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Lymphocyte subset reconstitution patterns in children with small bowel transplantation induced with steroid‐free rabbit anti‐human thymocyte globulin

Identifieur interne : 00AE54 ( Main/Merge ); précédent : 00AE53; suivant : 00AE55

Lymphocyte subset reconstitution patterns in children with small bowel transplantation induced with steroid‐free rabbit anti‐human thymocyte globulin

Auteurs : Anjan J. Talukdar [États-Unis] ; Chethan Ashokkumar [États-Unis] ; Patrick Wilson [États-Unis] ; Ankit Gupta [États-Unis] ; Qing Sun [États-Unis] ; Linda Boig [États-Unis] ; Kareem Abu-Elmagd [États-Unis] ; George Mazariegos [États-Unis] ; Michael Green [États-Unis] ; Rakesh Sindhi [États-Unis]

Source :

Pediatric Transplantation [ 1397-3142 ] ; 2009-05.

RBID : ISTEX:EE9C375F18CF5FE49ACED3E25B5A23B3892C82D4

English descriptors

KwdEn :
- Cell counts, Enteritis, Graft, Higher counts, Immunosuppression, Inverse relationship, Lymphocyte, Lymphocyte subsets, Opportunistic, Opportunistic infections, Pediatric, Rabbit thymocyte globulin, Ratg, Reconstitution, Rejectors, Sbtx, Sbtx recipients, Second year, Small bowel transplantation, Subset, Tacrolimus, Time period, Time periods, Transplantation, Viral, Viral load, Viral loads.
Teeft :
- Cell counts, Enteritis, Graft, Higher counts, Immunosuppression, Inverse relationship, Lymphocyte, Lymphocyte subsets, Opportunistic, Opportunistic infections, Pediatric, Rabbit thymocyte globulin, Ratg, Reconstitution, Rejectors, Sbtx, Sbtx recipients, Second year, Small bowel transplantation, Subset, Tacrolimus, Time period, Time periods, Transplantation, Viral, Viral load, Viral loads.

Abstract

Abstract: Multiple measurements (n = 212) of lymphocyte subsets in 67 children treated with steroid‐free Tacrolimus, and rabbit anti‐human thymocyte globulin induction demonstrate early reconstitution of T‐cytotoxic and NK cells. Reconstitution of CD4+ cells is complete after the second post‐transplant year. During the period at risk for rejection, NK and T‐cytotoxic cell counts are significantly higher among Rejectors. During periods at increased risk for EBV viral infection, CD4 counts bear a significant inverse relationship to EBV viral load in a subset of at‐risk recipients. Rejection‐prone children also demonstrate significantly higher counts of total lymphocytes, Tc and NK cells prior to SBTx, and may illustrate one basis for enhanced baseline immunocompetence.

Url:

https://api.istex.fr/document/EE9C375F18CF5FE49ACED3E25B5A23B3892C82D4/fulltext/pdf

DOI: 10.1111/j.1399-3046.2008.01010.x

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ISTEX:EE9C375F18CF5FE49ACED3E25B5A23B3892C82D4

Le document en format XML

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<author><name sortKey="Abu Lmagd, Kareem" sort="Abu Lmagd, Kareem" uniqKey="Abu Lmagd K" first="Kareem" last="Abu-Elmagd">Kareem Abu-Elmagd</name>
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<term>Inverse relationship</term>
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<term>Inverse relationship</term>
<term>Lymphocyte</term>
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<front><div type="abstract">Abstract:  Multiple measurements (n = 212) of lymphocyte subsets in 67 children treated with steroid‐free Tacrolimus, and rabbit anti‐human thymocyte globulin induction demonstrate early reconstitution of T‐cytotoxic and NK cells. Reconstitution of CD4+ cells is complete after the second post‐transplant year. During the period at risk for rejection, NK and T‐cytotoxic cell counts are significantly higher among Rejectors. During periods at increased risk for EBV viral infection, CD4 counts bear a significant inverse relationship to EBV viral load in a subset of at‐risk recipients. Rejection‐prone children also demonstrate significantly higher counts of total lymphocytes, Tc and NK cells prior to SBTx, and may illustrate one basis for enhanced baseline immunocompetence.</div>
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Lymphocyte subset reconstitution patterns in children with small bowel transplantation induced with steroid‐free rabbit anti‐human thymocyte globulin

Lymphocyte subset reconstitution patterns in children with small bowel transplantation induced with steroid‐free rabbit anti‐human thymocyte globulin

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English descriptors

Abstract

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