PittsburghV1, Main, Merge, bibRecord, 008169

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

Identifieur interne : 008169 ( Main/Merge ); précédent : 008168; suivant : 008170

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

Auteurs : La. Birder [États-Unis] ; M. Ruggieri [États-Unis] ; M. Takeda [Japon] ; G. Van Koeveringe [Pays-Bas] ; S. Veltkamp [Pays-Bas] ; C. Korstanje [Pays-Bas] ; B. Parsons [Royaume-Uni] ; Ch. Fry [Royaume-Uni]

Source :

Neurourology and Urodynamics [ 0733-2467 ] ; 2012-03.

RBID : ISTEX:D95825FFD07465ABEA911FC4A0D7D2DC626A85E0

English descriptors

Abstract

The urothelium is a multifunctional tissue that not only acts as a barrier between the vesical contents of the lower urinary tract and the underlying tissues but also acts as a sensory organ by transducing physical and chemical stresses to the attendant afferent nervous system and underlying smooth muscle. This review will consider the nature of the stresses that the urothelium can transduce; the transmitters that mediate the transduction process; and how lower urinary pathologies, including overactive bladder syndrome, painful bladder syndrome and bacterial infections, are associated with alterations to this sensory system. In particular, the role of muscarinic receptors and the TRPV channels system will be discussed in this context. The urothelium also influences the contractile state of detrusor smooth muscle, both through modifying its contractility and the extent of spontaneous activity; potential pathways are discussed. The potential role that the urothelium may play in bladder underactivity is introduced, as well as potential biomarkers for the condition that may cross the urothelium to the urine. Finally, consideration is given to vesical administration of therapeutic agents that influence urinary tract function and how the properties of the urothelium may determine the effectiveness of this mode of delivery. Neurourol. Urodynam. 31:293–299, 2012. © 2012 Wiley Periodicals, Inc.

Url:

https://api.istex.fr/document/D95825FFD07465ABEA911FC4A0D7D2DC626A85E0/fulltext/pdf

DOI: 10.1002/nau.22195

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 003379
to stream Istex, to step Curation: 003379
to stream Istex, to step Checkpoint: 001644

Links to Exploration step

ISTEX:D95825FFD07465ABEA911FC4A0D7D2DC626A85E0

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011</title>
<author><name sortKey="Birder, La" sort="Birder, La" uniqKey="Birder L" first="La." last="Birder">La. Birder</name>
</author>
<author><name sortKey="Ruggieri, M" sort="Ruggieri, M" uniqKey="Ruggieri M" first="M." last="Ruggieri">M. Ruggieri</name>
</author>
<author><name sortKey="Takeda, M" sort="Takeda, M" uniqKey="Takeda M" first="M." last="Takeda">M. Takeda</name>
</author>
<author><name sortKey="Van Koeveringe, G" sort="Van Koeveringe, G" uniqKey="Van Koeveringe G" first="G." last="Van Koeveringe">G. Van Koeveringe</name>
</author>
<author><name sortKey="Veltkamp, S" sort="Veltkamp, S" uniqKey="Veltkamp S" first="S." last="Veltkamp">S. Veltkamp</name>
</author>
<author><name sortKey="Korstanje, C" sort="Korstanje, C" uniqKey="Korstanje C" first="C." last="Korstanje">C. Korstanje</name>
</author>
<author><name sortKey="Parsons, B" sort="Parsons, B" uniqKey="Parsons B" first="B." last="Parsons">B. Parsons</name>
</author>
<author><name sortKey="Fry, Ch" sort="Fry, Ch" uniqKey="Fry C" first="Ch." last="Fry">Ch. Fry</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D95825FFD07465ABEA911FC4A0D7D2DC626A85E0</idno>
<date when="2012" year="2012">2012</date>
<idno type="doi">10.1002/nau.22195</idno>
<idno type="url">https://api.istex.fr/document/D95825FFD07465ABEA911FC4A0D7D2DC626A85E0/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">003379</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003379</idno>
<idno type="wicri:Area/Istex/Curation">003379</idno>
<idno type="wicri:Area/Istex/Checkpoint">001644</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001644</idno>
<idno type="wicri:doubleKey">0733-2467:2012:Birder L:how:does:the</idno>
<idno type="wicri:Area/Main/Merge">008169</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011<ref type="note" target="#fn1"></ref>
<ref type="note" target="#fn2"></ref>
</title>
<author><name sortKey="Birder, La" sort="Birder, La" uniqKey="Birder L" first="La." last="Birder">La. Birder</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country>
</affiliation>
<affiliation wicri:level="4"><orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruggieri, M" sort="Ruggieri, M" uniqKey="Ruggieri M" first="M." last="Ruggieri">M. Ruggieri</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Urology, Temple University School of Medicine, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Takeda, M" sort="Takeda, M" uniqKey="Takeda M" first="M." last="Takeda">M. Takeda</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Urology, University of Yamanashi, Yamanashi</wicri:regionArea>
<wicri:noRegion>Yamanashi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Koeveringe, G" sort="Van Koeveringe, G" uniqKey="Van Koeveringe G" first="G." last="Van Koeveringe">G. Van Koeveringe</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Urology, Maastricht University Medical Centre, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Veltkamp, S" sort="Veltkamp, S" uniqKey="Veltkamp S" first="S." last="Veltkamp">S. Veltkamp</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Astellas Pharma Europe, Leiderdorp</wicri:regionArea>
<wicri:noRegion>Leiderdorp</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Korstanje, C" sort="Korstanje, C" uniqKey="Korstanje C" first="C." last="Korstanje">C. Korstanje</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Astellas Pharma Europe, Leiderdorp</wicri:regionArea>
<wicri:noRegion>Leiderdorp</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parsons, B" sort="Parsons, B" uniqKey="Parsons B" first="B." last="Parsons">B. Parsons</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Bristol Urological Institute, Southmead Hospital, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fry, Ch" sort="Fry, Ch" uniqKey="Fry C" first="Ch." last="Fry">Ch. Fry</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Clinical Medicine, University of Surrey, Guildford Surrey</wicri:regionArea>
<wicri:noRegion>Guildford Surrey</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Neurourology and Urodynamics</title>
<title level="j" type="alt">NEUROUROLOGY AND URODYNAMICS</title>
<idno type="ISSN">0733-2467</idno>
<idno type="eISSN">1520-6777</idno>
<imprint><biblScope unit="vol">31</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="293">293</biblScope>
<biblScope unit="page" to="299">299</biblScope>
<biblScope unit="page-count">7</biblScope>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2012-03">2012-03</date>
</imprint>
<idno type="ISSN">0733-2467</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0733-2467</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Afferent</term>
<term>Agonist</term>
<term>Biol chem</term>
<term>Birder</term>
<term>Bladder</term>
<term>Bladder contractility</term>
<term>Bladder dysfunction</term>
<term>Bladder epithelial cells</term>
<term>Bladder function</term>
<term>Bladder mucosa</term>
<term>Bladder outlet obstruction</term>
<term>Bladder urothelium</term>
<term>Bladder wall</term>
<term>Contractile</term>
<term>Contractile response</term>
<term>Contractility</term>
<term>Cystitis</term>
<term>Detrusor</term>
<term>Detrusor overactivity</term>
<term>Dysfunction</term>
<term>Epithelial</term>
<term>Epithelium</term>
<term>Human bladder</term>
<term>Human bladder urothelium</term>
<term>Inhibitory effect</term>
<term>Interstitial</term>
<term>Interstitial cells</term>
<term>Interstitial cystitis</term>
<term>Intravesical</term>
<term>Mechanosensitive channels</term>
<term>Mucosa</term>
<term>Mucosal</term>
<term>Muscarinic</term>
<term>Muscarinic receptors</term>
<term>Neurourol urodyn</term>
<term>Neurourology</term>
<term>Nitric oxide</term>
<term>Overactive</term>
<term>Overactive bladder</term>
<term>Overactive bladder syndrome</term>
<term>Overactivity</term>
<term>Oxidative stress</term>
<term>Painful bladder syndrome</term>
<term>Pathway</term>
<term>Pharmacol</term>
<term>Physiol</term>
<term>Purinergic</term>
<term>Purinergic receptor expression</term>
<term>Receptor</term>
<term>Smooth muscle</term>
<term>Spinal</term>
<term>Spinal cord injury</term>
<term>Spontaneous activity</term>
<term>Spontaneous contractile activity</term>
<term>Suburothelial</term>
<term>Suburothelium</term>
<term>Transient receptor</term>
<term>Trpv4</term>
<term>Urethral</term>
<term>Urethral pressure</term>
<term>Urinary</term>
<term>Urinary bladder</term>
<term>Urine</term>
<term>Urodynamics</term>
<term>Urol</term>
<term>Urology</term>
<term>Urothelial</term>
<term>Urothelial function</term>
<term>Urothelial layer</term>
<term>Urothelial structure</term>
<term>Urothelium</term>
<term>Voiding</term>
<term>Wave propagation</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Afferent</term>
<term>Agonist</term>
<term>Biol chem</term>
<term>Birder</term>
<term>Bladder</term>
<term>Bladder contractility</term>
<term>Bladder dysfunction</term>
<term>Bladder epithelial cells</term>
<term>Bladder function</term>
<term>Bladder mucosa</term>
<term>Bladder outlet obstruction</term>
<term>Bladder urothelium</term>
<term>Bladder wall</term>
<term>Contractile</term>
<term>Contractile response</term>
<term>Contractility</term>
<term>Cystitis</term>
<term>Detrusor</term>
<term>Detrusor overactivity</term>
<term>Dysfunction</term>
<term>Epithelial</term>
<term>Epithelium</term>
<term>Human bladder</term>
<term>Human bladder urothelium</term>
<term>Inhibitory effect</term>
<term>Interstitial</term>
<term>Interstitial cells</term>
<term>Interstitial cystitis</term>
<term>Intravesical</term>
<term>Mechanosensitive channels</term>
<term>Mucosa</term>
<term>Mucosal</term>
<term>Muscarinic</term>
<term>Muscarinic receptors</term>
<term>Neurourol urodyn</term>
<term>Neurourology</term>
<term>Nitric oxide</term>
<term>Overactive</term>
<term>Overactive bladder</term>
<term>Overactive bladder syndrome</term>
<term>Overactivity</term>
<term>Oxidative stress</term>
<term>Painful bladder syndrome</term>
<term>Pathway</term>
<term>Pharmacol</term>
<term>Physiol</term>
<term>Purinergic</term>
<term>Purinergic receptor expression</term>
<term>Receptor</term>
<term>Smooth muscle</term>
<term>Spinal</term>
<term>Spinal cord injury</term>
<term>Spontaneous activity</term>
<term>Spontaneous contractile activity</term>
<term>Suburothelial</term>
<term>Suburothelium</term>
<term>Transient receptor</term>
<term>Trpv4</term>
<term>Urethral</term>
<term>Urethral pressure</term>
<term>Urinary</term>
<term>Urinary bladder</term>
<term>Urine</term>
<term>Urodynamics</term>
<term>Urol</term>
<term>Urology</term>
<term>Urothelial</term>
<term>Urothelial function</term>
<term>Urothelial layer</term>
<term>Urothelial structure</term>
<term>Urothelium</term>
<term>Voiding</term>
<term>Wave propagation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The urothelium is a multifunctional tissue that not only acts as a barrier between the vesical contents of the lower urinary tract and the underlying tissues but also acts as a sensory organ by transducing physical and chemical stresses to the attendant afferent nervous system and underlying smooth muscle. This review will consider the nature of the stresses that the urothelium can transduce; the transmitters that mediate the transduction process; and how lower urinary pathologies, including overactive bladder syndrome, painful bladder syndrome and bacterial infections, are associated with alterations to this sensory system. In particular, the role of muscarinic receptors and the TRPV channels system will be discussed in this context. The urothelium also influences the contractile state of detrusor smooth muscle, both through modifying its contractility and the extent of spontaneous activity; potential pathways are discussed. The potential role that the urothelium may play in bladder underactivity is introduced, as well as potential biomarkers for the condition that may cross the urothelium to the urine. Finally, consideration is given to vesical administration of therapeutic agents that influence urinary tract function and how the properties of the urothelium may determine the effectiveness of this mode of delivery. Neurourol. Urodynam. 31:293–299, 2012. © 2012 Wiley Periodicals, Inc.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008169 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 008169 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     ISTEX:D95825FFD07465ABEA911FC4A0D7D2DC626A85E0
   |texte=   How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011
}}

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur Pittsburgh

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri