Impaired default network functional connectivity in autosomal dominant Alzheimer disease
Identifieur interne : 007162 ( Main/Merge ); précédent : 007161; suivant : 007163Impaired default network functional connectivity in autosomal dominant Alzheimer disease
Auteurs : Jasmeer P. Chhatwal [États-Unis] ; Aaron P. Schultz [États-Unis] ; Keith Johnson [États-Unis] ; Tammie L. S. Benzinger [États-Unis] ; Clifford Jr Jack [États-Unis] ; Beau M. Ances [États-Unis] ; Caroline A. Sullivan [États-Unis] ; Stephen P. Salloway [États-Unis] ; John M. Ringman [États-Unis] ; Robert A. Koeppe [États-Unis] ; Daniel S. Marcus [États-Unis] ; Paul Thompson [États-Unis] ; Andrew J. Saykin ; Stephen Correia [États-Unis] ; Peter R. Schofield [Australie] ; Christopher C. Rowe [Australie] ; Nick C. Fox [Royaume-Uni] ; Adam M. Brickman [États-Unis] ; Richard Mayeux [États-Unis] ; Eric Mcdade [États-Unis] ; Randall Bateman [États-Unis] ; Anne M. Fagan [États-Unis] ; Allison M. Goate [États-Unis] ; CHENGJIE XIONG [États-Unis] ; Virginia D. Buckles [États-Unis] ; John C. Morris [États-Unis] ; Reisa A. Sperling [États-Unis]Source :
- Neurology [ 0028-3878 ] ; 2013.
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Abstract
Objective: To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in a large cross-sectional cohort of subjects from families harboring pathogenic presenilin-1 (PSEN1), presenilin-2 (PSEN2), and amyloid precursor protein (APP) mutations participating in the Dominantly Inherited Alzheimer Network. Methods: Eighty-three mutation carriers and 37 asymptomatic noncarriers from the same families underwent fMRI during resting state at 8 centers in the United States, United Kingdom, and Australia. Using group-independent component analysis, fcMRI was compared using mutation status and Clinical Dementia Rating to stratify groups, and related to each participant's estimated years from expected symptom onset (eYO). Results: We observed significantly decreased DMN fcMRI in mutation carriers with increasing Clinical Dementia Rating, most evident in the precuneus/posterior cingulate and parietal cortices (p < 0.001). Comparison of asymptomatic mutation carriers with noncarriers demonstrated decreased fcMRI in the precuneus/posterior cingulate (p = 0.014) and right parietal cortex (p = 0.0016). We observed a significant interaction between mutation carrier status and eYO, with decreases in DMN fcMRI observed as mutation carriers approached and surpassed their eYO. Conclusion: Functional disruption of the DMN occurs early in the course of autosomal dominant Alzheimer disease, beginning before clinically evident symptoms, and worsening with increased impairment. These findings suggest that DMN fcMRI may prove useful as a biomarker across a wide spectrum of disease, and support the feasibility of DMN fcMRI as a secondary endpoint in upcoming multicenter clinical trials in Alzheimer disease.
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Salloway</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, Butler Hospital</s1><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Butler Hospital</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Radiology IU Center for Neuroimaging, Indiana University School of Medicine</s1><s2>Indianapolis</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Indianapolis</wicri:noRegion></affiliation></author><author><name sortKey="Ringman, John M" sort="Ringman, John M" uniqKey="Ringman J" first="John M." last="Ringman">John M. Ringman</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology Easton Center for Alzheimer's Disease Research, University of California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Koeppe, Robert A" sort="Koeppe, Robert A" uniqKey="Koeppe R" first="Robert A." last="Koeppe">Robert A. Koeppe</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Radiology University of Michigan School of Medicine</s1><s2>Ann Arbor</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Radiology University of Michigan School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Marcus, Daniel S" sort="Marcus, Daniel S" uniqKey="Marcus D" first="Daniel S." last="Marcus">Daniel S. Marcus</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Radiology, Section of Neuroradiology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Thompson, Paul" sort="Thompson, Paul" uniqKey="Thompson P" first="Paul" last="Thompson">Paul Thompson</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology Easton Center for Alzheimer's Disease Research, University of California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Saykin, Andrew J" sort="Saykin, Andrew J" uniqKey="Saykin A" first="Andrew J." last="Saykin">Andrew J. Saykin</name></author><author><name sortKey="Correia, Stephen" sort="Correia, Stephen" uniqKey="Correia S" first="Stephen" last="Correia">Stephen Correia</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Psychiatry Brown University School of Medicine</s1><s2>Providence, RI</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Psychiatry Brown University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name><affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Neuroscience Research Australia</s1><s2>Sydney</s2><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>School of Medical Sciences, University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Nuclear Medicine and Centre for PET, University of Melbourne</s1><s3>AUS</s3><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Department of Nuclear Medicine and Centre for PET, University of Melbourne</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Austin Health, University of Melbourne</s1><s3>AUS</s3><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Department of Austin Health, University of Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><affiliation wicri:level="4"><inist:fA14 i1="20"><s1>Department of Neurology, University College London</s1><s3>GBR</s3><sZ>17 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Brickman, Adam M" sort="Brickman, Adam M" uniqKey="Brickman A" first="Adam M." last="Brickman">Adam M. Brickman</name><affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Department of Neurology, Columbia University College of Physicians and Surgeons</s1><s2>New York</s2><s3>USA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Department of Neurology, Columbia University College of Physicians and Surgeons</s1><s2>New York</s2><s3>USA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mcdade, Eric" sort="Mcdade, Eric" uniqKey="Mcdade E" first="Eric" last="Mcdade">Eric Mcdade</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Department of Neurology, University of Pittsburgh School of Medicine</s1><s2>PA</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>PA</wicri:noRegion></affiliation></author><author><name sortKey="Bateman, Randall" sort="Bateman, Randall" uniqKey="Bateman R" first="Randall" last="Bateman">Randall Bateman</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Fagan, Anne M" sort="Fagan, Anne M" uniqKey="Fagan A" first="Anne M." last="Fagan">Anne M. Fagan</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Goate, Allison M" sort="Goate, Allison M" uniqKey="Goate A" first="Allison M." last="Goate">Allison M. Goate</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Genetics, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Psychiatry, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Chengjie Xiong" sort="Chengjie Xiong" uniqKey="Chengjie Xiong" last="Chengjie Xiong">CHENGJIE XIONG</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Division of Biostatistics, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Buckles, Virginia D" sort="Buckles, Virginia D" uniqKey="Buckles V" first="Virginia D." last="Buckles">Virginia D. Buckles</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Morris, John C" sort="Morris, John C" uniqKey="Morris J" first="John C." last="Morris">John C. Morris</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Sperling, Reisa A" sort="Sperling, Reisa A" uniqKey="Sperling R" first="Reisa A." last="Sperling">Reisa A. Sperling</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0280198</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0280198 INIST</idno><idno type="RBID">Pascal:13-0280198</idno><idno type="wicri:Area/PascalFrancis/Corpus">001C09</idno><idno type="wicri:Area/PascalFrancis/Curation">002D47</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001941</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001941</idno><idno type="wicri:doubleKey">0028-3878:2013:Chhatwal J:impaired:default:network</idno><idno type="wicri:Area/Main/Merge">007162</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Impaired default network functional connectivity in autosomal dominant Alzheimer disease</title><author><name sortKey="Chhatwal, Jasmeer P" sort="Chhatwal, Jasmeer P" uniqKey="Chhatwal J" first="Jasmeer P." last="Chhatwal">Jasmeer P. Chhatwal</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schultz, Aaron P" sort="Schultz, Aaron P" uniqKey="Schultz A" first="Aaron P." last="Schultz">Aaron P. Schultz</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Johnson, Keith" sort="Johnson, Keith" uniqKey="Johnson K" first="Keith" last="Johnson">Keith Johnson</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Benzinger, Tammie L S" sort="Benzinger, Tammie L S" uniqKey="Benzinger T" first="Tammie L. S." last="Benzinger">Tammie L. S. Benzinger</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Radiology, Section of Neuroradiology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Jack, Clifford Jr" sort="Jack, Clifford Jr" uniqKey="Jack C" first="Clifford Jr" last="Jack">Clifford Jr Jack</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Radiology Mayo Clinic</s1><s2>Rochester, MN</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Radiology Mayo Clinic</wicri:noRegion></affiliation></author><author><name sortKey="Ances, Beau M" sort="Ances, Beau M" uniqKey="Ances B" first="Beau M." last="Ances">Beau M. Ances</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Sullivan, Caroline A" sort="Sullivan, Caroline A" uniqKey="Sullivan C" first="Caroline A." last="Sullivan">Caroline A. Sullivan</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author><author><name sortKey="Salloway, Stephen P" sort="Salloway, Stephen P" uniqKey="Salloway S" first="Stephen P." last="Salloway">Stephen P. Salloway</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, Butler Hospital</s1><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Neurology, Butler Hospital</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Radiology IU Center for Neuroimaging, Indiana University School of Medicine</s1><s2>Indianapolis</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Indianapolis</wicri:noRegion></affiliation></author><author><name sortKey="Ringman, John M" sort="Ringman, John M" uniqKey="Ringman J" first="John M." last="Ringman">John M. Ringman</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology Easton Center for Alzheimer's Disease Research, University of California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Koeppe, Robert A" sort="Koeppe, Robert A" uniqKey="Koeppe R" first="Robert A." last="Koeppe">Robert A. Koeppe</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Radiology University of Michigan School of Medicine</s1><s2>Ann Arbor</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Radiology University of Michigan School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Marcus, Daniel S" sort="Marcus, Daniel S" uniqKey="Marcus D" first="Daniel S." last="Marcus">Daniel S. Marcus</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Radiology, Section of Neuroradiology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Mallinckrodt Institute of Radiology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Thompson, Paul" sort="Thompson, Paul" uniqKey="Thompson P" first="Paul" last="Thompson">Paul Thompson</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Neurology Easton Center for Alzheimer's Disease Research, University of California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Saykin, Andrew J" sort="Saykin, Andrew J" uniqKey="Saykin A" first="Andrew J." last="Saykin">Andrew J. Saykin</name></author><author><name sortKey="Correia, Stephen" sort="Correia, Stephen" uniqKey="Correia S" first="Stephen" last="Correia">Stephen Correia</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Psychiatry Brown University School of Medicine</s1><s2>Providence, RI</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Psychiatry Brown University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name><affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Neuroscience Research Australia</s1><s2>Sydney</s2><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>School of Medical Sciences, University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Nuclear Medicine and Centre for PET, University of Melbourne</s1><s3>AUS</s3><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Department of Nuclear Medicine and Centre for PET, University of Melbourne</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Austin Health, University of Melbourne</s1><s3>AUS</s3><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Department of Austin Health, University of Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><affiliation wicri:level="4"><inist:fA14 i1="20"><s1>Department of Neurology, University College London</s1><s3>GBR</s3><sZ>17 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Brickman, Adam M" sort="Brickman, Adam M" uniqKey="Brickman A" first="Adam M." last="Brickman">Adam M. Brickman</name><affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Department of Neurology, Columbia University College of Physicians and Surgeons</s1><s2>New York</s2><s3>USA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Department of Neurology, Columbia University College of Physicians and Surgeons</s1><s2>New York</s2><s3>USA</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mcdade, Eric" sort="Mcdade, Eric" uniqKey="Mcdade E" first="Eric" last="Mcdade">Eric Mcdade</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Department of Neurology, University of Pittsburgh School of Medicine</s1><s2>PA</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>PA</wicri:noRegion></affiliation></author><author><name sortKey="Bateman, Randall" sort="Bateman, Randall" uniqKey="Bateman R" first="Randall" last="Bateman">Randall Bateman</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Fagan, Anne M" sort="Fagan, Anne M" uniqKey="Fagan A" first="Anne M." last="Fagan">Anne M. Fagan</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Goate, Allison M" sort="Goate, Allison M" uniqKey="Goate A" first="Allison M." last="Goate">Allison M. Goate</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Genetics, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Psychiatry, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Chengjie Xiong" sort="Chengjie Xiong" uniqKey="Chengjie Xiong" last="Chengjie Xiong">CHENGJIE XIONG</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Division of Biostatistics, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Buckles, Virginia D" sort="Buckles, Virginia D" uniqKey="Buckles V" first="Virginia D." last="Buckles">Virginia D. Buckles</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Morris, John C" sort="Morris, John C" uniqKey="Morris J" first="John C." last="Morris">John C. Morris</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Neurology, Washington University School of Medicine</s1><s2>St. Louis, MO</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><orgName type="institution">Université Washington de Saint-Louis</orgName></affiliation></author><author><name sortKey="Sperling, Reisa A" sort="Sperling, Reisa A" uniqKey="Sperling R" first="Reisa A." last="Sperling">Reisa A. Sperling</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>27 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Boston, MA</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Nervous system diseases</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Démence d'Alzheimer</term><term>Pathologie du système nerveux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in a large cross-sectional cohort of subjects from families harboring pathogenic presenilin-1 (PSEN1), presenilin-2 (PSEN2), and amyloid precursor protein (APP) mutations participating in the Dominantly Inherited Alzheimer Network. Methods: Eighty-three mutation carriers and 37 asymptomatic noncarriers from the same families underwent fMRI during resting state at 8 centers in the United States, United Kingdom, and Australia. Using group-independent component analysis, fcMRI was compared using mutation status and Clinical Dementia Rating to stratify groups, and related to each participant's estimated years from expected symptom onset (eYO). Results: We observed significantly decreased DMN fcMRI in mutation carriers with increasing Clinical Dementia Rating, most evident in the precuneus/posterior cingulate and parietal cortices (p < 0.001). Comparison of asymptomatic mutation carriers with noncarriers demonstrated decreased fcMRI in the precuneus/posterior cingulate (p = 0.014) and right parietal cortex (p = 0.0016). We observed a significant interaction between mutation carrier status and eYO, with decreases in DMN fcMRI observed as mutation carriers approached and surpassed their eYO. Conclusion: Functional disruption of the DMN occurs early in the course of autosomal dominant Alzheimer disease, beginning before clinically evident symptoms, and worsening with increased impairment. These findings suggest that DMN fcMRI may prove useful as a biomarker across a wide spectrum of disease, and support the feasibility of DMN fcMRI as a secondary endpoint in upcoming multicenter clinical trials in Alzheimer disease.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Grand Londres</li><li>Massachusetts</li><li>Missouri (État)</li><li>Nouvelle-Galles du Sud</li><li>État de New York</li></region><settlement><li>Boston</li><li>Londres</li><li>Los Angeles</li><li>Saint-Louis (Missouri)</li><li>Sydney</li></settlement><orgName><li>University College de Londres</li><li>Université Washington de Saint-Louis</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><noCountry><name sortKey="Saykin, Andrew J" sort="Saykin, Andrew J" uniqKey="Saykin A" first="Andrew J." last="Saykin">Andrew J. Saykin</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Chhatwal, Jasmeer P" sort="Chhatwal, Jasmeer P" uniqKey="Chhatwal J" first="Jasmeer P." last="Chhatwal">Jasmeer P. Chhatwal</name></region><name sortKey="Ances, Beau M" sort="Ances, Beau M" uniqKey="Ances B" first="Beau M." last="Ances">Beau M. Ances</name><name sortKey="Ances, Beau M" sort="Ances, Beau M" uniqKey="Ances B" first="Beau M." last="Ances">Beau M. Ances</name><name sortKey="Bateman, Randall" sort="Bateman, Randall" uniqKey="Bateman R" first="Randall" last="Bateman">Randall Bateman</name><name sortKey="Benzinger, Tammie L S" sort="Benzinger, Tammie L S" uniqKey="Benzinger T" first="Tammie L. S." last="Benzinger">Tammie L. S. Benzinger</name><name sortKey="Benzinger, Tammie L S" sort="Benzinger, Tammie L S" uniqKey="Benzinger T" first="Tammie L. S." last="Benzinger">Tammie L. S. Benzinger</name><name sortKey="Brickman, Adam M" sort="Brickman, Adam M" uniqKey="Brickman A" first="Adam M." last="Brickman">Adam M. Brickman</name><name sortKey="Buckles, Virginia D" sort="Buckles, Virginia D" uniqKey="Buckles V" first="Virginia D." last="Buckles">Virginia D. Buckles</name><name sortKey="Chengjie Xiong" sort="Chengjie Xiong" uniqKey="Chengjie Xiong" last="Chengjie Xiong">CHENGJIE XIONG</name><name sortKey="Chhatwal, Jasmeer P" sort="Chhatwal, Jasmeer P" uniqKey="Chhatwal J" first="Jasmeer P." last="Chhatwal">Jasmeer P. Chhatwal</name><name sortKey="Correia, Stephen" sort="Correia, Stephen" uniqKey="Correia S" first="Stephen" last="Correia">Stephen Correia</name><name sortKey="Fagan, Anne M" sort="Fagan, Anne M" uniqKey="Fagan A" first="Anne M." last="Fagan">Anne M. Fagan</name><name sortKey="Goate, Allison M" sort="Goate, Allison M" uniqKey="Goate A" first="Allison M." last="Goate">Allison M. Goate</name><name sortKey="Goate, Allison M" sort="Goate, Allison M" uniqKey="Goate A" first="Allison M." last="Goate">Allison M. Goate</name><name sortKey="Jack, Clifford Jr" sort="Jack, Clifford Jr" uniqKey="Jack C" first="Clifford Jr" last="Jack">Clifford Jr Jack</name><name sortKey="Johnson, Keith" sort="Johnson, Keith" uniqKey="Johnson K" first="Keith" last="Johnson">Keith Johnson</name><name sortKey="Johnson, Keith" sort="Johnson, Keith" uniqKey="Johnson K" first="Keith" last="Johnson">Keith Johnson</name><name sortKey="Johnson, Keith" sort="Johnson, Keith" uniqKey="Johnson K" first="Keith" last="Johnson">Keith Johnson</name><name sortKey="Koeppe, Robert A" sort="Koeppe, Robert A" uniqKey="Koeppe R" first="Robert A." last="Koeppe">Robert A. Koeppe</name><name sortKey="Marcus, Daniel S" sort="Marcus, Daniel S" uniqKey="Marcus D" first="Daniel S." last="Marcus">Daniel S. Marcus</name><name sortKey="Marcus, Daniel S" sort="Marcus, Daniel S" uniqKey="Marcus D" first="Daniel S." last="Marcus">Daniel S. Marcus</name><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><name sortKey="Mcdade, Eric" sort="Mcdade, Eric" uniqKey="Mcdade E" first="Eric" last="Mcdade">Eric Mcdade</name><name sortKey="Morris, John C" sort="Morris, John C" uniqKey="Morris J" first="John C." last="Morris">John C. Morris</name><name sortKey="Ringman, John M" sort="Ringman, John M" uniqKey="Ringman J" first="John M." last="Ringman">John M. Ringman</name><name sortKey="Salloway, Stephen P" sort="Salloway, Stephen P" uniqKey="Salloway S" first="Stephen P." last="Salloway">Stephen P. Salloway</name><name sortKey="Salloway, Stephen P" sort="Salloway, Stephen P" uniqKey="Salloway S" first="Stephen P." last="Salloway">Stephen P. Salloway</name><name sortKey="Schultz, Aaron P" sort="Schultz, Aaron P" uniqKey="Schultz A" first="Aaron P." last="Schultz">Aaron P. Schultz</name><name sortKey="Schultz, Aaron P" sort="Schultz, Aaron P" uniqKey="Schultz A" first="Aaron P." last="Schultz">Aaron P. Schultz</name><name sortKey="Sperling, Reisa A" sort="Sperling, Reisa A" uniqKey="Sperling R" first="Reisa A." last="Sperling">Reisa A. Sperling</name><name sortKey="Sperling, Reisa A" sort="Sperling, Reisa A" uniqKey="Sperling R" first="Reisa A." last="Sperling">Reisa A. Sperling</name><name sortKey="Sperling, Reisa A" sort="Sperling, Reisa A" uniqKey="Sperling R" first="Reisa A." last="Sperling">Reisa A. Sperling</name><name sortKey="Sullivan, Caroline A" sort="Sullivan, Caroline A" uniqKey="Sullivan C" first="Caroline A." last="Sullivan">Caroline A. Sullivan</name><name sortKey="Sullivan, Caroline A" sort="Sullivan, Caroline A" uniqKey="Sullivan C" first="Caroline A." last="Sullivan">Caroline A. Sullivan</name><name sortKey="Sullivan, Caroline A" sort="Sullivan, Caroline A" uniqKey="Sullivan C" first="Caroline A." last="Sullivan">Caroline A. Sullivan</name><name sortKey="Thompson, Paul" sort="Thompson, Paul" uniqKey="Thompson P" first="Paul" last="Thompson">Paul Thompson</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name></region><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C." last="Rowe">Christopher C. Rowe</name><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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