Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways.
Identifieur interne : 000778 ( Main/Exploration ); précédent : 000777; suivant : 000779Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways.
Auteurs : Linda P. O'Reilly [États-Unis] ; Joshua A. Benson ; Erin E. Cummings ; David H. Perlmutter ; Gary A. Silverman ; Stephen C. PakSource :
- Expert opinion on drug discovery [ 1746-045X ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Caenorhabditis elegans (physiologie), Découverte de médicament (), Humains, Insuline (physiologie), Longévité (physiologie), Pliage des protéines, Somatomédines (physiologie), Stress physiologique (physiologie), Structure tertiaire des protéines (physiologie), Tests de criblage à haut débit (), Transduction du signal (physiologie).
- MESH :
English descriptors
- KwdEn :
- Animals, Caenorhabditis elegans (physiology), Drug Discovery (methods), High-Throughput Screening Assays (methods), Humans, Insulin (physiology), Longevity (physiology), Protein Folding, Protein Structure, Tertiary (physiology), Signal Transduction (physiology), Somatomedins (physiology), Stress, Physiological (physiology).
- MESH :
- chemical , physiology : Insulin, Somatomedins.
- methods : Drug Discovery, High-Throughput Screening Assays.
- physiology : Caenorhabditis elegans, Longevity, Protein Structure, Tertiary, Signal Transduction, Stress, Physiological.
- Animals, Humans, Protein Folding.
Abstract
Many human diseases result from a failure of a single protein to achieve the correct folding and tertiary conformation. These so-called 'conformational diseases' involve diverse proteins and distinctive cellular pathologies. They all engage the proteostasis network (PN), to varying degrees in an attempt to mange cellular stress and restore protein homeostasis. The insulin/insulin-like growth factor signaling (IIS) pathway is a master regulator of cellular stress response, which is implicated in regulating components of the PN.
DOI: 10.1517/17460441.2014.930125
PubMed: 24998976
Affiliations:
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These so-called 'conformational diseases' involve diverse proteins and distinctive cellular pathologies. They all engage the proteostasis network (PN), to varying degrees in an attempt to mange cellular stress and restore protein homeostasis. The insulin/insulin-like growth factor signaling (IIS) pathway is a master regulator of cellular stress response, which is implicated in regulating components of the PN.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><noCountry><name sortKey="Benson, Joshua A" sort="Benson, Joshua A" uniqKey="Benson J" first="Joshua A" last="Benson">Joshua A. Benson</name><name sortKey="Cummings, Erin E" sort="Cummings, Erin E" uniqKey="Cummings E" first="Erin E" last="Cummings">Erin E. Cummings</name><name sortKey="Pak, Stephen C" sort="Pak, Stephen C" uniqKey="Pak S" first="Stephen C" last="Pak">Stephen C. 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