Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells.
Identifieur interne : 002433 ( Main/Curation ); précédent : 002432; suivant : 002434Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells.
Auteurs : Heng-Wei Hsu [États-Unis] ; Rosalia De Necochea-Campion [États-Unis] ; Vonetta Williams [États-Unis] ; Penelope J. Duerksen-Hughes [États-Unis] ; Alfred A. Simental [États-Unis] ; Robert L. Ferris [États-Unis] ; Chien-Shing Chen [États-Unis] ; Saied Mirshahidi [États-Unis]Source :
- Oral oncology [ 1879-0593 ] ; 2014.
Descripteurs français
- KwdFr :
- Apoptose (), Benzimidazoles (pharmacologie), Carcinome épidermoïde (traitement médicamenteux), Cassures de l'ADN (), Histone (métabolisme), Humains, Indazoles (pharmacologie), Inhibiteurs de poly(ADP-ribose) polymérases, Lignée cellulaire tumorale, Phénylurées (pharmacologie), Poly(ADP-ribose) polymerases (métabolisme), Rad51 Recombinase (métabolisme), Survie cellulaire (), Tumeurs de la tête et du cou (traitement médicamenteux).
- MESH :
- métabolisme : Histone, Poly(ADP-ribose) polymerases, Rad51 Recombinase.
- pharmacologie : Benzimidazoles, Indazoles, Phénylurées.
- traitement médicamenteux : Carcinome épidermoïde, Tumeurs de la tête et du cou.
- Apoptose, Cassures de l'ADN, Humains, Inhibiteurs de poly(ADP-ribose) polymérases, Lignée cellulaire tumorale, Survie cellulaire.
English descriptors
- KwdEn :
- Apoptosis (drug effects), Benzimidazoles (pharmacology), Carcinoma, Squamous Cell (drug therapy), Cell Line, Tumor, Cell Survival (drug effects), DNA Breaks (drug effects), Head and Neck Neoplasms (drug therapy), Histones (metabolism), Humans, Indazoles (pharmacology), Phenylurea Compounds (pharmacology), Poly(ADP-ribose) Polymerase Inhibitors, Poly(ADP-ribose) Polymerases (metabolism), Rad51 Recombinase (metabolism).
- MESH :
- chemical , metabolism : Histones, Poly(ADP-ribose) Polymerases, Rad51 Recombinase.
- chemical , pharmacology : Benzimidazoles, Indazoles, Phenylurea Compounds.
- drug effects : Apoptosis, Cell Survival, DNA Breaks.
- drug therapy : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- Cell Line, Tumor, Humans, Poly(ADP-ribose) Polymerase Inhibitors.
Abstract
PARP inhibitors (PARPi) may provide an opportunity to gain selective killing of tumor cells which have deficiencies in cellular DNA repair systems. We previously demonstrated linifanib (ABT-869), a multi-receptor tyrosine kinase inhibitor of VEGF and PDGF receptor families, radiosensitized Head and Neck Squamous Cell Carcinoma cells (HNSCC) via inhibiting STAT3 activation. Given that STAT3 can modulate DNA damage response (DDR) pathway, in this study, we evaluate the effects of linifanib to enhance cytotoxicity with the PARPi, veliparib (ABT-888), in HNSCC.
DOI: 10.1016/j.oraloncology.2014.03.006
PubMed: 24735547
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pubmed:24735547Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apoptosis (drug effects)</term>
<term>Benzimidazoles (pharmacology)</term>
<term>Carcinoma, Squamous Cell (drug therapy)</term>
<term>Cell Line, Tumor</term>
<term>Cell Survival (drug effects)</term>
<term>DNA Breaks (drug effects)</term>
<term>Head and Neck Neoplasms (drug therapy)</term>
<term>Histones (metabolism)</term>
<term>Humans</term>
<term>Indazoles (pharmacology)</term>
<term>Phenylurea Compounds (pharmacology)</term>
<term>Poly(ADP-ribose) Polymerase Inhibitors</term>
<term>Poly(ADP-ribose) Polymerases (metabolism)</term>
<term>Rad51 Recombinase (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Apoptose ()</term>
<term>Benzimidazoles (pharmacologie)</term>
<term>Carcinome épidermoïde (traitement médicamenteux)</term>
<term>Cassures de l'ADN ()</term>
<term>Histone (métabolisme)</term>
<term>Humains</term>
<term>Indazoles (pharmacologie)</term>
<term>Inhibiteurs de poly(ADP-ribose) polymérases</term>
<term>Lignée cellulaire tumorale</term>
<term>Phénylurées (pharmacologie)</term>
<term>Poly(ADP-ribose) polymerases (métabolisme)</term>
<term>Rad51 Recombinase (métabolisme)</term>
<term>Survie cellulaire ()</term>
<term>Tumeurs de la tête et du cou (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Histones</term>
<term>Poly(ADP-ribose) Polymerases</term>
<term>Rad51 Recombinase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Benzimidazoles</term>
<term>Indazoles</term>
<term>Phenylurea Compounds</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term>
<term>Cell Survival</term>
<term>DNA Breaks</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Carcinoma, Squamous Cell</term>
<term>Head and Neck Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Histone</term>
<term>Poly(ADP-ribose) polymerases</term>
<term>Rad51 Recombinase</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Benzimidazoles</term>
<term>Indazoles</term>
<term>Phénylurées</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome épidermoïde</term>
<term>Tumeurs de la tête et du cou</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term>
<term>Humans</term>
<term>Poly(ADP-ribose) Polymerase Inhibitors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term>
<term>Cassures de l'ADN</term>
<term>Humains</term>
<term>Inhibiteurs de poly(ADP-ribose) polymérases</term>
<term>Lignée cellulaire tumorale</term>
<term>Survie cellulaire</term>
</keywords>
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<front><div type="abstract" xml:lang="en">PARP inhibitors (PARPi) may provide an opportunity to gain selective killing of tumor cells which have deficiencies in cellular DNA repair systems. We previously demonstrated linifanib (ABT-869), a multi-receptor tyrosine kinase inhibitor of VEGF and PDGF receptor families, radiosensitized Head and Neck Squamous Cell Carcinoma cells (HNSCC) via inhibiting STAT3 activation. Given that STAT3 can modulate DNA damage response (DDR) pathway, in this study, we evaluate the effects of linifanib to enhance cytotoxicity with the PARPi, veliparib (ABT-888), in HNSCC.</div>
</front>
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