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Right prosubiculum amyloid plaque density correlates with anosognosia in Alzheimer’s disease

Identifieur interne : 00B656 ( Main/Merge ); précédent : 00B655; suivant : 00B657

Right prosubiculum amyloid plaque density correlates with anosognosia in Alzheimer’s disease

Auteurs : G A Marshall [États-Unis] ; D I Kaufer [États-Unis] ; O L Lopez ; G R Rao ; R L Hamilton ; S T Dekosky [États-Unis]

Source :

Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2004-10.

RBID : ISTEX:796FADF533B7FEAEA13E1DE89BB3AF0C3114118D

English descriptors

Abstract

Background: Anosognosia is a common manifestation of Alzheimer’s disease. There is an association between impaired awareness and frontal-executive cognitive deficits. Anosognosia is also correlated with decreased metabolism in the right hemisphere, particularly in frontal lobe regions. Objective: To investigate pathological correlates of anosognosia in Alzheimer’s disease. Design: 41 subjects followed longitudinally in the University of Pittsburgh memory disorders clinic and with necropsy verified Alzheimer’s disease were divided into two groups, based on previous clinical assessment: +Aware (n = 23) and −Aware (n = 18). A subset analysis matching subjects for dementia severity using mini-mental state examination scores was also carried out (13 +Aware; 13 −Aware). Histopathological data from necropsy brain tissue consisted of senile plaque (SP) and neurofibrillary tangle (NFT) counts (regional density) from four different brain regions in the right and left hemispheres: superior and middle frontal gyri (SMF), superior temporal isocortex (ST), the prosubiculum of the hippocampus (PRO), and the entorhinal cortex (EC). Results: SP density was greater in the right PRO region of −Aware subjects (F = 6.54, p = 0.015) than +Aware subjects. Significant differences between SP or NFT density were not observed in any other regions. In the subset analysis matching for dementia severity, SP density was again greater in the right PRO region of −Aware subjects than in the other regions (F = 12.72, p = 0.002). Conclusions: Increased SP density in the right PRO region suggests that selective pathological involvement of this area contributes to awareness deficits in Alzheimer’s disease. The putative role of the PRO in self appraisal may reflect its interconnections with other medial temporal and prefrontal regions.

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https://api.istex.fr/document/796FADF533B7FEAEA13E1DE89BB3AF0C3114118D/fulltext/pdf

DOI: 10.1136/jnnp.2003.030007

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<term>Anterior cingulate cortex</term>
<term>Arch neurol</term>
<term>Aware subjects</term>
<term>Brain regions</term>
<term>Chapel hill</term>
<term>Cholinergic</term>
<term>Clinical data</term>
<term>Clinicopathological correlation studies</term>
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<term>Deficit awareness</term>
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<term>Dementia severity</term>
<term>Different brain regions</term>
<term>Disease subjects</term>
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<term>Entorhinal cortex</term>
<term>Feedback projections</term>
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<term>Future studies</term>
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<term>Hippocampus</term>
<term>Kaufer</term>
<term>Last examination</term>
<term>Medical center</term>
<term>Mmse score</term>
<term>Multiple comparisons</term>
<term>National institute</term>
<term>Neural networks</term>
<term>Neurofibrillary tangle</term>
<term>Neurol</term>
<term>Neurol neurosurg psychiatry</term>
<term>Neuropathological</term>
<term>Neuropathological data</term>
<term>Neuropsychiatry clin neurosci</term>
<term>Other regions</term>
<term>Pathological correlates</term>
<term>Pathological substrates</term>
<term>Plaque</term>
<term>Prosubiculum</term>
<term>Putative role</term>
<term>Right hemisphere</term>
<term>Right prosubiculum region</term>
<term>Senile plaque</term>
<term>Senile plaque counts</term>
<term>Several studies</term>
<term>State examination scores</term>
<term>Subset analysis</term>
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<term>Clinical data</term>
<term>Clinicopathological correlation studies</term>
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<term>Cognitive deficits</term>
<term>Current study</term>
<term>Deficit awareness</term>
<term>Dementia</term>
<term>Dementia severity</term>
<term>Different brain regions</term>
<term>Disease subjects</term>
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<term>Entorhinal cortex</term>
<term>Feedback projections</term>
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<term>Future studies</term>
<term>Hippocampal formation</term>
<term>Hippocampus</term>
<term>Kaufer</term>
<term>Last examination</term>
<term>Medical center</term>
<term>Mmse score</term>
<term>Multiple comparisons</term>
<term>National institute</term>
<term>Neural networks</term>
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<term>Neurol neurosurg psychiatry</term>
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<term>Right prosubiculum region</term>
<term>Senile plaque</term>
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<front><div type="abstract" xml:lang="en">Background: Anosognosia is a common manifestation of Alzheimer’s disease. There is an association between impaired awareness and frontal-executive cognitive deficits. Anosognosia is also correlated with decreased metabolism in the right hemisphere, particularly in frontal lobe regions. Objective: To investigate pathological correlates of anosognosia in Alzheimer’s disease. Design: 41 subjects followed longitudinally in the University of Pittsburgh memory disorders clinic and with necropsy verified Alzheimer’s disease were divided into two groups, based on previous clinical assessment: +Aware (n = 23) and −Aware (n = 18). A subset analysis matching subjects for dementia severity using mini-mental state examination scores was also carried out (13 +Aware; 13 −Aware). Histopathological data from necropsy brain tissue consisted of senile plaque (SP) and neurofibrillary tangle (NFT) counts (regional density) from four different brain regions in the right and left hemispheres: superior and middle frontal gyri (SMF), superior temporal isocortex (ST), the prosubiculum of the hippocampus (PRO), and the entorhinal cortex (EC). Results: SP density was greater in the right PRO region of −Aware subjects (F = 6.54, p = 0.015) than +Aware subjects. Significant differences between SP or NFT density were not observed in any other regions. In the subset analysis matching for dementia severity, SP density was again greater in the right PRO region of −Aware subjects than in the other regions (F = 12.72, p = 0.002). Conclusions: Increased SP density in the right PRO region suggests that selective pathological involvement of this area contributes to awareness deficits in Alzheimer’s disease. The putative role of the PRO in self appraisal may reflect its interconnections with other medial temporal and prefrontal regions.</div>
</front>
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Right prosubiculum amyloid plaque density correlates with anosognosia in Alzheimer’s disease

Right prosubiculum amyloid plaque density correlates with anosognosia in Alzheimer’s disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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