Classification of amyloid-positivity in controls: Comparison of visual read and quantitative approachs
Identifieur interne : 007750 ( Main/Merge ); précédent : 007749; suivant : 007751Classification of amyloid-positivity in controls: Comparison of visual read and quantitative approachs
Auteurs : Ann D. Cohen [États-Unis] ; Wenzhu Mowrey [États-Unis] ; Lisa A. Weissfeld [États-Unis] ; Howard J. Aizenstein [États-Unis] ; Eric Mcdade [États-Unis] ; James M. Mountz [États-Unis] ; Robert D. Nebes [États-Unis] ; Judith A. Saxton [États-Unis] ; Beth Snitz [États-Unis] ; Steven Dekosky [États-Unis] ; Jeff Williamson [États-Unis] ; Oscar L. Lopez [États-Unis] ; Julie C. Price [États-Unis] ; Chester A. Mathis [États-Unis] ; William E. Klunk [États-Unis]Source :
- NeuroImage : (Orlando, Fla.) [ 1053-8119 ] ; 2013.
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English descriptors
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Abstract
An important research application of amyloid imaging with positron emission tomography (PET) is detection of the earliest evidence of fibrillar amyloid-beta (Aβ) deposition. Use of amyloid PET for this purpose, requires a reproducible method for defining a cutoff that separates individuals with no significant Aβ deposition from those in which Aβ deposition has begun. We previously reported the iterative outlier approach (10) for the analysis of Pittsburgh Compound-B (PiB) PET data. Developments in amyloid imaging since the initial report of 10 have led us to re-examine the generalizability of this method. IO was developed using full-dynamic atrophy-corrected PiB PET data obtained from a group of control subjects with a fairly distinct separation between PiB-positive [PiB(+)] and PiB-negative [PiB(-)] subjects. Methods: We tested the performance of IO using late-summed tissue ratio data with atrophy correction or with an automated template method without atrophy correction and tested the robustness of the method when applied to a cohort of older subjects in which separation between PiB(+) and PiB(-) subjects was not so distinct. Results: The 10 method did not perform consistently across analyses and performed particularly poorly when separation was less clear. We found that a sparse k-means (SKM) cluster analysis approach performed significantly better; performing more consistently across methods and subject cohorts. We also compared SKM to a consensus visual read approach and found very good correspondence. Conclusion: The visual read and SKM methods, applied together, may optimize the identification of early Aβ deposition. These methods have the potential to provide a standard approach to the detection of PiB-positivity that is generalizable across centers.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Classification of amyloid-positivity in controls: Comparison of visual read and quantitative approachs</title><author><name sortKey="Cohen, Ann D" sort="Cohen, Ann D" uniqKey="Cohen A" first="Ann D." last="Cohen">Ann D. Cohen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Mowrey, Wenzhu" sort="Mowrey, Wenzhu" uniqKey="Mowrey W" first="Wenzhu" last="Mowrey">Wenzhu Mowrey</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biostatistics, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Weissfeld, Lisa A" sort="Weissfeld, Lisa A" uniqKey="Weissfeld L" first="Lisa A." last="Weissfeld">Lisa A. Weissfeld</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biostatistics, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J." last="Aizenstein">Howard J. Aizenstein</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Mcdade, Eric" sort="Mcdade, Eric" uniqKey="Mcdade E" first="Eric" last="Mcdade">Eric Mcdade</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Mountz, James M" sort="Mountz, James M" uniqKey="Mountz J" first="James M." last="Mountz">James M. Mountz</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Office of the Dean and Department of Neurology, University of Virginia</s1><s2>Charlottesville, VA, 22908</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville, VA, 22908</wicri:noRegion></affiliation></author><author><name sortKey="Nebes, Robert D" sort="Nebes, Robert D" uniqKey="Nebes R" first="Robert D." last="Nebes">Robert D. Nebes</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Saxton, Judith A" sort="Saxton, Judith A" uniqKey="Saxton J" first="Judith A." last="Saxton">Judith A. Saxton</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Snitz, Beth" sort="Snitz, Beth" uniqKey="Snitz B" first="Beth" last="Snitz">Beth Snitz</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Dekosky, Steven" sort="Dekosky, Steven" uniqKey="Dekosky S" first="Steven" last="Dekosky">Steven Dekosky</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Office of the Dean and Department of Neurology, University of Virginia</s1><s2>Charlottesville, VA, 22908</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville, VA, 22908</wicri:noRegion></affiliation></author><author><name sortKey="Williamson, Jeff" sort="Williamson, Jeff" uniqKey="Williamson J" first="Jeff" last="Williamson">Jeff Williamson</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Sticht Center on Aging, Wake Forest University Baptist Medical Center</s1><s2>Winston-Salem, NC, 27157</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Winston-Salem, NC, 27157</wicri:noRegion></affiliation></author><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. 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Cohen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Mowrey, Wenzhu" sort="Mowrey, Wenzhu" uniqKey="Mowrey W" first="Wenzhu" last="Mowrey">Wenzhu Mowrey</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biostatistics, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Weissfeld, Lisa A" sort="Weissfeld, Lisa A" uniqKey="Weissfeld L" first="Lisa A." last="Weissfeld">Lisa A. Weissfeld</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biostatistics, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J." last="Aizenstein">Howard J. Aizenstein</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Mcdade, Eric" sort="Mcdade, Eric" uniqKey="Mcdade E" first="Eric" last="Mcdade">Eric Mcdade</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Mountz, James M" sort="Mountz, James M" uniqKey="Mountz J" first="James M." last="Mountz">James M. Mountz</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Office of the Dean and Department of Neurology, University of Virginia</s1><s2>Charlottesville, VA, 22908</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville, VA, 22908</wicri:noRegion></affiliation></author><author><name sortKey="Nebes, Robert D" sort="Nebes, Robert D" uniqKey="Nebes R" first="Robert D." last="Nebes">Robert D. Nebes</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Saxton, Judith A" sort="Saxton, Judith A" uniqKey="Saxton J" first="Judith A." last="Saxton">Judith A. Saxton</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Snitz, Beth" sort="Snitz, Beth" uniqKey="Snitz B" first="Beth" last="Snitz">Beth Snitz</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Dekosky, Steven" sort="Dekosky, Steven" uniqKey="Dekosky S" first="Steven" last="Dekosky">Steven Dekosky</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Office of the Dean and Department of Neurology, University of Virginia</s1><s2>Charlottesville, VA, 22908</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville, VA, 22908</wicri:noRegion></affiliation></author><author><name sortKey="Williamson, Jeff" sort="Williamson, Jeff" uniqKey="Williamson J" first="Jeff" last="Williamson">Jeff Williamson</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Sticht Center on Aging, Wake Forest University Baptist Medical Center</s1><s2>Winston-Salem, NC, 27157</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Winston-Salem, NC, 27157</wicri:noRegion></affiliation></author><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Price, Julie C" sort="Price, Julie C" uniqKey="Price J" first="Julie C." last="Price">Julie C. Price</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Radiology, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Mathis, Chester A" sort="Mathis, Chester A" uniqKey="Mathis C" first="Chester A." last="Mathis">Chester A. Mathis</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Radiology, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author><author><name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E." last="Klunk">William E. Klunk</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA, 15213</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA, 15213</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">NeuroImage : (Orlando, Fla.)</title><title level="j" type="abbreviated">NeuroImage : (Orlando Fla.)</title><idno type="ISSN">1053-8119</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">NeuroImage : (Orlando, Fla.)</title><title level="j" type="abbreviated">NeuroImage : (Orlando Fla.)</title><idno type="ISSN">1053-8119</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amyloid</term><term>Emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Amyloïde</term><term>Tomoscintigraphie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An important research application of amyloid imaging with positron emission tomography (PET) is detection of the earliest evidence of fibrillar amyloid-beta (Aβ) deposition. Use of amyloid PET for this purpose, requires a reproducible method for defining a cutoff that separates individuals with no significant Aβ deposition from those in which Aβ deposition has begun. We previously reported the iterative outlier approach (10) for the analysis of Pittsburgh Compound-B (PiB) PET data. Developments in amyloid imaging since the initial report of 10 have led us to re-examine the generalizability of this method. IO was developed using full-dynamic atrophy-corrected PiB PET data obtained from a group of control subjects with a fairly distinct separation between PiB-positive [PiB(+)] and PiB-negative [PiB(-)] subjects. Methods: We tested the performance of IO using late-summed tissue ratio data with atrophy correction or with an automated template method without atrophy correction and tested the robustness of the method when applied to a cohort of older subjects in which separation between PiB(+) and PiB(-) subjects was not so distinct. Results: The 10 method did not perform consistently across analyses and performed particularly poorly when separation was less clear. We found that a sparse k-means (SKM) cluster analysis approach performed significantly better; performing more consistently across methods and subject cohorts. We also compared SKM to a consensus visual read approach and found very good correspondence. Conclusion: The visual read and SKM methods, applied together, may optimize the identification of early Aβ deposition. These methods have the potential to provide a standard approach to the detection of PiB-positivity that is generalizable across centers.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Cohen, Ann D" sort="Cohen, Ann D" uniqKey="Cohen A" first="Ann D." last="Cohen">Ann D. Cohen</name></noRegion><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J." last="Aizenstein">Howard J. Aizenstein</name><name sortKey="Dekosky, Steven" sort="Dekosky, Steven" uniqKey="Dekosky S" first="Steven" last="Dekosky">Steven Dekosky</name><name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E." last="Klunk">William E. Klunk</name><name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E." last="Klunk">William E. Klunk</name><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name><name sortKey="Mathis, Chester A" sort="Mathis, Chester A" uniqKey="Mathis C" first="Chester A." last="Mathis">Chester A. Mathis</name><name sortKey="Mcdade, Eric" sort="Mcdade, Eric" uniqKey="Mcdade E" first="Eric" last="Mcdade">Eric Mcdade</name><name sortKey="Mountz, James M" sort="Mountz, James M" uniqKey="Mountz J" first="James M." last="Mountz">James M. Mountz</name><name sortKey="Mowrey, Wenzhu" sort="Mowrey, Wenzhu" uniqKey="Mowrey W" first="Wenzhu" last="Mowrey">Wenzhu Mowrey</name><name sortKey="Nebes, Robert D" sort="Nebes, Robert D" uniqKey="Nebes R" first="Robert D." last="Nebes">Robert D. Nebes</name><name sortKey="Price, Julie C" sort="Price, Julie C" uniqKey="Price J" first="Julie C." last="Price">Julie C. Price</name><name sortKey="Saxton, Judith A" sort="Saxton, Judith A" uniqKey="Saxton J" first="Judith A." last="Saxton">Judith A. Saxton</name><name sortKey="Snitz, Beth" sort="Snitz, Beth" uniqKey="Snitz B" first="Beth" last="Snitz">Beth Snitz</name><name sortKey="Weissfeld, Lisa A" sort="Weissfeld, Lisa A" uniqKey="Weissfeld L" first="Lisa A." last="Weissfeld">Lisa A. Weissfeld</name><name sortKey="Williamson, Jeff" sort="Williamson, Jeff" uniqKey="Williamson J" first="Jeff" last="Williamson">Jeff Williamson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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