Genome-wide association study of Alzheimer's disease with psychotic symptoms
Identifieur interne : 009778 ( Main/Merge ); précédent : 009777; suivant : 009779Genome-wide association study of Alzheimer's disease with psychotic symptoms
Auteurs : P. Hollingworth [Royaume-Uni] ; R. Sweet [États-Unis] ; R. Sims [Royaume-Uni] ; D. Harold [Royaume-Uni] ; G. Russo [Royaume-Uni] ; R. Abraham [Royaume-Uni] ; A. Stretton [Royaume-Uni] ; N. Jones [Royaume-Uni] ; A. Gerrish [Royaume-Uni] ; J. Chapman [Royaume-Uni] ; D. Ivanov [Royaume-Uni] ; V. Moskvina [Royaume-Uni] ; S. Lovestone [Royaume-Uni] ; P. Priotsi [Royaume-Uni] ; M. Lupton [Royaume-Uni] ; C. Brayne [Royaume-Uni] ; M. Gill [Irlande (pays)] ; B. Lawlor [Irlande (pays)] ; A. Lynch [Irlande (pays)] ; D. Craig [Royaume-Uni] ; B. Mcguinness [Royaume-Uni] ; J. Johnston [Royaume-Uni] ; C. Holmes [Royaume-Uni] ; G. Livingston [Royaume-Uni] ; N. J. Bass [Royaume-Uni] ; H. Gurling [Royaume-Uni] ; A. Mcquillin [Royaume-Uni, États-Unis] ; P. Holmans [Royaume-Uni] ; L. Jones [Royaume-Uni] ; B. Devlin ; L. Klei [États-Unis] ; M. M. Barmada [États-Unis] ; F. Y. Demirci ; S. T. Dekosky [États-Unis] ; O. L. Lopez [États-Unis] ; P. Passmore [Royaume-Uni] ; M. J. Owen [Royaume-Uni] ; M. C. O'Donovan [Royaume-Uni, États-Unis] ; R. Mayeux [États-Unis] ; M. I. Kamboh [États-Unis] ; J. Williams [Royaume-Uni]Source :
- Molecular psychiatry [ 1359-4184 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Génétique.
English descriptors
Abstract
Psychotic symptoms occur in ∼40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. We undertook a combined analysis of three genome-wide association studies (GWASs) to identify loci that (1) increase susceptibility to an AD and subsequent psychotic symptoms; or (2) modify risk of psychotic symptoms in the presence of neurodegeneration caused by AD. In all, 1299 AD cases with psychosis (AD + P), 735 AD cases without psychosis (AD-P) and 5659 controls were drawn from Genetic and Environmental Risk in AD Consortium 1 (GERAD1), the National Institute on Aging Late-Onset Alzheimer's Disease (NIA-LOAD) family study and the University of Pittsburgh Alzheimer Disease Research Center (ADRC) GWASs. Unobserved genotypes were imputed to provide data on > 1.8 million single-nucleotide polymorphisms (SNPs). Analyses in each data set were completed comparing (1) AD + P to AD-P cases, and (2) AD + P cases with controls (GERAD1, ADRC only). Aside from the apolipoprotein E (APOE) locus, the strongest evidence for association was observed in an intergenic region on chromosome 4 (rs753129; 'AD+PvAD-P' P=2.85 × 10-7; 'AD+PvControls' P=1.11×10-4). SNPs upstream of SLC2A9 (rs6834555, P=3.0×107) and within VSNL1 (rs4038131, P=5.9×10-7) showed strongest evidence for association with AD+P when compared with controls. These findings warrant further investigation in larger, appropriately powered samples in which the presence of psychotic symptoms in AD has been well characterized.
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Hollingworth</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Sweet, R" sort="Sweet, R" uniqKey="Sweet R" first="R." last="Sweet">R. Sweet</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>31 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>VISN 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA Pittsburgh Healthcare System</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Sims, R" sort="Sims, R" uniqKey="Sims R" first="R." last="Sims">R. Sims</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Harold, D" sort="Harold, D" uniqKey="Harold D" first="D." last="Harold">D. Harold</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Russo, G" sort="Russo, G" uniqKey="Russo G" first="G." last="Russo">G. Russo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Abraham, R" sort="Abraham, R" uniqKey="Abraham R" first="R." last="Abraham">R. Abraham</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Stretton, A" sort="Stretton, A" uniqKey="Stretton A" first="A." last="Stretton">A. Stretton</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Jones, N" sort="Jones, N" uniqKey="Jones N" first="N." last="Jones">N. Jones</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Gerrish, A" sort="Gerrish, A" uniqKey="Gerrish A" first="A." last="Gerrish">A. Gerrish</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Chapman, J" sort="Chapman, J" uniqKey="Chapman J" first="J." last="Chapman">J. Chapman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Ivanov, D" sort="Ivanov, D" uniqKey="Ivanov D" first="D." last="Ivanov">D. Ivanov</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Moskvina, V" sort="Moskvina, V" uniqKey="Moskvina V" first="V." last="Moskvina">V. Moskvina</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Lovestone, S" sort="Lovestone, S" uniqKey="Lovestone S" first="S." last="Lovestone">S. Lovestone</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Kings College London, Department of Neuroscience, Institute of Psychiatry</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Priotsi, P" sort="Priotsi, P" uniqKey="Priotsi P" first="P." last="Priotsi">P. Priotsi</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Kings College London, Department of Neuroscience, Institute of Psychiatry</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lupton, M" sort="Lupton, M" uniqKey="Lupton M" first="M." last="Lupton">M. Lupton</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Kings College London, Department of Neuroscience, Institute of Psychiatry</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Brayne, C" sort="Brayne, C" uniqKey="Brayne C" first="C." last="Brayne">C. Brayne</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Institute of Public Health, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Gill, M" sort="Gill, M" uniqKey="Gill M" first="M." last="Gill">M. Gill</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Mercer's Institute for Research on Aging, St James Hospital and Trinity College</s1><s2>Dublin</s2><s3>IRL</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Lawlor, B" sort="Lawlor, B" uniqKey="Lawlor B" first="B." last="Lawlor">B. Lawlor</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Mercer's Institute for Research on Aging, St James Hospital and Trinity College</s1><s2>Dublin</s2><s3>IRL</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, A" sort="Lynch, A" uniqKey="Lynch A" first="A." last="Lynch">A. Lynch</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Mercer's Institute for Research on Aging, St James Hospital and Trinity College</s1><s2>Dublin</s2><s3>IRL</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Craig, D" sort="Craig, D" uniqKey="Craig D" first="D." last="Craig">D. Craig</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University of Belfast</s1><s2>Belfast</s2><s3>GBR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Mcguinness, B" sort="Mcguinness, B" uniqKey="Mcguinness B" first="B." last="Mcguinness">B. Mcguinness</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University of Belfast</s1><s2>Belfast</s2><s3>GBR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Johnston, J" sort="Johnston, J" uniqKey="Johnston J" first="J." last="Johnston">J. Johnston</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University of Belfast</s1><s2>Belfast</s2><s3>GBR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Holmes, C" sort="Holmes, C" uniqKey="Holmes C" first="C." last="Holmes">C. Holmes</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Division of Clinical Neurosciences, School of Medicine, University of Southampton</s1><s2>Southampton</s2><s3>GBR</s3><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Livingston, G" sort="Livingston, G" uniqKey="Livingston G" first="G." last="Livingston">G. Livingston</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Bass, N J" sort="Bass, N J" uniqKey="Bass N" first="N. J." last="Bass">N. J. Bass</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Gurling, H" sort="Gurling, H" uniqKey="Gurling H" first="H." last="Gurling">H. Gurling</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Mcquillin, A" sort="Mcquillin, A" uniqKey="Mcquillin A" first="A." last="Mcquillin">A. Mcquillin</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Columbia University, College of Physicians and Surgeons</s1><s2>New York, NY</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion><orgName type="university">Université Columbia</orgName><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Holmans, P" sort="Holmans, P" uniqKey="Holmans P" first="P." last="Holmans">P. Holmans</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Jones, L" sort="Jones, L" uniqKey="Jones L" first="L." last="Jones">L. Jones</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Devlin, B" sort="Devlin, B" uniqKey="Devlin B" first="B." last="Devlin">B. Devlin</name></author><author><name sortKey="Klei, L" sort="Klei, L" uniqKey="Klei L" first="L." last="Klei">L. Klei</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>31 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Barmada, M M" sort="Barmada, M M" uniqKey="Barmada M" first="M. M." last="Barmada">M. M. Barmada</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>31 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Taub Institute and the Department of Neurology, Columbia University, College of Physicians and Surgeons</s1><s2>New York, NY</s2><s3>USA</s3><sZ>32 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion><orgName type="university">Université Columbia</orgName><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Demirci, F Y" sort="Demirci, F Y" uniqKey="Demirci F" first="F. Y." last="Demirci">F. Y. Demirci</name></author><author><name sortKey="Dekosky, S T" sort="Dekosky, S T" uniqKey="Dekosky S" first="S. T." last="Dekosky">S. T. Dekosky</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>University of Virginia School of Medicine</s1><s2>Charlottesville, VA</s2><s3>USA</s3><sZ>34 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University of Virginia School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Lopez, O L" sort="Lopez, O L" uniqKey="Lopez O" first="O. L." last="Lopez">O. L. Lopez</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Passmore, P" sort="Passmore, P" uniqKey="Passmore P" first="P." last="Passmore">P. Passmore</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University of Belfast</s1><s2>Belfast</s2><s3>GBR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M. J." last="Owen">M. J. Owen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M. C." last="O'Donovan">M. C. O'Donovan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>38 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Mayeux, R" sort="Mayeux, R" uniqKey="Mayeux R" first="R." last="Mayeux">R. Mayeux</name><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Taub Institute and the Department of Neurology, Columbia University, College of Physicians and Surgeons</s1><s2>New York, NY</s2><s3>USA</s3><sZ>32 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion><orgName type="university">Université Columbia</orgName><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kamboh, M I" sort="Kamboh, M I" uniqKey="Kamboh M" first="M. I." last="Kamboh">M. I. Kamboh</name><affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>38 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Williams, J" sort="Williams, J" uniqKey="Williams J" first="J." last="Williams">J. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0023329</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 13-0023329 INIST</idno><idno type="RBID">Pascal:13-0023329</idno><idno type="wicri:Area/PascalFrancis/Corpus">002B10</idno><idno type="stanalyst">FRANCIS 13-0023329 INIST</idno><idno type="wicri:Area/PascalFrancis/Corpus">003254</idno><idno type="wicri:Area/PascalFrancis/Curation">001D89</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">003492</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">003492</idno><idno type="wicri:doubleKey">1359-4184:2012:Hollingworth P:genome:wide:association</idno><idno type="wicri:Area/Main/Merge">009778</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genome-wide association study of Alzheimer's disease with psychotic symptoms</title><author><name sortKey="Hollingworth, P" sort="Hollingworth, P" uniqKey="Hollingworth P" first="P." last="Hollingworth">P. Hollingworth</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Sweet, R" sort="Sweet, R" uniqKey="Sweet R" first="R." last="Sweet">R. Sweet</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>31 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>VISN 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA Pittsburgh Healthcare System</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Sims, R" sort="Sims, R" uniqKey="Sims R" first="R." last="Sims">R. Sims</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Harold, D" sort="Harold, D" uniqKey="Harold D" first="D." last="Harold">D. Harold</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Russo, G" sort="Russo, G" uniqKey="Russo G" first="G." last="Russo">G. Russo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Abraham, R" sort="Abraham, R" uniqKey="Abraham R" first="R." last="Abraham">R. Abraham</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Stretton, A" sort="Stretton, A" uniqKey="Stretton A" first="A." last="Stretton">A. Stretton</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Jones, N" sort="Jones, N" uniqKey="Jones N" first="N." last="Jones">N. Jones</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Gerrish, A" sort="Gerrish, A" uniqKey="Gerrish A" first="A." last="Gerrish">A. Gerrish</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Chapman, J" sort="Chapman, J" uniqKey="Chapman J" first="J." last="Chapman">J. Chapman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Ivanov, D" sort="Ivanov, D" uniqKey="Ivanov D" first="D." last="Ivanov">D. Ivanov</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Moskvina, V" sort="Moskvina, V" uniqKey="Moskvina V" first="V." last="Moskvina">V. Moskvina</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Lovestone, S" sort="Lovestone, S" uniqKey="Lovestone S" first="S." last="Lovestone">S. Lovestone</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Kings College London, Department of Neuroscience, Institute of Psychiatry</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Priotsi, P" sort="Priotsi, P" uniqKey="Priotsi P" first="P." last="Priotsi">P. Priotsi</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Kings College London, Department of Neuroscience, Institute of Psychiatry</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lupton, M" sort="Lupton, M" uniqKey="Lupton M" first="M." last="Lupton">M. Lupton</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Kings College London, Department of Neuroscience, Institute of Psychiatry</s1><s2>London</s2><s3>GBR</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Brayne, C" sort="Brayne, C" uniqKey="Brayne C" first="C." last="Brayne">C. Brayne</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Institute of Public Health, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Gill, M" sort="Gill, M" uniqKey="Gill M" first="M." last="Gill">M. Gill</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Mercer's Institute for Research on Aging, St James Hospital and Trinity College</s1><s2>Dublin</s2><s3>IRL</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Lawlor, B" sort="Lawlor, B" uniqKey="Lawlor B" first="B." last="Lawlor">B. Lawlor</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Mercer's Institute for Research on Aging, St James Hospital and Trinity College</s1><s2>Dublin</s2><s3>IRL</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, A" sort="Lynch, A" uniqKey="Lynch A" first="A." last="Lynch">A. Lynch</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Mercer's Institute for Research on Aging, St James Hospital and Trinity College</s1><s2>Dublin</s2><s3>IRL</s3><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Craig, D" sort="Craig, D" uniqKey="Craig D" first="D." last="Craig">D. Craig</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University of Belfast</s1><s2>Belfast</s2><s3>GBR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Mcguinness, B" sort="Mcguinness, B" uniqKey="Mcguinness B" first="B." last="Mcguinness">B. Mcguinness</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University of Belfast</s1><s2>Belfast</s2><s3>GBR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Johnston, J" sort="Johnston, J" uniqKey="Johnston J" first="J." last="Johnston">J. Johnston</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University of Belfast</s1><s2>Belfast</s2><s3>GBR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Holmes, C" sort="Holmes, C" uniqKey="Holmes C" first="C." last="Holmes">C. Holmes</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Division of Clinical Neurosciences, School of Medicine, University of Southampton</s1><s2>Southampton</s2><s3>GBR</s3><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Livingston, G" sort="Livingston, G" uniqKey="Livingston G" first="G." last="Livingston">G. Livingston</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Bass, N J" sort="Bass, N J" uniqKey="Bass N" first="N. J." last="Bass">N. J. Bass</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Gurling, H" sort="Gurling, H" uniqKey="Gurling H" first="H." last="Gurling">H. Gurling</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Mcquillin, A" sort="Mcquillin, A" uniqKey="Mcquillin A" first="A." last="Mcquillin">A. Mcquillin</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Columbia University, College of Physicians and Surgeons</s1><s2>New York, NY</s2><s3>USA</s3><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion><orgName type="university">Université Columbia</orgName><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Holmans, P" sort="Holmans, P" uniqKey="Holmans P" first="P." last="Holmans">P. Holmans</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Jones, L" sort="Jones, L" uniqKey="Jones L" first="L." last="Jones">L. Jones</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Devlin, B" sort="Devlin, B" uniqKey="Devlin B" first="B." last="Devlin">B. Devlin</name></author><author><name sortKey="Klei, L" sort="Klei, L" uniqKey="Klei L" first="L." last="Klei">L. Klei</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>31 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Barmada, M M" sort="Barmada, M M" uniqKey="Barmada M" first="M. M." last="Barmada">M. M. Barmada</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>31 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Taub Institute and the Department of Neurology, Columbia University, College of Physicians and Surgeons</s1><s2>New York, NY</s2><s3>USA</s3><sZ>32 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion><orgName type="university">Université Columbia</orgName><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Demirci, F Y" sort="Demirci, F Y" uniqKey="Demirci F" first="F. Y." last="Demirci">F. Y. Demirci</name></author><author><name sortKey="Dekosky, S T" sort="Dekosky, S T" uniqKey="Dekosky S" first="S. T." last="Dekosky">S. T. Dekosky</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>University of Virginia School of Medicine</s1><s2>Charlottesville, VA</s2><s3>USA</s3><sZ>34 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University of Virginia School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Lopez, O L" sort="Lopez, O L" uniqKey="Lopez O" first="O. L." last="Lopez">O. L. Lopez</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh, School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>34 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Passmore, P" sort="Passmore, P" uniqKey="Passmore P" first="P." last="Passmore">P. Passmore</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University of Belfast</s1><s2>Belfast</s2><s3>GBR</s3><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M. J." last="Owen">M. J. Owen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M. C." last="O'Donovan">M. C. O'Donovan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>38 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Mayeux, R" sort="Mayeux, R" uniqKey="Mayeux R" first="R." last="Mayeux">R. Mayeux</name><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Taub Institute and the Department of Neurology, Columbia University, College of Physicians and Surgeons</s1><s2>New York, NY</s2><s3>USA</s3><sZ>32 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion><orgName type="university">Université Columbia</orgName><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kamboh, M I" sort="Kamboh, M I" uniqKey="Kamboh M" first="M. I." last="Kamboh">M. I. Kamboh</name><affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>38 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Williams, J" sort="Williams, J" uniqKey="Williams J" first="J." last="Williams">J. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>37 aut.</sZ><sZ>38 aut.</sZ><sZ>41 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Molecular psychiatry</title><title level="j" type="abbreviated">Mol. psychiatry</title><idno type="ISSN">1359-4184</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Molecular psychiatry</title><title level="j" type="abbreviated">Mol. psychiatry</title><idno type="ISSN">1359-4184</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Behavioral disorder</term><term>Genetics</term><term>Psychosis</term><term>Symptomatology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Démence d'Alzheimer</term><term>Psychose</term><term>Symptomatologie</term><term>Trouble du comportement</term><term>Génétique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Psychotic symptoms occur in ∼40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. We undertook a combined analysis of three genome-wide association studies (GWASs) to identify loci that (1) increase susceptibility to an AD and subsequent psychotic symptoms; or (2) modify risk of psychotic symptoms in the presence of neurodegeneration caused by AD. In all, 1299 AD cases with psychosis (AD + P), 735 AD cases without psychosis (AD-P) and 5659 controls were drawn from Genetic and Environmental Risk in AD Consortium 1 (GERAD1), the National Institute on Aging Late-Onset Alzheimer's Disease (NIA-LOAD) family study and the University of Pittsburgh Alzheimer Disease Research Center (ADRC) GWASs. Unobserved genotypes were imputed to provide data on > 1.8 million single-nucleotide polymorphisms (SNPs). Analyses in each data set were completed comparing (1) AD + P to AD-P cases, and (2) AD + P cases with controls (GERAD1, ADRC only). Aside from the apolipoprotein E (APOE) locus, the strongest evidence for association was observed in an intergenic region on chromosome 4 (rs753129; 'AD+PvAD-P' P=2.85 × 10<sup>-7</sup>; 'AD+PvControls' P=1.11×10<sup>-4</sup>). SNPs upstream of SLC2A9 (rs6834555, P=3.0×10<sup>7</sup>) and within VSNL1 (rs4038131, P=5.9×10<sup>-7</sup>) showed strongest evidence for association with AD+P when compared with controls. These findings warrant further investigation in larger, appropriately powered samples in which the presence of psychotic symptoms in AD has been well characterized.</div></front></TEI><affiliations><list><country><li>Irlande (pays)</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Grand Londres</li><li>Pennsylvanie</li><li>État de New York</li></region><settlement><li>Cambridge</li><li>Londres</li><li>New York</li><li>Pittsburgh</li></settlement><orgName><li>University College de Londres</li><li>Université Columbia</li><li>Université de Cambridge</li><li>Université de Pittsburgh</li></orgName></list><tree><noCountry><name sortKey="Demirci, F Y" sort="Demirci, F Y" uniqKey="Demirci F" first="F. Y." last="Demirci">F. Y. Demirci</name><name sortKey="Devlin, B" sort="Devlin, B" uniqKey="Devlin B" first="B." last="Devlin">B. Devlin</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Hollingworth, P" sort="Hollingworth, P" uniqKey="Hollingworth P" first="P." last="Hollingworth">P. Hollingworth</name></noRegion><name sortKey="Abraham, R" sort="Abraham, R" uniqKey="Abraham R" first="R." last="Abraham">R. Abraham</name><name sortKey="Bass, N J" sort="Bass, N J" uniqKey="Bass N" first="N. J." last="Bass">N. J. Bass</name><name sortKey="Brayne, C" sort="Brayne, C" uniqKey="Brayne C" first="C." last="Brayne">C. Brayne</name><name sortKey="Chapman, J" sort="Chapman, J" uniqKey="Chapman J" first="J." last="Chapman">J. Chapman</name><name sortKey="Craig, D" sort="Craig, D" uniqKey="Craig D" first="D." last="Craig">D. Craig</name><name sortKey="Gerrish, A" sort="Gerrish, A" uniqKey="Gerrish A" first="A." last="Gerrish">A. Gerrish</name><name sortKey="Gurling, H" sort="Gurling, H" uniqKey="Gurling H" first="H." last="Gurling">H. Gurling</name><name sortKey="Harold, D" sort="Harold, D" uniqKey="Harold D" first="D." last="Harold">D. Harold</name><name sortKey="Holmans, P" sort="Holmans, P" uniqKey="Holmans P" first="P." last="Holmans">P. Holmans</name><name sortKey="Holmes, C" sort="Holmes, C" uniqKey="Holmes C" first="C." last="Holmes">C. Holmes</name><name sortKey="Ivanov, D" sort="Ivanov, D" uniqKey="Ivanov D" first="D." last="Ivanov">D. Ivanov</name><name sortKey="Johnston, J" sort="Johnston, J" uniqKey="Johnston J" first="J." last="Johnston">J. Johnston</name><name sortKey="Jones, L" sort="Jones, L" uniqKey="Jones L" first="L." last="Jones">L. Jones</name><name sortKey="Jones, N" sort="Jones, N" uniqKey="Jones N" first="N." last="Jones">N. Jones</name><name sortKey="Livingston, G" sort="Livingston, G" uniqKey="Livingston G" first="G." last="Livingston">G. Livingston</name><name sortKey="Lovestone, S" sort="Lovestone, S" uniqKey="Lovestone S" first="S." last="Lovestone">S. Lovestone</name><name sortKey="Lupton, M" sort="Lupton, M" uniqKey="Lupton M" first="M." last="Lupton">M. Lupton</name><name sortKey="Mcguinness, B" sort="Mcguinness, B" uniqKey="Mcguinness B" first="B." last="Mcguinness">B. Mcguinness</name><name sortKey="Mcquillin, A" sort="Mcquillin, A" uniqKey="Mcquillin A" first="A." last="Mcquillin">A. Mcquillin</name><name sortKey="Moskvina, V" sort="Moskvina, V" uniqKey="Moskvina V" first="V." last="Moskvina">V. Moskvina</name><name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M. C." last="O'Donovan">M. C. O'Donovan</name><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M. J." last="Owen">M. J. Owen</name><name sortKey="Passmore, P" sort="Passmore, P" uniqKey="Passmore P" first="P." last="Passmore">P. Passmore</name><name sortKey="Priotsi, P" sort="Priotsi, P" uniqKey="Priotsi P" first="P." last="Priotsi">P. Priotsi</name><name sortKey="Russo, G" sort="Russo, G" uniqKey="Russo G" first="G." last="Russo">G. Russo</name><name sortKey="Sims, R" sort="Sims, R" uniqKey="Sims R" first="R." last="Sims">R. Sims</name><name sortKey="Stretton, A" sort="Stretton, A" uniqKey="Stretton A" first="A." last="Stretton">A. Stretton</name><name sortKey="Williams, J" sort="Williams, J" uniqKey="Williams J" first="J." last="Williams">J. Williams</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Sweet, R" sort="Sweet, R" uniqKey="Sweet R" first="R." last="Sweet">R. Sweet</name></region><name sortKey="Barmada, M M" sort="Barmada, M M" uniqKey="Barmada M" first="M. M." last="Barmada">M. M. Barmada</name><name sortKey="Barmada, M M" sort="Barmada, M M" uniqKey="Barmada M" first="M. M." last="Barmada">M. M. Barmada</name><name sortKey="Dekosky, S T" sort="Dekosky, S T" uniqKey="Dekosky S" first="S. T." last="Dekosky">S. T. Dekosky</name><name sortKey="Dekosky, S T" sort="Dekosky, S T" uniqKey="Dekosky S" first="S. T." last="Dekosky">S. T. Dekosky</name><name sortKey="Kamboh, M I" sort="Kamboh, M I" uniqKey="Kamboh M" first="M. I." last="Kamboh">M. I. Kamboh</name><name sortKey="Klei, L" sort="Klei, L" uniqKey="Klei L" first="L." last="Klei">L. Klei</name><name sortKey="Lopez, O L" sort="Lopez, O L" uniqKey="Lopez O" first="O. L." last="Lopez">O. L. Lopez</name><name sortKey="Mayeux, R" sort="Mayeux, R" uniqKey="Mayeux R" first="R." last="Mayeux">R. Mayeux</name><name sortKey="Mcquillin, A" sort="Mcquillin, A" uniqKey="Mcquillin A" first="A." last="Mcquillin">A. Mcquillin</name><name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M. C." last="O'Donovan">M. C. O'Donovan</name><name sortKey="Sweet, R" sort="Sweet, R" uniqKey="Sweet R" first="R." last="Sweet">R. Sweet</name><name sortKey="Sweet, R" sort="Sweet, R" uniqKey="Sweet R" first="R." last="Sweet">R. Sweet</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Gill, M" sort="Gill, M" uniqKey="Gill M" first="M." last="Gill">M. Gill</name></noRegion><name sortKey="Lawlor, B" sort="Lawlor, B" uniqKey="Lawlor B" first="B." last="Lawlor">B. Lawlor</name><name sortKey="Lynch, A" sort="Lynch, A" uniqKey="Lynch A" first="A." last="Lynch">A. Lynch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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