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25-Hydroxyvitamin D in Obese Youth Across the Spectrum of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes

Identifieur interne : 007B07 ( Main/Merge ); précédent : 007B06; suivant : 007B08

25-Hydroxyvitamin D in Obese Youth Across the Spectrum of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes

Auteurs : Javier De Las Heras [Espagne, États-Unis] ; Kumaravel Rajakumar [États-Unis] ; Sojung Lee [États-Unis] ; Fida Bacha [États-Unis] ; Michael F. Holick [États-Unis] ; Silva A. Arslanian [États-Unis]

Source :

Diabetes care [ 0149-5992 ] ; 2013.

RBID : Pascal:13-0233515

Descripteurs français

Pascal (Inist)
- Obésité, Cholécalciférol(25-hydroxy), Adolescent, Diabète de type 2, Glucose, Tolérance, Normal, Endocrinologie, Maladie métabolique, Nutrition, Etat nutritionnel.
Wicri :
- topic : Glucose, Nutrition.

English descriptors

KwdEn :
- Adolescent, Cholecalciferol(25-hydroxy), Endocrinology, Glucose, Metabolic diseases, Normal, Nutrition, Nutritional status, Obesity, Tolerance, Type 2 diabetes.

Abstract

OBJECTIVE-To 1) determine if plasma 25-hydroxyvitamin D (25[OH]D) concentrations differ among obese youth with normal glucose tolerance (NGT) versus prediabetes versus type 2 diabetes and 2) assess the relationships between 25(OH)D and in vivo insulin sensitivity and β-cell function in this cohort. RESEARCH DESIGN AND METHODS-Plasma 25(OH)D concentrations were examined in banked specimens in 9- to 20-year-old obese youth (n = 175; male 42.3%, black 46.3%) (NGT, n = 105; impaired glucose tolerance [IGT], n = 43; type 2 diabetes, n = 27) who had in vivo insulin sensitivity and secretion measured by hyperinsulinemic-euglycemic and hyperglycemic clamp techniques and had an assessment of total body composition and abdominal adiposity. RESULTS-The mean age and BMI of the subjects were 14.3 ± 2.1 years and 35.7 ± 5.6 kg/m², respectively. BMI, plasma 25(OH)D, and the proportion of vitamin D-deficient and -insufficient children did not differ across the three groups. Furthermore, there was no association between 25(OH)D and in vivo insulin sensitivity or β-cell function relative to insulin sensitivity (disposition index) in all groups combined or in each group separately. CONCLUSIONS-Our data in obese youth show 1) no differences in plasma 25(OH)D concentrations across the glucose tolerance groups and 2) no relationship between 25(OH)D and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in any of the groups. It remains uncertain if enhancement of the vitamin D status could improve pathophysiological mechanisms of prediabetes and type 2 diabetes in obese youth.

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Pascal:13-0233515

Le document en format XML

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<series><title level="j" type="main">Diabetes care</title>
<title level="j" type="abbreviated">Diabetes care</title>
<idno type="ISSN">0149-5992</idno>
<imprint><date when="2013">2013</date>
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<seriesStmt><title level="j" type="main">Diabetes care</title>
<title level="j" type="abbreviated">Diabetes care</title>
<idno type="ISSN">0149-5992</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Cholecalciferol(25-hydroxy)</term>
<term>Endocrinology</term>
<term>Glucose</term>
<term>Metabolic diseases</term>
<term>Normal</term>
<term>Nutrition</term>
<term>Nutritional status</term>
<term>Obesity</term>
<term>Tolerance</term>
<term>Type 2 diabetes</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Obésité</term>
<term>Cholécalciférol(25-hydroxy)</term>
<term>Adolescent</term>
<term>Diabète de type 2</term>
<term>Glucose</term>
<term>Tolérance</term>
<term>Normal</term>
<term>Endocrinologie</term>
<term>Maladie métabolique</term>
<term>Nutrition</term>
<term>Etat nutritionnel</term>
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<front><div type="abstract" xml:lang="en">OBJECTIVE-To 1) determine if plasma 25-hydroxyvitamin D (25[OH]D) concentrations differ among obese youth with normal glucose tolerance (NGT) versus prediabetes versus type 2 diabetes and 2) assess the relationships between 25(OH)D and in vivo insulin sensitivity and β-cell function in this cohort. RESEARCH DESIGN AND METHODS-Plasma 25(OH)D concentrations were examined in banked specimens in 9- to 20-year-old obese youth (n = 175; male 42.3%, black 46.3%) (NGT, n = 105; impaired glucose tolerance [IGT], n = 43; type 2 diabetes, n = 27) who had in vivo insulin sensitivity and secretion measured by hyperinsulinemic-euglycemic and hyperglycemic clamp techniques and had an assessment of total body composition and abdominal adiposity. RESULTS-The mean age and BMI of the subjects were 14.3 ± 2.1 years and 35.7 ± 5.6 kg/m<sup>2</sup>
, respectively. BMI, plasma 25(OH)D, and the proportion of vitamin D-deficient and -insufficient children did not differ across the three groups. Furthermore, there was no association between 25(OH)D and in vivo insulin sensitivity or β-cell function relative to insulin sensitivity (disposition index) in all groups combined or in each group separately. CONCLUSIONS-Our data in obese youth show 1) no differences in plasma 25(OH)D concentrations across the glucose tolerance groups and 2) no relationship between 25(OH)D and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in any of the groups. It remains uncertain if enhancement of the vitamin D status could improve pathophysiological mechanisms of prediabetes and type 2 diabetes in obese youth.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
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<li>Pennsylvanie</li>
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<tree><country name="Espagne"><noRegion><name sortKey="De Las Heras, Javier" sort="De Las Heras, Javier" uniqKey="De Las Heras J" first="Javier" last="De Las Heras">Javier De Las Heras</name>
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<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="De Las Heras, Javier" sort="De Las Heras, Javier" uniqKey="De Las Heras J" first="Javier" last="De Las Heras">Javier De Las Heras</name>
</region>
<name sortKey="Arslanian, Silva A" sort="Arslanian, Silva A" uniqKey="Arslanian S" first="Silva A." last="Arslanian">Silva A. Arslanian</name>
<name sortKey="Arslanian, Silva A" sort="Arslanian, Silva A" uniqKey="Arslanian S" first="Silva A." last="Arslanian">Silva A. Arslanian</name>
<name sortKey="Bacha, Fida" sort="Bacha, Fida" uniqKey="Bacha F" first="Fida" last="Bacha">Fida Bacha</name>
<name sortKey="Bacha, Fida" sort="Bacha, Fida" uniqKey="Bacha F" first="Fida" last="Bacha">Fida Bacha</name>
<name sortKey="Holick, Michael F" sort="Holick, Michael F" uniqKey="Holick M" first="Michael F." last="Holick">Michael F. Holick</name>
<name sortKey="Lee, Sojung" sort="Lee, Sojung" uniqKey="Lee S" first="Sojung" last="Lee">Sojung Lee</name>
<name sortKey="Rajakumar, Kumaravel" sort="Rajakumar, Kumaravel" uniqKey="Rajakumar K" first="Kumaravel" last="Rajakumar">Kumaravel Rajakumar</name>
</country>
</tree>
</affiliations>
</record>

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25-Hydroxyvitamin D in Obese Youth Across the Spectrum of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes

25-Hydroxyvitamin D in Obese Youth Across the Spectrum of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri