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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevention of Bipolar Disorder in At-Risk Children: Theoretical Assumptions and Empirical Foundations</title><author><name sortKey="Miklowitz, David J" sort="Miklowitz, David J" uniqKey="Miklowitz D" first="David J." last="Miklowitz">David J. Miklowitz</name></author><author><name sortKey="Chang, Kiki D" sort="Chang, Kiki D" uniqKey="Chang K" first="Kiki D." last="Chang">Kiki D. Chang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18606036</idno><idno type="pmc">2504732</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504732</idno><idno type="RBID">PMC:2504732</idno><idno type="doi">10.1017/S0954579408000424</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000224</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000224</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prevention of Bipolar Disorder in At-Risk Children: Theoretical Assumptions and Empirical Foundations</title><author><name sortKey="Miklowitz, David J" sort="Miklowitz, David J" uniqKey="Miklowitz D" first="David J." last="Miklowitz">David J. Miklowitz</name></author><author><name sortKey="Chang, Kiki D" sort="Chang, Kiki D" uniqKey="Chang K" first="Kiki D." last="Chang">Kiki D. Chang</name></author></analytic><series><title level="j">Development and psychopathology</title><idno type="ISSN">0954-5794</idno><idno type="eISSN">1469-2198</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">This article examines how bipolar symptoms emerge during development, and the potential role of psychosocial and pharmacological interventions in the prevention of the onset of the disorder. Early signs of bipolarity can be observed among children of bipolar parents and often take the form of subsyndromal presentations (e.g., mood lability, episodic elation or irritability, depression, inattention, and psychosocial impairment). However, many of these early presentations are diagnostically nonspecific. The few studies that have followed at-risk youth into adulthood find developmental discontinuities from childhood to adulthood. Biological markers (e.g., amygdalar volume) may ultimately increase our accuracy in identifying children who later develop bipolar I disorder, but few such markers have been identified. Stress, in the form of childhood adversity or highly conflictual families, is not a diagnostically-specific causal agent but does place genetically and biologically vulnerable individuals at risk for a more pernicious course of illness. A preventative family-focused treatment for children with (a) at least one first-degree relative with bipolar disorder, and (b) subsyndromal signs of bipolar disorder, is described. This model attempts to address the multiple interactions of psychosocial and biological risk factors in the onset and course of bipolar disorder.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8910645</journal-id><journal-id journal-id-type="pubmed-jr-id">20550</journal-id><journal-id journal-id-type="nlm-ta">Dev Psychopathol</journal-id><journal-title>Development and psychopathology</journal-title><issn pub-type="ppub">0954-5794</issn><issn pub-type="epub">1469-2198</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18606036</article-id><article-id pub-id-type="pmc">2504732</article-id><article-id pub-id-type="doi">10.1017/S0954579408000424</article-id><article-id pub-id-type="manuscript">NIHMS36691</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Prevention of Bipolar Disorder in At-Risk Children: Theoretical Assumptions and Empirical Foundations</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Miklowitz</surname><given-names>David J.</given-names></name><aff id="A1">University of Colorado, Boulder</aff></contrib><contrib contrib-type="author"><name><surname>Chang</surname><given-names>Kiki D.</given-names></name><aff id="A2">Stanford University School of Medicine</aff></contrib></contrib-group><pub-date pub-type="nihms-submitted"><day>28</day><month>12</month><year>2007</year></pub-date><pub-date pub-type="ppub"><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>8</month><year>2008</year></pub-date><volume>20</volume><issue>3</issue><fpage>881</fpage><lpage>897</lpage><abstract><p id="P1">This article examines how bipolar symptoms emerge during development, and the potential role of psychosocial and pharmacological interventions in the prevention of the onset of the disorder. Early signs of bipolarity can be observed among children of bipolar parents and often take the form of subsyndromal presentations (e.g., mood lability, episodic elation or irritability, depression, inattention, and psychosocial impairment). However, many of these early presentations are diagnostically nonspecific. The few studies that have followed at-risk youth into adulthood find developmental discontinuities from childhood to adulthood. Biological markers (e.g., amygdalar volume) may ultimately increase our accuracy in identifying children who later develop bipolar I disorder, but few such markers have been identified. Stress, in the form of childhood adversity or highly conflictual families, is not a diagnostically-specific causal agent but does place genetically and biologically vulnerable individuals at risk for a more pernicious course of illness. A preventative family-focused treatment for children with (a) at least one first-degree relative with bipolar disorder, and (b) subsyndromal signs of bipolar disorder, is described. This model attempts to address the multiple interactions of psychosocial and biological risk factors in the onset and course of bipolar disorder.</p></abstract><kwd-group><kwd>expressed emotion</kwd><kwd>high-risk study</kwd><kwd>subsyndromal</kwd><kwd>prevention</kwd><kwd>family-focused treatment</kwd><kwd>early intervention</kwd></kwd-group><contract-num rid="MH1">R34 MH077856-01A1</contract-num><contract-sponsor id="MH1">National Institute of Mental Health : NIMH</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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