Emotion reactivity and regulation in late-life generalized anxiety disorder: Functional connectivity at baseline and post-treatment
Identifieur interne : 003205 ( Main/Merge ); précédent : 003204; suivant : 003206Emotion reactivity and regulation in late-life generalized anxiety disorder: Functional connectivity at baseline and post-treatment
Auteurs : Carmen Andreescu ; Lei K. Sheu [États-Unis] ; Dana Tudorascu ; James J. Gross ; Sarah Walker ; Layla Banihashemi [États-Unis] ; Howard Aizenstein [États-Unis]Source :
- The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [ 1064-7481 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Cartographie cérébrale, Citalopram (pharmacologie), Citalopram (usage thérapeutique), Cortex cérébral (), Cortex cérébral (physiopathologie), Cortex préfrontal (), Cortex préfrontal (physiopathologie), Femelle, Humains, Imagerie par résonance magnétique, Inhibiteurs de la capture de la sérotonine (pharmacologie), Inhibiteurs de la capture de la sérotonine (usage thérapeutique), Mâle, Noyau paraventriculaire de l'hypothalamus (), Noyau paraventriculaire de l'hypothalamus (physiopathologie), Noyaux du septum (), Noyaux du septum (physiopathologie), Sujet âgé, Troubles anxieux (physiopathologie), Troubles anxieux (psychologie), Troubles anxieux (traitement médicamenteux), Vieillissement (), Vieillissement (physiologie), Vieillissement (psychologie), Voies nerveuses (), Voies nerveuses (physiopathologie), Émotions (), Émotions (physiologie), Études cas-témoins.
- MESH :
- pharmacologie : Citalopram, Inhibiteurs de la capture de la sérotonine.
- physiologie : Vieillissement, Émotions.
- physiopathologie : Cortex cérébral, Cortex préfrontal, Noyau paraventriculaire de l'hypothalamus, Noyaux du septum, Troubles anxieux, Voies nerveuses.
- psychologie : Troubles anxieux, Vieillissement.
- traitement médicamenteux : Troubles anxieux.
- usage thérapeutique : Citalopram, Inhibiteurs de la capture de la sérotonine.
- Adulte d'âge moyen, Cartographie cérébrale, Cortex cérébral, Cortex préfrontal, Femelle, Humains, Imagerie par résonance magnétique, Mâle, Noyau paraventriculaire de l'hypothalamus, Noyaux du septum, Sujet âgé, Vieillissement, Voies nerveuses, Émotions, Études cas-témoins.
English descriptors
- KwdEn :
- Aged, Aging (drug effects), Aging (physiology), Aging (psychology), Anxiety Disorders (drug therapy), Anxiety Disorders (physiopathology), Anxiety Disorders (psychology), Brain Mapping, Case-Control Studies, Cerebral Cortex (drug effects), Cerebral Cortex (physiopathology), Citalopram (pharmacology), Citalopram (therapeutic use), Emotions (drug effects), Emotions (physiology), Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways (drug effects), Neural Pathways (physiopathology), Paraventricular Hypothalamic Nucleus (drug effects), Paraventricular Hypothalamic Nucleus (physiopathology), Prefrontal Cortex (drug effects), Prefrontal Cortex (physiopathology), Septal Nuclei (drug effects), Septal Nuclei (physiopathology), Serotonin Uptake Inhibitors (pharmacology), Serotonin Uptake Inhibitors (therapeutic use).
- MESH :
- chemical , pharmacology : Citalopram, Serotonin Uptake Inhibitors.
- drug effects : Aging, Cerebral Cortex, Emotions, Neural Pathways, Paraventricular Hypothalamic Nucleus, Prefrontal Cortex, Septal Nuclei.
- drug therapy : Anxiety Disorders.
- physiology : Aging, Emotions.
- physiopathology : Anxiety Disorders, Cerebral Cortex, Neural Pathways, Paraventricular Hypothalamic Nucleus, Prefrontal Cortex, Septal Nuclei.
- psychology : Aging, Anxiety Disorders.
- chemical , therapeutic use : Citalopram, Serotonin Uptake Inhibitors.
- Aged, Brain Mapping, Case-Control Studies, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Generalized Anxiety Disorder (GAD) is one of the most prevalent mental disorders in the elderly, but its functional neuroanatomy is not well understood. Given the role of emotion dysregulation in GAD, we sought to describe the neural bases of emotion regulation in late-life GAD by analyzing the functional connectivity (FC) in the Salience Network and the Executive Control Network during worry induction and worry reappraisal.
Twenty-eight elderly GAD and thirty-one non-anxious comparison participants were included. Twelve elderly GAD completed a 12-week pharmacotherapy trial. We used an in-scanner worry script that alternates blocks of worry induction and reappraisal. We assessed network FC, employing the following seeds: anterior insula (AI), dorso-lateral prefrontal cortex (dlPFC), the bed nucleus of stria terminalis (BNST), the paraventricular nucleus (PVN).
GAD participants exhibited greater FC during worry induction between the left AI and the right orbito-frontal cortex (OFC), and between the BNST and the subgenual cingulate. During worry reappraisal, the non-anxious participants had greater FC between the left dlPFC and the medial PFC, as well as between the left AI and the medial PFC, while elderly GAD had greater FC between the PVN and the amygdala. Following twelve weeks of pharmacotherapy, GAD participants had greater connectivity between the dlPFC and several prefrontal regions during worry reappraisal.
FC during worry induction and reappraisal points toward abnormalities in both worry generation and worry reappraisal. Following successful pharmacologic treatment, we observed greater connectivity in the prefrontal nodes of the Executive Control Network during reappraisal of worry.
Url:
DOI: 10.1016/j.jagp.2014.05.003
PubMed: 24996397
PubMed Central: 4234701
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001836
- to stream Pmc, to step Curation: 001811
- to stream Pmc, to step Checkpoint: 001443
- to stream PubMed, to step Corpus: 000659
- to stream PubMed, to step Curation: 000659
- to stream PubMed, to step Checkpoint: 000659
- to stream Ncbi, to step Merge: 002880
- to stream Ncbi, to step Curation: 002880
- to stream Ncbi, to step Checkpoint: 002880
Links to Exploration step
PMC:4234701Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Emotion reactivity and regulation in late-life generalized anxiety disorder: Functional connectivity at baseline and post-treatment</title>
<author><name sortKey="Andreescu, Carmen" sort="Andreescu, Carmen" uniqKey="Andreescu C" first="Carmen" last="Andreescu">Carmen Andreescu</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry, University of Pittsburgh School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">University of Pittsburgh School of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sheu, Lei K" sort="Sheu, Lei K" uniqKey="Sheu L" first="Lei K." last="Sheu">Lei K. Sheu</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, University of Pittsburgh</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Tudorascu, Dana" sort="Tudorascu, Dana" uniqKey="Tudorascu D" first="Dana" last="Tudorascu">Dana Tudorascu</name>
<affiliation><nlm:aff id="A3">Department of Internal Medicine, University of Pittsburgh School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">University of Pittsburgh School of Medicine</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A4">Biostatistics Department, University of Pittsburgh School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">University of Pittsburgh School of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gross, James J" sort="Gross, James J" uniqKey="Gross J" first="James J." last="Gross">James J. Gross</name>
<affiliation><nlm:aff id="A5">Department of Psychology, Stanford University</nlm:aff>
<wicri:noCountry code="subfield">Stanford University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Walker, Sarah" sort="Walker, Sarah" uniqKey="Walker S" first="Sarah" last="Walker">Sarah Walker</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry, University of Pittsburgh School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">University of Pittsburgh School of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Banihashemi, Layla" sort="Banihashemi, Layla" uniqKey="Banihashemi L" first="Layla" last="Banihashemi">Layla Banihashemi</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, University of Pittsburgh</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Aizenstein, Howard" sort="Aizenstein, Howard" uniqKey="Aizenstein H" first="Howard" last="Aizenstein">Howard Aizenstein</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry, University of Pittsburgh School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">University of Pittsburgh School of Medicine</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A6">Bioengineering Department, University of Pittsburgh</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24996397</idno>
<idno type="pmc">4234701</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234701</idno>
<idno type="RBID">PMC:4234701</idno>
<idno type="doi">10.1016/j.jagp.2014.05.003</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001836</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001836</idno>
<idno type="wicri:Area/Pmc/Curation">001811</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001811</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001443</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001443</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000659</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000659</idno>
<idno type="wicri:Area/PubMed/Curation">000659</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000659</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000659</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000659</idno>
<idno type="wicri:Area/Ncbi/Merge">002880</idno>
<idno type="wicri:Area/Ncbi/Curation">002880</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002880</idno>
<idno type="wicri:doubleKey">1064-7481:2014:Andreescu C:emotion:reactivity:and</idno>
<idno type="wicri:Area/Main/Merge">003205</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Emotion reactivity and regulation in late-life generalized anxiety disorder: Functional connectivity at baseline and post-treatment</title>
<author><name sortKey="Andreescu, Carmen" sort="Andreescu, Carmen" uniqKey="Andreescu C" first="Carmen" last="Andreescu">Carmen Andreescu</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry, University of Pittsburgh School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">University of Pittsburgh School of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sheu, Lei K" sort="Sheu, Lei K" uniqKey="Sheu L" first="Lei K." last="Sheu">Lei K. Sheu</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, University of Pittsburgh</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Tudorascu, Dana" sort="Tudorascu, Dana" uniqKey="Tudorascu D" first="Dana" last="Tudorascu">Dana Tudorascu</name>
<affiliation><nlm:aff id="A3">Department of Internal Medicine, University of Pittsburgh School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">University of Pittsburgh School of Medicine</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A4">Biostatistics Department, University of Pittsburgh School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">University of Pittsburgh School of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gross, James J" sort="Gross, James J" uniqKey="Gross J" first="James J." last="Gross">James J. Gross</name>
<affiliation><nlm:aff id="A5">Department of Psychology, Stanford University</nlm:aff>
<wicri:noCountry code="subfield">Stanford University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Walker, Sarah" sort="Walker, Sarah" uniqKey="Walker S" first="Sarah" last="Walker">Sarah Walker</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry, University of Pittsburgh School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">University of Pittsburgh School of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Banihashemi, Layla" sort="Banihashemi, Layla" uniqKey="Banihashemi L" first="Layla" last="Banihashemi">Layla Banihashemi</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, University of Pittsburgh</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Aizenstein, Howard" sort="Aizenstein, Howard" uniqKey="Aizenstein H" first="Howard" last="Aizenstein">Howard Aizenstein</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry, University of Pittsburgh School of Medicine</nlm:aff>
<wicri:noCountry code="subfield">University of Pittsburgh School of Medicine</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A6">Bioengineering Department, University of Pittsburgh</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry</title>
<idno type="ISSN">1064-7481</idno>
<idno type="eISSN">1545-7214</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aging (drug effects)</term>
<term>Aging (physiology)</term>
<term>Aging (psychology)</term>
<term>Anxiety Disorders (drug therapy)</term>
<term>Anxiety Disorders (physiopathology)</term>
<term>Anxiety Disorders (psychology)</term>
<term>Brain Mapping</term>
<term>Case-Control Studies</term>
<term>Cerebral Cortex (drug effects)</term>
<term>Cerebral Cortex (physiopathology)</term>
<term>Citalopram (pharmacology)</term>
<term>Citalopram (therapeutic use)</term>
<term>Emotions (drug effects)</term>
<term>Emotions (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neural Pathways (drug effects)</term>
<term>Neural Pathways (physiopathology)</term>
<term>Paraventricular Hypothalamic Nucleus (drug effects)</term>
<term>Paraventricular Hypothalamic Nucleus (physiopathology)</term>
<term>Prefrontal Cortex (drug effects)</term>
<term>Prefrontal Cortex (physiopathology)</term>
<term>Septal Nuclei (drug effects)</term>
<term>Septal Nuclei (physiopathology)</term>
<term>Serotonin Uptake Inhibitors (pharmacology)</term>
<term>Serotonin Uptake Inhibitors (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Cartographie cérébrale</term>
<term>Citalopram (pharmacologie)</term>
<term>Citalopram (usage thérapeutique)</term>
<term>Cortex cérébral ()</term>
<term>Cortex cérébral (physiopathologie)</term>
<term>Cortex préfrontal ()</term>
<term>Cortex préfrontal (physiopathologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Inhibiteurs de la capture de la sérotonine (pharmacologie)</term>
<term>Inhibiteurs de la capture de la sérotonine (usage thérapeutique)</term>
<term>Mâle</term>
<term>Noyau paraventriculaire de l'hypothalamus ()</term>
<term>Noyau paraventriculaire de l'hypothalamus (physiopathologie)</term>
<term>Noyaux du septum ()</term>
<term>Noyaux du septum (physiopathologie)</term>
<term>Sujet âgé</term>
<term>Troubles anxieux (physiopathologie)</term>
<term>Troubles anxieux (psychologie)</term>
<term>Troubles anxieux (traitement médicamenteux)</term>
<term>Vieillissement ()</term>
<term>Vieillissement (physiologie)</term>
<term>Vieillissement (psychologie)</term>
<term>Voies nerveuses ()</term>
<term>Voies nerveuses (physiopathologie)</term>
<term>Émotions ()</term>
<term>Émotions (physiologie)</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Citalopram</term>
<term>Serotonin Uptake Inhibitors</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Aging</term>
<term>Cerebral Cortex</term>
<term>Emotions</term>
<term>Neural Pathways</term>
<term>Paraventricular Hypothalamic Nucleus</term>
<term>Prefrontal Cortex</term>
<term>Septal Nuclei</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Anxiety Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Citalopram</term>
<term>Inhibiteurs de la capture de la sérotonine</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Vieillissement</term>
<term>Émotions</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term>
<term>Emotions</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Cortex cérébral</term>
<term>Cortex préfrontal</term>
<term>Noyau paraventriculaire de l'hypothalamus</term>
<term>Noyaux du septum</term>
<term>Troubles anxieux</term>
<term>Voies nerveuses</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Anxiety Disorders</term>
<term>Cerebral Cortex</term>
<term>Neural Pathways</term>
<term>Paraventricular Hypothalamic Nucleus</term>
<term>Prefrontal Cortex</term>
<term>Septal Nuclei</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Troubles anxieux</term>
<term>Vieillissement</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Aging</term>
<term>Anxiety Disorders</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Citalopram</term>
<term>Serotonin Uptake Inhibitors</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Troubles anxieux</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Citalopram</term>
<term>Inhibiteurs de la capture de la sérotonine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Brain Mapping</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Cartographie cérébrale</term>
<term>Cortex cérébral</term>
<term>Cortex préfrontal</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Mâle</term>
<term>Noyau paraventriculaire de l'hypothalamus</term>
<term>Noyaux du septum</term>
<term>Sujet âgé</term>
<term>Vieillissement</term>
<term>Voies nerveuses</term>
<term>Émotions</term>
<term>Études cas-témoins</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
<p id="P1">Generalized Anxiety Disorder (GAD) is one of the most prevalent mental disorders in the elderly, but its functional neuroanatomy is not well understood. Given the role of emotion dysregulation in GAD, we sought to describe the neural bases of emotion regulation in late-life GAD by analyzing the functional connectivity (FC) in the Salience Network and the Executive Control Network during worry induction and worry reappraisal.</p>
</sec>
<sec id="S2"><title>Design, setting and participants</title>
<p id="P2">Twenty-eight elderly GAD and thirty-one non-anxious comparison participants were included. Twelve elderly GAD completed a 12-week pharmacotherapy trial. We used an in-scanner worry script that alternates blocks of worry induction and reappraisal. We assessed network FC, employing the following seeds: anterior insula (AI), dorso-lateral prefrontal cortex (dlPFC), the bed nucleus of stria terminalis (BNST), the paraventricular nucleus (PVN).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">GAD participants exhibited greater FC during worry induction between the left AI and the right orbito-frontal cortex (OFC), and between the BNST and the subgenual cingulate. During worry reappraisal, the non-anxious participants had greater FC between the left dlPFC and the medial PFC, as well as between the left AI and the medial PFC, while elderly GAD had greater FC between the PVN and the amygdala. Following twelve weeks of pharmacotherapy, GAD participants had greater connectivity between the dlPFC and several prefrontal regions during worry reappraisal.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">FC during worry induction and reappraisal points toward abnormalities in both worry generation and worry reappraisal. Following successful pharmacologic treatment, we observed greater connectivity in the prefrontal nodes of the Executive Control Network during reappraisal of worry.</p>
</sec>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003205 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003205 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Amérique |area= PittsburghV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:4234701 |texte= Emotion reactivity and regulation in late-life generalized anxiety disorder: Functional connectivity at baseline and post-treatment }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:24996397" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a PittsburghV1
This area was generated with Dilib version V0.6.38. |