Carbon Nanotubes: Biodegradation of Single‐Walled Carbon Nanotubes by Eosinophil Peroxidase (Small 16/2013)
Identifieur interne : 006513 ( Main/Merge ); précédent : 006512; suivant : 006514Carbon Nanotubes: Biodegradation of Single‐Walled Carbon Nanotubes by Eosinophil Peroxidase (Small 16/2013)
Auteurs : Fernando T. And N [Suède] ; Alexandr A. Kapralov [États-Unis] ; Naveena Yanamala [États-Unis] ; Weihong Feng [États-Unis] ; Arjang Baygan [Suède] ; Benedict J. Chambers [Suède] ; Kjell Hultenby [Suède] ; Fei Ye [Suède] ; Muhammet S. Toprak [Suède] ; Birgit D. Brandner [Suède] ; Andrea Fornara [Suède] ; Judith Klein-Seetharaman [États-Unis] ; Gregg P. Kotchey [États-Unis] ; Alexander Star [États-Unis] ; Anna A. Shvedova [États-Unis] ; Bengt Fadeel [Suède, États-Unis] ; Valerian E. Kagan [États-Unis]Source :
- Small [ 1613-6810 ] ; 2013-08-26.
Descripteurs français
- Wicri :
- topic : Stockholm.
English descriptors
- KwdEn :
- Binding sites, Biodegradation, Carbon nanotubes, Catalysis, Catalytic site, Distal side, Eosinophil, Eosinophil peroxidase, Eosinophils catalyses, Fadeel, Image courtesy, Kagan, Karolinska, Karolinska institute, Molecular modeling studies, Murine, Nanotube, Oxidant, Oxidative, Oxidative biodegradation, Oxidized, Oxidized carbon nanotube, Peroxidase, Same side, Stockholm, Swcnt, Swcnts, Szekely.
- Teeft :
- Binding sites, Biodegradation, Carbon nanotubes, Catalysis, Catalytic site, Distal side, Eosinophil, Eosinophil peroxidase, Eosinophils catalyses, Fadeel, Image courtesy, Kagan, Karolinska, Karolinska institute, Molecular modeling studies, Murine, Nanotube, Oxidant, Oxidative, Oxidative biodegradation, Oxidized, Oxidized carbon nanotube, Peroxidase, Same side, Stockholm, Swcnt, Swcnts, Szekely.
Abstract
B. Fadeel, V. E. Kagan, and co‐workers report on page 2721 the interaction of one oxidized single‐walled carbon nanotube (SWCNT) with two molecules of eosinophil peroxidase (EPO), one of the major human oxidant generating enzymes. Their study demonstrates that human EPO (in vitro) and murine EPO of ex vivo activated eosinophils catalyses the oxidative biodegradation of SWCNTs. Molecular modeling studies reveal two binding sites for SWCNTs on EPO, one located at the same side as the catalytic site and the other on the distal side of EPO. Eosinophils are key players of the innate immune system and these results are relevant to potential respiratory exposures to carbon nanotubes. Image courtesy of Dr. L. Szekely, Karolinska Institute, Stockholm.
Url:
DOI: 10.1002/smll.201370096
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<term>Distal side</term>
<term>Eosinophil</term>
<term>Eosinophil peroxidase</term>
<term>Eosinophils catalyses</term>
<term>Fadeel</term>
<term>Image courtesy</term>
<term>Kagan</term>
<term>Karolinska</term>
<term>Karolinska institute</term>
<term>Molecular modeling studies</term>
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<term>Nanotube</term>
<term>Oxidant</term>
<term>Oxidative</term>
<term>Oxidative biodegradation</term>
<term>Oxidized</term>
<term>Oxidized carbon nanotube</term>
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<term>Distal side</term>
<term>Eosinophil</term>
<term>Eosinophil peroxidase</term>
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<term>Fadeel</term>
<term>Image courtesy</term>
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<term>Karolinska</term>
<term>Karolinska institute</term>
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<front><div type="abstract" xml:lang="en">B. Fadeel, V. E. Kagan, and co‐workers report on page 2721 the interaction of one oxidized single‐walled carbon nanotube (SWCNT) with two molecules of eosinophil peroxidase (EPO), one of the major human oxidant generating enzymes. Their study demonstrates that human EPO (in vitro) and murine EPO of ex vivo activated eosinophils catalyses the oxidative biodegradation of SWCNTs. Molecular modeling studies reveal two binding sites for SWCNTs on EPO, one located at the same side as the catalytic site and the other on the distal side of EPO. Eosinophils are key players of the innate immune system and these results are relevant to potential respiratory exposures to carbon nanotubes. Image courtesy of Dr. L. Szekely, Karolinska Institute, Stockholm.</div>
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