PittsburghV1, Hal, Checkpoint, bibRecord, 000199

Towards a foundational representation of potential drug-drug interaction knowledge

Identifieur interne : 000199 ( Hal/Checkpoint ); précédent : 000198; suivant : 000200

Towards a foundational representation of potential drug-drug interaction knowledge

Auteurs : Mathias Brochhausen [États-Unis] ; Jodi Schneider [France] ; Malone Daniel [États-Unis] ; Philip E. Empey [États-Unis] ; William R. Hogan [États-Unis] ; Richard D. Boyce [États-Unis]

Source :

RBID : Hal:hal-01076294

English descriptors

mix :
- Potential drug-drug interactions, knowledge management, ontologies.

Abstract

Inadequate representation of evidence and knowledge about potential drug-drug interactions is a major factor underlying disagreements among sources of drug information that are used by clinicians. In this paper we describe the initial steps toward developing a foundational domain representation that allows tracing the evidence underlying potential drug-drug interaction knowledge. The new representation includes biological and biomedical entities represented in existing ontologies and terminologies to foster integration of data from relevant fields such as physiology, anatomy, and laboratory sciences.

Url:

https://hal.archives-ouvertes.fr/hal-01076294

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000654
to stream Hal, to step Curation: 000654

Links to Exploration step

Hal:hal-01076294

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Towards a foundational representation of potential drug-drug interaction knowledge</title>
<author><name sortKey="Brochhausen, Mathias" sort="Brochhausen, Mathias" uniqKey="Brochhausen M" first="Mathias" last="Brochhausen">Mathias Brochhausen</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-406599" status="INCOMING">          <orgName>Division of Biomedical Informatics</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-18304" type="direct"></relation>
            <relation active="#struct-306848" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-18304" type="direct"><org type="laboratory" xml:id="struct-18304" status="INCOMING">          <orgName>University of Arkansas for Medical Sciences</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-306848" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-306848" type="indirect"><org type="institution" xml:id="struct-306848" status="INCOMING">          <orgName>University of Arkansas for Medical Sciences</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Schneider, Jodi" sort="Schneider, Jodi" uniqKey="Schneider J" first="Jodi" last="Schneider">Jodi Schneider</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-178918" status="VALID">          <idno type="RNSR">201221031M</idno>
          <orgName>Web-Instrumented Man-Machine Interactions, Communities and Semantics</orgName>
          <orgName type="acronym">WIMMICS</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://wimmics.inria.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-34586" type="direct"></relation>
            <relation active="#struct-300009" type="indirect"></relation>
            <relation active="#struct-452156" type="direct"></relation>
            <relation active="#struct-13009" type="indirect"></relation>
            <relation active="#struct-117617" type="indirect"></relation>
            <relation active="#struct-425168" type="indirect"></relation>
            <relation name="UMR7271" active="#struct-441569" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-34586" type="direct"><org type="laboratory" xml:id="struct-34586" status="VALID">          <idno type="RNSR">198318250R</idno>
          <orgName>Inria Sophia Antipolis - Méditerranée </orgName>
          <orgName type="acronym">CRISAM</orgName>
          <desc>            <address>              <addrLine>2004 route des Lucioles BP 93 06902 Sophia Antipolis</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inria.fr/centre/sophia/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300009" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-300009" type="indirect"><org type="institution" xml:id="struct-300009" status="VALID"><orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
<orgName type="acronym">Inria</orgName>
<desc><address><addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/en/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-452156" type="direct"><org type="department" xml:id="struct-452156" status="VALID">          <orgName>Scalable and Pervasive softwARe and Knowledge Systems</orgName>
          <orgName type="acronym">SPARKS</orgName>
          <date type="start">2016-03-03</date>
          <desc>            <address>              <addrLine>Laboratoire I3SCS 4012106903 Sophia Antipolis Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.i3s.unice.fr/sparks</ref>
          </desc>
          <listRelation>            <relation active="#struct-13009" type="direct"></relation>
            <relation active="#struct-117617" type="indirect"></relation>
            <relation active="#struct-425168" type="indirect"></relation>
            <relation name="UMR7271" active="#struct-441569" type="indirect"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-13009" type="indirect"><org type="laboratory" xml:id="struct-13009" status="VALID">          <orgName>Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis</orgName>
          <orgName type="acronym">I3S</orgName>
          <desc>            <address>              <addrLine>2000, route des Lucioles - Les Algorithmes - bât. Euclide B 06900 Sophia Antipolis</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.i3s.unice.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-117617" type="direct"></relation>
            <relation active="#struct-425168" type="direct"></relation>
            <relation name="UMR7271" active="#struct-441569" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-117617" type="indirect"><org type="institution" xml:id="struct-117617" status="VALID">          <orgName>Université Nice Sophia Antipolis</orgName>
          <orgName type="acronym">UNS</orgName>
          <desc>            <address>              <addrLine>Parc Valrose - BP 2135 - 06103 Nice cedex 2</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://unice.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-425168" type="indirect"><org type="institution" xml:id="struct-425168" status="VALID">          <orgName>Université Côte d'Azur</orgName>
          <orgName type="acronym">UCA</orgName>
          <desc>            <address>              <addrLine>Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://univ-cotedazur.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7271" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nice</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université Nice Sophia Antipolis</orgName>
</affiliation>
</author>
<author><name sortKey="Daniel, Malone" sort="Daniel, Malone" uniqKey="Daniel M" first="Malone" last="Daniel">Malone Daniel</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-406600" status="INCOMING">          <orgName>College of Pharmacy</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-23624" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-23624" type="direct"><org type="institution" xml:id="struct-23624" status="VALID">          <orgName>University of Arizona</orgName>
          <desc>            <address>              <addrLine>Tucson AZ 85721 USA</addrLine>
              <country key="US"></country>
            </address>
            <ref type="url">http://www.arizona.edu/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Empey, Philip E" sort="Empey, Philip E" uniqKey="Empey P" first="Philip E." last="Empey">Philip E. Empey</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-406601" status="INCOMING">          <orgName>Department of Pharmacy and Therapeutics</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-184330" type="direct"></relation>
            <relation active="#struct-378064" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-184330" type="direct"><org type="laboratory" xml:id="struct-184330" status="VALID">          <orgName>University of Pittsburgh [Pittsburg]</orgName>
          <desc>            <address>              <addrLine>4200 Fifth Avenue Pittsburgh, PA 15260</addrLine>
              <country key="US"></country>
            </address>
            <ref type="url">http://www.pitt.edu/</ref>
          </desc>
          <listRelation>            <relation active="#struct-378064" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-378064" type="indirect"><org type="institution" xml:id="struct-378064" status="INCOMING">          <orgName>University of Pittsburgh</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Hogan, William R" sort="Hogan, William R" uniqKey="Hogan W" first="William R." last="Hogan">William R. Hogan</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-406602" status="INCOMING">          <orgName>Department of Health Outcomes and Policy</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-302308" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-302308" type="direct"><org type="institution" xml:id="struct-302308" status="VALID">          <orgName>University of Florida [Gainesville]</orgName>
          <desc>            <address>              <addrLine>Gainesville, FL 32611</addrLine>
              <country key="US"></country>
            </address>
            <ref type="url">http://www.ufl.edu/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Boyce, Richard D" sort="Boyce, Richard D" uniqKey="Boyce R" first="Richard D." last="Boyce">Richard D. Boyce</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-406596" status="INCOMING">          <orgName>Department of Biomedical Informatics</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-184330" type="direct"></relation>
            <relation active="#struct-378064" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-184330" type="direct"><org type="laboratory" xml:id="struct-184330" status="VALID">          <orgName>University of Pittsburgh [Pittsburg]</orgName>
          <desc>            <address>              <addrLine>4200 Fifth Avenue Pittsburgh, PA 15260</addrLine>
              <country key="US"></country>
            </address>
            <ref type="url">http://www.pitt.edu/</ref>
          </desc>
          <listRelation>            <relation active="#struct-378064" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-378064" type="indirect"><org type="institution" xml:id="struct-378064" status="INCOMING">          <orgName>University of Pittsburgh</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01076294</idno>
<idno type="halId">hal-01076294</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-01076294</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-01076294</idno>
<date when="2014-10-06">2014-10-06</date>
<idno type="wicri:Area/Hal/Corpus">000654</idno>
<idno type="wicri:Area/Hal/Curation">000654</idno>
<idno type="wicri:Area/Hal/Checkpoint">000199</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000199</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Towards a foundational representation of potential drug-drug interaction knowledge</title>
<author><name sortKey="Brochhausen, Mathias" sort="Brochhausen, Mathias" uniqKey="Brochhausen M" first="Mathias" last="Brochhausen">Mathias Brochhausen</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-406599" status="INCOMING">          <orgName>Division of Biomedical Informatics</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-18304" type="direct"></relation>
            <relation active="#struct-306848" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-18304" type="direct"><org type="laboratory" xml:id="struct-18304" status="INCOMING">          <orgName>University of Arkansas for Medical Sciences</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-306848" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-306848" type="indirect"><org type="institution" xml:id="struct-306848" status="INCOMING">          <orgName>University of Arkansas for Medical Sciences</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Schneider, Jodi" sort="Schneider, Jodi" uniqKey="Schneider J" first="Jodi" last="Schneider">Jodi Schneider</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-178918" status="VALID">          <idno type="RNSR">201221031M</idno>
          <orgName>Web-Instrumented Man-Machine Interactions, Communities and Semantics</orgName>
          <orgName type="acronym">WIMMICS</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://wimmics.inria.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-34586" type="direct"></relation>
            <relation active="#struct-300009" type="indirect"></relation>
            <relation active="#struct-452156" type="direct"></relation>
            <relation active="#struct-13009" type="indirect"></relation>
            <relation active="#struct-117617" type="indirect"></relation>
            <relation active="#struct-425168" type="indirect"></relation>
            <relation name="UMR7271" active="#struct-441569" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-34586" type="direct"><org type="laboratory" xml:id="struct-34586" status="VALID">          <idno type="RNSR">198318250R</idno>
          <orgName>Inria Sophia Antipolis - Méditerranée </orgName>
          <orgName type="acronym">CRISAM</orgName>
          <desc>            <address>              <addrLine>2004 route des Lucioles BP 93 06902 Sophia Antipolis</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inria.fr/centre/sophia/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300009" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-300009" type="indirect"><org type="institution" xml:id="struct-300009" status="VALID"><orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
<orgName type="acronym">Inria</orgName>
<desc><address><addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inria.fr/en/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-452156" type="direct"><org type="department" xml:id="struct-452156" status="VALID">          <orgName>Scalable and Pervasive softwARe and Knowledge Systems</orgName>
          <orgName type="acronym">SPARKS</orgName>
          <date type="start">2016-03-03</date>
          <desc>            <address>              <addrLine>Laboratoire I3SCS 4012106903 Sophia Antipolis Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.i3s.unice.fr/sparks</ref>
          </desc>
          <listRelation>            <relation active="#struct-13009" type="direct"></relation>
            <relation active="#struct-117617" type="indirect"></relation>
            <relation active="#struct-425168" type="indirect"></relation>
            <relation name="UMR7271" active="#struct-441569" type="indirect"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-13009" type="indirect"><org type="laboratory" xml:id="struct-13009" status="VALID">          <orgName>Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis</orgName>
          <orgName type="acronym">I3S</orgName>
          <desc>            <address>              <addrLine>2000, route des Lucioles - Les Algorithmes - bât. Euclide B 06900 Sophia Antipolis</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.i3s.unice.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-117617" type="direct"></relation>
            <relation active="#struct-425168" type="direct"></relation>
            <relation name="UMR7271" active="#struct-441569" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-117617" type="indirect"><org type="institution" xml:id="struct-117617" status="VALID">          <orgName>Université Nice Sophia Antipolis</orgName>
          <orgName type="acronym">UNS</orgName>
          <desc>            <address>              <addrLine>Parc Valrose - BP 2135 - 06103 Nice cedex 2</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://unice.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-425168" type="indirect"><org type="institution" xml:id="struct-425168" status="VALID">          <orgName>Université Côte d'Azur</orgName>
          <orgName type="acronym">UCA</orgName>
          <desc>            <address>              <addrLine>Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://univ-cotedazur.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7271" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nice</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université Nice Sophia Antipolis</orgName>
</affiliation>
</author>
<author><name sortKey="Daniel, Malone" sort="Daniel, Malone" uniqKey="Daniel M" first="Malone" last="Daniel">Malone Daniel</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-406600" status="INCOMING">          <orgName>College of Pharmacy</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-23624" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-23624" type="direct"><org type="institution" xml:id="struct-23624" status="VALID">          <orgName>University of Arizona</orgName>
          <desc>            <address>              <addrLine>Tucson AZ 85721 USA</addrLine>
              <country key="US"></country>
            </address>
            <ref type="url">http://www.arizona.edu/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Empey, Philip E" sort="Empey, Philip E" uniqKey="Empey P" first="Philip E." last="Empey">Philip E. Empey</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-406601" status="INCOMING">          <orgName>Department of Pharmacy and Therapeutics</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-184330" type="direct"></relation>
            <relation active="#struct-378064" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-184330" type="direct"><org type="laboratory" xml:id="struct-184330" status="VALID">          <orgName>University of Pittsburgh [Pittsburg]</orgName>
          <desc>            <address>              <addrLine>4200 Fifth Avenue Pittsburgh, PA 15260</addrLine>
              <country key="US"></country>
            </address>
            <ref type="url">http://www.pitt.edu/</ref>
          </desc>
          <listRelation>            <relation active="#struct-378064" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-378064" type="indirect"><org type="institution" xml:id="struct-378064" status="INCOMING">          <orgName>University of Pittsburgh</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Hogan, William R" sort="Hogan, William R" uniqKey="Hogan W" first="William R." last="Hogan">William R. Hogan</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-406602" status="INCOMING">          <orgName>Department of Health Outcomes and Policy</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-302308" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-302308" type="direct"><org type="institution" xml:id="struct-302308" status="VALID">          <orgName>University of Florida [Gainesville]</orgName>
          <desc>            <address>              <addrLine>Gainesville, FL 32611</addrLine>
              <country key="US"></country>
            </address>
            <ref type="url">http://www.ufl.edu/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Boyce, Richard D" sort="Boyce, Richard D" uniqKey="Boyce R" first="Richard D." last="Boyce">Richard D. Boyce</name>
<affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-406596" status="INCOMING">          <orgName>Department of Biomedical Informatics</orgName>
          <desc>            <address>              <country key="US"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-184330" type="direct"></relation>
            <relation active="#struct-378064" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-184330" type="direct"><org type="laboratory" xml:id="struct-184330" status="VALID">          <orgName>University of Pittsburgh [Pittsburg]</orgName>
          <desc>            <address>              <addrLine>4200 Fifth Avenue Pittsburgh, PA 15260</addrLine>
              <country key="US"></country>
            </address>
            <ref type="url">http://www.pitt.edu/</ref>
          </desc>
          <listRelation>            <relation active="#struct-378064" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-378064" type="indirect"><org type="institution" xml:id="struct-378064" status="INCOMING">          <orgName>University of Pittsburgh</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
</analytic>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Potential drug-drug interactions</term>
<term>knowledge management</term>
<term>ontologies</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Inadequate representation of evidence and knowledge about potential drug-drug interactions is a major factor underlying disagreements among sources of drug information that are used by clinicians. In this paper we describe the initial steps toward developing a foundational domain representation that allows tracing the evidence underlying potential drug-drug interaction knowledge. The new representation includes biological and biomedical entities represented in existing ontologies and terminologies to foster integration of data from relevant fields such as physiology, anatomy, and laboratory sciences.</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Towards a foundational representation of potential drug-drug interaction knowledge</title>
            <author role="aut">              <persName>                <forename type="first">Mathias</forename>
                <surname>Brochhausen</surname>
              </persName>
              <idno type="halauthorid">732162</idno>
              <affiliation ref="#struct-406599"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Jodi</forename>
                <surname>Schneider</surname>
              </persName>
              <email type="md5">e0bac074723c4c35b86071fe2e9fe1e7</email>
              <email type="domain">inria.fr</email>
              <idno type="halauthorid">1089092</idno>
              <affiliation ref="#struct-178918"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Malone</forename>
                <surname>Daniel</surname>
              </persName>
              <idno type="halauthorid">1089104</idno>
              <affiliation ref="#struct-406600"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Philip E.</forename>
                <surname>Empey</surname>
              </persName>
              <idno type="halauthorid">1089105</idno>
              <affiliation ref="#struct-406601"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">William R.</forename>
                <surname>Hogan</surname>
              </persName>
              <idno type="halauthorid">1089106</idno>
              <affiliation ref="#struct-406602"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Richard D.</forename>
                <surname>Boyce</surname>
              </persName>
              <idno type="halauthorid">1089107</idno>
              <orgName ref="#struct-321452"></orgName>
              <affiliation ref="#struct-406596"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Jodi</forename>
                <surname>Schneider</surname>
              </persName>
              <email type="md5">be21c672e064382ae27a894858a890f0</email>
              <email type="domain">pobox.com</email>
            </editor>
            <funder>For all authors: This project is supported by a grant from the National Library of Medicine: “Addressing gaps in clinically useful evidence on drug-drug interactions” (R01LM011838-01) and the National Institute of Aging “Improving medication safety for nursing home residents prescribed psychotropic drugs” (K01 AG044433-01). The authors thank Michel Dumontier and Alan Ruttenberg for their valuable comments, which have significantly improved the paper.For PE: This work is supported by the National Center For Advancing Translational Sciences of the National Institutes of Health under Award Number KL2TR000146.For DM: This work is partially supported by the Agency for Healthcare Research and Quality (AHRQ) Grant No. 1R13HS021826-01 (Malone DC-PI)For JS: This work was carried out during the tenure of an ERCIM “Alain Bensoussan” Fellowship Programme. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no 246016.</funder>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2014-10-21 16:37:38</date>
              <date type="whenWritten">2014</date>
              <date type="whenModified">2015-07-29 01:19:45</date>
              <date type="whenReleased">2014-10-21 16:37:38</date>
              <date type="whenProduced">2014-10-06</date>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="300897">                <persName>                  <forename>Jodi</forename>
                  <surname>Schneider</surname>
                </persName>
                <email type="md5">be21c672e064382ae27a894858a890f0</email>
                <email type="domain">pobox.com</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">hal-01076294</idno>
            <idno type="halUri">https://hal.archives-ouvertes.fr/hal-01076294</idno>
            <idno type="halBibtex">brochhausen:hal-01076294</idno>
            <idno type="halRefHtml">First International Workshop on Drug Interaction Knowledge Representation (DIKR-2014) at the International Conference on Biomedical Ontologies (ICBO 2014), Oct 2014, Houston, Texas, United States. 2014</idno>
            <idno type="halRef">First International Workshop on Drug Interaction Knowledge Representation (DIKR-2014) at the International Conference on Biomedical Ontologies (ICBO 2014), Oct 2014, Houston, Texas, United States. 2014</idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="I3S">Laboratoire d'Informatique, Signaux et Systèmes de Sophia-Antipolis</idno>
            <idno type="stamp" n="INRIASO">INRIA-SOPHIA</idno>
            <idno type="stamp" n="WIMMICS">WIMMICS: Web-Instrumented Man-Machine Interactions, Communities, and Semantics</idno>
            <idno type="stamp" n="UNICE">Université Nice Sophia Antipolis</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INRIA">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
            <idno type="stamp" n="INRIA-SOPHIA">INRIA Sophia Antipolis - Méditerranée</idno>
            <idno type="stamp" n="INRIA_TEST">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="invited" n="0">No</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
            <note type="proceedings" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Towards a foundational representation of potential drug-drug interaction knowledge</title>
                <author role="aut">                  <persName>                    <forename type="first">Mathias</forename>
                    <surname>Brochhausen</surname>
                  </persName>
                  <idno type="halauthorid">732162</idno>
                  <affiliation ref="#struct-406599"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Jodi</forename>
                    <surname>Schneider</surname>
                  </persName>
                  <email type="md5">e0bac074723c4c35b86071fe2e9fe1e7</email>
                  <email type="domain">inria.fr</email>
                  <idno type="halauthorid">1089092</idno>
                  <affiliation ref="#struct-178918"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Malone</forename>
                    <surname>Daniel</surname>
                  </persName>
                  <idno type="halauthorid">1089104</idno>
                  <affiliation ref="#struct-406600"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Philip E.</forename>
                    <surname>Empey</surname>
                  </persName>
                  <idno type="halauthorid">1089105</idno>
                  <affiliation ref="#struct-406601"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">William R.</forename>
                    <surname>Hogan</surname>
                  </persName>
                  <idno type="halauthorid">1089106</idno>
                  <affiliation ref="#struct-406602"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Richard D.</forename>
                    <surname>Boyce</surname>
                  </persName>
                  <idno type="halauthorid">1089107</idno>
                  <orgName ref="#struct-321452"></orgName>
                  <affiliation ref="#struct-406596"></affiliation>
                </author>
              </analytic>
              <monogr>                <meeting>                  <title>First International Workshop on Drug Interaction Knowledge Representation (DIKR-2014) at the International Conference on Biomedical Ontologies (ICBO 2014)</title>
                  <date type="start">2014-10-06</date>
                  <date type="end">2014-10-06</date>
                  <settlement>Houston, Texas</settlement>
                  <country key="US">United States</country>
                </meeting>
                <imprint>                  <date type="datePub">2014-10-06</date>
                </imprint>
              </monogr>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <keywords scheme="author">                <term xml:lang="en">Potential drug-drug interactions</term>
                <term xml:lang="en">ontologies</term>
                <term xml:lang="en">knowledge management</term>
              </keywords>
              <classCode scheme="halDomain" n="info.info-db">Computer Science [cs]/Databases [cs.DB]</classCode>
              <classCode scheme="halDomain" n="info.info-dl">Computer Science [cs]/Digital Libraries [cs.DL]</classCode>
              <classCode scheme="halDomain" n="info.info-bi">Computer Science [cs]/Bioinformatics [q-bio.QM]</classCode>
              <classCode scheme="halDomain" n="info.info-ai">Computer Science [cs]/Artificial Intelligence [cs.AI]</classCode>
              <classCode scheme="halTypology" n="COMM">Conference papers</classCode>
            </textClass>
            <abstract xml:lang="en">Inadequate representation of evidence and knowledge about potential drug-drug interactions is a major factor underlying disagreements among sources of drug information that are used by clinicians. In this paper we describe the initial steps toward developing a foundational domain representation that allows tracing the evidence underlying potential drug-drug interaction knowledge. The new representation includes biological and biomedical entities represented in existing ontologies and terminologies to foster integration of data from relevant fields such as physiology, anatomy, and laboratory sciences.</abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Hal/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000199 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000199 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Hal
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Hal:hal-01076294
   |texte=   Towards a foundational representation of potential drug-drug interaction knowledge
}}

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur Pittsburgh

Towards a foundational representation of potential drug-drug interaction knowledge

Towards a foundational representation of potential drug-drug interaction knowledge

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri