Chemoprevention of Oral Cancer by Topical Application of Black Raspberries on High At-Risk Mucosa
Identifieur interne : 003966 ( Main/Exploration ); précédent : 003965; suivant : 003967Chemoprevention of Oral Cancer by Topical Application of Black Raspberries on High At-Risk Mucosa
Auteurs : Blake M. Warner [États-Unis] ; Bruce C. Casto ; Thomas J. Knobloch ; Brent T. Accurso ; Christopher M. WeghorstSource :
- Oral surgery, oral medicine, oral pathology and oral radiology [ 2212-4403 ] ; 2014.
Descripteurs français
- KwdFr :
- Administration par voie topique, Animaux, Carcinome épidermoïde (), Carcinome épidermoïde (anatomopathologie), Chimioprévention (), Cricetinae, Marqueurs biologiques tumoraux (analyse), Modèles animaux de maladie humaine, Muqueuse de la bouche (), Muqueuse de la bouche (anatomopathologie), Mâle, Prolifération cellulaire (), Rubus, Tumeurs de la bouche (), Tumeurs de la bouche (anatomopathologie), États précancéreux (traitement médicamenteux), Évolution de la maladie.
- MESH :
- analyse : Marqueurs biologiques tumoraux.
- anatomopathologie : Carcinome épidermoïde, Muqueuse de la bouche, Tumeurs de la bouche.
- traitement médicamenteux : États précancéreux.
- Administration par voie topique, Animaux, Carcinome épidermoïde, Chimioprévention, Cricetinae, Modèles animaux de maladie humaine, Muqueuse de la bouche, Mâle, Prolifération cellulaire, Rubus, Tumeurs de la bouche, Évolution de la maladie.
English descriptors
- KwdEn :
- Administration, Topical, Animals, Biomarkers, Tumor (analysis), Carcinoma, Squamous Cell (pathology), Carcinoma, Squamous Cell (prevention & control), Cell Proliferation (drug effects), Chemoprevention (methods), Cricetinae, Disease Models, Animal, Disease Progression, Male, Mouth Mucosa (drug effects), Mouth Mucosa (pathology), Mouth Neoplasms (pathology), Mouth Neoplasms (prevention & control), Precancerous Conditions (drug therapy), Rubus.
- MESH :
- chemical , analysis : Biomarkers, Tumor.
- drug effects : Cell Proliferation, Mouth Mucosa.
- drug therapy : Precancerous Conditions.
- methods : Chemoprevention.
- pathology : Carcinoma, Squamous Cell, Mouth Mucosa, Mouth Neoplasms.
- prevention & control : Carcinoma, Squamous Cell, Mouth Neoplasms.
- Administration, Topical, Animals, Cricetinae, Disease Models, Animal, Disease Progression, Male, Rubus.
Abstract
To evaluate the preclinical efficacy of topical administration of freeze-dried black raspberries (BRBs) to inhibit the progression of premalignant oral lesions and modulate biomarkers of cancer development in high at-risk mucosa (HARM).
Hamster cheek pouches (HCPs) were treated with carcinogen for six weeks to initiate a HARM microenvironment. Subsequently, right HCPs were topically administered a BRB suspension in short-term or long-term studies. After 12 weeks, SCC multiplicity, SCC incidence, and cell proliferation rates were evaluated. mRNA expression was measured in short-term treated pouches for selected oral cancer biomarkers.
SCC multiplicity (−41.3%), tumor incidence (−37.1%), and proliferation rate (−6.9%) were reduced in HCPs receiving BRBs. Topical BRBs correlated with an increase in
Topical BRBs inhibit SCC development when targeted to HARM tissues. These results support the translational role of BRBs to prevent oral cancer development in humans.
Url:
DOI: 10.1016/j.oooo.2014.09.005
PubMed: 25457886
PubMed Central: 4254525
Affiliations:
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Warner</name><affiliation><nlm:aff id="A1">University College of Public Health, The Ohio State University, Columbus, OH, 43210</nlm:aff><wicri:noCountry code="subfield">43210</wicri:noCountry></affiliation><affiliation><nlm:aff id="A3">College of Dentistry, The Ohio State University, Columbus, OH, 43210</nlm:aff><wicri:noCountry code="subfield">43210</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>School of Dental Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Casto, Bruce C" sort="Casto, Bruce C" uniqKey="Casto B" first="Bruce C." last="Casto">Bruce C. 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Warner</name><affiliation><nlm:aff id="A1">University College of Public Health, The Ohio State University, Columbus, OH, 43210</nlm:aff><wicri:noCountry code="subfield">43210</wicri:noCountry></affiliation><affiliation><nlm:aff id="A3">College of Dentistry, The Ohio State University, Columbus, OH, 43210</nlm:aff><wicri:noCountry code="subfield">43210</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>School of Dental Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Casto, Bruce C" sort="Casto, Bruce C" uniqKey="Casto B" first="Bruce C." last="Casto">Bruce C. 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Weghorst</name><affiliation><nlm:aff id="A1">University College of Public Health, The Ohio State University, Columbus, OH, 43210</nlm:aff><wicri:noCountry code="subfield">43210</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210</nlm:aff><wicri:noCountry code="subfield">43210</wicri:noCountry></affiliation></author></analytic><series><title level="j">Oral surgery, oral medicine, oral pathology and oral radiology</title><idno type="ISSN">2212-4403</idno><idno type="eISSN">2212-4411</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Topical</term><term>Animals</term><term>Biomarkers, Tumor (analysis)</term><term>Carcinoma, Squamous Cell (pathology)</term><term>Carcinoma, Squamous Cell (prevention & control)</term><term>Cell Proliferation (drug effects)</term><term>Chemoprevention (methods)</term><term>Cricetinae</term><term>Disease Models, Animal</term><term>Disease Progression</term><term>Male</term><term>Mouth Mucosa (drug effects)</term><term>Mouth Mucosa (pathology)</term><term>Mouth Neoplasms (pathology)</term><term>Mouth Neoplasms (prevention & control)</term><term>Precancerous Conditions (drug therapy)</term><term>Rubus</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie topique</term><term>Animaux</term><term>Carcinome épidermoïde ()</term><term>Carcinome épidermoïde (anatomopathologie)</term><term>Chimioprévention ()</term><term>Cricetinae</term><term>Marqueurs biologiques tumoraux (analyse)</term><term>Modèles animaux de maladie humaine</term><term>Muqueuse de la bouche ()</term><term>Muqueuse de la bouche (anatomopathologie)</term><term>Mâle</term><term>Prolifération cellulaire ()</term><term>Rubus</term><term>Tumeurs de la bouche ()</term><term>Tumeurs de la bouche (anatomopathologie)</term><term>États précancéreux (traitement médicamenteux)</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers, Tumor</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Marqueurs biologiques tumoraux</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Muqueuse de la bouche</term><term>Tumeurs de la bouche</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Mouth Mucosa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Precancerous Conditions</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chemoprevention</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Mouth Mucosa</term><term>Mouth Neoplasms</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Mouth Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>États précancéreux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Topical</term><term>Animals</term><term>Cricetinae</term><term>Disease Models, Animal</term><term>Disease Progression</term><term>Male</term><term>Rubus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie topique</term><term>Animaux</term><term>Carcinome épidermoïde</term><term>Chimioprévention</term><term>Cricetinae</term><term>Modèles animaux de maladie humaine</term><term>Muqueuse de la bouche</term><term>Mâle</term><term>Prolifération cellulaire</term><term>Rubus</term><term>Tumeurs de la bouche</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P2">To evaluate the preclinical efficacy of topical administration of freeze-dried black raspberries (BRBs) to inhibit the progression of premalignant oral lesions and modulate biomarkers of cancer development in high at-risk mucosa (HARM).</p></sec><sec id="S2"><title>Study Design</title><p id="P3">Hamster cheek pouches (HCPs) were treated with carcinogen for six weeks to initiate a HARM microenvironment. Subsequently, right HCPs were topically administered a BRB suspension in short-term or long-term studies. After 12 weeks, SCC multiplicity, SCC incidence, and cell proliferation rates were evaluated. mRNA expression was measured in short-term treated pouches for selected oral cancer biomarkers.</p></sec><sec id="S3"><title>Results</title><p id="P4">SCC multiplicity (−41.3%), tumor incidence (−37.1%), and proliferation rate (−6.9%) were reduced in HCPs receiving BRBs. Topical BRBs correlated with an increase in <italic>Rb1</italic> expression in developing oral lesions.</p></sec><sec id="S4"><title>Conclusion</title><p id="P5">Topical BRBs inhibit SCC development when targeted to HARM tissues. These results support the translational role of BRBs to prevent oral cancer development in humans.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><noCountry><name sortKey="Accurso, Brent T" sort="Accurso, Brent T" uniqKey="Accurso B" first="Brent T." last="Accurso">Brent T. Accurso</name><name sortKey="Casto, Bruce C" sort="Casto, Bruce C" uniqKey="Casto B" first="Bruce C." last="Casto">Bruce C. Casto</name><name sortKey="Knobloch, Thomas J" sort="Knobloch, Thomas J" uniqKey="Knobloch T" first="Thomas J." last="Knobloch">Thomas J. Knobloch</name><name sortKey="Weghorst, Christopher M" sort="Weghorst, Christopher M" uniqKey="Weghorst C" first="Christopher M." last="Weghorst">Christopher M. Weghorst</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Warner, Blake M" sort="Warner, Blake M" uniqKey="Warner B" first="Blake M." last="Warner">Blake M. Warner</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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