Gene-environment interaction.
Identifieur interne : 002C46 ( Main/Exploration ); précédent : 002C45; suivant : 002C47Gene-environment interaction.
Auteurs : Stephen B. Manuck [États-Unis] ; Jeanne M. MccafferySource :
- Annual review of psychology [ 1545-2085 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Troubles mentaux.
- psychologie : Troubles mentaux.
- étiologie : Troubles mentaux.
- Environnement, Humains, Interaction entre gènes et environnement, Modèles psychologiques, Phénotype, Prédisposition génétique à une maladie, Variation génétique.
English descriptors
- KwdEn :
- MESH :
- etiology : Mental Disorders.
- genetics : Mental Disorders.
- psychology : Mental Disorders.
- Environment, Gene-Environment Interaction, Genetic Predisposition to Disease, Genetic Variation, Humans, Models, Psychological, Phenotype.
Abstract
With the advent of increasingly accessible technologies for typing genetic variation, studies of gene-environment (G×E) interactions have proliferated in psychological research. Among the aims of such studies are testing developmental hypotheses and models of the etiology of behavioral disorders, defining boundaries of genetic and environmental influences, and identifying individuals most susceptible to risk exposures or most amenable to preventive and therapeutic interventions. This research also coincides with the emergence of unanticipated difficulties in detecting genetic variants of direct association with behavioral traits and disorders, which may be obscured if genetic effects are expressed only in predisposing environments. In this essay we consider these and other rationales for positing G×E interactions, review conceptual models meant to inform G×E interpretations from a psychological perspective, discuss points of common critique to which G×E research is vulnerable, and address the role of the environment in G×E interactions.
DOI: 10.1146/annurev-psych-010213-115100
PubMed: 24405358
Affiliations:
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Manuck</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260; email: manuck@pitt.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Mccaffery, Jeanne M" sort="Mccaffery, Jeanne M" uniqKey="Mccaffery J" first="Jeanne M" last="Mccaffery">Jeanne M. 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Among the aims of such studies are testing developmental hypotheses and models of the etiology of behavioral disorders, defining boundaries of genetic and environmental influences, and identifying individuals most susceptible to risk exposures or most amenable to preventive and therapeutic interventions. This research also coincides with the emergence of unanticipated difficulties in detecting genetic variants of direct association with behavioral traits and disorders, which may be obscured if genetic effects are expressed only in predisposing environments. In this essay we consider these and other rationales for positing G×E interactions, review conceptual models meant to inform G×E interpretations from a psychological perspective, discuss points of common critique to which G×E research is vulnerable, and address the role of the environment in G×E interactions.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><noCountry><name sortKey="Mccaffery, Jeanne M" sort="Mccaffery, Jeanne M" uniqKey="Mccaffery J" first="Jeanne M" last="Mccaffery">Jeanne M. Mccaffery</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Manuck, Stephen B" sort="Manuck, Stephen B" uniqKey="Manuck S" first="Stephen B" last="Manuck">Stephen B. Manuck</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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