid">24417953</idno><idno type="doi">10.1016/j.survophthal.2013.09.004</idno><idno type="wicri:Area/PubMed/Corpus">003918</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003918</idno><idno type="wicri:Area/PubMed/Curation">003892</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003892</idno><idno type="wicri:Area/PubMed/Checkpoint">003892</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003892</idno><idno type="wicri:Area/Ncbi/Merge">000B91</idno><idno type="wicri:Area/Ncbi/Curation">000B91</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B91</idno><idno type="wicri:Area/Main/Merge">00D613</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Trophic factors in the pathogenesis and therapy for retinal degenerative diseases.</title><author><name sortKey="Kolomeyer, Anton M" sort="Kolomeyer, Anton M" uniqKey="Kolomeyer A" first="Anton M" last="Kolomeyer">Anton M. Kolomeyer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Zarbin, Marco A" sort="Zarbin, Marco A" uniqKey="Zarbin M" first="Marco A" last="Zarbin">Marco A. Zarbin</name><affiliation wicri:level="2"><nlm:affiliation>The Institute of Ophthalmology and Visual Science, New Jersey Medical School, Rutgers University, Newark, New Jersey. 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In the eye, the major contributors of these molecules are the retinal pigment epithelial (RPE) and Müller cells. The primary paracrine targets of these secreted proteins include the photoreceptors and choriocapillaris. Retinal degenerative diseases such as age-related macular degeneration and retinitis pigmentosa are characterized by aberrant function and/or eventual death of RPE cells, photoreceptors, choriocapillaris, and other retinal cells. We discuss results of in vitro and in vivo animal studies in which candidate trophic factors, either singly or in combination, were used in an attempt to ameliorate photoreceptor and/or retinal degeneration. We also examine current trophic factor therapies as they relate to the treatment of retinal degenerative diseases in clinical studies.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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