Estimation of single‐kidney glomerular filtration rate without exogenous contrast agent
Identifieur interne : 002F83 ( Istex/Corpus ); précédent : 002F82; suivant : 002F84Estimation of single‐kidney glomerular filtration rate without exogenous contrast agent
Auteurs : Xiang He ; Ayaz Aghayev ; Serter Gumus ; K. Ty BaeSource :
- Magnetic Resonance in Medicine [ 0740-3194 ] ; 2014-01.
Abstract
Measurement of single‐kidney filtration fraction and glomerular filtration rate (GFR) without exogenous contrast is clinically important to assess renal function and pathophysiology, especially for patients with comprised renal function. The objective of this study is to develop a novel MR‐based tool for noninvasive quantification of renal function using conventional MR arterial spin labeling water as endogenous tracer.
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DOI: 10.1002/mrm.24668
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Ty Bae</name><affiliation><mods:affiliation>Department of Radiology, University of Pittsburgh, Pennsylvania, Pittsburgh, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Magnetic Resonance in Medicine</title><title level="j" type="alt">MAGNETIC RESONANCE IN MEDICINE</title><idno type="ISSN">0740-3194</idno><idno type="eISSN">1522-2594</idno><imprint><biblScope unit="vol">71</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="257">257</biblScope><biblScope unit="page" to="266">266</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2014-01">2014-01</date></imprint><idno type="ISSN">0740-3194</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0740-3194</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Measurement of single‐kidney filtration fraction and glomerular filtration rate (GFR) without exogenous contrast is clinically important to assess renal function and pathophysiology, especially for patients with comprised renal function. The objective of this study is to develop a novel MR‐based tool for noninvasive quantification of renal function using conventional MR arterial spin labeling water as endogenous tracer.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Xiang He</name><affiliations><json:string>Department of Radiology, University of Pittsburgh, Pennsylvania, Pittsburgh, USA</json:string><json:string>E-mail: hex@upmc.edu</json:string></affiliations></json:item><json:item><name>Ayaz Aghayev</name><affiliations><json:string>Department of Radiology, University of Pittsburgh, Pennsylvania, Pittsburgh, USA</json:string></affiliations></json:item><json:item><name>Serter Gumus</name><affiliations><json:string>Department of Radiology, University of Pittsburgh, Pennsylvania, Pittsburgh, USA</json:string></affiliations></json:item><json:item><name>K. Ty Bae</name><affiliations><json:string>Department of Radiology, University of Pittsburgh, Pennsylvania, Pittsburgh, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>single‐kidney GFR</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>renal filtration fraction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>arterial spin labeling (ASL)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>T1ρ</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>T2</value></json:item></subject><articleId><json:string>MRM24668</json:string></articleId><arkIstex>ark:/67375/WNG-PSWHGCMJ-Z</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Measurement of single‐kidney filtration fraction and glomerular filtration rate (GFR) without exogenous contrast is clinically important to assess renal function and pathophysiology, especially for patients with comprised renal function. 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E‐mail: hex@upmc.edu</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Ayaz</forename><surname>Aghayev</surname></persName><affiliation><orgName>Department of Radiology</orgName><orgName>University of Pittsburgh</orgName><address><settlement type="city">Pittsburgh</settlement><region>Pennsylvania</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Serter</forename><surname>Gumus</surname></persName><affiliation><orgName>Department of Radiology</orgName><orgName>University of Pittsburgh</orgName><address><settlement type="city">Pittsburgh</settlement><region>Pennsylvania</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">K. Ty</forename><surname>Bae</surname></persName><affiliation><orgName>Department of Radiology</orgName><orgName>University of Pittsburgh</orgName><address><settlement type="city">Pittsburgh</settlement><region>Pennsylvania</region><country key="US">USA</country></address></affiliation></author><idno type="istex">C8E5B329A7EB9CCBFDF881F730B57213DF220367</idno><idno type="ark">ark:/67375/WNG-PSWHGCMJ-Z</idno><idno type="DOI">10.1002/mrm.24668</idno><idno type="unit">MRM24668</idno><idno type="toTypesetVersion">file:MRM.MRM24668.pdf</idno></analytic><monogr><title level="j" type="main">Magnetic Resonance in Medicine</title><title level="j" type="alt">MAGNETIC RESONANCE IN MEDICINE</title><idno type="pISSN">0740-3194</idno><idno type="eISSN">1522-2594</idno><idno type="book-DOI">10.1002/(ISSN)1522-2594</idno><idno type="book-part-DOI">10.1002/mrm.v71.1</idno><idno type="product">MRM</idno><imprint><biblScope unit="vol">71</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="257">257</biblScope><biblScope unit="page" to="266">266</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2014-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main">
Purpose
<p>Measurement of single‐kidney filtration fraction and glomerular filtration rate (GFR) without exogenous contrast is clinically important to assess renal function and pathophysiology, especially for patients with comprised renal function. The objective of this study is to develop a novel MR‐based tool for noninvasive quantification of renal function using conventional MR arterial spin labeling water as endogenous tracer.</p>
Theory and Methods
<p>The regional differentiation of the arterial spin labeling water between the glomerular capsular space and the renal parenchyma was characterized and measured according to their MR relaxation properties (<hi rend="italic">T</hi><hi rend="subscript">1ρ</hi> or <hi rend="italic">T</hi><hi rend="subscript">2</hi>), and applied to the estimation of filtration fraction and single‐kidney GFR. The proposed approach was tested to quantify GFR in healthy volunteers at baseline and after a protein‐loading challenge.</p>
Results
<p>Biexponential decay of the cortical arterial spin labeling water MR signal was observed. The major component decays the same as parenchyma water; the minor component decays much slower as expected from glomerular ultra‐filtrates. The mean single‐kidney GFR was estimated to be 49 ± 9 mL/min at baseline and increased by 28% after a protein‐loading challenge.</p>
Conclusion
<p>We developed an arterial spin labeling‐based MR imaging method that allows us to estimate renal filtration fraction and singe‐kidney GFR without use of exogenous contrast. Magn Reson Med 71:257–266, 2014. © 2013 Wiley Periodicals, Inc.</p></abstract><textClass><keywords><term xml:id="mrm24668-kwd-0001">single‐kidney GFR</term><term xml:id="mrm24668-kwd-0002">renal filtration fraction</term><term xml:id="mrm24668-kwd-0003">arterial spin labeling (ASL)</term><term xml:id="mrm24668-kwd-0004"><hi rend="italic">T</hi><hi rend="subscript">1ρ</hi></term><term xml:id="mrm24668-kwd-0005"><hi rend="italic">T</hi><hi rend="subscript">2</hi></term></keywords><keywords rend="articleCategory"><term>Full Paper</term></keywords><keywords rend="tocHeading1"><term>Imaging Methodology—Full Papers</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="mrm24668"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1522-2594</doi><issn type="print">0740-3194</issn><issn type="electronic">1522-2594</issn><idGroup><id type="product" value="MRM"></id></idGroup><titleGroup><title type="main" sort="MAGNETIC RESONANCE IN MEDICINE">Magnetic Resonance in Medicine</title><title type="short">Magn. Reson. Med.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi>10.1002/mrm.v71.1</doi><copyright ownership="publisher">Copyright © 2013 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering type="journalVolume" number="71">71</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2014-01">January 2014</coverDate></publicationMeta><publicationMeta level="unit" position="300" type="article" status="forIssue"><doi>10.1002/mrm.24668</doi><idGroup><id type="unit" value="MRM24668"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Full Paper</title><title type="tocHeading1">Imaging Methodology—Full Papers</title></titleGroup><copyright ownership="publisher">Copyright © 2013 Wiley Periodicals, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2012-10-12"></event><event type="manuscriptRevised" date="2013-01-07"></event><event type="manuscriptAccepted" date="2013-01-10"></event><event type="xmlCreated" agent="Cenveo Publisher Services" date="2013-01-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.0 mode:FullText" date="2014-04-16"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-03-06"></event><event type="publishedOnlineFinalForm" date="2013-12-17"></event><event type="firstOnline" date="2013-03-06"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-07"></event></eventGroup><numberingGroup><numbering type="pageFirst">257</numbering><numbering type="pageLast">266</numbering></numberingGroup><correspondenceTo>Correspondence to: Xiang He, Ph.D., Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213. E‐mail: <email>hex@upmc.edu</email></correspondenceTo><objectNameGroup><objectName elementName="appendix">APPENDIX</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:MRM.MRM24668.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Estimation of single‐kidney glomerular filtration rate without exogenous contrast agent</title><title type="short">Noncontrast GFR Measurement</title><title type="shortAuthors">He et al</title></titleGroup><creators><creator affiliationRef="#mrm24668-aff-0001" corresponding="yes" creatorRole="author" xml:id="mrm24668-cr-0001"><personName><givenNames>Xiang</givenNames><familyName>He</familyName></personName></creator><creator affiliationRef="#mrm24668-aff-0001" creatorRole="author" xml:id="mrm24668-cr-0002"><personName><givenNames>Ayaz</givenNames><familyName>Aghayev</familyName></personName></creator><creator affiliationRef="#mrm24668-aff-0001" creatorRole="author" xml:id="mrm24668-cr-0003"><personName><givenNames>Serter</givenNames><familyName>Gumus</familyName></personName></creator><creator affiliationRef="#mrm24668-aff-0001" creatorRole="author" xml:id="mrm24668-cr-0004"><personName><givenNames>K. Ty</givenNames><familyName>Bae</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="US" type="organization" xml:id="mrm24668-aff-0001"><orgDiv>Department of Radiology</orgDiv><orgName>University of Pittsburgh</orgName><address><city>Pittsburgh</city><countryPart>Pennsylvania</countryPart><country>USA</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="mrm24668-kwd-0001">single‐kidney GFR</keyword><keyword xml:id="mrm24668-kwd-0002">renal filtration fraction</keyword><keyword xml:id="mrm24668-kwd-0003">arterial spin labeling (ASL)</keyword><keyword xml:id="mrm24668-kwd-0004"><i>T</i><sub>1ρ</sub></keyword><keyword xml:id="mrm24668-kwd-0005"><i>T</i><sub>2</sub></keyword></keywordGroup><abstractGroup><abstract type="main"><section xml:id="mrm24668-sec-0001"><title type="main">Purpose</title><p>Measurement of single‐kidney filtration fraction and glomerular filtration rate (GFR) without exogenous contrast is clinically important to assess renal function and pathophysiology, especially for patients with comprised renal function. The objective of this study is to develop a novel MR‐based tool for noninvasive quantification of renal function using conventional MR arterial spin labeling water as endogenous tracer.</p></section><section xml:id="mrm24668-sec-0102"><title type="main">Theory and Methods</title><p>The regional differentiation of the arterial spin labeling water between the glomerular capsular space and the renal parenchyma was characterized and measured according to their MR relaxation properties (<i>T</i><sub>1ρ</sub> or <i>T</i><sub>2</sub>), and applied to the estimation of filtration fraction and single‐kidney GFR. The proposed approach was tested to quantify GFR in healthy volunteers at baseline and after a protein‐loading challenge.</p></section><section xml:id="mrm24668-sec-0103"><title type="main">Results</title><p>Biexponential decay of the cortical arterial spin labeling water MR signal was observed. The major component decays the same as parenchyma water; the minor component decays much slower as expected from glomerular ultra‐filtrates. The mean single‐kidney GFR was estimated to be 49 ± 9 mL/min at baseline and increased by 28% after a protein‐loading challenge.</p></section><section xml:id="mrm24668-sec-0104"><title type="main">Conclusion</title><p>We developed an arterial spin labeling‐based MR imaging method that allows us to estimate renal filtration fraction and singe‐kidney GFR without use of exogenous contrast. Magn Reson Med 71:257–266, 2014. © 2013 Wiley Periodicals, Inc.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Estimation of single‐kidney glomerular filtration rate without exogenous contrast agent</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Noncontrast GFR Measurement</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Estimation of single‐kidney glomerular filtration rate without exogenous contrast agent</title></titleInfo><name type="personal"><namePart type="given">Xiang</namePart><namePart type="family">He</namePart><affiliation>Department of Radiology, University of Pittsburgh, Pennsylvania, Pittsburgh, USA</affiliation><affiliation>E-mail: hex@upmc.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ayaz</namePart><namePart type="family">Aghayev</namePart><affiliation>Department of Radiology, University of Pittsburgh, Pennsylvania, Pittsburgh, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Serter</namePart><namePart type="family">Gumus</namePart><affiliation>Department of Radiology, University of Pittsburgh, Pennsylvania, Pittsburgh, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. Ty</namePart><namePart type="family">Bae</namePart><affiliation>Department of Radiology, University of Pittsburgh, Pennsylvania, Pittsburgh, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-01</dateIssued><dateCreated encoding="w3cdtf">2013-01-24</dateCreated><dateCaptured encoding="w3cdtf">2012-10-12</dateCaptured><dateValid encoding="w3cdtf">2013-01-10</dateValid><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Measurement of single‐kidney filtration fraction and glomerular filtration rate (GFR) without exogenous contrast is clinically important to assess renal function and pathophysiology, especially for patients with comprised renal function. The objective of this study is to develop a novel MR‐based tool for noninvasive quantification of renal function using conventional MR arterial spin labeling water as endogenous tracer.</abstract><abstract>The regional differentiation of the arterial spin labeling water between the glomerular capsular space and the renal parenchyma was characterized and measured according to their MR relaxation properties (T1ρ or T2), and applied to the estimation of filtration fraction and single‐kidney GFR. The proposed approach was tested to quantify GFR in healthy volunteers at baseline and after a protein‐loading challenge.</abstract><abstract>Biexponential decay of the cortical arterial spin labeling water MR signal was observed. The major component decays the same as parenchyma water; the minor component decays much slower as expected from glomerular ultra‐filtrates. The mean single‐kidney GFR was estimated to be 49 ± 9 mL/min at baseline and increased by 28% after a protein‐loading challenge.</abstract><abstract>We developed an arterial spin labeling‐based MR imaging method that allows us to estimate renal filtration fraction and singe‐kidney GFR without use of exogenous contrast. Magn Reson Med 71:257–266, 2014. © 2013 Wiley Periodicals, Inc.</abstract><subject><genre>keywords</genre><topic>single‐kidney GFR</topic><topic>renal filtration fraction</topic><topic>arterial spin labeling (ASL)</topic><topic>T1ρ</topic><topic>T2</topic></subject><relatedItem type="host"><titleInfo><title>Magnetic Resonance in Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Magn. Reson. 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