PittsburghV1, Main, Merge, bibRecord, 001077

Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli

Identifieur interne : 001077 ( Main/Merge ); précédent : 001076; suivant : 001078

Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli

Auteurs : Callie A. Norris [États-Unis] ; Mu He [États-Unis] ; Liang-I Kang [États-Unis] ; Michael Qi Ding [États-Unis] ; Josiah E. Radder [États-Unis] ; Meagan M. Haynes [États-Unis] ; Yu Yang [États-Unis] ; Shirish Paranjpe [États-Unis] ; William C. Bowen [États-Unis] ; Anne Orr [États-Unis] ; George K. Michalopoulos [États-Unis] ; Donna B. Stolz [États-Unis] ; Wendy M. Mars [États-Unis]

Source :

PLoS ONE [ 1932-6203 ] ; 2014.

RBID : PMC:3999098

Descripteurs français

KwdFr :
- ARN messager (métabolisme), Animaux, Cellules cultivées, Communication autocrine, Facteur de croissance des hépatocytes (métabolisme), Facteur de croissance des hépatocytes (pharmacologie), Foie (), Foie (immunologie), Foie (métabolisme), Hépatocytes (), Hépatocytes (métabolisme), Interleukine-6 (biosynthèse), Interleukine-6 (génétique), Interleukine-6 (métabolisme), Lipopolysaccharides (pharmacologie), Macrophages (métabolisme), Milieux de culture sans sérum, Rats de lignée F344, Souris de lignée C57BL.
MESH :
- biosynthèse : Interleukine-6.
- génétique : Interleukine-6.
- immunologie : Foie.
- métabolisme : ARN messager, Facteur de croissance des hépatocytes, Foie, Hépatocytes, Interleukine-6, Macrophages.
- pharmacologie : Facteur de croissance des hépatocytes, Lipopolysaccharides.
- Animaux, Cellules cultivées, Communication autocrine, Foie, Hépatocytes, Milieux de culture sans sérum, Rats de lignée F344, Souris de lignée C57BL.

English descriptors

KwdEn :
- Animals, Autocrine Communication, Cells, Cultured, Culture Media, Serum-Free, Hepatocyte Growth Factor (metabolism), Hepatocyte Growth Factor (pharmacology), Hepatocytes (drug effects), Hepatocytes (metabolism), Interleukin-6 (biosynthesis), Interleukin-6 (genetics), Interleukin-6 (metabolism), Lipopolysaccharides (pharmacology), Liver (drug effects), Liver (immunology), Liver (metabolism), Macrophages (metabolism), Mice, Inbred C57BL, RNA, Messenger (metabolism), Rats, Inbred F344.
MESH :
- chemical , biosynthesis : Interleukin-6.
- chemical , genetics : Interleukin-6.
- chemical , metabolism : Hepatocyte Growth Factor, Interleukin-6, RNA, Messenger.
- chemical , pharmacology : Hepatocyte Growth Factor, Lipopolysaccharides.
- chemical : Culture Media, Serum-Free.
- drug effects : Hepatocytes, Liver.
- immunology : Liver.
- metabolism : Hepatocytes, Liver, Macrophages.
- Animals, Autocrine Communication, Cells, Cultured, Mice, Inbred C57BL, Rats, Inbred F344.

Abstract

Exogenous interleukin 6 (IL-6), synthesized at the initiation of the acute phase response, is considered responsible for signaling hepatocytes to produce acute phase proteins. It is widely posited that IL-6 is either delivered to the liver in an endocrine fashion from immune cells at the site of injury, or alternatively, in a paracrine manner by hepatic immune cells within the liver. A recent publication showed there was a muted IL-6 response in lipopolysaccharide (LPS)-injured mice when nuclear NFκB was specifically inactivated in the hepatocytes. This indicates hepatocellular signaling is also involved in regulating the acute phase production of IL-6. Herein, we present extensive in vitro and in vivo evidence that normal hepatocytes are directly induced to synthesize IL-6 mRNAs and protein by challenge with LPS, a bacterial hepatotoxin, and by HGF, an important regulator of hepatic homeostasis. As the IL-6 receptor is found on the hepatocyte, these results reveal that induction of the acute phase response can be regulated in an autocrine as well as endocrine/paracrine fashion. Further, herein we provide data indicating that following partial hepatectomy (PHx), HGF differentially regulates IL-6 production in hepatocytes (induces) versus immune cells (suppresses), signifying disparate regulation of the cell sources involved in IL-6 production is a biologically relevant mechanism that has previously been overlooked. These findings have wide ranging ramifications regarding how we currently interpret a variety of in vivo and in vitro biological models involving elements of IL-6 signaling and the hepatic acute phase response.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999098

DOI: 10.1371/journal.pone.0096053
PubMed: 24763697
PubMed Central: 3999098

Links to Exploration step

PMC:3999098

Le document en format XML

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<term>Interleukin-6 (genetics)</term>
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<front><div type="abstract" xml:lang="en"><p>Exogenous interleukin 6 (IL-6), synthesized at the initiation of the acute phase response, is considered responsible for signaling hepatocytes to produce acute phase proteins. It is widely posited that IL-6 is either delivered to the liver in an endocrine fashion from immune cells at the site of injury, or alternatively, in a paracrine manner by hepatic immune cells within the liver. A recent publication showed there was a muted IL-6 response in lipopolysaccharide (LPS)-injured mice when nuclear NFκB was specifically inactivated in the hepatocytes. This indicates hepatocellular signaling is also involved in regulating the acute phase production of IL-6. Herein, we present extensive <italic>in vitro</italic>
 and <italic>in vivo</italic>
 evidence that normal hepatocytes are directly induced to synthesize IL-6 mRNAs and protein by challenge with LPS, a bacterial hepatotoxin, and by HGF, an important regulator of hepatic homeostasis. As the IL-6 receptor is found on the hepatocyte, these results reveal that induction of the acute phase response can be regulated in an autocrine as well as endocrine/paracrine fashion. Further, herein we provide data indicating that following partial hepatectomy (PHx), HGF differentially regulates IL-6 production in hepatocytes (induces) versus immune cells (suppresses), signifying disparate regulation of the cell sources involved in IL-6 production is a biologically relevant mechanism that has previously been overlooked. These findings have wide ranging ramifications regarding how we currently interpret a variety of <italic>in vivo</italic>
 and <italic>in vitro</italic>
 biological models involving elements of IL-6 signaling and the hepatic acute phase response.</p>
</div>
</front>
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<author><name sortKey="Michalopoulos, Gk" uniqKey="Michalopoulos G">GK Michalopoulos</name>
</author>
<author><name sortKey="Mars, Wm" uniqKey="Mars W">WM Mars</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Braissant, O" uniqKey="Braissant O">O Braissant</name>
</author>
<author><name sortKey="Wahli, W" uniqKey="Wahli W">W Wahli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gkretsi, V" uniqKey="Gkretsi V">V Gkretsi</name>
</author>
<author><name sortKey="Apte, U" uniqKey="Apte U">U Apte</name>
</author>
<author><name sortKey="Mars, Wm" uniqKey="Mars W">WM Mars</name>
</author>
<author><name sortKey="Bowen, Wc" uniqKey="Bowen W">WC Bowen</name>
</author>
<author><name sortKey="Luo, Jh" uniqKey="Luo J">JH Luo</name>
</author>
</analytic>
</biblStruct>
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</back>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001077 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001077 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:3999098
   |texte=   Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i   -Sk "pubmed:24763697" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a PittsburghV1

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

Serveur d'exploration sur Pittsburgh

Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli

Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli

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English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.