Use of ceftaroline after glycopeptide failure to eradicate meticillin-resistant Staphylococcus aureus bacteraemia with elevated vancomycin minimum inhibitory concentrations.
Identifieur interne : 000970 ( Main/Exploration ); précédent : 000969; suivant : 000971Use of ceftaroline after glycopeptide failure to eradicate meticillin-resistant Staphylococcus aureus bacteraemia with elevated vancomycin minimum inhibitory concentrations.
Auteurs : Joseph A. Paladino [États-Unis] ; David M. Jacobs [États-Unis] ; Ryan K. Shields [États-Unis] ; Jerusha Taylor [États-Unis] ; Justin Bader [États-Unis] ; Martin H. Adelman [États-Unis] ; Greg J. Wilton [États-Unis] ; John K. Crane [États-Unis] ; Jerome J. Schentag [États-Unis]Source :
- International journal of antimicrobial agents [ 1872-7913 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antibactériens (usage thérapeutique), Bactériémie (), Bactériémie (microbiologie), Bactériémie (traitement médicamenteux), Céphalosporines (usage thérapeutique), Démographie, Facteurs temps, Femelle, Glycopeptides (usage thérapeutique), Humains, Infections à staphylocoques (), Infections à staphylocoques (microbiologie), Infections à staphylocoques (traitement médicamenteux), Mâle, Staphylococcus aureus résistant à la méticilline (), Sujet âgé, Sujet âgé de 80 ans ou plus, Tests de sensibilité microbienne, Vancomycine (usage thérapeutique), Échec thérapeutique, Éradication de maladie, Études cas-témoins, Études rétrospectives.
- MESH :
- microbiologie : Bactériémie, Infections à staphylocoques.
- traitement médicamenteux : Bactériémie, Infections à staphylocoques.
- usage thérapeutique : Antibactériens, Céphalosporines, Glycopeptides, Vancomycine.
- Adulte, Adulte d'âge moyen, Bactériémie, Démographie, Facteurs temps, Femelle, Humains, Infections à staphylocoques, Mâle, Staphylococcus aureus résistant à la méticilline, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests de sensibilité microbienne, Échec thérapeutique, Éradication de maladie, Études cas-témoins, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents (therapeutic use), Bacteremia (drug therapy), Bacteremia (microbiology), Bacteremia (prevention & control), Case-Control Studies, Cephalosporins (therapeutic use), Demography, Disease Eradication, Female, Glycopeptides (therapeutic use), Humans, Male, Methicillin-Resistant Staphylococcus aureus (drug effects), Microbial Sensitivity Tests, Middle Aged, Retrospective Studies, Staphylococcal Infections (drug therapy), Staphylococcal Infections (microbiology), Staphylococcal Infections (prevention & control), Time Factors, Treatment Failure, Vancomycin (therapeutic use).
- MESH :
- chemical , therapeutic use : Anti-Bacterial Agents, Cephalosporins, Glycopeptides, Vancomycin.
- drug effects : Methicillin-Resistant Staphylococcus aureus.
- drug therapy : Bacteremia, Staphylococcal Infections.
- microbiology : Bacteremia, Staphylococcal Infections.
- prevention & control : Bacteremia, Staphylococcal Infections.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Demography, Disease Eradication, Female, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Retrospective Studies, Time Factors, Treatment Failure.
Abstract
Elevated minimum inhibitory concentrations (MICs) of vancomycin against meticillin-resistant Staphylococcus aureus (MRSA) and the emergence of heteroresistant S. aureus strains have led to increased use of anti-MRSA antibiotics other than vancomycin. Ceftaroline fosamil is a novel cephalosporin with activity against MRSA, but there are limited clinical data on its use for MRSA bacteraemia (MRSAB) and against strains exhibiting high vancomycin MICs (2-4 μg/mL). This multicentre, retrospective, case-control study compared the microbiological and clinical effectiveness of ceftaroline used after vancomycin failure with that of vancomycin-treated controls for the treatment of MRSA with vancomycin MICs ≥ 2 μg/mL. In total, 32 patients were matched 1:1 with respect to vancomycin MIC, age and origin of bacteraemia. In the ceftaroline group, patients received prior MRSA therapy for a median of 5 days [interquartile range (IQR), 3-15.8 days] prior to switching to ceftaroline. Median time to eradication of MRSA was significantly less after treatment with ceftaroline compared with vancomycin [4 days (IQR, 3-7.5 days) vs. 8 days (IQR, 5.8-19.5 days); P=0.02]. Both clinical success at the end of treatment and recurrence of MRSA at Day 7 were trending towards being inferior in the vancomycin group, although the results did not attain statistical significance [81% vs. 44% (P=0.06) and 6% vs. 38% (P=0.08), respectively]. Ceftaroline added at the point of vancomycin failure resolves MRSAB more rapidly and with a higher rate of clinical success, therefore ceftaroline should be considered as an alternative for these difficult-to-treat infections.
DOI: 10.1016/j.ijantimicag.2014.07.024
PubMed: 25282169
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Elevated minimum inhibitory concentrations (MICs) of vancomycin against meticillin-resistant Staphylococcus aureus (MRSA) and the emergence of heteroresistant S. aureus strains have led to increased use of anti-MRSA antibiotics other than vancomycin. Ceftaroline fosamil is a novel cephalosporin with activity against MRSA, but there are limited clinical data on its use for MRSA bacteraemia (MRSAB) and against strains exhibiting high vancomycin MICs (2-4 μg/mL). This multicentre, retrospective, case-control study compared the microbiological and clinical effectiveness of ceftaroline used after vancomycin failure with that of vancomycin-treated controls for the treatment of MRSA with vancomycin MICs ≥ 2 μg/mL. In total, 32 patients were matched 1:1 with respect to vancomycin MIC, age and origin of bacteraemia. In the ceftaroline group, patients received prior MRSA therapy for a median of 5 days [interquartile range (IQR), 3-15.8 days] prior to switching to ceftaroline. Median time to eradication of MRSA was significantly less after treatment with ceftaroline compared with vancomycin [4 days (IQR, 3-7.5 days) vs. 8 days (IQR, 5.8-19.5 days); P=0.02]. Both clinical success at the end of treatment and recurrence of MRSA at Day 7 were trending towards being inferior in the vancomycin group, although the results did not attain statistical significance [81% vs. 44% (P=0.06) and 6% vs. 38% (P=0.08), respectively]. Ceftaroline added at the point of vancomycin failure resolves MRSAB more rapidly and with a higher rate of clinical success, therefore ceftaroline should be considered as an alternative for these difficult-to-treat infections.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Oregon</li>
<li>Pennsylvanie</li>
<li>État de New York</li>
</region>
<settlement><li>Pittsburgh</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Paladino, Joseph A" sort="Paladino, Joseph A" uniqKey="Paladino J" first="Joseph A" last="Paladino">Joseph A. Paladino</name>
</region>
<name sortKey="Adelman, Martin H" sort="Adelman, Martin H" uniqKey="Adelman M" first="Martin H" last="Adelman">Martin H. Adelman</name>
<name sortKey="Bader, Justin" sort="Bader, Justin" uniqKey="Bader J" first="Justin" last="Bader">Justin Bader</name>
<name sortKey="Crane, John K" sort="Crane, John K" uniqKey="Crane J" first="John K" last="Crane">John K. Crane</name>
<name sortKey="Jacobs, David M" sort="Jacobs, David M" uniqKey="Jacobs D" first="David M" last="Jacobs">David M. Jacobs</name>
<name sortKey="Schentag, Jerome J" sort="Schentag, Jerome J" uniqKey="Schentag J" first="Jerome J" last="Schentag">Jerome J. Schentag</name>
<name sortKey="Shields, Ryan K" sort="Shields, Ryan K" uniqKey="Shields R" first="Ryan K" last="Shields">Ryan K. Shields</name>
<name sortKey="Taylor, Jerusha" sort="Taylor, Jerusha" uniqKey="Taylor J" first="Jerusha" last="Taylor">Jerusha Taylor</name>
<name sortKey="Wilton, Greg J" sort="Wilton, Greg J" uniqKey="Wilton G" first="Greg J" last="Wilton">Greg J. Wilton</name>
</country>
</tree>
</affiliations>
</record>
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