PittsburghV1, Main, Merge, bibRecord, 005A11

Coronary Artery Calcification in Obese Youth: What Are the Phenotypic and Metabolic Determinants?

Identifieur interne : 005A11 ( Main/Merge ); précédent : 005A10; suivant : 005A12

Coronary Artery Calcification in Obese Youth: What Are the Phenotypic and Metabolic Determinants?

Auteurs : Fida Bacha [États-Unis] ; Daniel Edmundowicz [États-Unis] ; Kim Sutton-Tyrell [États-Unis] ; SOJUNG LEE [États-Unis] ; Hala Tfayli [Liban] ; Silva A. Arslanian [États-Unis]

Source :

Diabetes care [ 0149-5992 ] ; 2014.

RBID : Pascal:14-0235270

Descripteurs français

Pascal (Inist)
- Obésité, Artère coronaire, Calcification, Adolescent, Phénotype, Métabolisme, Déterminant, Endocrinologie, Maladie métabolique, Nutrition, Etat nutritionnel.
Wicri :
- topic : Nutrition.

English descriptors

KwdEn :
- Adolescent, Calcification, Coronary artery, Determinant, Endocrinology, Metabolic diseases, Metabolism, Nutrition, Nutritional status, Obesity, Phenotype.

Abstract

OBJECTIVE Obesity in adolescence has been associated with increased risk for coronary heart disease in adulthood. This study evaluated subclinical atherosclerosis in obese youth and the underlying risk factors. RESEARCH DESIGN AND METHODS Ninety obese adolescents (37 normal glucose tolerant, 27 prediabetes, and 26 type 2 diabetes) underwent evaluation of coronary artery calcifications (CACs) by electron beam computed tomography, aortic pulse wave velocity (PWV), carotid intima-media thickness (IMT), lipids, leptin, inflammatory markers, and body composition (DEXA). A total of 68 underwent evaluation of insulin sensitivity (IS) (hyperinsulinemic-euglycemic clamp) and abdominal adiposity (computed tomography). RESULTS A total of 50% had CACs (CAC+: Agatston CAC score ≥1). CAC+ youth had higher BMI, fat mass, and abdominal fat, with no difference in sex, race, IS per fat-free mass (IS_FFM), glucose tolerance, PWV, or IMT compared with the CAC- group. PWV was inversely related to IS. In multiple regression analyses with age, race, sex, HbA_1c, BMI (or waist circumference), IS_FFM, diastolic blood pressure, non-HDL cholesterol, and leptin as independent variables, BMI (or waist) (R²= 0.41; P = 0.001) was the significant determinant of CAC; leptin (R² = 0.37; P = 0.034) for PWV; and HbA_1c, race, and age (R² = 0.34; P = 0.02) for IMT. CONCLUSIONS Early in the course of obesity, there is evidence of CAC independent of glycemia. The different biomarkers of subclinical atherosclerosis appear to be differentially modulated, adiposity being the major determinant of CAC, hyperglycemia, age, and race for IMT, and leptin and IS for arterial stiffness. These findings highlight the increased cardiovascular disease risk in obese youth and the need for early interventions to reverse obesity and atherosclerosis.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000575
to stream PascalFrancis, to step Curation: 004061
to stream PascalFrancis, to step Checkpoint: 000A88

Links to Exploration step

Pascal:14-0235270

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Coronary Artery Calcification in Obese Youth: What Are the Phenotypic and Metabolic Determinants?</title>
<author><name sortKey="Bacha, Fida" sort="Bacha, Fida" uniqKey="Bacha F" first="Fida" last="Bacha">Fida Bacha</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Children's Nutrition Research Center, Baylor College of Medicine</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university">Baylor College of Medicine</orgName>
</affiliation>
</author>
<author><name sortKey="Edmundowicz, Daniel" sort="Edmundowicz, Daniel" uniqKey="Edmundowicz D" first="Daniel" last="Edmundowicz">Daniel Edmundowicz</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, Section of Cardiology, Temple University</s1>
<s2>Philadelphia, PA</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia, PA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sutton Tyrell, Kim" sort="Sutton Tyrell, Kim" uniqKey="Sutton Tyrell K" first="Kim" last="Sutton-Tyrell">Kim Sutton-Tyrell</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>School of Public Health, University of Pittsburgh</s1>
<s2>Pittsburgh, PA</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Sojung Lee" sort="Sojung Lee" uniqKey="Sojung Lee" last="Sojung Lee">SOJUNG LEE</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Weight Management and Wellness Center, Children's Hospital of Pittsburgh of UPMC</s1>
<s2>Pittsburgh, PA</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Pittsburgh, PA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tfayli, Hala" sort="Tfayli, Hala" uniqKey="Tfayli H" first="Hala" last="Tfayli">Hala Tfayli</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pediatrics, American University of Beirut</s1>
<s2>Beirut</s2>
<s3>LBN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Liban</country>
<wicri:noRegion>Beirut</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Arslanian, Silva A" sort="Arslanian, Silva A" uniqKey="Arslanian S" first="Silva A." last="Arslanian">Silva A. Arslanian</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Weight Management and Wellness Center, Children's Hospital of Pittsburgh of UPMC</s1>
<s2>Pittsburgh, PA</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Pittsburgh, PA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC</s1>
<s2>Pittsburgh, PA</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Pittsburgh, PA</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">14-0235270</idno>
<date when="2014">2014</date>
<idno type="stanalyst">PASCAL 14-0235270 INIST</idno>
<idno type="RBID">Pascal:14-0235270</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000575</idno>
<idno type="wicri:Area/PascalFrancis/Curation">004061</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000A88</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000A88</idno>
<idno type="wicri:doubleKey">0149-5992:2014:Bacha F:coronary:artery:calcification</idno>
<idno type="wicri:Area/Main/Merge">005A11</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Coronary Artery Calcification in Obese Youth: What Are the Phenotypic and Metabolic Determinants?</title>
<author><name sortKey="Bacha, Fida" sort="Bacha, Fida" uniqKey="Bacha F" first="Fida" last="Bacha">Fida Bacha</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Children's Nutrition Research Center, Baylor College of Medicine</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
<orgName type="university">Baylor College of Medicine</orgName>
</affiliation>
</author>
<author><name sortKey="Edmundowicz, Daniel" sort="Edmundowicz, Daniel" uniqKey="Edmundowicz D" first="Daniel" last="Edmundowicz">Daniel Edmundowicz</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, Section of Cardiology, Temple University</s1>
<s2>Philadelphia, PA</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia, PA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sutton Tyrell, Kim" sort="Sutton Tyrell, Kim" uniqKey="Sutton Tyrell K" first="Kim" last="Sutton-Tyrell">Kim Sutton-Tyrell</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>School of Public Health, University of Pittsburgh</s1>
<s2>Pittsburgh, PA</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Sojung Lee" sort="Sojung Lee" uniqKey="Sojung Lee" last="Sojung Lee">SOJUNG LEE</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Weight Management and Wellness Center, Children's Hospital of Pittsburgh of UPMC</s1>
<s2>Pittsburgh, PA</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Pittsburgh, PA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tfayli, Hala" sort="Tfayli, Hala" uniqKey="Tfayli H" first="Hala" last="Tfayli">Hala Tfayli</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pediatrics, American University of Beirut</s1>
<s2>Beirut</s2>
<s3>LBN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Liban</country>
<wicri:noRegion>Beirut</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Arslanian, Silva A" sort="Arslanian, Silva A" uniqKey="Arslanian S" first="Silva A." last="Arslanian">Silva A. Arslanian</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Weight Management and Wellness Center, Children's Hospital of Pittsburgh of UPMC</s1>
<s2>Pittsburgh, PA</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Pittsburgh, PA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC</s1>
<s2>Pittsburgh, PA</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Pittsburgh, PA</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Diabetes care</title>
<title level="j" type="abbreviated">Diabetes care</title>
<idno type="ISSN">0149-5992</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Diabetes care</title>
<title level="j" type="abbreviated">Diabetes care</title>
<idno type="ISSN">0149-5992</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Calcification</term>
<term>Coronary artery</term>
<term>Determinant</term>
<term>Endocrinology</term>
<term>Metabolic diseases</term>
<term>Metabolism</term>
<term>Nutrition</term>
<term>Nutritional status</term>
<term>Obesity</term>
<term>Phenotype</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Obésité</term>
<term>Artère coronaire</term>
<term>Calcification</term>
<term>Adolescent</term>
<term>Phénotype</term>
<term>Métabolisme</term>
<term>Déterminant</term>
<term>Endocrinologie</term>
<term>Maladie métabolique</term>
<term>Nutrition</term>
<term>Etat nutritionnel</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Nutrition</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">OBJECTIVE Obesity in adolescence has been associated with increased risk for coronary heart disease in adulthood. This study evaluated subclinical atherosclerosis in obese youth and the underlying risk factors. RESEARCH DESIGN AND METHODS Ninety obese adolescents (37 normal glucose tolerant, 27 prediabetes, and 26 type 2 diabetes) underwent evaluation of coronary artery calcifications (CACs) by electron beam computed tomography, aortic pulse wave velocity (PWV), carotid intima-media thickness (IMT), lipids, leptin, inflammatory markers, and body composition (DEXA). A total of 68 underwent evaluation of insulin sensitivity (IS) (hyperinsulinemic-euglycemic clamp) and abdominal adiposity (computed tomography). RESULTS A total of 50% had CACs (CAC+: Agatston CAC score ≥1). CAC+ youth had higher BMI, fat mass, and abdominal fat, with no difference in sex, race, IS per fat-free mass (IS<sub>FFM</sub>
), glucose tolerance, PWV, or IMT compared with the CAC- group. PWV was inversely related to IS. In multiple regression analyses with age, race, sex, HbA<sub>1c</sub>
, BMI (or waist circumference), IS<sub>FFM</sub>
, diastolic blood pressure, non-HDL cholesterol, and leptin as independent variables, BMI (or waist) (R<sup>2 </sup>
= 0.41; P = 0.001) was the significant determinant of CAC; leptin (R<sup>2</sup>
 = 0.37; P = 0.034) for PWV; and HbA<sub>1c</sub>
, race, and age (R<sup>2</sup>
 = 0.34; P = 0.02) for IMT. CONCLUSIONS Early in the course of obesity, there is evidence of CAC independent of glycemia. The different biomarkers of subclinical atherosclerosis appear to be differentially modulated, adiposity being the major determinant of CAC, hyperglycemia, age, and race for IMT, and leptin and IS for arterial stiffness. These findings highlight the increased cardiovascular disease risk in obese youth and the need for early interventions to reverse obesity and atherosclerosis.</div>
</front>
</TEI>
<affiliations><list><country><li>Liban</li>
<li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
<li>Texas</li>
</region>
<settlement><li>Houston</li>
<li>Pittsburgh</li>
</settlement>
<orgName><li>Baylor College of Medicine</li>
<li>Université de Pittsburgh</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Texas"><name sortKey="Bacha, Fida" sort="Bacha, Fida" uniqKey="Bacha F" first="Fida" last="Bacha">Fida Bacha</name>
</region>
<name sortKey="Arslanian, Silva A" sort="Arslanian, Silva A" uniqKey="Arslanian S" first="Silva A." last="Arslanian">Silva A. Arslanian</name>
<name sortKey="Arslanian, Silva A" sort="Arslanian, Silva A" uniqKey="Arslanian S" first="Silva A." last="Arslanian">Silva A. Arslanian</name>
<name sortKey="Edmundowicz, Daniel" sort="Edmundowicz, Daniel" uniqKey="Edmundowicz D" first="Daniel" last="Edmundowicz">Daniel Edmundowicz</name>
<name sortKey="Sojung Lee" sort="Sojung Lee" uniqKey="Sojung Lee" last="Sojung Lee">SOJUNG LEE</name>
<name sortKey="Sutton Tyrell, Kim" sort="Sutton Tyrell, Kim" uniqKey="Sutton Tyrell K" first="Kim" last="Sutton-Tyrell">Kim Sutton-Tyrell</name>
</country>
<country name="Liban"><noRegion><name sortKey="Tfayli, Hala" sort="Tfayli, Hala" uniqKey="Tfayli H" first="Hala" last="Tfayli">Hala Tfayli</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005A11 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 005A11 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     Pascal:14-0235270
   |texte=   Coronary Artery Calcification in Obese Youth: What Are the Phenotypic and Metabolic Determinants?
}}

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur Pittsburgh

Coronary Artery Calcification in Obese Youth: What Are the Phenotypic and Metabolic Determinants?

Coronary Artery Calcification in Obese Youth: What Are the Phenotypic and Metabolic Determinants?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri