The Haptoglobin 1 Allele Correlates With White Matter Hyperintensities in Middle-Aged Adults With Type 1 Diabetes
Identifieur interne : 000F00 ( Main/Exploration ); précédent : 000E99; suivant : 000F01The Haptoglobin 1 Allele Correlates With White Matter Hyperintensities in Middle-Aged Adults With Type 1 Diabetes
Auteurs : Tina Costacou [États-Unis] ; Caterina Rosano [États-Unis] ; Howard Aizenstein [États-Unis] ; Joseph M. Mettenburg [États-Unis] ; Karen Nunley [États-Unis] ; Robert E. Ferrell [États-Unis] ; Trevor J. Orchard [États-Unis]Source :
- Diabetes [ 0012-1797 ] ; 2014.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (génétique), Adulte, Adulte d'âge moyen, Diabète de type 1 (métabolisme), Facteurs de risque, Femelle, Génotype, Haptoglobines (génétique), Haptoglobines (métabolisme), Humains, Marqueurs génétiques, Mâle, Polymorphisme génétique, Prédisposition génétique à une maladie, Substance blanche (anatomopathologie).
- MESH :
- anatomopathologie : Substance blanche.
- génétique : Accident vasculaire cérébral, Haptoglobines.
- métabolisme : Diabète de type 1, Haptoglobines.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Génotype, Humains, Marqueurs génétiques, Mâle, Polymorphisme génétique, Prédisposition génétique à une maladie.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Haptoglobins.
- chemical , metabolism : Haptoglobins.
- chemical : Genetic Markers.
- genetics : Stroke.
- metabolism : Diabetes Mellitus, Type 1.
- pathology : White Matter.
- Adult, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors.
Abstract
Although the haptoglobin (Hp) 1-1 genotype is associated with a lower coronary artery disease (CAD) risk in diabetes, we recently reported an increased stroke incidence in type 1 diabetes with Hp 1-1. We, thus, evaluated differences in earlier brain vascular abnormality markers by Hp using neuroimaging. Neuroimaging was completed in 94 participants of the Pittsburgh Epidemiology of Diabetes Complications study with Hp genotyping available (mean age, 49; duration, 41 years). White matter hyperintensities (WMH) volume, lacunar infarcts, and gray matter atrophy were quantified. Sixteen percent were homozygous for Hp 1 and 43% for Hp 2. A significant trend toward increased WMH was observed with greater duration and the number of Hp 1 alleles. Associations were strongest for the interhemispheric connecting fibers of the corpus callosum. Allowing for duration, sex, waist-to-hip ratio, HbA1c, systolic blood pressure, and lipids in models with backward elimination, results were similar. No significant differences by Hp were noted for atrophy or lacunar infarcts. Consistent with its direct association with stroke, the Hp 1-1 genotype is associated with higher WMH in this population. Further, including mechanistic, studies on the role of the Hp genotype in cerebrovascular disease and the implications for worsening cognitive function are needed.
Url:
DOI: 10.2337/db14-0723
PubMed: 25213335
PubMed Central: 4303969
Affiliations:
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Le document en format XML
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Orchard</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Diabetes</title><idno type="ISSN">0012-1797</idno><idno type="eISSN">1939-327X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Diabetes Mellitus, Type 1 (metabolism)</term><term>Female</term><term>Genetic Markers</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Haptoglobins (genetics)</term><term>Haptoglobins (metabolism)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term><term>Risk Factors</term><term>Stroke (genetics)</term><term>White Matter (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (génétique)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Diabète de type 1 (métabolisme)</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Haptoglobines (génétique)</term><term>Haptoglobines (métabolisme)</term><term>Humains</term><term>Marqueurs génétiques</term><term>Mâle</term><term>Polymorphisme génétique</term><term>Prédisposition génétique à une maladie</term><term>Substance blanche (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Haptoglobins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Haptoglobins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Genetic Markers</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Substance blanche</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Haptoglobines</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Diabetes Mellitus, Type 1</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Diabète de type 1</term><term>Haptoglobines</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>White Matter</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Marqueurs génétiques</term><term>Mâle</term><term>Polymorphisme génétique</term><term>Prédisposition génétique à une maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Although the haptoglobin (Hp) 1-1 genotype is associated with a lower coronary artery disease (CAD) risk in diabetes, we recently reported an increased stroke incidence in type 1 diabetes with Hp 1-1. We, thus, evaluated differences in earlier brain vascular abnormality markers by Hp using neuroimaging. Neuroimaging was completed in 94 participants of the Pittsburgh Epidemiology of Diabetes Complications study with Hp genotyping available (mean age, 49; duration, 41 years). White matter hyperintensities (WMH) volume, lacunar infarcts, and gray matter atrophy were quantified. Sixteen percent were homozygous for Hp 1 and 43% for Hp 2. A significant trend toward increased WMH was observed with greater duration and the number of Hp 1 alleles. Associations were strongest for the interhemispheric connecting fibers of the corpus callosum. Allowing for duration, sex, waist-to-hip ratio, HbA<sub>1c</sub>, systolic blood pressure, and lipids in models with backward elimination, results were similar. No significant differences by Hp were noted for atrophy or lacunar infarcts. Consistent with its direct association with stroke, the Hp 1-1 genotype is associated with higher WMH in this population. Further, including mechanistic, studies on the role of the Hp genotype in cerebrovascular disease and the implications for worsening cognitive function are needed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Debette, S" uniqKey="Debette S">S Debette</name></author><author><name sortKey="Markus, Hs" uniqKey="Markus H">HS Markus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dufouil, C" uniqKey="Dufouil C">C Dufouil</name></author><author><name sortKey="Chalmers, J" uniqKey="Chalmers J">J Chalmers</name></author><author><name sortKey="Coskun, O" uniqKey="Coskun O">O Coskun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Staals, J" uniqKey="Staals J">J Staals</name></author><author><name sortKey="Pieters, Bm" uniqKey="Pieters B">BM Pieters</name></author><author><name sortKey="Knottnerus, Il" uniqKey="Knottnerus I">IL 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Rouhl</name></author><author><name sortKey="Van Oostenbrugge, Rj" uniqKey="Van Oostenbrugge R">RJ van Oostenbrugge</name></author><author><name sortKey="Damoiseaux, Jg" uniqKey="Damoiseaux J">JG Damoiseaux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farrall, Aj" uniqKey="Farrall A">AJ Farrall</name></author><author><name sortKey="Wardlaw, Jm" uniqKey="Wardlaw J">JM Wardlaw</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Durham, Jt" uniqKey="Durham J">JT Durham</name></author><author><name sortKey="Herman, Im" uniqKey="Herman I">IM Herman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Costacou, Tina" sort="Costacou, Tina" uniqKey="Costacou T" first="Tina" last="Costacou">Tina Costacou</name></region><name sortKey="Aizenstein, Howard" sort="Aizenstein, Howard" uniqKey="Aizenstein H" first="Howard" last="Aizenstein">Howard Aizenstein</name><name sortKey="Ferrell, Robert E" sort="Ferrell, Robert E" uniqKey="Ferrell R" first="Robert E." last="Ferrell">Robert E. Ferrell</name><name sortKey="Mettenburg, Joseph M" sort="Mettenburg, Joseph M" uniqKey="Mettenburg J" first="Joseph M." last="Mettenburg">Joseph M. Mettenburg</name><name sortKey="Nunley, Karen" sort="Nunley, Karen" uniqKey="Nunley K" first="Karen" last="Nunley">Karen Nunley</name><name sortKey="Orchard, Trevor J" sort="Orchard, Trevor J" uniqKey="Orchard T" first="Trevor J." last="Orchard">Trevor J. Orchard</name><name sortKey="Rosano, Caterina" sort="Rosano, Caterina" uniqKey="Rosano C" first="Caterina" last="Rosano">Caterina Rosano</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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