Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
Identifieur interne : 000367 ( Hal/Corpus ); précédent : 000366; suivant : 000368Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
Auteurs : Peter Szatmari ; Andrew Paterson ; Lonnie Zwaigenbaum ; Wendy Roberts ; Jessica Brian ; Xiao-Qing Liu ; John Vincent ; Jennifer Skaug ; Ann Thompson ; Lili Senman ; Lars Feuk ; Cheng Qian ; Susan Bryson ; Marshall Jones ; Christian Marshall ; Stephen Scherer ; Veronica Vieland ; Christopher Bartlett ; La Vonne Mangin ; Rhinda Goedken ; Alberto Segre ; Margaret Pericak-Vance ; Michael Cuccaro ; John Gilbert ; Harry Wright ; Ruth Abramson ; Catalina Betancur ; Thomas Bourgeron ; Christopher Gillberg ; Marion Leboyer ; Joseph Buxbaum ; Kenneth Davis ; Eric Hollander ; Jeremy Silverman ; Joachim Hallmayer ; Linda Lotspeich ; James Sutcliffe ; Jonathan Haines ; Susan Folstein ; Joseph Piven ; Thomas Wassink ; Val Sheffield ; Daniel Geschwind ; Maja Bucan ; Ted Brown ; Rita Cantor ; John Constantino ; Conrad Gilliam ; Martha Herbert ; Clara Lajonchere ; David Ledbetter ; Christa Lese-Martin ; Janet Miller ; Stan Nelson ; Carol Samango-Sprouse ; Sarah Spence ; Matthew State ; Rudolph Tanzi ; Hilary Coon ; Geraldine Dawson ; Bernie Devlin ; Annette Estes ; Pamela Flodman ; Lambertus Klei ; William Mcmahon ; Nancy Minshew ; Jeff Munson ; Elena Korvatska ; Patricia Rodier ; Gerard Schellenberg ; Moyra Smith ; Anne Spence ; Chris Stodgell ; Ping Guo Tepper ; Ellen Wijsman ; Chang-En Yu ; Bernadette Rogé ; Carine Mantoulan ; Kerstin Wittemeyer ; Annemarie Poustka ; B Rbel Felder ; Sabine Klauck ; Claudia Schuster ; Fritz Poustka ; Sven Bölte ; Sabine Feineis-Matthews ; Evelyn Herbrecht ; Gabi Schmötzer ; John Tsiantis ; Katerina Papanikolaou ; Elena Maestrini ; Elena Bacchelli ; Francesca Blasi ; Simona Carone ; Claudio Toma ; Herman Van Engeland ; Maretha De Jonge ; Chantal Kemner ; Frederieke Koop ; Marjolein Langemeijer ; Channa Hijmans ; Wouter Staal ; Gillian Baird ; Patrick Bolton ; Michael Rutter ; Emma Weisblatt ; Jonathan Green ; Catherine Aldred ; Julie-Anne Wilkinson ; Andrew Pickles ; Ann Le Couteur ; Tom Berney ; Helen Mcconachie ; Anthony Bailey ; Kostas Francis ; Gemma Honeyman ; Aislinn Hutchinson ; Jeremy Parr ; Simon Wallace ; Anthony Monaco ; Gabrielle Barnby ; Kazuhiro Kobayashi ; Janine Lamb ; Ines Sousa ; Nuala Sykes ; Edwin Cook ; Stephen Guter ; Bennett Leventhal ; Jeff Salt ; Catherine Lord ; Christina Corsello ; Vanessa Hus ; Daniel Weeks ; Fred Volkmar ; Maïté Tauber ; Eric Fombonne ; Andy Shih ; Kacie MeyerSource :
- Nature Genetics [ 1061-4036 ] ; 2007-03.
Abstract
Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,181 [corrected] families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these families. Linkage and copy number variation analyses implicate chromosome 11p12-p13 and neurexins, respectively, among other candidate loci. Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs.
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DOI: 10.1038/ng1985
Links to Exploration step
Hal:inserm-00937094Le document en format XML
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Macdonald Foundation Department of Human Genetics, Miami, Florida 33136</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-487994" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-487994" type="direct"><org type="institution" xml:id="struct-487994" status="VALID"> <orgName>University of Miami [Coral Gables]</orgName> <desc> <address> <addrLine> 1320 S Dixie Hwy, Coral Gables, FL 33146</addrLine> <country key="US"></country> </address> <ref type="url">http://welcome.miami.edu</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Piven, Joseph" sort="Piven, Joseph" uniqKey="Piven J" first="Joseph" last="Piven">Joseph Piven</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128978" status="VALID"> <orgName>Carolina Institute for Developmental Disabilities</orgName> <desc> <address> <addrLine>University of North Carolina Chapel Hill Campus Box # 7255 Chapel Hill, N.C. 27599-3366</addrLine> <country key="US"></country> </address> <ref type="url">http://www.cidd.unc.edu/</ref> </desc> <listRelation> <relation active="#struct-44261" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-44261" type="direct"><org type="institution" xml:id="struct-44261" status="VALID"> <orgName>The University of North Carolina at Chapel Hill</orgName> <desc> <address> <addrLine>250 East Franklin Street, Chapel Hill, NC,</addrLine> <country key="US"></country> </address> <ref type="url">http://www.unc.edu</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Wassink, Thomas" sort="Wassink, Thomas" uniqKey="Wassink T" first="Thomas" last="Wassink">Thomas Wassink</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128986" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Iowa City, Iowa 52242</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-331255" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-331255" type="direct"><org type="institution" xml:id="struct-331255" status="INCOMING"> <orgName>Carver College of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Sheffield, Val" sort="Sheffield, Val" uniqKey="Sheffield V" first="Val" last="Sheffield">Val Sheffield</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128982" status="INCOMING"> <orgName>Department of Pediatrics</orgName> <desc> <address> <addrLine>Iowa City, Iowa 52242</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-358145" type="direct"></relation> <relation active="#struct-358146" type="direct"></relation> <relation active="#struct-366215" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-358145" type="direct"><org type="institution" xml:id="struct-358145" status="INCOMING"> <orgName>Howard Hughes Medical</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-358146" type="direct"><org type="institution" xml:id="struct-358146" status="INCOMING"> <orgName>Institute Carver College of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-366215" type="direct"><org type="institution" xml:id="struct-366215" status="INCOMING"> <orgName>University of Iowa</orgName> <desc> <address> <country key="US"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Geschwind, Daniel" sort="Geschwind, Daniel" uniqKey="Geschwind D" first="Daniel" last="Geschwind">Daniel Geschwind</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242586" status="INCOMING"> <orgName>Department of Neurology</orgName> <desc> <address> <addrLine>Los Angeles, California</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-309330" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309330" type="direct"><org type="institution" xml:id="struct-309330" status="INCOMING"> <orgName>UCLA School of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bucan, Maja" sort="Bucan, Maja" uniqKey="Bucan M" first="Maja" last="Bucan">Maja Bucan</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242587" status="INCOMING"> <orgName>Department of Genetics</orgName> <desc> <address> <addrLine>3451 Walnut St, Philadelphia, PA 19104</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-115889" type="direct"></relation> <relation active="#struct-303723" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-115889" type="direct"><org type="institution" xml:id="struct-115889" status="VALID"><orgName>University of Pennsylvania [Philadelphia]</orgName><desc><address><addrLine>3451 Walnut Street, Philadelphia, PA 19104 | 215-898-5000</addrLine><country key="US"></country></address><ref type="url">http://www.upenn.edu/</ref></desc></org></tutelle><tutelle active="#struct-303723" type="direct"><org type="institution" xml:id="struct-303723" status="VALID"> <orgName>School of Medicine</orgName> <desc> <address> <country key="US"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Brown, Ted" sort="Brown, Ted" uniqKey="Brown T" first="Ted" last="Brown">Ted Brown</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242588" status="INCOMING"> <orgName>N.Y.S. Institute for Basic Research in Developmental Disabilities</orgName> <desc> <address> <addrLine>Staten Island, NY</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-358117" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-358117" type="direct"><org type="institution" xml:id="struct-358117" status="INCOMING"> <orgName>N.Y.S. 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Levi Hall 5801 South Ellis Avenue Chicago, Illinois 60637</addrLine><country key="US"></country></address><ref type="url">http://www.uchicago.edu/</ref></desc></hal:affiliation></affiliation></author><author><name sortKey="Herbert, Martha" sort="Herbert, Martha" uniqKey="Herbert M" first="Martha" last="Herbert">Martha Herbert</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242589" status="INCOMING"> <orgName>Harvard Medical School</orgName> <desc> <address> <addrLine>Boston, MA</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-161455" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-161455" type="direct"><org type="institution" xml:id="struct-161455" status="VALID"> <orgName>Massachusetts General Hospital [Boston]</orgName> <orgName type="acronym">MGH</orgName> <desc> <address> <addrLine>Massachusetts General Hospital 55 Fruit Street Boston, MA 02114</addrLine> <country key="US"></country> </address> <ref type="url">http://www.massgeneral.org/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lajonchere, Clara" sort="Lajonchere, Clara" uniqKey="Lajonchere C" first="Clara" last="Lajonchere">Clara Lajonchere</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128949" status="INCOMING"> <orgName>Autism Genetic Resource Exchange</orgName> <desc> <address> <addrLine>Los Angeles, California 90036-4234</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-331243" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-331243" type="direct"><org type="institution" xml:id="struct-331243" status="INCOMING"> <orgName>Autism Speaks</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Ledbetter, David" sort="Ledbetter, David" uniqKey="Ledbetter D" first="David" last="Ledbetter">David Ledbetter</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242590" status="INCOMING"> <orgName>Department of Genetics</orgName> <desc> <address> <addrLine>Atlanta, GA</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-301506" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301506" type="direct"><org type="institution" xml:id="struct-301506" status="VALID"> <orgName>Emory University [Atlanta, GA]</orgName> <desc> <address> <addrLine>201 Dowman Dr, Atlanta, GA 30322</addrLine> <country key="US"></country> </address> <ref type="url">http://www.emory.edu</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lese Martin, Christa" sort="Lese Martin, Christa" uniqKey="Lese Martin C" first="Christa" last="Lese-Martin">Christa Lese-Martin</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242590" status="INCOMING"> <orgName>Department of Genetics</orgName> <desc> <address> <addrLine>Atlanta, GA</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-301506" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301506" type="direct"><org type="institution" xml:id="struct-301506" status="VALID"> <orgName>Emory University [Atlanta, GA]</orgName> <desc> <address> <addrLine>201 Dowman Dr, Atlanta, GA 30322</addrLine> <country key="US"></country> </address> <ref type="url">http://www.emory.edu</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Miller, Janet" sort="Miller, Janet" uniqKey="Miller J" first="Janet" last="Miller">Janet Miller</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242591" status="INCOMING"> <orgName>Cure Autism Now</orgName> <desc> <address> <addrLine>Los Angeles, CA</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-358118" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-358118" type="direct"><org type="institution" xml:id="struct-358118" status="INCOMING"> <orgName>Cure Autism Now</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Nelson, Stan" sort="Nelson, Stan" uniqKey="Nelson S" first="Stan" last="Nelson">Stan Nelson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-168273" status="INCOMING"> <orgName>Institute of Human Genetics</orgName> <desc> <address> <addrLine>Regina-Pacis-Weg 3, 53113 Bonn</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-300970" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300970" type="direct"><org type="institution" xml:id="struct-300970" status="VALID"> <orgName>Bonn Universität [Bonn]</orgName> <desc> <address> <addrLine>Sigmund-Freud-Straße 25, 53127 Bonn</addrLine> <country key="DE"></country> </address> <ref type="url">https://www.uni-bonn.de/news-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Samango Sprouse, Carol" sort="Samango Sprouse, Carol" uniqKey="Samango Sprouse C" first="Carol" last="Samango-Sprouse">Carol Samango-Sprouse</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-27601" status="INCOMING"> <orgName>Children's National Medical Center</orgName> <desc> <address> <addrLine>School of Medicine - 2121 I St NW, Washington, DC 20052</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-304728" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-304728" type="direct"><org type="institution" xml:id="struct-304728" status="VALID"> <orgName>George Washington University</orgName> <orgName type="acronym">GW</orgName> <desc> <address> <addrLine>2121 Eye Street, NW , Washington, DC 20052 </addrLine> <country key="US"></country> </address> <ref type="url">https://www.gwu.edu</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Spence, Sarah" sort="Spence, Sarah" uniqKey="Spence S" first="Sarah" last="Spence">Sarah Spence</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-191541" status="INCOMING"> <orgName>Department of Human Genetics, UCLA</orgName> <desc> <address> <addrLine>David Geffen School of Medicine, CA 90095</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-72398" type="direct"></relation> <relation active="#struct-339234" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-72398" type="direct"><org type="institution" xml:id="struct-72398" status="VALID"> <orgName>University of California at Los Angeles [Los Angeles]</orgName> <orgName type="acronym">UCLA</orgName> <desc> <address> <addrLine> Los Angeles, Californie 90095</addrLine> <country key="US"></country> </address> <ref type="url">http://www.ucla.edu/</ref> </desc> </org></tutelle><tutelle active="#struct-339234" type="direct"><org type="institution" xml:id="struct-339234" status="INCOMING"> <orgName>Semel Institute</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="State, Matthew" sort="State, Matthew" uniqKey="State M" first="Matthew" last="State">Matthew State</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-168273" status="INCOMING"> <orgName>Institute of Human Genetics</orgName> <desc> <address> <addrLine>Regina-Pacis-Weg 3, 53113 Bonn</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-300970" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300970" type="direct"><org type="institution" xml:id="struct-300970" status="VALID"> <orgName>Bonn Universität [Bonn]</orgName> <desc> <address> <addrLine>Sigmund-Freud-Straße 25, 53127 Bonn</addrLine> <country key="DE"></country> </address> <ref type="url">https://www.uni-bonn.de/news-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Tanzi, Rudolph" sort="Tanzi, Rudolph" uniqKey="Tanzi R" first="Rudolph" last="Tanzi">Rudolph Tanzi</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242592" status="INCOMING"> <orgName>Massachusetts General Hospital</orgName> <desc> <address> <addrLine>Boston, MA</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-374583" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-374583" type="direct"><org type="institution" xml:id="struct-374583" status="INCOMING"> <orgName>Massachusetts General Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Coon, Hilary" sort="Coon, Hilary" uniqKey="Coon H" first="Hilary" last="Coon">Hilary Coon</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128956" status="INCOMING"> <orgName>Department of Developmental Neuroscience</orgName> <desc> <address> <addrLine>Viale del Tirreno 331 - 56128, Calambrone, Pisa</addrLine> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-361570" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-361570" type="direct"><org type="institution" xml:id="struct-361570" status="VALID"> <orgName>IRCCS Fondazione Stella Maris [Pisa]</orgName> <desc> <address> <addrLine>Viale del Tirreno, 331, 56128 Calambrone</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.fsm.unipi.it/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Dawson, Geraldine" sort="Dawson, Geraldine" uniqKey="Dawson G" first="Geraldine" last="Dawson">Geraldine Dawson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-173887" status="INCOMING"> <orgName>Autism Speaks and the Department of Psychiatry</orgName> <desc> <address> <addrLine>Chapel Hill, North Carolina</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-44261" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-44261" type="direct"><org type="institution" xml:id="struct-44261" status="VALID"> <orgName>The University of North Carolina at Chapel Hill</orgName> <desc> <address> <addrLine>250 East Franklin Street, Chapel Hill, NC,</addrLine> <country key="US"></country> </address> <ref type="url">http://www.unc.edu</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Devlin, Bernie" sort="Devlin, Bernie" uniqKey="Devlin B" first="Bernie" last="Devlin">Bernie Devlin</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128859" status="VALID"> <orgName>Department of Psychiatry [Pittsburgh]</orgName> <desc> <address> <addrLine>Thomas Detre Hall of the Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA 15213</addrLine> <country key="US"></country> </address> <ref type="url">http://www.wpic.pitt.edu/</ref> </desc> <listRelation> <relation active="#struct-309229" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309229" type="direct"><org type="institution" xml:id="struct-309229" status="VALID"> <orgName>University of Pittsburgh School of Medicine [Pittsburgh]</orgName> <desc> <address> <addrLine>4200 Fifth AvenuePittsburgh, PA 15260</addrLine> <country key="US"></country> </address> <ref type="url">http://www.pitt.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Estes, Annette" sort="Estes, Annette" uniqKey="Estes A" first="Annette" last="Estes">Annette Estes</name><affiliation><hal:affiliation type="department" xml:id="struct-128937" status="VALID"> <orgName>Department of Speech and Hearing Sciences [Washington]</orgName> <desc> <address> <addrLine>University of Washington, Seattle, WA 98195, USA</addrLine> <country key="US"></country> </address> <ref type="url">https://sphsc.washington.edu/</ref> </desc> <listRelation> <relation active="#struct-300433" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300433" type="direct"><org type="institution" xml:id="struct-300433" status="VALID"> <orgName>University of Washington [Seattle]</orgName> <desc> <address> <addrLine>Seattle, Washington 98105</addrLine> <country 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60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Tsiantis, John" sort="Tsiantis, John" uniqKey="Tsiantis J" first="John" last="Tsiantis">John Tsiantis</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112872" status="INCOMING"> <orgName>University Department of Child Psychiatry</orgName> <desc> <address> <addrLine>Medical School, Agia Sophia Children's Hospital, 115 27 Athens</addrLine> <country key="GR"></country> </address> </desc> <listRelation> <relation active="#struct-35091" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-35091" type="direct"><org type="institution" xml:id="struct-35091" status="VALID"> <orgName>University of Athens</orgName> <orgName type="acronym">UoA</orgName> <desc> <address> <addrLine>Zografou Campus, GR-157 80 Zografou</addrLine> <country key="GR"></country> </address> <ref type="url">http://uoa.gr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Papanikolaou, Katerina" sort="Papanikolaou, Katerina" uniqKey="Papanikolaou K" first="Katerina" last="Papanikolaou">Katerina Papanikolaou</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112872" status="INCOMING"> <orgName>University Department of Child Psychiatry</orgName> <desc> <address> <addrLine>Medical School, Agia Sophia Children's Hospital, 115 27 Athens</addrLine> <country key="GR"></country> </address> </desc> <listRelation> <relation active="#struct-35091" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-35091" type="direct"><org type="institution" xml:id="struct-35091" status="VALID"> <orgName>University of Athens</orgName> <orgName type="acronym">UoA</orgName> <desc> <address> <addrLine>Zografou Campus, GR-157 80 Zografou</addrLine> <country key="GR"></country> </address> <ref type="url">http://uoa.gr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Maestrini, Elena" sort="Maestrini, Elena" uniqKey="Maestrini E" first="Elena" last="Maestrini">Elena Maestrini</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-57919" status="INCOMING"> <orgName>Department of Pharmacy and Biotechnology</orgName> <desc> <address> <addrLine>Via Zamboni, 33, 40126 Bologna</addrLine> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-30978" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-30978" type="direct"><org type="institution" xml:id="struct-30978" status="VALID"> <orgName>Università di Bologna [Bologna]</orgName> <orgName type="acronym">UNIBO</orgName> <desc> <address> <addrLine>Via Zamboni, 33 - 40126 Bologna</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.eng.unibo.it/PortaleEn/default.htm</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bacchelli, Elena" sort="Bacchelli, Elena" uniqKey="Bacchelli E" first="Elena" last="Bacchelli">Elena Bacchelli</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-57919" status="INCOMING"> <orgName>Department of Pharmacy and Biotechnology</orgName> <desc> <address> <addrLine>Via Zamboni, 33, 40126 Bologna</addrLine> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-30978" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-30978" type="direct"><org type="institution" xml:id="struct-30978" status="VALID"> <orgName>Università di Bologna [Bologna]</orgName> <orgName type="acronym">UNIBO</orgName> <desc> <address> <addrLine>Via Zamboni, 33 - 40126 Bologna</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.eng.unibo.it/PortaleEn/default.htm</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Blasi, Francesca" sort="Blasi, Francesca" uniqKey="Blasi F" first="Francesca" last="Blasi">Francesca Blasi</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-57919" status="INCOMING"> <orgName>Department of Pharmacy and Biotechnology</orgName> <desc> <address> <addrLine>Via Zamboni, 33, 40126 Bologna</addrLine> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-30978" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-30978" type="direct"><org type="institution" xml:id="struct-30978" status="VALID"> <orgName>Università di Bologna [Bologna]</orgName> <orgName type="acronym">UNIBO</orgName> <desc> <address> <addrLine>Via Zamboni, 33 - 40126 Bologna</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.eng.unibo.it/PortaleEn/default.htm</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Carone, Simona" sort="Carone, Simona" uniqKey="Carone S" first="Simona" last="Carone">Simona Carone</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-57920" status="INCOMING"> <orgName>Medical Genetics Laboratory</orgName> <desc> <address> <addrLine>Via Pietro Albertoni, 15, 40138 Bologna</addrLine> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-313580" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-313580" type="direct"><org type="institution" xml:id="struct-313580" status="INCOMING"> <orgName>Policlinico S. Orsola-Malpighi</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Toma, Claudio" sort="Toma, Claudio" uniqKey="Toma C" first="Claudio" last="Toma">Claudio Toma</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-57919" status="INCOMING"> <orgName>Department of Pharmacy and Biotechnology</orgName> <desc> <address> <addrLine>Via Zamboni, 33, 40126 Bologna</addrLine> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-30978" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-30978" type="direct"><org type="institution" xml:id="struct-30978" status="VALID"> <orgName>Università di Bologna [Bologna]</orgName> <orgName type="acronym">UNIBO</orgName> <desc> <address> <addrLine>Via Zamboni, 33 - 40126 Bologna</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.eng.unibo.it/PortaleEn/default.htm</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Van Engeland, Herman" sort="Van Engeland, Herman" uniqKey="Van Engeland H" first="Herman" last="Van Engeland">Herman Van Engeland</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="De Jonge, Maretha" sort="De Jonge, Maretha" uniqKey="De Jonge M" first="Maretha" last="De Jonge">Maretha De Jonge</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Kemner, Chantal" sort="Kemner, Chantal" uniqKey="Kemner C" first="Chantal" last="Kemner">Chantal Kemner</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112799" status="INCOMING"> <orgName>Department of Neurocognition</orgName> <desc> <address> <addrLine>Faculty of Psychology - Minderbroedersberg 4, 6211 LK Maastricht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-83832" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-83832" type="direct"><org type="institution" xml:id="struct-83832" status="VALID"> <orgName>Maastricht University [Maastricht]</orgName> <desc> <address> <addrLine>Universiteitssingel 40;6200 MD Maastricht</addrLine> <country key="NL"></country> </address> <ref type="url">http://www.maastrichtuniversity.nl/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Koop, Frederieke" sort="Koop, Frederieke" uniqKey="Koop F" first="Frederieke" last="Koop">Frederieke Koop</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Langemeijer, Marjolein" sort="Langemeijer, Marjolein" uniqKey="Langemeijer M" first="Marjolein" last="Langemeijer">Marjolein Langemeijer</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Hijmans, Channa" sort="Hijmans, Channa" uniqKey="Hijmans C" first="Channa" last="Hijmans">Channa Hijmans</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Staal, Wouter" sort="Staal, Wouter" uniqKey="Staal W" first="Wouter" last="Staal">Wouter Staal</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Baird, Gillian" sort="Baird, Gillian" uniqKey="Baird G" first="Gillian" last="Baird">Gillian Baird</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128882" status="INCOMING"> <orgName>Newcomen Centre</orgName> <desc> <address> <addrLine>London, SE1 9RT</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-154945" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-154945" type="direct"><org type="institution" xml:id="struct-154945" status="VALID"> <orgName>Guy's Hospital [London]</orgName> <desc> <address> <addrLine>Great Maze Pond London SE1 9RT</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.guysandstthomas.nhs.uk/Home.aspx</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bolton, Patrick" sort="Bolton, Patrick" uniqKey="Bolton P" first="Patrick" last="Bolton">Patrick Bolton</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128884" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry</orgName> <desc> <address> <addrLine>London, SE5 8AF</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-311910" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-311910" type="direct"><org type="institution" xml:id="struct-311910" status="INCOMING"> <orgName>Institute of psychiatry</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Rutter, Michael" sort="Rutter, Michael" uniqKey="Rutter M" first="Michael" last="Rutter">Michael Rutter</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-131765" status="INCOMING"> <orgName>MRC Social, Genetic and Developmental Psychiatry Centre</orgName> <orgName type="acronym">SGDP</orgName> <desc> <address> <addrLine>Strand, London WC2R 2LS</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-356202" type="direct"></relation> <relation active="#struct-327716" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-356202" type="direct"><org type="institution" xml:id="struct-356202" status="INCOMING"> <orgName>The Institute of Psychiatry</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-327716" type="direct"><org type="institution" xml:id="struct-327716" status="VALID"> <orgName>King‘s College London [London]</orgName> <desc> <address> <addrLine>Strand Campus, London WC2R 2LS</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.kcl.ac.uk</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Weisblatt, Emma" sort="Weisblatt, Emma" uniqKey="Weisblatt E" first="Emma" last="Weisblatt">Emma Weisblatt</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242597" status="INCOMING"> <orgName>University of Cambridge Clinical School</orgName> <desc> <address> <addrLine>Cambridge</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-237843" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-237843" type="direct"><org type="institution" xml:id="struct-237843" status="VALID"> <orgName>University of Cambridge [UK]</orgName> <orgName type="acronym">CAM</orgName> <desc> <address> <addrLine>The Old Schools, Trinity Lane, Cambridge CB2 1TN</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.cam.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Green, Jonathan" sort="Green, Jonathan" uniqKey="Green J" first="Jonathan" last="Green">Jonathan Green</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112882" status="INCOMING"> <orgName>Manchester Academic Health Sciences Centre</orgName> <desc> <address> <addrLine>Manchester M13 9NT</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-342593" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-342593" type="direct"><org type="institution" xml:id="struct-342593" status="INCOMING"> <orgName>Manchester Academic Health Sciences Centre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Aldred, Catherine" sort="Aldred, Catherine" uniqKey="Aldred C" first="Catherine" last="Aldred">Catherine Aldred</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112882" status="INCOMING"> <orgName>Manchester Academic Health Sciences Centre</orgName> <desc> <address> <addrLine>Manchester M13 9NT</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-342593" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-342593" type="direct"><org type="institution" xml:id="struct-342593" status="INCOMING"> <orgName>Manchester Academic Health Sciences Centre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Wilkinson, Julie Anne" sort="Wilkinson, Julie Anne" uniqKey="Wilkinson J" first="Julie-Anne" last="Wilkinson">Julie-Anne Wilkinson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112882" status="INCOMING"> <orgName>Manchester Academic Health Sciences Centre</orgName> <desc> <address> <addrLine>Manchester M13 9NT</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-342593" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-342593" type="direct"><org type="institution" xml:id="struct-342593" status="INCOMING"> <orgName>Manchester Academic Health Sciences Centre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Pickles, Andrew" sort="Pickles, Andrew" uniqKey="Pickles A" first="Andrew" last="Pickles">Andrew Pickles</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-129077" status="INCOMING"> <orgName>Department of Medicine, Manchester</orgName> <desc> <address> <addrLine>Manchester M13 9PT</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-121172" type="direct"></relation> <relation active="#struct-331252" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-121172" type="direct"><org type="institution" xml:id="struct-121172" status="VALID"> <orgName>The University of Manchester [Manchester]</orgName> <desc> <address> <addrLine>Oxford Rd, Manchester M13 9PL</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.manchester.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-331252" type="direct"><org type="institution" xml:id="struct-331252" status="INCOMING"> <orgName>School of Epidemiology and Health Science</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Le Couteur, Ann" sort="Le Couteur, Ann" uniqKey="Le Couteur A" first="Ann" last="Le Couteur">Ann Le Couteur</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-150253" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry</orgName> <desc> <address> <addrLine>3rd Floor - Sir James Spence Institute - Royal Victoria Infirmary - Queen Victoria Road - Newcastle upon Tyne NE1 4LP</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-252912" type="direct"></relation> <relation active="#struct-360566" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-252912" type="direct"><org type="institution" xml:id="struct-252912" status="VALID"> <orgName>Newcastle University [Newcastle]</orgName> <desc> <address> <addrLine>Newcastle upon Tyne NE1 7RU</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ncl.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-360566" type="direct"><org type="institution" xml:id="struct-360566" status="INCOMING"> <orgName>Institute of Health & Society (Child & Adolescent Psychiatry)</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Berney, Tom" sort="Berney, Tom" uniqKey="Berney T" first="Tom" last="Berney">Tom Berney</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-150253" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry</orgName> <desc> <address> <addrLine>3rd Floor - Sir James Spence Institute - Royal Victoria Infirmary - Queen Victoria Road - Newcastle upon Tyne NE1 4LP</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-252912" type="direct"></relation> <relation active="#struct-360566" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-252912" type="direct"><org type="institution" xml:id="struct-252912" status="VALID"> <orgName>Newcastle University [Newcastle]</orgName> <desc> <address> <addrLine>Newcastle upon Tyne NE1 7RU</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ncl.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-360566" type="direct"><org type="institution" xml:id="struct-360566" status="INCOMING"> <orgName>Institute of Health & Society (Child & Adolescent Psychiatry)</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Mcconachie, Helen" sort="Mcconachie, Helen" uniqKey="Mcconachie H" first="Helen" last="Mcconachie">Helen Mcconachie</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128883" status="INCOMING"> <orgName>Child and Adolescent Mental Health</orgName> <desc> <address> <addrLine>Sir James Spence Institute, Newcastle upon Tyne, NE1 4LP</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-252912" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-252912" type="direct"><org type="institution" xml:id="struct-252912" status="VALID"> <orgName>Newcastle University [Newcastle]</orgName> <desc> <address> <addrLine>Newcastle upon Tyne NE1 7RU</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ncl.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bailey, Anthony" sort="Bailey, Anthony" uniqKey="Bailey A" first="Anthony" last="Bailey">Anthony Bailey</name><affiliation><hal:affiliation 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</org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Francis, Kostas" sort="Francis, Kostas" uniqKey="Francis K" first="Kostas" last="Francis">Kostas Francis</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128881" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Headington, Oxford, OX3 7JX</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> <relation active="#struct-322847" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-322847" type="direct"><org type="institution" xml:id="struct-322847" status="INCOMING"> <orgName>Warneford Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Honeyman, Gemma" sort="Honeyman, Gemma" uniqKey="Honeyman G" first="Gemma" last="Honeyman">Gemma Honeyman</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128881" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Headington, Oxford, OX3 7JX</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> <relation active="#struct-322847" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-322847" type="direct"><org type="institution" xml:id="struct-322847" status="INCOMING"> <orgName>Warneford Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Hutchinson, Aislinn" sort="Hutchinson, Aislinn" uniqKey="Hutchinson A" first="Aislinn" last="Hutchinson">Aislinn Hutchinson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128881" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Headington, Oxford, OX3 7JX</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> <relation active="#struct-322847" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-322847" type="direct"><org type="institution" xml:id="struct-322847" status="INCOMING"> <orgName>Warneford Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Parr, Jeremy" sort="Parr, Jeremy" uniqKey="Parr J" first="Jeremy" last="Parr">Jeremy Parr</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128881" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Headington, Oxford, OX3 7JX</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation 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Psychiatry</orgName> <desc> <address> <addrLine>Headington, Oxford, OX3 7JX</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> <relation active="#struct-322847" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-322847" type="direct"><org type="institution" xml:id="struct-322847" status="INCOMING"> <orgName>Warneford Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Monaco, Anthony" sort="Monaco, Anthony" uniqKey="Monaco A" first="Anthony" last="Monaco">Anthony Monaco</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Barnby, Gabrielle" sort="Barnby, Gabrielle" uniqKey="Barnby G" first="Gabrielle" last="Barnby">Gabrielle Barnby</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Kobayashi, Kazuhiro" sort="Kobayashi, Kazuhiro" uniqKey="Kobayashi K" first="Kazuhiro" last="Kobayashi">Kazuhiro Kobayashi</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lamb, Janine" sort="Lamb, Janine" uniqKey="Lamb J" first="Janine" last="Lamb">Janine Lamb</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Sousa, Ines" sort="Sousa, Ines" uniqKey="Sousa I" first="Ines" last="Sousa">Ines Sousa</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Sykes, Nuala" sort="Sykes, Nuala" uniqKey="Sykes N" first="Nuala" last="Sykes">Nuala Sykes</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Cook, Edwin" sort="Cook, Edwin" uniqKey="Cook E" first="Edwin" last="Cook">Edwin Cook</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128946" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>2035 W Taylor St, Chicago, IL 60612</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-331245" type="direct"></relation> <relation active="#struct-367491" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-331245" type="direct"><org type="institution" xml:id="struct-331245" status="INCOMING"> <orgName>Institute for Juvenile Research</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-367491" type="direct"><org type="institution" xml:id="struct-367491" status="VALID"><orgName>University of Illinois at Chicago</orgName><orgName type="acronym">UIC</orgName><desc><address><addrLine>1200 West Harrison St., Chicago, Illinois 60607</addrLine><country key="US"></country></address><ref type="url">http://www.uic.edu</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Guter, Stephen" sort="Guter, Stephen" uniqKey="Guter S" first="Stephen" last="Guter">Stephen Guter</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128946" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>2035 W Taylor St, Chicago, IL 60612</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-331245" type="direct"></relation> <relation active="#struct-367491" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-331245" type="direct"><org type="institution" xml:id="struct-331245" status="INCOMING"> <orgName>Institute for Juvenile Research</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-367491" type="direct"><org type="institution" xml:id="struct-367491" status="VALID"><orgName>University of Illinois at Chicago</orgName><orgName type="acronym">UIC</orgName><desc><address><addrLine>1200 West Harrison St., Chicago, Illinois 60607</addrLine><country key="US"></country></address><ref type="url">http://www.uic.edu</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Leventhal, Bennett" sort="Leventhal, Bennett" uniqKey="Leventhal B" first="Bennett" last="Leventhal">Bennett Leventhal</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-200668" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry</orgName> <desc> <address> <addrLine>NYU Child Study Center - 70 Washington Square S, New York, NY 10012</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-300459" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300459" type="direct"><org type="institution" xml:id="struct-300459" status="VALID"> <orgName>New York University [New York]</orgName> <desc> <address> <addrLine>70 Washington Square South, New York, NY 10012</addrLine> <country key="US"></country> </address> <ref type="url">http://www.nyu.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Salt, Jeff" sort="Salt, Jeff" uniqKey="Salt J" first="Jeff" last="Salt">Jeff Salt</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128859" status="VALID"> <orgName>Department of Psychiatry [Pittsburgh]</orgName> <desc> <address> <addrLine>Thomas Detre Hall of the Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA 15213</addrLine> <country key="US"></country> </address> <ref type="url">http://www.wpic.pitt.edu/</ref> </desc> <listRelation> <relation active="#struct-309229" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309229" type="direct"><org type="institution" xml:id="struct-309229" status="VALID"> <orgName>University of Pittsburgh School of Medicine [Pittsburgh]</orgName> <desc> <address> <addrLine>4200 Fifth AvenuePittsburgh, PA 15260</addrLine> <country key="US"></country> </address> <ref type="url">http://www.pitt.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lord, Catherine" sort="Lord, Catherine" uniqKey="Lord C" first="Catherine" last="Lord">Catherine Lord</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128932" status="INCOMING"> <orgName>Autism and Communicative Disorders Centre</orgName> <desc> <address> <addrLine>Ann Arbor, Michigan</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-24332" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-24332" type="direct"><org type="institution" xml:id="struct-24332" status="VALID"> <orgName>University of Michigan [Ann Arbor]</orgName> <desc> <address> <addrLine>500 Church Street Ann Arbor, MI 48109-1090</addrLine> <country key="US"></country> </address> <ref type="url">http://www.umich.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Corsello, Christina" sort="Corsello, Christina" uniqKey="Corsello C" first="Christina" last="Corsello">Christina Corsello</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128932" status="INCOMING"> <orgName>Autism and Communicative Disorders Centre</orgName> <desc> <address> <addrLine>Ann Arbor, Michigan</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-24332" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-24332" type="direct"><org type="institution" xml:id="struct-24332" status="VALID"> <orgName>University of Michigan [Ann Arbor]</orgName> <desc> <address> <addrLine>500 Church Street Ann Arbor, MI 48109-1090</addrLine> <country key="US"></country> </address> <ref type="url">http://www.umich.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Hus, Vanessa" sort="Hus, Vanessa" uniqKey="Hus V" first="Vanessa" last="Hus">Vanessa Hus</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128932" status="INCOMING"> <orgName>Autism and Communicative Disorders Centre</orgName> <desc> <address> <addrLine>Ann Arbor, Michigan</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-24332" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-24332" type="direct"><org type="institution" xml:id="struct-24332" status="VALID"> <orgName>University of Michigan [Ann Arbor]</orgName> <desc> <address> <addrLine>500 Church Street Ann Arbor, MI 48109-1090</addrLine> <country key="US"></country> </address> <ref type="url">http://www.umich.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Weeks, Daniel" sort="Weeks, Daniel" uniqKey="Weeks D" first="Daniel" last="Weeks">Daniel Weeks</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-142567" status="INCOMING"> <orgName>Human Genetics Department</orgName> <desc> <address> <addrLine>4200 Fifth Ave, Pittsburgh, PA 15260</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-378064" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-378064" type="direct"><org type="institution" xml:id="struct-378064" status="INCOMING"> <orgName>University of Pittsburgh</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Volkmar, Fred" sort="Volkmar, Fred" uniqKey="Volkmar F" first="Fred" last="Volkmar">Fred Volkmar</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128985" status="INCOMING"> <orgName>Child Study Centre</orgName> <desc> <address> <addrLine>New Haven, Connecticut 0652</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-300737" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300737" type="direct"><org type="institution" xml:id="struct-300737" status="VALID"> <orgName>Yale School of Medicine</orgName> <desc> <address> <addrLine>333 Cedar Street New Haven CT 06510</addrLine> <country key="US"></country> </address> <ref type="url">http://medicine.yale.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Tauber, Maite" sort="Tauber, Maite" uniqKey="Tauber M" first="Maïté" last="Tauber">Maïté Tauber</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-207731" status="INCOMING"> <orgName>Centre d'Endocrinologie, Maladies Osseuses, Génétique et Gynécologie Médicale</orgName> <desc> <address> <addrLine>330, avenue de Grande-Bretagne - TSA 70034 - 31059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> <relation active="#struct-307239" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300075" type="direct"><org type="institution" xml:id="struct-300075" status="VALID"> <orgName>CHU Toulouse [Toulouse]</orgName> <desc> <address> <addrLine>330 Avenue de Grande Bretagne, TSA 40031, 31059 Toulouse Cedex 09</addrLine> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-307239" type="direct"><org type="institution" xml:id="struct-307239" status="INCOMING"> <orgName>Hôpital des Enfants</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Fombonne, Eric" sort="Fombonne, Eric" uniqKey="Fombonne E" first="Eric" last="Fombonne">Eric Fombonne</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-129063" status="INCOMING"> <orgName>Department of Child Psychiatry</orgName> <desc> <address> <addrLine>2300 rue Tupper, Montreal, H3H 1P3</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-134741" type="direct"></relation> <relation active="#struct-312535" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-134741" type="direct"><org type="institution" xml:id="struct-134741" status="VALID"> <orgName>McGill University</orgName> <desc> <address> <addrLine>845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.mcgill.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-312535" type="direct"><org type="institution" xml:id="struct-312535" status="INCOMING"> <orgName>Montreal Children's Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Shih, Andy" sort="Shih, Andy" uniqKey="Shih A" first="Andy" last="Shih">Andy Shih</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128935" status="INCOMING"> <orgName>Scientific Affairs</orgName> <desc> <address> <addrLine>2 Park Avenue, 11th Floor, New York, NY 10016</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-331243" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-331243" type="direct"><org type="institution" xml:id="struct-331243" status="INCOMING"> <orgName>Autism Speaks</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Meyer, Kacie" sort="Meyer, Kacie" uniqKey="Meyer K" first="Kacie" last="Meyer">Kacie Meyer</name><affiliation><hal:affiliation type="institution" xml:id="struct-183914" status="VALID"> <orgName>University of Iowa [Iowa]</orgName> <desc> <address> <addrLine>Iowa City, IA 52242</addrLine> <country key="US"></country> </address> </desc> </hal:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:inserm-00937094</idno><idno type="halId">inserm-00937094</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00937094</idno><idno type="url">http://www.hal.inserm.fr/inserm-00937094</idno><idno type="doi">10.1038/ng1985</idno><date when="2007-03">2007-03</date><idno type="wicri:Area/Hal/Corpus">000367</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Mapping autism risk loci using genetic linkage and chromosomal rearrangements.</title><author><name sortKey="Szatmari, Peter" sort="Szatmari, Peter" uniqKey="Szatmari P" first="Peter" last="Szatmari">Peter Szatmari</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-142518" status="INCOMING"> <orgName>Department of Psychiatry and Behavioural Neurosciences</orgName> <desc> <address> <addrLine>Hamilton, Ontario, L8S 4K1</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-64587" type="direct"></relation> <relation active="#struct-361531" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-64587" type="direct"><org type="institution" xml:id="struct-64587" status="VALID"> <orgName>McMaster University [Hamilton, Ontario]</orgName> <desc> <address> <addrLine>1280 Main Street WestHamilton, Ontario L8S 4L8</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.mcmaster.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-361531" type="direct"><org type="institution" xml:id="struct-361531" status="INCOMING"> <orgName>Offord Centre for Child Studies</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Paterson, Andrew" sort="Paterson, Andrew" uniqKey="Paterson A" first="Andrew" last="Paterson">Andrew Paterson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-150249" status="INCOMING"> <orgName>The Centre for Applied Genomics, Toronto</orgName> <desc> <address> <addrLine>Toronto, Ontario, Canada M5G 1L7</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-300722" type="direct"></relation> <relation active="#struct-305187" type="direct"></relation> <relation active="#struct-322377" type="direct"></relation> <relation active="#struct-339724" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300722" type="direct"><org type="institution" xml:id="struct-300722" status="VALID"> <orgName>University of Toronto</orgName> <desc> <address> <addrLine>27 King's College Circle, Toronto M5S 1A1</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.utoronto.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-305187" type="direct"><org type="institution" xml:id="struct-305187" status="INCOMING"> <orgName>The Hospital for Sick Children</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-322377" type="direct"><org type="institution" xml:id="struct-322377" status="INCOMING"> <orgName>Department of Molecular Genetics</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-339724" type="direct"><org type="institution" xml:id="struct-339724" status="INCOMING"> <orgName>McLaughlin Centre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Zwaigenbaum, Lonnie" sort="Zwaigenbaum, Lonnie" uniqKey="Zwaigenbaum L" first="Lonnie" last="Zwaigenbaum">Lonnie Zwaigenbaum</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-129078" status="INCOMING"> <orgName>Department of Pediatrics</orgName> <desc> <address> <addrLine>Edmonton, AL T6G 2J3</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-98298" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-98298" type="direct"><org type="institution" xml:id="struct-98298" status="VALID"> <orgName>University of Alberta [Edmonton]</orgName> <desc> <address> <addrLine>116 St & 85 Ave, Edmonton, AB T6G 2R3</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.ualberta.ca/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Roberts, Wendy" sort="Roberts, Wendy" uniqKey="Roberts W" first="Wendy" last="Roberts">Wendy Roberts</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128885" status="INCOMING"> <orgName>Autism Research Unit</orgName> <desc> <address> <addrLine>Toronto, Ontario, M5G 1X8</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-300722" type="direct"></relation> <relation active="#struct-305187" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300722" type="direct"><org type="institution" xml:id="struct-300722" status="VALID"> <orgName>University of Toronto</orgName> <desc> <address> <addrLine>27 King's College Circle, Toronto M5S 1A1</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.utoronto.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-305187" type="direct"><org type="institution" xml:id="struct-305187" status="INCOMING"> <orgName>The Hospital for Sick Children</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Brian, Jessica" sort="Brian, Jessica" uniqKey="Brian J" first="Jessica" last="Brian">Jessica Brian</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128885" status="INCOMING"> <orgName>Autism Research Unit</orgName> <desc> <address> <addrLine>Toronto, Ontario, M5G 1X8</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-300722" type="direct"></relation> <relation active="#struct-305187" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300722" type="direct"><org type="institution" xml:id="struct-300722" status="VALID"> <orgName>University of Toronto</orgName> <desc> <address> <addrLine>27 King's College Circle, Toronto M5S 1A1</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.utoronto.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-305187" type="direct"><org type="institution" xml:id="struct-305187" status="INCOMING"> <orgName>The Hospital for Sick Children</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Liu, Xiao Qing" sort="Liu, Xiao Qing" uniqKey="Liu X" first="Xiao-Qing" last="Liu">Xiao-Qing Liu</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-150249" status="INCOMING"> <orgName>The Centre for Applied Genomics, Toronto</orgName> <desc> <address> <addrLine>Toronto, Ontario, Canada M5G 1L7</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-300722" type="direct"></relation> <relation active="#struct-305187" type="direct"></relation> <relation active="#struct-322377" type="direct"></relation> <relation active="#struct-339724" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300722" type="direct"><org type="institution" xml:id="struct-300722" status="VALID"> <orgName>University of Toronto</orgName> <desc> <address> <addrLine>27 King's College Circle, Toronto M5S 1A1</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.utoronto.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-305187" type="direct"><org type="institution" xml:id="struct-305187" status="INCOMING"> <orgName>The Hospital for Sick Children</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-322377" type="direct"><org type="institution" xml:id="struct-322377" status="INCOMING"> <orgName>Department of Molecular Genetics</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-339724" type="direct"><org type="institution" xml:id="struct-339724" status="INCOMING"> <orgName>McLaughlin Centre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Vincent, John" sort="Vincent, John" uniqKey="Vincent J" first="John" last="Vincent">John Vincent</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128974" status="VALID"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Department of Psychiatry University of Toronto 250 College Street 8th floor Toronto, Ontario M5T 1R8</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.utpsychiatry.ca/</ref> </desc> <listRelation> <relation active="#struct-300722" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300722" type="direct"><org type="institution" xml:id="struct-300722" status="VALID"> <orgName>University of Toronto</orgName> <desc> <address> <addrLine>27 King's College Circle, Toronto M5S 1A1</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.utoronto.ca/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Skaug, Jennifer" sort="Skaug, Jennifer" uniqKey="Skaug J" first="Jennifer" last="Skaug">Jennifer Skaug</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-150249" status="INCOMING"> <orgName>The Centre for Applied Genomics, Toronto</orgName> <desc> <address> <addrLine>Toronto, Ontario, Canada M5G 1L7</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-300722" type="direct"></relation> <relation active="#struct-305187" type="direct"></relation> <relation active="#struct-322377" type="direct"></relation> <relation active="#struct-339724" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300722" type="direct"><org type="institution" xml:id="struct-300722" status="VALID"> <orgName>University of Toronto</orgName> <desc> <address> <addrLine>27 King's College Circle, Toronto M5S 1A1</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.utoronto.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-305187" type="direct"><org type="institution" xml:id="struct-305187" status="INCOMING"> <orgName>The Hospital for Sick Children</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-322377" type="direct"><org type="institution" xml:id="struct-322377" status="INCOMING"> <orgName>Department of Molecular Genetics</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-339724" type="direct"><org type="institution" xml:id="struct-339724" status="INCOMING"> <orgName>McLaughlin 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</address> <ref type="url">http://www.mcmaster.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-361531" type="direct"><org type="institution" xml:id="struct-361531" status="INCOMING"> <orgName>Offord Centre for Child Studies</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Senman, Lili" sort="Senman, Lili" uniqKey="Senman L" first="Lili" last="Senman">Lili Senman</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128885" status="INCOMING"> <orgName>Autism Research Unit</orgName> <desc> <address> <addrLine>Toronto, Ontario, M5G 1X8</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-300722" type="direct"></relation> <relation active="#struct-305187" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300722" type="direct"><org type="institution" xml:id="struct-300722" status="VALID"> <orgName>University of Toronto</orgName> <desc> <address> <addrLine>27 King's College Circle, Toronto M5S 1A1</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.utoronto.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-305187" type="direct"><org type="institution" xml:id="struct-305187" status="INCOMING"> <orgName>The Hospital for Sick Children</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Feuk, Lars" sort="Feuk, Lars" uniqKey="Feuk L" first="Lars" last="Feuk">Lars Feuk</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-150249" status="INCOMING"> <orgName>The Centre for Applied Genomics, Toronto</orgName> <desc> <address> <addrLine>Toronto, Ontario, Canada M5G 1L7</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-300722" type="direct"></relation> <relation active="#struct-305187" type="direct"></relation> <relation active="#struct-322377" type="direct"></relation> <relation active="#struct-339724" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300722" type="direct"><org type="institution" xml:id="struct-300722" status="VALID"> <orgName>University of Toronto</orgName> <desc> <address> <addrLine>27 King's College Circle, Toronto M5S 1A1</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.utoronto.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-305187" type="direct"><org type="institution" xml:id="struct-305187" status="INCOMING"> <orgName>The Hospital for Sick Children</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-322377" type="direct"><org type="institution" xml:id="struct-322377" status="INCOMING"> <orgName>Department of Molecular Genetics</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-339724" type="direct"><org type="institution" xml:id="struct-339724" status="INCOMING"> <orgName>McLaughlin Centre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Qian, Cheng" sort="Qian, Cheng" uniqKey="Qian C" first="Cheng" last="Qian">Cheng Qian</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-150249" status="INCOMING"> <orgName>The Centre for Applied Genomics, Toronto</orgName> <desc> <address> <addrLine>Toronto, Ontario, Canada M5G 1L7</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-300722" type="direct"></relation> <relation active="#struct-305187" type="direct"></relation> <relation active="#struct-322377" type="direct"></relation> <relation active="#struct-339724" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300722" type="direct"><org type="institution" xml:id="struct-300722" status="VALID"> <orgName>University of Toronto</orgName> <desc> <address> <addrLine>27 King's College Circle, Toronto M5S 1A1</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.utoronto.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-305187" type="direct"><org type="institution" xml:id="struct-305187" status="INCOMING"> <orgName>The Hospital for Sick Children</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-322377" type="direct"><org type="institution" xml:id="struct-322377" status="INCOMING"> <orgName>Department of Molecular Genetics</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-339724" type="direct"><org type="institution" xml:id="struct-339724" status="INCOMING"> <orgName>McLaughlin Centre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bryson, Susan" sort="Bryson, Susan" uniqKey="Bryson S" first="Susan" last="Bryson">Susan Bryson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242581" status="INCOMING"> <orgName>Departments of Pediatrics and Psychology</orgName> <desc> <address> <addrLine>Izaak Walton Killam Health Centre - Halifax</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-32440" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-32440" type="direct"><org type="institution" xml:id="struct-32440" status="VALID"> <orgName>Dalhousie University [Halifax]</orgName> <desc> <address> <addrLine> 6299 South St, Halifax, NS B3H 4R2</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.dal.ca/</ref> </desc> 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</org></tutelle><tutelle active="#struct-322377" type="direct"><org type="institution" xml:id="struct-322377" status="INCOMING"> <orgName>Department of Molecular Genetics</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-339724" type="direct"><org type="institution" xml:id="struct-339724" status="INCOMING"> <orgName>McLaughlin Centre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Vieland, Veronica" sort="Vieland, Veronica" uniqKey="Vieland V" first="Veronica" last="Vieland">Veronica Vieland</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-150256" status="INCOMING"> <orgName>Battelle Center for Mathematical Medicine</orgName> <desc> <address> <addrLine>700 Childrens Dr, Columbus, OH 43205</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation 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Hall Psychiatric Institute</orgName> <desc> <address> <addrLine>Columbia, South Carolina</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-82529" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-82529" type="direct"><org type="institution" xml:id="struct-82529" status="VALID"> <orgName>University of South Carolina [Columbia]</orgName> <desc> <address> <addrLine>Columbia, SC 29208</addrLine> <country key="US"></country> </address> <ref type="url">http://www.sc.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Abramson, Ruth" sort="Abramson, Ruth" uniqKey="Abramson R" first="Ruth" last="Abramson">Ruth Abramson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242584" status="INCOMING"> <orgName>W.S. 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B, 4ème étage, case courrier 37 9 quai Saint Bernard 75252 Paris Cedex 05</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U952" active="#struct-303623" type="direct"></relation> <relation name="UMR7224" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle name="U952" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> 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de Gaulle - 94010 Créteil cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-pec.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Buxbaum, Joseph" sort="Buxbaum, Joseph" uniqKey="Buxbaum J" first="Joseph" last="Buxbaum">Joseph Buxbaum</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-201158" status="INCOMING"> <orgName>Friedman Brain Institute, Mount Sinai</orgName> <desc> <address> <addrLine>New York 10029</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-354552" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-354552" type="direct"><org type="institution" xml:id="struct-354552" status="VALID"> <orgName>Icahn School of Medicine at Mount Sinai [New York]</orgName> <desc> <address> <addrLine>1 Gustave L. 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Hussman Institute for Human Genomics</orgName> <desc> <address> <addrLine>Dr John T. 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7255 Chapel Hill, N.C. 27599-3366</addrLine> <country key="US"></country> </address> <ref type="url">http://www.cidd.unc.edu/</ref> </desc> <listRelation> <relation active="#struct-44261" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-44261" type="direct"><org type="institution" xml:id="struct-44261" status="VALID"> <orgName>The University of North Carolina at Chapel Hill</orgName> <desc> <address> <addrLine>250 East Franklin Street, Chapel Hill, NC,</addrLine> <country key="US"></country> </address> <ref type="url">http://www.unc.edu</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Wassink, Thomas" sort="Wassink, Thomas" uniqKey="Wassink T" first="Thomas" last="Wassink">Thomas Wassink</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128986" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Iowa City, Iowa 52242</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-331255" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-331255" type="direct"><org type="institution" xml:id="struct-331255" status="INCOMING"> <orgName>Carver College of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Sheffield, Val" sort="Sheffield, Val" uniqKey="Sheffield V" first="Val" last="Sheffield">Val Sheffield</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128982" status="INCOMING"> <orgName>Department of Pediatrics</orgName> <desc> <address> <addrLine>Iowa City, Iowa 52242</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-358145" type="direct"></relation> <relation active="#struct-358146" type="direct"></relation> <relation active="#struct-366215" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-358145" type="direct"><org type="institution" xml:id="struct-358145" status="INCOMING"> <orgName>Howard Hughes Medical</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-358146" type="direct"><org type="institution" xml:id="struct-358146" status="INCOMING"> <orgName>Institute Carver College of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-366215" type="direct"><org type="institution" xml:id="struct-366215" status="INCOMING"> <orgName>University of Iowa</orgName> <desc> <address> <country key="US"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Geschwind, Daniel" sort="Geschwind, Daniel" uniqKey="Geschwind D" first="Daniel" last="Geschwind">Daniel Geschwind</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242586" status="INCOMING"> <orgName>Department of Neurology</orgName> <desc> <address> <addrLine>Los Angeles, California</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-309330" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309330" type="direct"><org type="institution" xml:id="struct-309330" status="INCOMING"> <orgName>UCLA School of Medicine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bucan, Maja" sort="Bucan, Maja" uniqKey="Bucan M" first="Maja" last="Bucan">Maja Bucan</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242587" status="INCOMING"> <orgName>Department of Genetics</orgName> <desc> <address> <addrLine>3451 Walnut St, Philadelphia, PA 19104</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-115889" type="direct"></relation> <relation active="#struct-303723" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-115889" type="direct"><org type="institution" xml:id="struct-115889" status="VALID"><orgName>University of Pennsylvania [Philadelphia]</orgName><desc><address><addrLine>3451 Walnut Street, Philadelphia, PA 19104 | 215-898-5000</addrLine><country key="US"></country></address><ref type="url">http://www.upenn.edu/</ref></desc></org></tutelle><tutelle active="#struct-303723" type="direct"><org type="institution" xml:id="struct-303723" status="VALID"> <orgName>School of Medicine</orgName> <desc> <address> <country key="US"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Brown, Ted" sort="Brown, Ted" uniqKey="Brown T" first="Ted" last="Brown">Ted Brown</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242588" status="INCOMING"> <orgName>N.Y.S. Institute for Basic Research in Developmental Disabilities</orgName> <desc> <address> <addrLine>Staten Island, NY</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-358117" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-358117" type="direct"><org type="institution" xml:id="struct-358117" status="INCOMING"> <orgName>N.Y.S. 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Levi Hall 5801 South Ellis Avenue Chicago, Illinois 60637</addrLine><country key="US"></country></address><ref type="url">http://www.uchicago.edu/</ref></desc></hal:affiliation></affiliation></author><author><name sortKey="Herbert, Martha" sort="Herbert, Martha" uniqKey="Herbert M" first="Martha" last="Herbert">Martha Herbert</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242589" status="INCOMING"> <orgName>Harvard Medical School</orgName> <desc> <address> <addrLine>Boston, MA</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-161455" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-161455" type="direct"><org type="institution" xml:id="struct-161455" status="VALID"> <orgName>Massachusetts General Hospital [Boston]</orgName> <orgName type="acronym">MGH</orgName> <desc> <address> <addrLine>Massachusetts General Hospital 55 Fruit Street Boston, MA 02114</addrLine> <country key="US"></country> </address> <ref type="url">http://www.massgeneral.org/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lajonchere, Clara" sort="Lajonchere, Clara" uniqKey="Lajonchere C" first="Clara" last="Lajonchere">Clara Lajonchere</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128949" status="INCOMING"> <orgName>Autism Genetic Resource Exchange</orgName> <desc> <address> <addrLine>Los Angeles, California 90036-4234</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-331243" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-331243" type="direct"><org type="institution" xml:id="struct-331243" status="INCOMING"> <orgName>Autism Speaks</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Ledbetter, David" sort="Ledbetter, David" uniqKey="Ledbetter D" first="David" last="Ledbetter">David Ledbetter</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242590" status="INCOMING"> <orgName>Department of Genetics</orgName> <desc> <address> <addrLine>Atlanta, GA</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-301506" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301506" type="direct"><org type="institution" xml:id="struct-301506" status="VALID"> <orgName>Emory University [Atlanta, GA]</orgName> <desc> <address> <addrLine>201 Dowman Dr, Atlanta, GA 30322</addrLine> <country key="US"></country> </address> <ref type="url">http://www.emory.edu</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lese Martin, Christa" sort="Lese Martin, Christa" uniqKey="Lese Martin C" first="Christa" last="Lese-Martin">Christa Lese-Martin</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242590" status="INCOMING"> <orgName>Department of Genetics</orgName> <desc> <address> <addrLine>Atlanta, GA</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-301506" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301506" type="direct"><org type="institution" xml:id="struct-301506" status="VALID"> <orgName>Emory University [Atlanta, GA]</orgName> <desc> <address> <addrLine>201 Dowman Dr, Atlanta, GA 30322</addrLine> <country key="US"></country> </address> <ref type="url">http://www.emory.edu</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Miller, Janet" sort="Miller, Janet" uniqKey="Miller J" first="Janet" last="Miller">Janet Miller</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242591" status="INCOMING"> <orgName>Cure Autism Now</orgName> <desc> <address> <addrLine>Los Angeles, CA</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-358118" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-358118" type="direct"><org type="institution" xml:id="struct-358118" status="INCOMING"> <orgName>Cure Autism Now</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Nelson, Stan" sort="Nelson, Stan" uniqKey="Nelson S" first="Stan" last="Nelson">Stan Nelson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-168273" status="INCOMING"> <orgName>Institute of Human Genetics</orgName> <desc> <address> <addrLine>Regina-Pacis-Weg 3, 53113 Bonn</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-300970" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300970" type="direct"><org type="institution" xml:id="struct-300970" status="VALID"> <orgName>Bonn Universität [Bonn]</orgName> <desc> <address> <addrLine>Sigmund-Freud-Straße 25, 53127 Bonn</addrLine> <country key="DE"></country> </address> <ref type="url">https://www.uni-bonn.de/news-1</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Samango Sprouse, Carol" sort="Samango Sprouse, Carol" uniqKey="Samango Sprouse C" first="Carol" last="Samango-Sprouse">Carol Samango-Sprouse</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-27601" status="INCOMING"> <orgName>Children's National Medical Center</orgName> <desc> <address> <addrLine>School of Medicine - 2121 I St NW, Washington, DC 20052</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-304728" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-304728" type="direct"><org type="institution" xml:id="struct-304728" status="VALID"> <orgName>George Washington University</orgName> <orgName type="acronym">GW</orgName> <desc> <address> <addrLine>2121 Eye Street, NW , Washington, DC 20052 </addrLine> <country key="US"></country> </address> <ref type="url">https://www.gwu.edu</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Spence, Sarah" sort="Spence, Sarah" uniqKey="Spence S" first="Sarah" last="Spence">Sarah Spence</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-191541" status="INCOMING"> <orgName>Department of Human Genetics, UCLA</orgName> <desc> <address> <addrLine>David Geffen School of Medicine, CA 90095</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-72398" type="direct"></relation> <relation active="#struct-339234" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-72398" type="direct"><org type="institution" xml:id="struct-72398" status="VALID"> <orgName>University of California at Los Angeles [Los Angeles]</orgName> <orgName type="acronym">UCLA</orgName> <desc> <address> <addrLine> Los Angeles, Californie 90095</addrLine> <country key="US"></country> </address> <ref type="url">http://www.ucla.edu/</ref> </desc> </org></tutelle><tutelle active="#struct-339234" type="direct"><org type="institution" xml:id="struct-339234" status="INCOMING"> <orgName>Semel Institute</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="State, Matthew" sort="State, Matthew" uniqKey="State M" first="Matthew" last="State">Matthew State</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-168273" status="INCOMING"> <orgName>Institute of Human Genetics</orgName> <desc> <address> <addrLine>Regina-Pacis-Weg 3, 53113 Bonn</addrLine> <country key="DE"></country> </address> </desc> 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15260</addrLine> <country key="US"></country> </address> <ref type="url">http://www.pitt.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Estes, Annette" sort="Estes, Annette" uniqKey="Estes A" first="Annette" last="Estes">Annette Estes</name><affiliation><hal:affiliation type="department" xml:id="struct-128937" status="VALID"> <orgName>Department of Speech and Hearing Sciences [Washington]</orgName> <desc> <address> <addrLine>University of Washington, Seattle, WA 98195, USA</addrLine> <country key="US"></country> </address> <ref type="url">https://sphsc.washington.edu/</ref> </desc> <listRelation> <relation active="#struct-300433" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300433" type="direct"><org type="institution" xml:id="struct-300433" status="VALID"> <orgName>University of Washington [Seattle]</orgName> <desc> <address> <addrLine>Seattle, Washington 98105</addrLine> <country 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Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bolte, Sven" sort="Bolte, Sven" uniqKey="Bolte S" first="Sven" last="Bölte">Sven Bölte</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112863" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy</orgName> <desc> <address> <addrLine>Senckenberganlage 31 - 60325 Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Feineis Matthews, Sabine" sort="Feineis Matthews, Sabine" uniqKey="Feineis Matthews S" first="Sabine" last="Feineis-Matthews">Sabine Feineis-Matthews</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112863" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy</orgName> <desc> <address> <addrLine>Senckenberganlage 31 - 60325 Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Herbrecht, Evelyn" sort="Herbrecht, Evelyn" uniqKey="Herbrecht E" first="Evelyn" last="Herbrecht">Evelyn Herbrecht</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112863" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy</orgName> <desc> <address> <addrLine>Senckenberganlage 31 - 60325 Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Schmotzer, Gabi" sort="Schmotzer, Gabi" uniqKey="Schmotzer G" first="Gabi" last="Schmötzer">Gabi Schmötzer</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112863" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy</orgName> <desc> <address> <addrLine>Senckenberganlage 31 - 60325 Frankfurt am Main</addrLine> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-302435" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302435" type="direct"><org type="institution" xml:id="struct-302435" status="VALID"> <orgName>Goethe-Universität Frankfurt am Main</orgName> <desc> <address> <addrLine>Theodor-W.-Adorno-Platz 1 , 60323 Frankfurt am Main</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.goethe-university-frankfurt.de/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Tsiantis, John" sort="Tsiantis, John" uniqKey="Tsiantis J" first="John" last="Tsiantis">John Tsiantis</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112872" status="INCOMING"> <orgName>University Department of Child Psychiatry</orgName> <desc> <address> <addrLine>Medical School, Agia Sophia Children's Hospital, 115 27 Athens</addrLine> <country key="GR"></country> </address> </desc> <listRelation> <relation active="#struct-35091" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-35091" type="direct"><org type="institution" xml:id="struct-35091" status="VALID"> <orgName>University of Athens</orgName> <orgName type="acronym">UoA</orgName> <desc> <address> <addrLine>Zografou Campus, GR-157 80 Zografou</addrLine> <country key="GR"></country> </address> <ref type="url">http://uoa.gr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Papanikolaou, Katerina" sort="Papanikolaou, Katerina" uniqKey="Papanikolaou K" first="Katerina" last="Papanikolaou">Katerina Papanikolaou</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112872" status="INCOMING"> <orgName>University Department of Child Psychiatry</orgName> <desc> <address> <addrLine>Medical School, Agia Sophia Children's Hospital, 115 27 Athens</addrLine> <country key="GR"></country> </address> </desc> <listRelation> <relation active="#struct-35091" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-35091" type="direct"><org type="institution" xml:id="struct-35091" status="VALID"> <orgName>University of Athens</orgName> <orgName type="acronym">UoA</orgName> <desc> <address> <addrLine>Zografou Campus, GR-157 80 Zografou</addrLine> <country key="GR"></country> </address> <ref type="url">http://uoa.gr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Maestrini, Elena" sort="Maestrini, Elena" uniqKey="Maestrini E" first="Elena" last="Maestrini">Elena Maestrini</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-57919" status="INCOMING"> <orgName>Department of Pharmacy and Biotechnology</orgName> <desc> <address> <addrLine>Via Zamboni, 33, 40126 Bologna</addrLine> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-30978" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-30978" type="direct"><org type="institution" xml:id="struct-30978" status="VALID"> <orgName>Università di Bologna [Bologna]</orgName> <orgName type="acronym">UNIBO</orgName> <desc> <address> <addrLine>Via Zamboni, 33 - 40126 Bologna</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.eng.unibo.it/PortaleEn/default.htm</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bacchelli, Elena" sort="Bacchelli, Elena" uniqKey="Bacchelli E" first="Elena" last="Bacchelli">Elena Bacchelli</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-57919" status="INCOMING"> <orgName>Department of Pharmacy and Biotechnology</orgName> <desc> <address> <addrLine>Via Zamboni, 33, 40126 Bologna</addrLine> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-30978" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-30978" type="direct"><org type="institution" xml:id="struct-30978" status="VALID"> <orgName>Università di Bologna [Bologna]</orgName> <orgName type="acronym">UNIBO</orgName> <desc> <address> <addrLine>Via Zamboni, 33 - 40126 Bologna</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.eng.unibo.it/PortaleEn/default.htm</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Blasi, Francesca" sort="Blasi, Francesca" uniqKey="Blasi F" first="Francesca" last="Blasi">Francesca Blasi</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-57919" status="INCOMING"> <orgName>Department of Pharmacy and Biotechnology</orgName> <desc> <address> <addrLine>Via Zamboni, 33, 40126 Bologna</addrLine> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-30978" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-30978" type="direct"><org type="institution" xml:id="struct-30978" status="VALID"> <orgName>Università di Bologna [Bologna]</orgName> <orgName type="acronym">UNIBO</orgName> <desc> <address> <addrLine>Via Zamboni, 33 - 40126 Bologna</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.eng.unibo.it/PortaleEn/default.htm</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Carone, Simona" sort="Carone, Simona" uniqKey="Carone S" first="Simona" last="Carone">Simona Carone</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-57920" status="INCOMING"> <orgName>Medical Genetics Laboratory</orgName> <desc> <address> <addrLine>Via Pietro Albertoni, 15, 40138 Bologna</addrLine> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-313580" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-313580" type="direct"><org type="institution" xml:id="struct-313580" status="INCOMING"> <orgName>Policlinico S. Orsola-Malpighi</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Toma, Claudio" sort="Toma, Claudio" uniqKey="Toma C" first="Claudio" last="Toma">Claudio Toma</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-57919" status="INCOMING"> <orgName>Department of Pharmacy and Biotechnology</orgName> <desc> <address> <addrLine>Via Zamboni, 33, 40126 Bologna</addrLine> <country key="IT"></country> </address> </desc> <listRelation> <relation active="#struct-30978" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-30978" type="direct"><org type="institution" xml:id="struct-30978" status="VALID"> <orgName>Università di Bologna [Bologna]</orgName> <orgName type="acronym">UNIBO</orgName> <desc> <address> <addrLine>Via Zamboni, 33 - 40126 Bologna</addrLine> <country key="IT"></country> </address> <ref type="url">http://www.eng.unibo.it/PortaleEn/default.htm</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Van Engeland, Herman" sort="Van Engeland, Herman" uniqKey="Van Engeland H" first="Herman" last="Van Engeland">Herman Van Engeland</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="De Jonge, Maretha" sort="De Jonge, Maretha" uniqKey="De Jonge M" first="Maretha" last="De Jonge">Maretha De Jonge</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Kemner, Chantal" sort="Kemner, Chantal" uniqKey="Kemner C" first="Chantal" last="Kemner">Chantal Kemner</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112799" status="INCOMING"> <orgName>Department of Neurocognition</orgName> <desc> <address> <addrLine>Faculty of Psychology - Minderbroedersberg 4, 6211 LK Maastricht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-83832" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-83832" type="direct"><org type="institution" xml:id="struct-83832" status="VALID"> <orgName>Maastricht University [Maastricht]</orgName> <desc> <address> <addrLine>Universiteitssingel 40;6200 MD Maastricht</addrLine> <country key="NL"></country> </address> <ref type="url">http://www.maastrichtuniversity.nl/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Koop, Frederieke" sort="Koop, Frederieke" uniqKey="Koop F" first="Frederieke" last="Koop">Frederieke Koop</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Langemeijer, Marjolein" sort="Langemeijer, Marjolein" uniqKey="Langemeijer M" first="Marjolein" last="Langemeijer">Marjolein Langemeijer</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Hijmans, Channa" sort="Hijmans, Channa" uniqKey="Hijmans C" first="Channa" last="Hijmans">Channa Hijmans</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Staal, Wouter" sort="Staal, Wouter" uniqKey="Staal W" first="Wouter" last="Staal">Wouter Staal</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128605" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Heidelberglaan 100, 3584 CX Utrecht</addrLine> <country key="NL"></country> </address> </desc> <listRelation> <relation active="#struct-309434" type="direct"></relation> <relation active="#struct-361530" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309434" type="direct"><org type="institution" xml:id="struct-309434" status="INCOMING"> <orgName>University Medical Center Utrecht</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-361530" type="direct"><org type="institution" xml:id="struct-361530" status="INCOMING"> <orgName>Brain Center Rudolf Magnus</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Baird, Gillian" sort="Baird, Gillian" uniqKey="Baird G" first="Gillian" last="Baird">Gillian Baird</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128882" status="INCOMING"> <orgName>Newcomen Centre</orgName> <desc> <address> <addrLine>London, SE1 9RT</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-154945" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-154945" type="direct"><org type="institution" xml:id="struct-154945" status="VALID"> <orgName>Guy's Hospital [London]</orgName> <desc> <address> <addrLine>Great Maze Pond London SE1 9RT</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.guysandstthomas.nhs.uk/Home.aspx</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Bolton, Patrick" sort="Bolton, Patrick" uniqKey="Bolton P" first="Patrick" last="Bolton">Patrick Bolton</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128884" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry</orgName> <desc> <address> <addrLine>London, SE5 8AF</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-311910" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-311910" type="direct"><org type="institution" xml:id="struct-311910" status="INCOMING"> <orgName>Institute of psychiatry</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Rutter, Michael" sort="Rutter, Michael" uniqKey="Rutter M" first="Michael" last="Rutter">Michael Rutter</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-131765" status="INCOMING"> <orgName>MRC Social, Genetic and Developmental Psychiatry Centre</orgName> <orgName type="acronym">SGDP</orgName> <desc> <address> <addrLine>Strand, London WC2R 2LS</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-356202" type="direct"></relation> <relation active="#struct-327716" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-356202" type="direct"><org type="institution" xml:id="struct-356202" status="INCOMING"> <orgName>The Institute of Psychiatry</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-327716" type="direct"><org type="institution" xml:id="struct-327716" status="VALID"> <orgName>King‘s College London [London]</orgName> <desc> <address> <addrLine>Strand Campus, London WC2R 2LS</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.kcl.ac.uk</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Weisblatt, Emma" sort="Weisblatt, Emma" uniqKey="Weisblatt E" first="Emma" last="Weisblatt">Emma Weisblatt</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-242597" status="INCOMING"> <orgName>University of Cambridge Clinical School</orgName> <desc> <address> <addrLine>Cambridge</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-237843" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-237843" type="direct"><org type="institution" xml:id="struct-237843" status="VALID"> <orgName>University of Cambridge [UK]</orgName> <orgName type="acronym">CAM</orgName> <desc> <address> <addrLine>The Old Schools, Trinity Lane, Cambridge CB2 1TN</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.cam.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Green, Jonathan" sort="Green, Jonathan" uniqKey="Green J" first="Jonathan" last="Green">Jonathan Green</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112882" status="INCOMING"> <orgName>Manchester Academic Health Sciences Centre</orgName> <desc> <address> <addrLine>Manchester M13 9NT</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-342593" 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Health Sciences Centre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Wilkinson, Julie Anne" sort="Wilkinson, Julie Anne" uniqKey="Wilkinson J" first="Julie-Anne" last="Wilkinson">Julie-Anne Wilkinson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-112882" status="INCOMING"> <orgName>Manchester Academic Health Sciences Centre</orgName> <desc> <address> <addrLine>Manchester M13 9NT</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-342593" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-342593" type="direct"><org type="institution" xml:id="struct-342593" status="INCOMING"> <orgName>Manchester Academic Health Sciences Centre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> 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type="direct"><org type="institution" xml:id="struct-331252" status="INCOMING"> <orgName>School of Epidemiology and Health Science</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Le Couteur, Ann" sort="Le Couteur, Ann" uniqKey="Le Couteur A" first="Ann" last="Le Couteur">Ann Le Couteur</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-150253" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry</orgName> <desc> <address> <addrLine>3rd Floor - Sir James Spence Institute - Royal Victoria Infirmary - Queen Victoria Road - Newcastle upon Tyne NE1 4LP</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-252912" type="direct"></relation> <relation active="#struct-360566" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-252912" type="direct"><org type="institution" xml:id="struct-252912" status="VALID"> <orgName>Newcastle University [Newcastle]</orgName> <desc> <address> <addrLine>Newcastle upon Tyne NE1 7RU</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ncl.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-360566" type="direct"><org type="institution" xml:id="struct-360566" status="INCOMING"> <orgName>Institute of Health & Society (Child & Adolescent Psychiatry)</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Berney, Tom" sort="Berney, Tom" uniqKey="Berney T" first="Tom" last="Berney">Tom Berney</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-150253" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry</orgName> <desc> <address> <addrLine>3rd Floor - Sir James Spence Institute - Royal Victoria Infirmary - Queen Victoria Road - Newcastle upon Tyne NE1 4LP</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-252912" type="direct"></relation> <relation active="#struct-360566" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-252912" type="direct"><org type="institution" xml:id="struct-252912" status="VALID"> <orgName>Newcastle University [Newcastle]</orgName> <desc> <address> <addrLine>Newcastle upon Tyne NE1 7RU</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ncl.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-360566" type="direct"><org type="institution" xml:id="struct-360566" status="INCOMING"> <orgName>Institute of Health & Society (Child & Adolescent Psychiatry)</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Mcconachie, Helen" sort="Mcconachie, Helen" uniqKey="Mcconachie H" 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</org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Francis, Kostas" sort="Francis, Kostas" uniqKey="Francis K" first="Kostas" last="Francis">Kostas Francis</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128881" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Headington, Oxford, OX3 7JX</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> <relation active="#struct-322847" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-322847" type="direct"><org type="institution" xml:id="struct-322847" status="INCOMING"> <orgName>Warneford Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Honeyman, Gemma" sort="Honeyman, Gemma" uniqKey="Honeyman G" first="Gemma" last="Honeyman">Gemma Honeyman</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128881" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Headington, Oxford, OX3 7JX</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> <relation active="#struct-322847" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-322847" type="direct"><org type="institution" xml:id="struct-322847" status="INCOMING"> <orgName>Warneford Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Hutchinson, Aislinn" sort="Hutchinson, Aislinn" uniqKey="Hutchinson A" first="Aislinn" last="Hutchinson">Aislinn Hutchinson</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128881" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Headington, Oxford, OX3 7JX</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> <relation active="#struct-322847" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-322847" type="direct"><org type="institution" xml:id="struct-322847" status="INCOMING"> <orgName>Warneford Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Parr, Jeremy" sort="Parr, Jeremy" uniqKey="Parr J" first="Jeremy" last="Parr">Jeremy Parr</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128881" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>Headington, Oxford, OX3 7JX</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation 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Psychiatry</orgName> <desc> <address> <addrLine>Headington, Oxford, OX3 7JX</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> <relation active="#struct-322847" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle><tutelle active="#struct-322847" type="direct"><org type="institution" xml:id="struct-322847" status="INCOMING"> <orgName>Warneford Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Monaco, Anthony" sort="Monaco, Anthony" uniqKey="Monaco A" first="Anthony" last="Monaco">Anthony Monaco</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Barnby, Gabrielle" sort="Barnby, Gabrielle" uniqKey="Barnby G" first="Gabrielle" last="Barnby">Gabrielle Barnby</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Kobayashi, Kazuhiro" sort="Kobayashi, Kazuhiro" uniqKey="Kobayashi K" first="Kazuhiro" last="Kobayashi">Kazuhiro Kobayashi</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lamb, Janine" sort="Lamb, Janine" uniqKey="Lamb J" first="Janine" last="Lamb">Janine Lamb</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Sousa, Ines" sort="Sousa, Ines" uniqKey="Sousa I" first="Ines" last="Sousa">Ines Sousa</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Sykes, Nuala" sort="Sykes, Nuala" uniqKey="Sykes N" first="Nuala" last="Sykes">Nuala Sykes</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128858" status="INCOMING"> <orgName>Wellcome Trust Centre for Human Genetics</orgName> <desc> <address> <addrLine>Roosevelt Drive - Headington, Oxford OX3 7BN</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Cook, Edwin" sort="Cook, Edwin" uniqKey="Cook E" first="Edwin" last="Cook">Edwin Cook</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128946" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>2035 W Taylor St, Chicago, IL 60612</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-331245" type="direct"></relation> <relation active="#struct-367491" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-331245" type="direct"><org type="institution" xml:id="struct-331245" status="INCOMING"> <orgName>Institute for Juvenile Research</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-367491" type="direct"><org type="institution" xml:id="struct-367491" status="VALID"><orgName>University of Illinois at Chicago</orgName><orgName type="acronym">UIC</orgName><desc><address><addrLine>1200 West Harrison St., Chicago, Illinois 60607</addrLine><country key="US"></country></address><ref type="url">http://www.uic.edu</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Guter, Stephen" sort="Guter, Stephen" uniqKey="Guter S" first="Stephen" last="Guter">Stephen Guter</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128946" status="INCOMING"> <orgName>Department of Psychiatry</orgName> <desc> <address> <addrLine>2035 W Taylor St, Chicago, IL 60612</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-331245" type="direct"></relation> <relation active="#struct-367491" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-331245" type="direct"><org type="institution" xml:id="struct-331245" status="INCOMING"> <orgName>Institute for Juvenile Research</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-367491" type="direct"><org type="institution" xml:id="struct-367491" status="VALID"><orgName>University of Illinois at Chicago</orgName><orgName type="acronym">UIC</orgName><desc><address><addrLine>1200 West Harrison St., Chicago, Illinois 60607</addrLine><country key="US"></country></address><ref type="url">http://www.uic.edu</ref></desc></org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Leventhal, Bennett" sort="Leventhal, Bennett" uniqKey="Leventhal B" first="Bennett" last="Leventhal">Bennett Leventhal</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-200668" status="INCOMING"> <orgName>Department of Child and Adolescent Psychiatry</orgName> <desc> <address> <addrLine>NYU Child Study Center - 70 Washington Square S, New York, NY 10012</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-300459" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300459" type="direct"><org type="institution" xml:id="struct-300459" status="VALID"> <orgName>New York University [New York]</orgName> <desc> <address> <addrLine>70 Washington Square South, New York, NY 10012</addrLine> <country key="US"></country> </address> <ref type="url">http://www.nyu.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Salt, Jeff" sort="Salt, Jeff" uniqKey="Salt J" first="Jeff" last="Salt">Jeff Salt</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128859" status="VALID"> <orgName>Department of Psychiatry [Pittsburgh]</orgName> <desc> <address> <addrLine>Thomas Detre Hall of the Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA 15213</addrLine> <country key="US"></country> </address> <ref type="url">http://www.wpic.pitt.edu/</ref> </desc> <listRelation> <relation active="#struct-309229" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-309229" type="direct"><org type="institution" xml:id="struct-309229" status="VALID"> <orgName>University of Pittsburgh School of Medicine [Pittsburgh]</orgName> <desc> <address> <addrLine>4200 Fifth AvenuePittsburgh, PA 15260</addrLine> <country key="US"></country> </address> <ref type="url">http://www.pitt.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lord, Catherine" sort="Lord, Catherine" uniqKey="Lord C" first="Catherine" last="Lord">Catherine Lord</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128932" status="INCOMING"> <orgName>Autism and Communicative Disorders Centre</orgName> <desc> <address> <addrLine>Ann Arbor, Michigan</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-24332" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-24332" type="direct"><org type="institution" xml:id="struct-24332" status="VALID"> <orgName>University of Michigan [Ann Arbor]</orgName> <desc> <address> <addrLine>500 Church Street Ann Arbor, MI 48109-1090</addrLine> <country key="US"></country> </address> <ref type="url">http://www.umich.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Corsello, Christina" sort="Corsello, Christina" uniqKey="Corsello C" first="Christina" last="Corsello">Christina Corsello</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128932" status="INCOMING"> <orgName>Autism and Communicative Disorders Centre</orgName> <desc> <address> <addrLine>Ann Arbor, Michigan</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-24332" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-24332" type="direct"><org type="institution" xml:id="struct-24332" status="VALID"> <orgName>University of Michigan [Ann Arbor]</orgName> <desc> <address> <addrLine>500 Church Street Ann Arbor, MI 48109-1090</addrLine> <country key="US"></country> </address> <ref type="url">http://www.umich.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Hus, Vanessa" sort="Hus, Vanessa" uniqKey="Hus V" first="Vanessa" last="Hus">Vanessa Hus</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128932" status="INCOMING"> <orgName>Autism and Communicative Disorders Centre</orgName> <desc> <address> <addrLine>Ann Arbor, Michigan</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-24332" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-24332" type="direct"><org type="institution" xml:id="struct-24332" status="VALID"> <orgName>University of Michigan [Ann Arbor]</orgName> <desc> <address> <addrLine>500 Church Street Ann Arbor, MI 48109-1090</addrLine> <country key="US"></country> </address> <ref type="url">http://www.umich.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Weeks, Daniel" sort="Weeks, Daniel" uniqKey="Weeks D" first="Daniel" last="Weeks">Daniel Weeks</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-142567" status="INCOMING"> <orgName>Human Genetics Department</orgName> <desc> <address> <addrLine>4200 Fifth Ave, Pittsburgh, PA 15260</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-378064" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-378064" type="direct"><org type="institution" xml:id="struct-378064" status="INCOMING"> <orgName>University of Pittsburgh</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Volkmar, Fred" sort="Volkmar, Fred" uniqKey="Volkmar F" first="Fred" last="Volkmar">Fred Volkmar</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128985" status="INCOMING"> <orgName>Child Study Centre</orgName> <desc> <address> <addrLine>New Haven, Connecticut 0652</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-300737" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300737" type="direct"><org type="institution" xml:id="struct-300737" status="VALID"> <orgName>Yale School of Medicine</orgName> <desc> <address> <addrLine>333 Cedar Street New Haven CT 06510</addrLine> <country key="US"></country> </address> <ref type="url">http://medicine.yale.edu/</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Tauber, Maite" sort="Tauber, Maite" uniqKey="Tauber M" first="Maïté" last="Tauber">Maïté Tauber</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-207731" status="INCOMING"> <orgName>Centre d'Endocrinologie, Maladies Osseuses, Génétique et Gynécologie Médicale</orgName> <desc> <address> <addrLine>330, avenue de Grande-Bretagne - TSA 70034 - 31059 Toulouse cedex 9</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300075" type="direct"></relation> <relation active="#struct-307239" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300075" type="direct"><org type="institution" xml:id="struct-300075" status="VALID"> <orgName>CHU Toulouse [Toulouse]</orgName> <desc> <address> <addrLine>330 Avenue de Grande Bretagne, TSA 40031, 31059 Toulouse Cedex 09</addrLine> <country key="FR"></country> </address> </desc></org></tutelle><tutelle active="#struct-307239" type="direct"><org type="institution" xml:id="struct-307239" status="INCOMING"> <orgName>Hôpital des Enfants</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Fombonne, Eric" sort="Fombonne, Eric" uniqKey="Fombonne E" first="Eric" last="Fombonne">Eric Fombonne</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-129063" status="INCOMING"> <orgName>Department of Child Psychiatry</orgName> <desc> <address> <addrLine>2300 rue Tupper, Montreal, H3H 1P3</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-134741" type="direct"></relation> <relation active="#struct-312535" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-134741" type="direct"><org type="institution" xml:id="struct-134741" status="VALID"> <orgName>McGill University</orgName> <desc> <address> <addrLine>845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.mcgill.ca/</ref> </desc> </org></tutelle><tutelle active="#struct-312535" type="direct"><org type="institution" xml:id="struct-312535" status="INCOMING"> <orgName>Montreal Children's Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Shih, Andy" sort="Shih, Andy" uniqKey="Shih A" first="Andy" last="Shih">Andy Shih</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-128935" status="INCOMING"> <orgName>Scientific Affairs</orgName> <desc> <address> <addrLine>2 Park Avenue, 11th Floor, New York, NY 10016</addrLine> <country key="US"></country> </address> </desc> <listRelation> <relation active="#struct-331243" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-331243" type="direct"><org type="institution" xml:id="struct-331243" status="INCOMING"> <orgName>Autism Speaks</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Meyer, Kacie" sort="Meyer, Kacie" uniqKey="Meyer K" first="Kacie" last="Meyer">Kacie Meyer</name><affiliation><hal:affiliation type="institution" xml:id="struct-183914" status="VALID"> <orgName>University of Iowa [Iowa]</orgName> <desc> <address> <addrLine>Iowa City, IA 52242</addrLine> <country key="US"></country> </address> </desc> </hal:affiliation></affiliation></author></analytic><idno type="DOI">10.1038/ng1985</idno><series><title level="j">Nature Genetics</title><idno type="ISSN">1061-4036</idno><imprint><date type="datePub">2007-03</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,181 [corrected] families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these families. Linkage and copy number variation analyses implicate chromosome 11p12-p13 and neurexins, respectively, among other candidate loci. Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs.</div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Mapping autism risk loci using genetic linkage and chromosomal rearrangements.</title> <author role="aut"> <persName> <forename type="first">Peter</forename> <surname>Szatmari</surname> </persName> <idno type="halauthorid">529553</idno> <affiliation ref="#struct-142518"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Andrew</forename> <forename type="middle">D.</forename> <surname>Paterson</surname> </persName> <idno type="halauthorid">529550</idno> <affiliation ref="#struct-150249"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Lonnie</forename> <surname>Zwaigenbaum</surname> </persName> <idno type="halauthorid">529536</idno> <affiliation ref="#struct-129078"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Wendy</forename> <surname>Roberts</surname> </persName> <idno type="halauthorid">529499</idno> <affiliation ref="#struct-128885"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jessica</forename> <surname>Brian</surname> </persName> <idno type="halauthorid">529425</idno> <affiliation ref="#struct-128885"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Xiao-Qing</forename> <surname>Liu</surname> </persName> <idno type="halauthorid">529467</idno> <affiliation ref="#struct-150249"></affiliation> </author> <author role="aut"> <persName> <forename type="first">John</forename> <forename type="middle">B.</forename> <surname>Vincent</surname> </persName> <idno type="halauthorid">529524</idno> <affiliation ref="#struct-128974"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jennifer</forename> <forename type="middle">L.</forename> <surname>Skaug</surname> </persName> <idno type="halauthorid">976848</idno> <affiliation ref="#struct-150249"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Ann</forename> <forename type="middle">P.</forename> <surname>Thompson</surname> </persName> <idno type="halauthorid">529520</idno> <affiliation ref="#struct-142518"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Lili</forename> <surname>Senman</surname> </persName> <idno type="halauthorid">529509</idno> <affiliation ref="#struct-128885"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Lars</forename> <surname>Feuk</surname> </persName> <idno type="halauthorid">976149</idno> <affiliation ref="#struct-150249"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Cheng</forename> <surname>Qian</surname> </persName> <idno type="halauthorid">976150</idno> <affiliation ref="#struct-150249"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Susan</forename> <forename type="middle">E.</forename> <surname>Bryson</surname> </persName> <idno type="halauthorid">529426</idno> <affiliation ref="#struct-242581"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Marshall</forename> <forename type="middle">B.</forename> <surname>Jones</surname> </persName> <idno type="halauthorid">976849</idno> <affiliation ref="#struct-242582"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christian</forename> <forename type="middle">R.</forename> <surname>Marshall</surname> </persName> <idno type="halauthorid">529473</idno> <affiliation ref="#struct-150249"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Stephen</forename> <forename type="middle">W.</forename> <surname>Scherer</surname> </persName> <email type="md5">ad97073937220fe68e64de530a8dc4d0</email> <email type="domain">sickkids.ca</email> <idno type="halauthorid">529557</idno> <affiliation ref="#struct-150249"></affiliation> <affiliation ref="#struct-88489"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Veronica</forename> <forename type="middle">J.</forename> <surname>Vieland</surname> </persName> <idno type="halauthorid">529555</idno> <affiliation ref="#struct-150256"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christopher</forename> <surname>Bartlett</surname> </persName> <idno type="halauthorid">75977</idno> <affiliation ref="#struct-55852"></affiliation> </author> <author role="aut"> <persName> <forename type="first">La Vonne</forename> <surname>Mangin</surname> </persName> <idno type="halauthorid">976156</idno> <affiliation ref="#struct-150256"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Rhinda</forename> <surname>Goedken</surname> </persName> <idno type="halauthorid">976157</idno> <affiliation ref="#struct-28457"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alberto</forename> <surname>Segre</surname> </persName> <idno type="halauthorid">976158</idno> <affiliation ref="#struct-28457"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Margaret</forename> <forename type="middle">A.</forename> <surname>Pericak-Vance</surname> </persName> <idno type="halauthorid">529551</idno> <affiliation ref="#struct-128942"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Michael</forename> <forename type="middle">L.</forename> <surname>Cuccaro</surname> </persName> <idno type="halauthorid">529540</idno> <affiliation ref="#struct-128942"></affiliation> </author> <author role="aut"> <persName> <forename type="first">John</forename> <forename type="middle">R.</forename> <surname>Gilbert</surname> </persName> <idno type="halauthorid">976850</idno> <affiliation ref="#struct-128942"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Harry</forename> <forename type="middle">H.</forename> <surname>Wright</surname> </persName> <idno type="halauthorid">976851</idno> <affiliation ref="#struct-242584"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Ruth</forename> <forename type="middle">K.</forename> <surname>Abramson</surname> </persName> <idno type="halauthorid">976852</idno> <affiliation ref="#struct-242584"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Catalina</forename> <surname>Betancur</surname> </persName> <idno type="idhal" notation="string">catalina-betancur</idno> <idno type="idhal" notation="numeric">13320</idno> <idno type="halauthorid">117624</idno> <idno type="ORCID">http://orcid.org/0000-0002-3327-4804</idno> <affiliation ref="#struct-81502"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thomas</forename> <surname>Bourgeron</surname> </persName> <idno type="halauthorid">157767</idno> <affiliation ref="#struct-27316"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christopher</forename> <surname>Gillberg</surname> </persName> <idno type="halauthorid">140686</idno> <affiliation ref="#struct-239304"></affiliation> <affiliation ref="#struct-239310"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Marion</forename> <surname>Leboyer</surname> </persName> <idno type="halauthorid">117627</idno> <affiliation ref="#struct-266797"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Joseph</forename> <forename type="middle">D.</forename> <surname>Buxbaum</surname> </persName> <idno type="halauthorid">158585</idno> <affiliation ref="#struct-201158"></affiliation> <affiliation ref="#struct-226895"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Kenneth</forename> <forename type="middle">L.</forename> <surname>Davis</surname> </persName> <idno type="halauthorid">976853</idno> <affiliation ref="#struct-201158"></affiliation> <affiliation ref="#struct-60892"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Hollander</surname> </persName> <idno type="halauthorid">158591</idno> <affiliation ref="#struct-201158"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jeremy</forename> <forename type="middle">M.</forename> <surname>Silverman</surname> </persName> <idno type="halauthorid">158590</idno> <affiliation ref="#struct-128859"></affiliation> <affiliation ref="#struct-201158"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Joachim</forename> <surname>Hallmayer</surname> </persName> <idno type="halauthorid">529546</idno> <affiliation ref="#struct-179626"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Linda</forename> <surname>Lotspeich</surname> </persName> <idno type="halauthorid">529469</idno> <affiliation ref="#struct-129072"></affiliation> </author> <author role="aut"> <persName> <forename type="first">James</forename> <forename type="middle">S.</forename> <surname>Sutcliffe</surname> </persName> <idno type="halauthorid">529558</idno> <affiliation ref="#struct-128988"></affiliation> <affiliation ref="#struct-128933"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jonathan</forename> <forename type="middle">L.</forename> <surname>Haines</surname> </persName> <idno type="halauthorid">529545</idno> <affiliation ref="#struct-128988"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Susan</forename> <forename type="middle">E.</forename> <surname>Folstein</surname> </persName> <idno type="halauthorid">529443</idno> <affiliation ref="#struct-128942"></affiliation> <affiliation ref="#struct-242585"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Joseph</forename> <surname>Piven</surname> </persName> <idno type="halauthorid">529492</idno> <affiliation ref="#struct-128978"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thomas</forename> <forename type="middle">H.</forename> <surname>Wassink</surname> </persName> <idno type="halauthorid">529529</idno> <affiliation ref="#struct-128986"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Val</forename> <surname>Sheffield</surname> </persName> <idno type="halauthorid">976169</idno> <affiliation ref="#struct-128982"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Daniel</forename> <forename type="middle">H.</forename> <surname>Geschwind</surname> </persName> <idno type="halauthorid">529544</idno> <affiliation ref="#struct-242586"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Maja</forename> <surname>Bucan</surname> </persName> <idno 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2007, 39 (3), pp.319-28. 〈10.1038/ng1985〉</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="PASTEUR">Institut Pasteur</idno> <idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="RIIP_PARIS">Institut Pasteur de Paris</idno> <idno type="stamp" n="IMRB" p="CV_IMRB">Institut Mondor de Recherche Biomédicale</idno> <idno type="stamp" n="UNIV-TLSE2">Université Toulouse 2</idno> <idno type="stamp" n="OCTOGONE" p="UNIV-TLSE2">Unité de Recherche Interdisciplinaire Octogone-Lordat</idno> <idno type="stamp" n="PMSNC">U952 - Physiopathologie des Maladies du Système Nerveux Central</idno> <idno type="stamp" n="UPEC-UPEM">UPEC-UPEM</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" 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<affiliation ref="#struct-128858"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Edwin</forename> <forename type="middle">H.</forename> <surname>Cook</surname> </persName> <idno type="halauthorid">529538</idno> <affiliation ref="#struct-128946"></affiliation> <affiliation ref="#struct-239315"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Stephen</forename> <forename type="middle">J.</forename> <surname>Guter</surname> </persName> <idno type="halauthorid">529448</idno> <affiliation ref="#struct-128946"></affiliation> <affiliation ref="#struct-128716"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Bennett</forename> <forename type="middle">L.</forename> <surname>Leventhal</surname> </persName> <idno type="halauthorid">529465</idno> <affiliation ref="#struct-200668"></affiliation> <affiliation ref="#struct-128946"></affiliation> </author> <author role="aut"> <persName> <forename 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ref="#struct-142567"></affiliation> <affiliation ref="#struct-51656"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Fred</forename> <surname>Volkmar</surname> </persName> <idno type="halauthorid">529525</idno> <affiliation ref="#struct-128985"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Maïté</forename> <surname>Tauber</surname> </persName> <idno type="halauthorid">120180</idno> <affiliation ref="#struct-207731"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Fombonne</surname> </persName> <idno type="halauthorid">264437</idno> <affiliation ref="#struct-129063"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Andy</forename> <surname>Shih</surname> </persName> <idno type="halauthorid">976220</idno> <affiliation ref="#struct-128935"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Kacie</forename> <forename type="middle">J.</forename> <surname>Meyer</surname> </persName> <idno type="halauthorid">976860</idno> <affiliation ref="#struct-183914"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">7336</idno> <idno type="issn">1061-4036</idno> <idno type="eissn">1546-1718</idno> <title level="j">Nature Genetics</title> <imprint> <publisher>Nature Publishing Group</publisher> <biblScope unit="volume">39</biblScope> <biblScope unit="issue">3</biblScope> <biblScope unit="pp">319-28</biblScope> <date type="datePub">2007-03</date> <date type="dateEpub">2007-02-18</date> </imprint> </monogr> <idno type="doi">10.1038/ng1985</idno> <idno type="pubmed">17322880</idno> <idno type="pubmedcentral">PMC4867008</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <classCode scheme="mesh">Chromosome Aberrations</classCode> <classCode scheme="mesh">Lod Score</classCode> <classCode scheme="mesh">Female</classCode> <classCode scheme="mesh">Genetic Linkage</classCode> <classCode scheme="mesh">Genetic Predisposition to Disease</classCode> <classCode scheme="mesh">Genetic Testing</classCode> <classCode scheme="mesh">Genetic Variation</classCode> <classCode scheme="mesh">Humans</classCode> <classCode scheme="mesh">Male</classCode> <classCode scheme="mesh">Risk Factors</classCode> <classCode scheme="mesh">Autistic Disorder</classCode> <classCode scheme="mesh">Chromosome Mapping</classCode> <classCode scheme="mesh">Family</classCode> <classCode scheme="halDomain" n="sdv.gen">Life Sciences [q-bio]/Genetics</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en">Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,181 [corrected] families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these families. Linkage and copy number variation analyses implicate chromosome 11p12-p13 and neurexins, respectively, among other candidate loci. Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs.</abstract> <particDesc> <org type="consortium">Autism Genome Project Consortium</org> </particDesc> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
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