PittsburghV1, Main, Merge, bibRecord, 006318

Histological Predictors of Outcome in Ependymoma are Dependent on Anatomic Site Within the Central Nervous System

Identifieur interne : 006318 ( Main/Merge ); précédent : 006317; suivant : 006319

Histological Predictors of Outcome in Ependymoma are Dependent on Anatomic Site Within the Central Nervous System

Auteurs : Aditya Raghunathan [États-Unis] ; Khalida Wani [États-Unis] ; Terri S. Armstrong [États-Unis] ; Elizabeth Vera-Bolanos [États-Unis] ; Maryam Fouladi ; Richard Gilbertson ; Amar Gajjar ; Stewart Goldman [États-Unis] ; Norman L. Lehman ; Phillipe Metellus [France] ; Tom Mikkelsen ; Mary Jo T. Necesito-Reyes [États-Unis] ; Antonio Omuro [États-Unis] ; Roger J. Packer [États-Unis] ; Sonia Partap ; Ian F. Pollack [États-Unis] ; Michael D. Prados [États-Unis] ; H. Ian Robins ; Riccardo Soffietti [Italie] ; Jing Wu ; C. Ryan Miller ; Mark R. Gilbert [États-Unis] ; Kenneth D. Aldape [États-Unis]

Source :

Brain Pathology [ 1015-6305 ] ; 2013-09.

RBID : ISTEX:5B444A4327C13DDAA09AA7F6A766BDF5A6B00818

Descripteurs français

Wicri :
- topic : Adjuvant, Histologie.

English descriptors

Abstract

Ependymomas originate in posterior fossa (PF), supratentorial (ST) or spinal cord (SC) compartments. At present, grading schemes are applied independent of anatomic site. We performed detailed histological examination on 238 World Health Organization grade II and III ependymomas. Among PF ependymomas, the presence of hypercellular areas, necrosis, microvascular proliferation and elevated mitotic rate (all P < 0.01) were significantly associated with worse progression‐free survival (PFS), while extensive ependymal canal formation was not (P = 0.89). Similar to the PF tumors, microvascular proliferation (P = 0.01) and elevated mitotic rate (P = 0.03) were significantly associated with worse PFS in the ST tumors. However, in contrast to PF tumors, extensive ependymal canals (P = 0.03) were associated with worse clinical outcome in ST ependymomas, but hypercellularity (P = 0.57) and necrosis (P = 0.47) were not. On multivariate Cox regression, after adjusting for relevant clinical variables, individual histological factors and a composite histological score remained significant among ST and PF ependymoma. In contrast to both PF and ST ependymoma, histological features were not found to be associated with PFS in SC tumors. Taken together, the clinical relevance of specific histological features in ependymoma appears to be related to the anatomic site of origin and suggests that site‐specific grading criteria be considered in future classification systems.

Url:

https://api.istex.fr/document/5B444A4327C13DDAA09AA7F6A766BDF5A6B00818/fulltext/pdf

DOI: 10.1111/bpa.12050

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<author><name sortKey="Necesito Eyes, Mary Jo T" sort="Necesito Eyes, Mary Jo T" uniqKey="Necesito Eyes M" first="Mary Jo T." last="Necesito-Reyes">Mary Jo T. Necesito-Reyes</name>
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</placeName>
<wicri:orgArea>The University of Texas MD Anderson Cancer Center, TX</wicri:orgArea>
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<affiliation></affiliation>
<affiliation><wicri:noCountry code="no comma">E-mail: kaldape@mdanderson.org</wicri:noCountry>
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<term>Adjuvant</term>
<term>Adult patients</term>
<term>Anaplasia</term>
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<term>Anaplastic ependymomas</term>
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<term>Fossa</term>
<term>Guideline</term>
<term>Histological</term>
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<term>Initial diagnosis</term>
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<term>Intracranial ependymomas</term>
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<term>Microvascular proliferation</term>
<term>Mitotic</term>
<term>Mitotic rate</term>
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<term>Additional radiation</term>
<term>Adjacent tissue</term>
<term>Adjuvant</term>
<term>Adult patients</term>
<term>Anaplasia</term>
<term>Anaplastic</term>
<term>Anaplastic ependymomas</term>
<term>Anatomic</term>
<term>Anatomic site</term>
<term>Brain pathology</term>
<term>Canal</term>
<term>Chemotherapy</term>
<term>Chemotherapy information</term>
<term>Clinical factors</term>
<term>Different compartments</term>
<term>Distinct groups</term>
<term>Ependymal</term>
<term>Ependymal canals</term>
<term>Ependymoma</term>
<term>Ependymoma raghunathan</term>
<term>Ependymomas</term>
<term>Ependymomas patient population</term>
<term>Extensive ependymal canals</term>
<term>Focal areas</term>
<term>Fossa</term>
<term>Guideline</term>
<term>Histological</term>
<term>Histological features</term>
<term>Histological score</term>
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<term>Hypercellular</term>
<term>Hypercellular areas</term>
<term>Hypercellularity</term>
<term>Individual histological factors</term>
<term>Individual histological features</term>
<term>Infratentorial ependymomas</term>
<term>Initial diagnosis</term>
<term>International society</term>
<term>Intracranial</term>
<term>Intracranial ependymoma</term>
<term>Intracranial ependymomas</term>
<term>Last contact</term>
<term>Metagene</term>
<term>Microvascular</term>
<term>Microvascular proliferation</term>
<term>Mitotic</term>
<term>Mitotic rate</term>
<term>Multivariate</term>
<term>Multivariate analysis</term>
<term>Necrosis</term>
<term>Neuropathology</term>
<term>Neuropathology raghunathan</term>
<term>Papillary structures</term>
<term>Patient outcomes</term>
<term>Pediatric</term>
<term>Pediatric patients</term>
<term>Posterior fossa</term>
<term>Prognostic</term>
<term>Prognostic factors</term>
<term>Progressionfree survival</term>
<term>Proliferation</term>
<term>Pseudorosettes</term>
<term>Radiation therapy</term>
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<term>Recurrence</term>
<term>Regression analyses</term>
<term>Regression analysis</term>
<term>Resection</term>
<term>Spinal</term>
<term>Spinal cord</term>
<term>Spinal cord compartments</term>
<term>Study population</term>
<term>Subtotal resections</term>
<term>Supratentorial</term>
<term>Supratentorial ependymomas</term>
<term>Surgical resection</term>
<term>Survival curves</term>
<term>Tumor necrosis</term>
<term>Tumor recurrence</term>
<term>Univariate</term>
<term>Univariate analysis</term>
<term>World health organization grade</term>
<term>Worse outcome</term>
<term>Worse survival</term>
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<front><div type="abstract">Ependymomas originate in posterior fossa (PF), supratentorial (ST) or spinal cord (SC) compartments. At present, grading schemes are applied independent of anatomic site. We performed detailed histological examination on 238 World Health Organization grade II and III ependymomas. Among PF ependymomas, the presence of hypercellular areas, necrosis, microvascular proliferation and elevated mitotic rate (all P < 0.01) were significantly associated with worse progression‐free survival (PFS), while extensive ependymal canal formation was not (P = 0.89). Similar to the PF tumors, microvascular proliferation (P = 0.01) and elevated mitotic rate (P = 0.03) were significantly associated with worse PFS in the ST tumors. However, in contrast to PF tumors, extensive ependymal canals (P = 0.03) were associated with worse clinical outcome in ST ependymomas, but hypercellularity (P = 0.57) and necrosis (P = 0.47) were not. On multivariate Cox regression, after adjusting for relevant clinical variables, individual histological factors and a composite histological score remained significant among ST and PF ependymoma. In contrast to both PF and ST ependymoma, histological features were not found to be associated with PFS in SC tumors. Taken together, the clinical relevance of specific histological features in ependymoma appears to be related to the anatomic site of origin and suggests that site‐specific grading criteria be considered in future classification systems.</div>
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Histological Predictors of Outcome in Ependymoma are Dependent on Anatomic Site Within the Central Nervous System

Histological Predictors of Outcome in Ependymoma are Dependent on Anatomic Site Within the Central Nervous System

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