Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron.
Identifieur interne : 000570 ( Main/Curation ); précédent : 000569; suivant : 000571Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron.
Auteurs : P. Kranke [Allemagne] ; J P Thompson [Royaume-Uni] ; P L Dalby [États-Unis] ; L H Eberhart [Allemagne] ; E. Novikova [Russie] ; B M Johnson [États-Unis] ; S F Russ [États-Unis] ; R. Noble [États-Unis] ; R A Brigandi [États-Unis]Source :
- British journal of anaesthesia [ 1471-6771 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antagonistes du récepteur de la neurokinine-1 (usage thérapeutique), Antiémétiques (usage thérapeutique), Femelle, Fluorobenzènes (usage thérapeutique), Humains, Jeune adulte, Mâle, Méthode en simple aveugle, Ondansétron (usage thérapeutique), Pipéridines (usage thérapeutique), Relation dose-effet des médicaments, Résultat thérapeutique, Sujet âgé, Vomissements et nausées postopératoires (traitement médicamenteux), Échec thérapeutique.
- MESH :
- traitement médicamenteux : Vomissements et nausées postopératoires.
- usage thérapeutique : Antagonistes du récepteur de la neurokinine-1, Antiémétiques, Fluorobenzènes, Ondansétron, Pipéridines.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Méthode en simple aveugle, Relation dose-effet des médicaments, Résultat thérapeutique, Sujet âgé, Échec thérapeutique.
English descriptors
- KwdEn :
- Adult, Aged, Antiemetics (therapeutic use), Dose-Response Relationship, Drug, Female, Fluorobenzenes (therapeutic use), Humans, Male, Middle Aged, Neurokinin-1 Receptor Antagonists (therapeutic use), Ondansetron (therapeutic use), Piperidines (therapeutic use), Postoperative Nausea and Vomiting (drug therapy), Single-Blind Method, Treatment Failure, Treatment Outcome, Young Adult.
- MESH :
- chemical , therapeutic use : Antiemetics, Fluorobenzenes, Neurokinin-1 Receptor Antagonists, Ondansetron, Piperidines.
- drug therapy : Postoperative Nausea and Vomiting.
- Adult, Aged, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Single-Blind Method, Treatment Failure, Treatment Outcome, Young Adult.
Abstract
Postoperative nausea and vomiting (PONV) is common; ondansetron is often used as prophylaxis or for breakthrough episodes. Vestipitant is a neurokinin 1 (NK-1) receptor antagonist that is effective for prophylaxis, but its efficacy for treating established PONV is unknown. This study was performed to evaluate the efficacy and safety of vestipitant, compared with ondansetron for the treatment of breakthrough PONV in patients who had already received prophylactic ondansetron before surgery.
DOI: 10.1093/bja/aeu376
PubMed: 25488303
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pubmed:25488303Le document en format XML
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<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Fluorobenzenes (therapeutic use)</term>
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<term>Adulte d'âge moyen</term>
<term>Antagonistes du récepteur de la neurokinine-1 (usage thérapeutique)</term>
<term>Antiémétiques (usage thérapeutique)</term>
<term>Femelle</term>
<term>Fluorobenzènes (usage thérapeutique)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Méthode en simple aveugle</term>
<term>Ondansétron (usage thérapeutique)</term>
<term>Pipéridines (usage thérapeutique)</term>
<term>Relation dose-effet des médicaments</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Vomissements et nausées postopératoires (traitement médicamenteux)</term>
<term>Échec thérapeutique</term>
</keywords>
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<term>Fluorobenzenes</term>
<term>Neurokinin-1 Receptor Antagonists</term>
<term>Ondansetron</term>
<term>Piperidines</term>
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<term>Antiémétiques</term>
<term>Fluorobenzènes</term>
<term>Ondansétron</term>
<term>Pipéridines</term>
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<term>Humans</term>
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<term>Femelle</term>
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<term>Jeune adulte</term>
<term>Mâle</term>
<term>Méthode en simple aveugle</term>
<term>Relation dose-effet des médicaments</term>
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<front><div type="abstract" xml:lang="en">Postoperative nausea and vomiting (PONV) is common; ondansetron is often used as prophylaxis or for breakthrough episodes. Vestipitant is a neurokinin 1 (NK-1) receptor antagonist that is effective for prophylaxis, but its efficacy for treating established PONV is unknown. This study was performed to evaluate the efficacy and safety of vestipitant, compared with ondansetron for the treatment of breakthrough PONV in patients who had already received prophylactic ondansetron before surgery.</div>
</front>
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