Porous magnesium/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction.
Identifieur interne : 000378 ( Main/Exploration ); précédent : 000377; suivant : 000379Porous magnesium/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction.
Auteurs : Andrew Brown [États-Unis] ; Samer Zaky [États-Unis] ; Herbert Ray [États-Unis] ; Charles Sfeir [États-Unis]Source :
- Acta biomaterialia [ 1878-7568 ] ; 2015.
Descripteurs français
- KwdFr :
- Acide lactique (), Acide polyglycolique (), Analyse de panne d'appareillage, Animaux, Chiens, Conception d'appareillage, Extraction dentaire (), Femelle, Magnésium (), Porosité, Régénération osseuse (physiologie), Régénération tissulaire guidée parodontale (), Régénération tissulaire guidée parodontale (instrumentation), Structures d'échafaudage tissulaires.
- MESH :
English descriptors
- KwdEn :
- Animals, Bone Regeneration (physiology), Dogs, Equipment Design, Equipment Failure Analysis, Female, Guided Tissue Regeneration, Periodontal (instrumentation), Guided Tissue Regeneration, Periodontal (methods), Lactic Acid (chemistry), Magnesium (chemistry), Polyglycolic Acid (chemistry), Porosity, Tissue Scaffolds, Tooth Extraction (methods).
- MESH :
- chemical , chemistry : Lactic Acid, Magnesium, Polyglycolic Acid.
- instrumentation : Guided Tissue Regeneration, Periodontal.
- methods : Guided Tissue Regeneration, Periodontal, Tooth Extraction.
- physiology : Bone Regeneration.
- Animals, Dogs, Equipment Design, Equipment Failure Analysis, Female, Porosity, Tissue Scaffolds.
Abstract
Sixty percent of implant-supported dental prostheses require bone grafting to enhance bone quantity and quality prior to implant placement. We have developed a metallic magnesium particle/PLGA composite scaffold to overcome the limitations of currently used dental bone grafting materials. This is the first report of porous metallic magnesium/PLGA scaffolds synthesized using a solvent casting, salt leaching method. We found that incorporation of varying amounts of magnesium into the PLGA scaffolds increased the compressive strength and modulus, as well as provided a porous structure suitable for cell infiltration, as measured by mercury intrusion porosimetry. Additionally, combining basic-degrading magnesium with acidic-degrading PLGA led to an overall pH buffering effect and long-term release of magnesium over the course of a 10-week degradation assay, as measured with inductively coupled plasma-atomic emission spectroscopy. Using an indirect proliferation assay adapted from ISO 10993:5, it was found that extracts of medium from degrading magnesium/PLGA scaffolds increased bone marrow stromal cell proliferation in vitro, a phenomenon observed by other groups investigating magnesium's impact on cells. Finally, magnesium/PLGA scaffold biocompatibility was assessed in a canine socket preservation model. Micro-computed tomography and histological analysis showed the magnesium/PLGA scaffolds to be safer and more effective at preserving bone height than empty controls. Three-dimensional magnesium/PLGA composite scaffolds show promise for dental socket preservation and also, potentially, orthopedic bone regeneration. These scaffolds could decrease inflammation observed with clinically used PLGA devices, as well as enhance osteogenesis, as observed with previously studied magnesium devices.
DOI: 10.1016/j.actbio.2014.09.008
PubMed: 25234156
Affiliations:
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The Center for Craniofacial Regeneration, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; Department of Bioengineering, 360B Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Biology, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; The Center for Craniofacial Regeneration, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; Department of Bioengineering, 360B Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Zaky, Samer" sort="Zaky, Samer" uniqKey="Zaky S" first="Samer" last="Zaky">Samer Zaky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Oral Biology, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; The Center for Craniofacial Regeneration, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Biology, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; The Center for Craniofacial Regeneration, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ray, Herbert" sort="Ray, Herbert" uniqKey="Ray H" first="Herbert" last="Ray">Herbert Ray</name><affiliation wicri:level="2"><nlm:affiliation>The Center for Craniofacial Regeneration, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; The McGowan Institute for Regenerative Medicine, Suite 300, 450 Technology Drive, Pittsburgh, PA 15219, USA; Department of Endodontics, 364 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Center for Craniofacial Regeneration, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; The McGowan Institute for Regenerative Medicine, Suite 300, 450 Technology Drive, Pittsburgh, PA 15219, USA; Department of Endodontics, 364 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Sfeir, Charles" sort="Sfeir, Charles" uniqKey="Sfeir C" first="Charles" last="Sfeir">Charles Sfeir</name><affiliation wicri:level="2"><nlm:affiliation>Department of Oral Biology, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; The Center for Craniofacial Regeneration, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; Department of Bioengineering, 360B Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, USA; The McGowan Institute for Regenerative Medicine, Suite 300, 450 Technology Drive, Pittsburgh, PA 15219, USA. Electronic address: csfeir@pitt.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral Biology, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; The Center for Craniofacial Regeneration, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA; Department of Bioengineering, 360B Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, USA; The McGowan Institute for Regenerative Medicine, Suite 300, 450 Technology Drive, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">Acta biomaterialia</title><idno type="eISSN">1878-7568</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bone Regeneration (physiology)</term><term>Dogs</term><term>Equipment Design</term><term>Equipment Failure Analysis</term><term>Female</term><term>Guided Tissue Regeneration, Periodontal (instrumentation)</term><term>Guided Tissue Regeneration, Periodontal (methods)</term><term>Lactic Acid (chemistry)</term><term>Magnesium (chemistry)</term><term>Polyglycolic Acid (chemistry)</term><term>Porosity</term><term>Tissue Scaffolds</term><term>Tooth Extraction (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide lactique ()</term><term>Acide polyglycolique ()</term><term>Analyse de panne d'appareillage</term><term>Animaux</term><term>Chiens</term><term>Conception d'appareillage</term><term>Extraction dentaire ()</term><term>Femelle</term><term>Magnésium ()</term><term>Porosité</term><term>Régénération osseuse (physiologie)</term><term>Régénération tissulaire guidée parodontale ()</term><term>Régénération tissulaire guidée parodontale (instrumentation)</term><term>Structures d'échafaudage tissulaires</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Lactic Acid</term><term>Magnesium</term><term>Polyglycolic Acid</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Guided Tissue Regeneration, Periodontal</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Guided Tissue Regeneration, Periodontal</term><term>Tooth Extraction</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Régénération osseuse</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bone Regeneration</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dogs</term><term>Equipment Design</term><term>Equipment Failure Analysis</term><term>Female</term><term>Porosity</term><term>Tissue Scaffolds</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acide lactique</term><term>Acide polyglycolique</term><term>Analyse de panne d'appareillage</term><term>Animaux</term><term>Chiens</term><term>Conception d'appareillage</term><term>Extraction dentaire</term><term>Femelle</term><term>Magnésium</term><term>Porosité</term><term>Régénération tissulaire guidée parodontale</term><term>Structures d'échafaudage tissulaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sixty percent of implant-supported dental prostheses require bone grafting to enhance bone quantity and quality prior to implant placement. We have developed a metallic magnesium particle/PLGA composite scaffold to overcome the limitations of currently used dental bone grafting materials. This is the first report of porous metallic magnesium/PLGA scaffolds synthesized using a solvent casting, salt leaching method. We found that incorporation of varying amounts of magnesium into the PLGA scaffolds increased the compressive strength and modulus, as well as provided a porous structure suitable for cell infiltration, as measured by mercury intrusion porosimetry. Additionally, combining basic-degrading magnesium with acidic-degrading PLGA led to an overall pH buffering effect and long-term release of magnesium over the course of a 10-week degradation assay, as measured with inductively coupled plasma-atomic emission spectroscopy. Using an indirect proliferation assay adapted from ISO 10993:5, it was found that extracts of medium from degrading magnesium/PLGA scaffolds increased bone marrow stromal cell proliferation in vitro, a phenomenon observed by other groups investigating magnesium's impact on cells. Finally, magnesium/PLGA scaffold biocompatibility was assessed in a canine socket preservation model. Micro-computed tomography and histological analysis showed the magnesium/PLGA scaffolds to be safer and more effective at preserving bone height than empty controls. Three-dimensional magnesium/PLGA composite scaffolds show promise for dental socket preservation and also, potentially, orthopedic bone regeneration. These scaffolds could decrease inflammation observed with clinically used PLGA devices, as well as enhance osteogenesis, as observed with previously studied magnesium devices.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Brown, Andrew" sort="Brown, Andrew" uniqKey="Brown A" first="Andrew" last="Brown">Andrew Brown</name></region><name sortKey="Ray, Herbert" sort="Ray, Herbert" uniqKey="Ray H" first="Herbert" last="Ray">Herbert Ray</name><name sortKey="Sfeir, Charles" sort="Sfeir, Charles" uniqKey="Sfeir C" first="Charles" last="Sfeir">Charles Sfeir</name><name sortKey="Zaky, Samer" sort="Zaky, Samer" uniqKey="Zaky S" first="Samer" last="Zaky">Samer Zaky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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