Dicer function is required in the metanephric mesenchyme for early kidney development
Identifieur interne : 003388 ( Main/Exploration ); précédent : 003387; suivant : 003389Dicer function is required in the metanephric mesenchyme for early kidney development
Auteurs : Jessica Y. S. Chu [États-Unis] ; Sunder Sims-Lucas [États-Unis] ; Daniel S. Bushnell [États-Unis] ; Andrew J. Bodnar [États-Unis] ; Jordan A. Kreidberg [États-Unis] ; Jacqueline Ho [États-Unis]Source :
- American Journal of Physiology - Renal Physiology [ 1931-857X ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Apoptose, Cellules souches embryonnaires (enzymologie), DEAD-box RNA helicases (déficit), DEAD-box RNA helicases (génétique), DEAD-box RNA helicases (métabolisme), Mésoderme (enzymologie), Mésoderme (malformations), Néphrons (enzymologie), Néphrons (malformations), Organogenèse, Protéine-11 analogue à Bcl-2, Protéines membranaires (génétique), Protéines membranaires (métabolisme), Protéines nucléaires (génétique), Protéines nucléaires (métabolisme), Protéines proto-oncogènes (génétique), Protéines proto-oncogènes (métabolisme), Protéines régulatrices de l'apoptose (génétique), Protéines régulatrices de l'apoptose (métabolisme), Rein (enzymologie), Rein (malformations), Ribonuclease III (déficit), Ribonuclease III (génétique), Ribonuclease III (métabolisme), Régulation de l'expression des gènes au cours du développement, Régulation de l'expression des gènes codant pour des enzymes, Souris, Souris knockout, Transactivateurs (génétique), Transactivateurs (métabolisme), Uretère (enzymologie), Uretère (malformations), microARN (métabolisme), Âge gestationnel.
- MESH :
- déficit : DEAD-box RNA helicases, Ribonuclease III.
- enzymologie : Cellules souches embryonnaires, Mésoderme, Néphrons, Rein, Uretère.
- génétique : DEAD-box RNA helicases, Protéines membranaires, Protéines nucléaires, Protéines proto-oncogènes, Protéines régulatrices de l'apoptose, Ribonuclease III, Transactivateurs.
- malformations : Mésoderme, Néphrons, Rein, Uretère.
- métabolisme : DEAD-box RNA helicases, Protéines membranaires, Protéines nucléaires, Protéines proto-oncogènes, Protéines régulatrices de l'apoptose, Ribonuclease III, Transactivateurs, microARN.
- Animaux, Apoptose, Organogenèse, Protéine-11 analogue à Bcl-2, Régulation de l'expression des gènes au cours du développement, Régulation de l'expression des gènes codant pour des enzymes, Souris, Souris knockout, Âge gestationnel.
English descriptors
- KwdEn :
- Animals, Apoptosis, Apoptosis Regulatory Proteins (genetics), Apoptosis Regulatory Proteins (metabolism), Bcl-2-Like Protein 11, DEAD-box RNA Helicases (deficiency), DEAD-box RNA Helicases (genetics), DEAD-box RNA Helicases (metabolism), Embryonic Stem Cells (enzymology), Gene Expression Regulation, Developmental, Gene Expression Regulation, Enzymologic, Gestational Age, Kidney (abnormalities), Kidney (enzymology), Membrane Proteins (genetics), Membrane Proteins (metabolism), Mesoderm (abnormalities), Mesoderm (enzymology), Mice, Mice, Knockout, MicroRNAs (metabolism), Nephrons (abnormalities), Nephrons (enzymology), Nuclear Proteins (genetics), Nuclear Proteins (metabolism), Organogenesis, Proto-Oncogene Proteins (genetics), Proto-Oncogene Proteins (metabolism), Ribonuclease III (deficiency), Ribonuclease III (genetics), Ribonuclease III (metabolism), Trans-Activators (genetics), Trans-Activators (metabolism), Ureter (abnormalities), Ureter (enzymology).
- MESH :
- chemical , deficiency : DEAD-box RNA Helicases, Ribonuclease III.
- chemical , genetics : Apoptosis Regulatory Proteins, DEAD-box RNA Helicases, Membrane Proteins, Nuclear Proteins, Proto-Oncogene Proteins, Ribonuclease III, Trans-Activators.
- chemical , metabolism : Apoptosis Regulatory Proteins, DEAD-box RNA Helicases, Membrane Proteins, MicroRNAs, Nuclear Proteins, Proto-Oncogene Proteins, Ribonuclease III, Trans-Activators.
- abnormalities : Kidney, Mesoderm, Nephrons, Ureter.
- enzymology : Embryonic Stem Cells, Kidney, Mesoderm, Nephrons, Ureter.
- Animals, Apoptosis, Bcl-2-Like Protein 11, Gene Expression Regulation, Developmental, Gene Expression Regulation, Enzymologic, Gestational Age, Mice, Mice, Knockout, Organogenesis.
Abstract
MicroRNAs (miRNAs) are small, noncoding regulatory RNAs that act as posttranscriptional repressors by binding to the 3′-untranslated region (3′-UTR) of target genes. They require processing by Dicer, an RNase III enzyme, to become mature regulatory RNAs. Previous work from our laboratory revealed critical roles for miRNAs in nephron progenitors at midgestation (Ho J, Pandey P, Schatton T, Sims-Lucas S, Khalid M, Frank MH, Hartwig S, Kreidberg JA.
Url:
DOI: 10.1152/ajprenal.00426.2013
PubMed: 24500693
PubMed Central: 3962603
Affiliations:
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Apoptosis</term>
<term>Apoptosis Regulatory Proteins (genetics)</term>
<term>Apoptosis Regulatory Proteins (metabolism)</term>
<term>Bcl-2-Like Protein 11</term>
<term>DEAD-box RNA Helicases (deficiency)</term>
<term>DEAD-box RNA Helicases (genetics)</term>
<term>DEAD-box RNA Helicases (metabolism)</term>
<term>Embryonic Stem Cells (enzymology)</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Gene Expression Regulation, Enzymologic</term>
<term>Gestational Age</term>
<term>Kidney (abnormalities)</term>
<term>Kidney (enzymology)</term>
<term>Membrane Proteins (genetics)</term>
<term>Membrane Proteins (metabolism)</term>
<term>Mesoderm (abnormalities)</term>
<term>Mesoderm (enzymology)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>MicroRNAs (metabolism)</term>
<term>Nephrons (abnormalities)</term>
<term>Nephrons (enzymology)</term>
<term>Nuclear Proteins (genetics)</term>
<term>Nuclear Proteins (metabolism)</term>
<term>Organogenesis</term>
<term>Proto-Oncogene Proteins (genetics)</term>
<term>Proto-Oncogene Proteins (metabolism)</term>
<term>Ribonuclease III (deficiency)</term>
<term>Ribonuclease III (genetics)</term>
<term>Ribonuclease III (metabolism)</term>
<term>Trans-Activators (genetics)</term>
<term>Trans-Activators (metabolism)</term>
<term>Ureter (abnormalities)</term>
<term>Ureter (enzymology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Apoptose</term>
<term>Cellules souches embryonnaires (enzymologie)</term>
<term>DEAD-box RNA helicases (déficit)</term>
<term>DEAD-box RNA helicases (génétique)</term>
<term>DEAD-box RNA helicases (métabolisme)</term>
<term>Mésoderme (enzymologie)</term>
<term>Mésoderme (malformations)</term>
<term>Néphrons (enzymologie)</term>
<term>Néphrons (malformations)</term>
<term>Organogenèse</term>
<term>Protéine-11 analogue à Bcl-2</term>
<term>Protéines membranaires (génétique)</term>
<term>Protéines membranaires (métabolisme)</term>
<term>Protéines nucléaires (génétique)</term>
<term>Protéines nucléaires (métabolisme)</term>
<term>Protéines proto-oncogènes (génétique)</term>
<term>Protéines proto-oncogènes (métabolisme)</term>
<term>Protéines régulatrices de l'apoptose (génétique)</term>
<term>Protéines régulatrices de l'apoptose (métabolisme)</term>
<term>Rein (enzymologie)</term>
<term>Rein (malformations)</term>
<term>Ribonuclease III (déficit)</term>
<term>Ribonuclease III (génétique)</term>
<term>Ribonuclease III (métabolisme)</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Régulation de l'expression des gènes codant pour des enzymes</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Transactivateurs (génétique)</term>
<term>Transactivateurs (métabolisme)</term>
<term>Uretère (enzymologie)</term>
<term>Uretère (malformations)</term>
<term>microARN (métabolisme)</term>
<term>Âge gestationnel</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>DEAD-box RNA Helicases</term>
<term>Ribonuclease III</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apoptosis Regulatory Proteins</term>
<term>DEAD-box RNA Helicases</term>
<term>Membrane Proteins</term>
<term>Nuclear Proteins</term>
<term>Proto-Oncogene Proteins</term>
<term>Ribonuclease III</term>
<term>Trans-Activators</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Apoptosis Regulatory Proteins</term>
<term>DEAD-box RNA Helicases</term>
<term>Membrane Proteins</term>
<term>MicroRNAs</term>
<term>Nuclear Proteins</term>
<term>Proto-Oncogene Proteins</term>
<term>Ribonuclease III</term>
<term>Trans-Activators</term>
</keywords>
<keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Kidney</term>
<term>Mesoderm</term>
<term>Nephrons</term>
<term>Ureter</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>DEAD-box RNA helicases</term>
<term>Ribonuclease III</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Cellules souches embryonnaires</term>
<term>Mésoderme</term>
<term>Néphrons</term>
<term>Rein</term>
<term>Uretère</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Embryonic Stem Cells</term>
<term>Kidney</term>
<term>Mesoderm</term>
<term>Nephrons</term>
<term>Ureter</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>DEAD-box RNA helicases</term>
<term>Protéines membranaires</term>
<term>Protéines nucléaires</term>
<term>Protéines proto-oncogènes</term>
<term>Protéines régulatrices de l'apoptose</term>
<term>Ribonuclease III</term>
<term>Transactivateurs</term>
</keywords>
<keywords scheme="MESH" qualifier="malformations" xml:lang="fr"><term>Mésoderme</term>
<term>Néphrons</term>
<term>Rein</term>
<term>Uretère</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>DEAD-box RNA helicases</term>
<term>Protéines membranaires</term>
<term>Protéines nucléaires</term>
<term>Protéines proto-oncogènes</term>
<term>Protéines régulatrices de l'apoptose</term>
<term>Ribonuclease III</term>
<term>Transactivateurs</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Apoptosis</term>
<term>Bcl-2-Like Protein 11</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Gene Expression Regulation, Enzymologic</term>
<term>Gestational Age</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Organogenesis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Apoptose</term>
<term>Organogenèse</term>
<term>Protéine-11 analogue à Bcl-2</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Régulation de l'expression des gènes codant pour des enzymes</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Âge gestationnel</term>
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<front><div type="abstract" xml:lang="en"><p>MicroRNAs (miRNAs) are small, noncoding regulatory RNAs that act as posttranscriptional repressors by binding to the 3′-untranslated region (3′-UTR) of target genes. They require processing by Dicer, an RNase III enzyme, to become mature regulatory RNAs. Previous work from our laboratory revealed critical roles for miRNAs in nephron progenitors at midgestation (Ho J, Pandey P, Schatton T, Sims-Lucas S, Khalid M, Frank MH, Hartwig S, Kreidberg JA. <italic>J Am Soc Nephrol</italic>
22: 1053–1063, 2011). To interrogate roles for miRNAs in the early metanephric mesenchyme, which gives rise to nephron progenitors as well as the renal stroma during kidney development, we conditionally ablated Dicer function in this lineage. Despite normal ureteric bud outgrowth and condensation of the metanephric mesenchyme to form nephron progenitors, early loss of miRNAs in the metanephric mesenchyme resulted in severe renal dysgenesis. Nephron progenitors are initially correctly specified in the mutant kidneys, with normal expression of several transcription factors known to be critical in progenitors, including Six2, Pax2, Sall1, and Wt1. However, there is premature loss of the nephron progenitor marker Cited1, marked apoptosis, and increased expression of the proapoptotic protein Bim shortly after the initial inductive events in early kidney development. Subsequently, there is a failure in ureteric bud branching and nephron progenitor differentiation. Taken together, our data demonstrate a previously undetermined requirement for miRNAs during early kidney organogenesis and indicate a crucial role for miRNAs in regulating the survival of this lineage.</p>
</div>
</front>
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</region>
<name sortKey="Bodnar, Andrew J" sort="Bodnar, Andrew J" uniqKey="Bodnar A" first="Andrew J." last="Bodnar">Andrew J. Bodnar</name>
<name sortKey="Bushnell, Daniel S" sort="Bushnell, Daniel S" uniqKey="Bushnell D" first="Daniel S." last="Bushnell">Daniel S. Bushnell</name>
<name sortKey="Ho, Jacqueline" sort="Ho, Jacqueline" uniqKey="Ho J" first="Jacqueline" last="Ho">Jacqueline Ho</name>
<name sortKey="Kreidberg, Jordan A" sort="Kreidberg, Jordan A" uniqKey="Kreidberg J" first="Jordan A." last="Kreidberg">Jordan A. Kreidberg</name>
<name sortKey="Kreidberg, Jordan A" sort="Kreidberg, Jordan A" uniqKey="Kreidberg J" first="Jordan A." last="Kreidberg">Jordan A. Kreidberg</name>
<name sortKey="Sims Lucas, Sunder" sort="Sims Lucas, Sunder" uniqKey="Sims Lucas S" first="Sunder" last="Sims-Lucas">Sunder Sims-Lucas</name>
</country>
</tree>
</affiliations>
</record>
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