Improving intermittent androgen deprivation therapy: lessons learned from basic and translational research
Identifieur interne : 002910 ( Main/Merge ); précédent : 002909; suivant : 002911Improving intermittent androgen deprivation therapy: lessons learned from basic and translational research
Auteurs : Rahul A. Parikh [États-Unis] ; Laura E. Pascal [États-Unis] ; Benjamin J. Davies [États-Unis] ; Zhou Wang [États-Unis]Source :
- Asian Journal of Andrology [ 1008-682X ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Antagonistes des androgènes (administration et posologie), Antagonistes des androgènes (usage thérapeutique), Humains, Mâle, Qualité de vie, Recherche médicale translationnelle, Tumeurs de la prostate (anatomopathologie), Tumeurs de la prostate (traitement médicamenteux), Évolution de la maladie.
- MESH :
- administration et posologie : Antagonistes des androgènes.
- anatomopathologie : Tumeurs de la prostate.
- traitement médicamenteux : Tumeurs de la prostate.
- usage thérapeutique : Antagonistes des androgènes.
- Animaux, Humains, Mâle, Qualité de vie, Recherche médicale translationnelle, Évolution de la maladie.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Androgen Antagonists.
- chemical , therapeutic use : Androgen Antagonists.
- drug therapy : Prostatic Neoplasms.
- pathology : Prostatic Neoplasms.
- Animals, Disease Progression, Humans, Male, Quality of Life, Translational Medical Research.
Abstract
Intermittent androgen deprivation therapy (IADT) is an alternative to continuous androgen deprivation therapy (ADT) in prostate cancer patients with nonmetastatic disease. ADT is associated with numerous side effects such as hot flashes, sexual dysfunction, anemia, fatigue, loss of muscle mass, osteoporosis, metabolic syndrome and premature cardiovascular disease. IADT was developed with the intention of improving the quality of life and to delay progression of prostate cancer to castration resistance. The benefits of slightly improved quality of life by IADT compared to ADT were demonstrated in multiple clinical trials. IADT was noted to be noninferior to ADT in patients with biochemical recurrence of prostate cancer but in studies performed in patients with metastatic prostate cancer, the results were inconclusive. Our recent studies suggested that the administration of 5 alpha-reductase inhibitors during the off-cycle of IADT can significantly prolong the survival of mice bearing androgen-sensitive prostate tumors when off-cycle duration was short. This review discusses the survival benefit of 5 alpha-reductase inhibition in IADT in animal models and the potential translation of this finding into clinic.
Url:
DOI: 10.4103/1008-682X.125410
PubMed: 24759577
PubMed Central: 4104071
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Parikh</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Hillman Cancer Centre, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Hillman Cancer Centre, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Pascal, Laura E" sort="Pascal, Laura E" uniqKey="Pascal L" first="Laura E" last="Pascal">Laura E. 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Medical Research</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antagonistes des androgènes (administration et posologie)</term><term>Antagonistes des androgènes (usage thérapeutique)</term><term>Humains</term><term>Mâle</term><term>Qualité de vie</term><term>Recherche médicale translationnelle</term><term>Tumeurs de la prostate (anatomopathologie)</term><term>Tumeurs de la prostate (traitement médicamenteux)</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Androgen Antagonists</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Androgen Antagonists</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antagonistes des androgènes</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antagonistes des androgènes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Progression</term><term>Humans</term><term>Male</term><term>Quality of Life</term><term>Translational Medical Research</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Mâle</term><term>Qualité de vie</term><term>Recherche médicale translationnelle</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Intermittent androgen deprivation therapy (IADT) is an alternative to continuous androgen deprivation therapy (ADT) in prostate cancer patients with nonmetastatic disease. ADT is associated with numerous side effects such as hot flashes, sexual dysfunction, anemia, fatigue, loss of muscle mass, osteoporosis, metabolic syndrome and premature cardiovascular disease. IADT was developed with the intention of improving the quality of life and to delay progression of prostate cancer to castration resistance. The benefits of slightly improved quality of life by IADT compared to ADT were demonstrated in multiple clinical trials. IADT was noted to be noninferior to ADT in patients with biochemical recurrence of prostate cancer but in studies performed in patients with metastatic prostate cancer, the results were inconclusive. Our recent studies suggested that the administration of 5 alpha-reductase inhibitors during the off-cycle of IADT can significantly prolong the survival of mice bearing androgen-sensitive prostate tumors when off-cycle duration was short. This review discusses the survival benefit of 5 alpha-reductase inhibition in IADT in animal models and the potential translation of this finding into clinic.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Siegel, R" uniqKey="Siegel R">R Siegel</name></author><author><name sortKey="Naishadham, D" uniqKey="Naishadham D">D Naishadham</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Shin, Hr" uniqKey="Shin H">HR Shin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, Sc" uniqKey="Ren S">SC 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