PittsburghV1, Main, Exploration, bibRecord, 001167

Streptozotocin-associated lymphopenia in cynomolgus monkeys

Identifieur interne : 001167 ( Main/Exploration ); précédent : 001166; suivant : 001168

Streptozotocin-associated lymphopenia in cynomolgus monkeys

Auteurs : Santosh Nagaraju [États-Unis] ; Suzanne Bertera [États-Unis] ; Amber Funair [États-Unis] ; Martin Wijkstrom [États-Unis] ; Massimo Trucco [États-Unis] ; David Kc Cooper [États-Unis] ; Rita Bottino [États-Unis]

Source :

Islets [ 1938-2014 ] ; 2014.

RBID : PMC:4292713

Descripteurs français

KwdFr :
- Animaux, Chimiokine CCL2 (sang), Diabète expérimental (sang), Hyperglycémie provoquée, Hémoglobine A glycosylée (analyse), Lymphopénie (), Lymphopénie (sang), Macaca fascicularis, Numération des lymphocytes, Streptozocine (administration et posologie), Streptozocine (effets indésirables).
MESH :
- administration et posologie : Streptozocine.
- analyse : Hémoglobine A glycosylée.
- effets indésirables : Streptozocine.
- sang : Chimiokine CCL2, Diabète expérimental, Lymphopénie.
- Animaux, Hyperglycémie provoquée, Lymphopénie, Macaca fascicularis, Numération des lymphocytes.

English descriptors

KwdEn :
- Animals, Chemokine CCL2 (blood), Diabetes Mellitus, Experimental (blood), Glucose Tolerance Test, Hemoglobin A, Glycosylated (analysis), Lymphocyte Count, Lymphopenia (blood), Lymphopenia (chemically induced), Macaca fascicularis, Streptozocin (administration & dosage), Streptozocin (adverse effects).
MESH :
- chemical , administration & dosage : Streptozocin.
- chemical , adverse effects : Streptozocin.
- chemical , analysis : Hemoglobin A, Glycosylated.
- chemical , blood : Chemokine CCL2.
- blood : Diabetes Mellitus, Experimental, Lymphopenia.
- chemically induced : Lymphopenia.
- Animals, Glucose Tolerance Test, Lymphocyte Count, Macaca fascicularis.

Abstract

Streptozotocin (STZ) is used to induce diabetes in experimental animals. It has a variety of adverse effects, ranging from nausea, emesis, and weight loss to liver damage, renal failure, and metabolic acidosis. STZ also has effects on the immune system, being associated with lymphopenia in rodents, the mechanism of which is not fully understood. We present data on a significant STZ-associated reduction in lymphocyte count in nonhuman primates. We report a significant reduction in absolute lymphocyte count; in 2 monkeys, the lymphopenia persisted for >100 d. However, a significant increase in absolute monocyte count was noted. Furthermore, an increase in serum monocyte chemoattractant protein-1 (MCP-1) was observed. The reduction in lymphocyte numbers may contribute to immunomodulation that may be beneficial to a subsequent islet graft, and may reduce the need for immunosuppressive therapy. The increase in monocytes and MCP-1, however, may be detrimental to the islet graft. Studies are warranted to explore the mechanism by which STZ has its effect.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292713

DOI: 10.4161/19382014.2014.944441
PubMed: 25322828
PubMed Central: 4292713

Affiliations:

États-Unis

Le document en format XML

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<author><name sortKey="Nagaraju, Santosh" sort="Nagaraju, Santosh" uniqKey="Nagaraju S" first="Santosh" last="Nagaraju">Santosh Nagaraju</name>
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<author><name sortKey="Bertera, Suzanne" sort="Bertera, Suzanne" uniqKey="Bertera S" first="Suzanne" last="Bertera">Suzanne Bertera</name>
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<term>Diabetes Mellitus, Experimental (blood)</term>
<term>Glucose Tolerance Test</term>
<term>Hemoglobin A, Glycosylated (analysis)</term>
<term>Lymphocyte Count</term>
<term>Lymphopenia (blood)</term>
<term>Lymphopenia (chemically induced)</term>
<term>Macaca fascicularis</term>
<term>Streptozocin (administration & dosage)</term>
<term>Streptozocin (adverse effects)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
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<term>Diabète expérimental (sang)</term>
<term>Hyperglycémie provoquée</term>
<term>Hémoglobine A glycosylée (analyse)</term>
<term>Lymphopénie ()</term>
<term>Lymphopénie (sang)</term>
<term>Macaca fascicularis</term>
<term>Numération des lymphocytes</term>
<term>Streptozocine (administration et posologie)</term>
<term>Streptozocine (effets indésirables)</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Streptozocin</term>
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<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Diabetes Mellitus, Experimental</term>
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<term>Lymphopénie</term>
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<term>Glucose Tolerance Test</term>
<term>Lymphocyte Count</term>
<term>Macaca fascicularis</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Hyperglycémie provoquée</term>
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<front><div type="abstract" xml:lang="en"><p>Streptozotocin (STZ) is used to induce diabetes in experimental animals. It has a variety
of adverse effects, ranging from nausea, emesis, and weight loss to liver damage, renal
failure, and metabolic acidosis. STZ also has effects on the immune system, being
associated with lymphopenia in rodents, the mechanism of which is not fully understood. We
present data on a significant STZ-associated reduction in lymphocyte count in nonhuman
primates. We report a significant reduction in absolute lymphocyte count; in 2 monkeys,
the lymphopenia persisted for >100 d. However, a significant increase in absolute
monocyte count was noted. Furthermore, an increase in serum monocyte chemoattractant
protein-1 (MCP-1) was observed. The reduction in lymphocyte numbers may contribute to
immunomodulation that may be beneficial to a subsequent islet graft, and may reduce the
need for immunosuppressive therapy. The increase in monocytes and MCP-1, however, may be
detrimental to the islet graft. Studies are warranted to explore the mechanism by which
STZ has its effect.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Nagaraju, Santosh" sort="Nagaraju, Santosh" uniqKey="Nagaraju S" first="Santosh" last="Nagaraju">Santosh Nagaraju</name>
</noRegion>
<name sortKey="Bertera, Suzanne" sort="Bertera, Suzanne" uniqKey="Bertera S" first="Suzanne" last="Bertera">Suzanne Bertera</name>
<name sortKey="Bottino, Rita" sort="Bottino, Rita" uniqKey="Bottino R" first="Rita" last="Bottino">Rita Bottino</name>
<name sortKey="Cooper, David Kc" sort="Cooper, David Kc" uniqKey="Cooper D" first="David Kc" last="Cooper">David Kc Cooper</name>
<name sortKey="Funair, Amber" sort="Funair, Amber" uniqKey="Funair A" first="Amber" last="Funair">Amber Funair</name>
<name sortKey="Trucco, Massimo" sort="Trucco, Massimo" uniqKey="Trucco M" first="Massimo" last="Trucco">Massimo Trucco</name>
<name sortKey="Wijkstrom, Martin" sort="Wijkstrom, Martin" uniqKey="Wijkstrom M" first="Martin" last="Wijkstrom">Martin Wijkstrom</name>
</country>
</tree>
</affiliations>
</record>

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Streptozotocin-associated lymphopenia in cynomolgus monkeys

Streptozotocin-associated lymphopenia in cynomolgus monkeys

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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