Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009
Identifieur interne : 001301 ( Istex/Corpus ); précédent : 001300; suivant : 001302Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009
Auteurs : Lakshmi N. Yatham ; Sidney H. Kennedy ; Ayal Schaffer ; Sagar V. Parikh ; Serge Beaulieu ; Claire O'Donovan ; Glenda Macqueen ; Roger S. Mcintyre ; Verinder Sharma ; Arun Ravindran ; L Trevor Young ; Allan H. Young ; Martin Alda ; Roumen Milev ; Eduard Vieta ; Joseph R. Calabrese ; Michael Berk ; Kyooseob Ha ; Flávio KapczinskiSource :
- Bipolar Disorders [ 1398-5647 ] ; 2009-05.
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Abstract
The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update. This second update, in conjunction with the International Society for Bipolar Disorders (ISBD), reviews new evidence and is designed to be used in conjunction with the previous publications. The recommendations for the management of acute mania remain mostly unchanged. Lithium, valproate, and several atypical antipsychotics continue to be first‐line treatments for acute mania. Tamoxifen is now suggested as a third‐line augmentation option. The combination of olanzapine and carbamazepine is not recommended. For the management of bipolar depression, lithium, lamotrigine, and quetiapine monotherapy, olanzapine plus selective serotonin reuptake inhibitor (SSRI), and lithium or divalproex plus SSRI/bupropion remain first‐line options. New data support the use of adjunctive modafinil as a second‐line option, but also indicate that aripiprazole should not be used as monotherapy for bipolar depression. Lithium, lamotrigine, valproate, and olanzapine continue to be first‐line options for maintenance treatment of bipolar disorder. New data support the use of quetiapine monotherapy and adjunctive therapy for the prevention of manic and depressive events, aripiprazole monotherapy for the prevention of manic events, and risperidone long‐acting injection monotherapy and adjunctive therapy, and adjunctive ziprasidone for the prevention of mood events. Bipolar II disorder is frequently overlooked in treatment guidelines, but has an important clinical impact on patients’ lives. This update provides an expanded look at bipolar II disorder.
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DOI: 10.1111/j.1399-5618.2009.00672.x
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ISTEX:C46746CBD7A9C801528285335F3131C36D3A3BD2Le document en format XML
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Yatham</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Kennedy, Sidney H" sort="Kennedy, Sidney H" uniqKey="Kennedy S" first="Sidney H" last="Kennedy">Sidney H. Kennedy</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Schaffer, Ayal" sort="Schaffer, Ayal" uniqKey="Schaffer A" first="Ayal" last="Schaffer">Ayal Schaffer</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Parikh, Sagar V" sort="Parikh, Sagar V" uniqKey="Parikh S" first="Sagar V" last="Parikh">Sagar V. Parikh</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Beaulieu, Serge" sort="Beaulieu, Serge" uniqKey="Beaulieu S" first="Serge" last="Beaulieu">Serge Beaulieu</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="O Donovan, Claire" sort="O Donovan, Claire" uniqKey="O Donovan C" first="Claire" last="O'Donovan">Claire O'Donovan</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Macqueen, Glenda" sort="Macqueen, Glenda" uniqKey="Macqueen G" first="Glenda" last="Macqueen">Glenda Macqueen</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Mcintyre, Roger S" sort="Mcintyre, Roger S" uniqKey="Mcintyre R" first="Roger S" last="Mcintyre">Roger S. Mcintyre</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Sharma, Verinder" sort="Sharma, Verinder" uniqKey="Sharma V" first="Verinder" last="Sharma">Verinder Sharma</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Ravindran, Arun" sort="Ravindran, Arun" uniqKey="Ravindran A" first="Arun" last="Ravindran">Arun Ravindran</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Young, L Trevor" sort="Young, L Trevor" uniqKey="Young L" first="L Trevor" last="Young">L Trevor Young</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Young, Allan H" sort="Young, Allan H" uniqKey="Young A" first="Allan H" last="Young">Allan H. Young</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Milev, Roumen" sort="Milev, Roumen" uniqKey="Milev R" first="Roumen" last="Milev">Roumen Milev</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Calabrese, Joseph R" sort="Calabrese, Joseph R" uniqKey="Calabrese J" first="Joseph R" last="Calabrese">Joseph R. Calabrese</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Berk, Michael" sort="Berk, Michael" uniqKey="Berk M" first="Michael" last="Berk">Michael Berk</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Ha, Kyooseob" sort="Ha, Kyooseob" uniqKey="Ha K" first="Kyooseob" last="Ha">Kyooseob Ha</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Kapczinski, Flavio" sort="Kapczinski, Flavio" uniqKey="Kapczinski F" first="Flávio" last="Kapczinski">Flávio Kapczinski</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C46746CBD7A9C801528285335F3131C36D3A3BD2</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1111/j.1399-5618.2009.00672.x</idno><idno type="url">https://api.istex.fr/document/C46746CBD7A9C801528285335F3131C36D3A3BD2/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001301</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001301</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009</title><author><name sortKey="Yatham, Lakshmi N" sort="Yatham, Lakshmi N" uniqKey="Yatham L" first="Lakshmi N" last="Yatham">Lakshmi N. Yatham</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Kennedy, Sidney H" sort="Kennedy, Sidney H" uniqKey="Kennedy S" first="Sidney H" last="Kennedy">Sidney H. Kennedy</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Schaffer, Ayal" sort="Schaffer, Ayal" uniqKey="Schaffer A" first="Ayal" last="Schaffer">Ayal Schaffer</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Parikh, Sagar V" sort="Parikh, Sagar V" uniqKey="Parikh S" first="Sagar V" last="Parikh">Sagar V. Parikh</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Beaulieu, Serge" sort="Beaulieu, Serge" uniqKey="Beaulieu S" first="Serge" last="Beaulieu">Serge Beaulieu</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="O Donovan, Claire" sort="O Donovan, Claire" uniqKey="O Donovan C" first="Claire" last="O'Donovan">Claire O'Donovan</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Macqueen, Glenda" sort="Macqueen, Glenda" uniqKey="Macqueen G" first="Glenda" last="Macqueen">Glenda Macqueen</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Mcintyre, Roger S" sort="Mcintyre, Roger S" uniqKey="Mcintyre R" first="Roger S" last="Mcintyre">Roger S. Mcintyre</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Sharma, Verinder" sort="Sharma, Verinder" uniqKey="Sharma V" first="Verinder" last="Sharma">Verinder Sharma</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Ravindran, Arun" sort="Ravindran, Arun" uniqKey="Ravindran A" first="Arun" last="Ravindran">Arun Ravindran</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Young, L Trevor" sort="Young, L Trevor" uniqKey="Young L" first="L Trevor" last="Young">L Trevor Young</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Young, Allan H" sort="Young, Allan H" uniqKey="Young A" first="Allan H" last="Young">Allan H. Young</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Milev, Roumen" sort="Milev, Roumen" uniqKey="Milev R" first="Roumen" last="Milev">Roumen Milev</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Calabrese, Joseph R" sort="Calabrese, Joseph R" uniqKey="Calabrese J" first="Joseph R" last="Calabrese">Joseph R. Calabrese</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Berk, Michael" sort="Berk, Michael" uniqKey="Berk M" first="Michael" last="Berk">Michael Berk</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Ha, Kyooseob" sort="Ha, Kyooseob" uniqKey="Ha K" first="Kyooseob" last="Ha">Kyooseob Ha</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Kapczinski, Flavio" sort="Kapczinski, Flavio" uniqKey="Kapczinski F" first="Flávio" last="Kapczinski">Flávio Kapczinski</name><affiliation><mods:affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Bipolar Disorders</title><idno type="ISSN">1398-5647</idno><idno type="eISSN">1399-5618</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-05">2009-05</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="225">225</biblScope><biblScope unit="page" to="255">255</biblScope></imprint><idno type="ISSN">1398-5647</idno></series><idno type="istex">C46746CBD7A9C801528285335F3131C36D3A3BD2</idno><idno type="DOI">10.1111/j.1399-5618.2009.00672.x</idno><idno type="ArticleID">BDI672</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1398-5647</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CANMAT</term><term>bipolar</term><term>depression</term><term>guidelines</term><term>mania</term><term>treatment</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update. This second update, in conjunction with the International Society for Bipolar Disorders (ISBD), reviews new evidence and is designed to be used in conjunction with the previous publications. The recommendations for the management of acute mania remain mostly unchanged. Lithium, valproate, and several atypical antipsychotics continue to be first‐line treatments for acute mania. Tamoxifen is now suggested as a third‐line augmentation option. The combination of olanzapine and carbamazepine is not recommended. For the management of bipolar depression, lithium, lamotrigine, and quetiapine monotherapy, olanzapine plus selective serotonin reuptake inhibitor (SSRI), and lithium or divalproex plus SSRI/bupropion remain first‐line options. New data support the use of adjunctive modafinil as a second‐line option, but also indicate that aripiprazole should not be used as monotherapy for bipolar depression. Lithium, lamotrigine, valproate, and olanzapine continue to be first‐line options for maintenance treatment of bipolar disorder. New data support the use of quetiapine monotherapy and adjunctive therapy for the prevention of manic and depressive events, aripiprazole monotherapy for the prevention of manic events, and risperidone long‐acting injection monotherapy and adjunctive therapy, and adjunctive ziprasidone for the prevention of mood events. Bipolar II disorder is frequently overlooked in treatment guidelines, but has an important clinical impact on patients’ lives. This update provides an expanded look at bipolar II disorder.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Lakshmi N Yatham</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Sidney H Kennedy</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Ayal Schaffer</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Sagar V Parikh</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Serge Beaulieu</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Claire O'Donovan</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Glenda MacQueen</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Roger S McIntyre</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Verinder Sharma</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Arun Ravindran</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>L Trevor Young</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Allan H Young</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Martin Alda</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Roumen Milev</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Eduard Vieta</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Joseph R Calabrese</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Michael Berk</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Kyooseob Ha</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>Flávio Kapczinski</name><affiliations><json:string>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>bipolar</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CANMAT</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>guidelines</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mania</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>treatment</value></json:item></subject><articleId><json:string>BDI672</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>miscellaneous</json:string></originalGenre><abstract>The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update. This second update, in conjunction with the International Society for Bipolar Disorders (ISBD), reviews new evidence and is designed to be used in conjunction with the previous publications. The recommendations for the management of acute mania remain mostly unchanged. Lithium, valproate, and several atypical antipsychotics continue to be first‐line treatments for acute mania. Tamoxifen is now suggested as a third‐line augmentation option. The combination of olanzapine and carbamazepine is not recommended. For the management of bipolar depression, lithium, lamotrigine, and quetiapine monotherapy, olanzapine plus selective serotonin reuptake inhibitor (SSRI), and lithium or divalproex plus SSRI/bupropion remain first‐line options. New data support the use of adjunctive modafinil as a second‐line option, but also indicate that aripiprazole should not be used as monotherapy for bipolar depression. Lithium, lamotrigine, valproate, and olanzapine continue to be first‐line options for maintenance treatment of bipolar disorder. New data support the use of quetiapine monotherapy and adjunctive therapy for the prevention of manic and depressive events, aripiprazole monotherapy for the prevention of manic events, and risperidone long‐acting injection monotherapy and adjunctive therapy, and adjunctive ziprasidone for the prevention of mood events. Bipolar II disorder is frequently overlooked in treatment guidelines, but has an important clinical impact on patients’ lives. This update provides an expanded look at bipolar II disorder.</abstract><qualityIndicators><score>7.82</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1698</abstractCharCount><pdfWordCount>19718</pdfWordCount><pdfCharCount>132229</pdfCharCount><pdfPageCount>31</pdfPageCount><abstractWordCount>235</abstractWordCount></qualityIndicators><title>Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009</title><genre><json:string>other</json:string></genre><host><volume>11</volume><publisherId><json:string>BDI</json:string></publisherId><pages><total>31</total><last>255</last><first>225</first></pages><issn><json:string>1398-5647</json:string></issn><issue>3</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1399-5618</json:string></eissn><title>Bipolar Disorders</title><doi><json:string>10.1111/(ISSN)1399-5618</json:string></doi></host><categories><wos><json:string>social science</json:string><json:string>psychiatry</json:string><json:string>science</json:string><json:string>neurosciences</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>psychiatry</json:string></scienceMetrix><inist><json:string>sciences humaines et sociales</json:string></inist></categories><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1111/j.1399-5618.2009.00672.x</json:string></doi><id>C46746CBD7A9C801528285335F3131C36D3A3BD2</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/C46746CBD7A9C801528285335F3131C36D3A3BD2/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/C46746CBD7A9C801528285335F3131C36D3A3BD2/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/C46746CBD7A9C801528285335F3131C36D3A3BD2/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>© 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard</p></availability><date>2009</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009</title><author xml:id="author-1"><persName><forename type="first">Lakshmi N</forename><surname>Yatham</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-2"><persName><forename type="first">Sidney H</forename><surname>Kennedy</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-3"><persName><forename type="first">Ayal</forename><surname>Schaffer</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-4"><persName><forename type="first">Sagar V</forename><surname>Parikh</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-5"><persName><forename type="first">Serge</forename><surname>Beaulieu</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-6"><persName><forename type="first">Claire</forename><surname>O'Donovan</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-7"><persName><forename type="first">Glenda</forename><surname>MacQueen</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-8"><persName><forename type="first">Roger S</forename><surname>McIntyre</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-9"><persName><forename type="first">Verinder</forename><surname>Sharma</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-10"><persName><forename type="first">Arun</forename><surname>Ravindran</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-11"><persName><forename type="first">L Trevor</forename><surname>Young</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-12"><persName><forename type="first">Allan H</forename><surname>Young</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-13"><persName><forename type="first">Martin</forename><surname>Alda</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-14"><persName><forename type="first">Roumen</forename><surname>Milev</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-15"><persName><forename type="first">Eduard</forename><surname>Vieta</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-16"><persName><forename type="first">Joseph R</forename><surname>Calabrese</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-17"><persName><forename type="first">Michael</forename><surname>Berk</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-18"><persName><forename type="first">Kyooseob</forename><surname>Ha</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author><author xml:id="author-19"><persName><forename type="first">Flávio</forename><surname>Kapczinski</surname></persName><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation></author></analytic><monogr><title level="j">Bipolar Disorders</title><idno type="pISSN">1398-5647</idno><idno type="eISSN">1399-5618</idno><idno type="DOI">10.1111/(ISSN)1399-5618</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-05"></date><biblScope unit="volume">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="225">225</biblScope><biblScope unit="page" to="255">255</biblScope></imprint></monogr><idno type="istex">C46746CBD7A9C801528285335F3131C36D3A3BD2</idno><idno type="DOI">10.1111/j.1399-5618.2009.00672.x</idno><idno type="ArticleID">BDI672</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update. This second update, in conjunction with the International Society for Bipolar Disorders (ISBD), reviews new evidence and is designed to be used in conjunction with the previous publications. The recommendations for the management of acute mania remain mostly unchanged. Lithium, valproate, and several atypical antipsychotics continue to be first‐line treatments for acute mania. Tamoxifen is now suggested as a third‐line augmentation option. The combination of olanzapine and carbamazepine is not recommended. For the management of bipolar depression, lithium, lamotrigine, and quetiapine monotherapy, olanzapine plus selective serotonin reuptake inhibitor (SSRI), and lithium or divalproex plus SSRI/bupropion remain first‐line options. New data support the use of adjunctive modafinil as a second‐line option, but also indicate that aripiprazole should not be used as monotherapy for bipolar depression. Lithium, lamotrigine, valproate, and olanzapine continue to be first‐line options for maintenance treatment of bipolar disorder. New data support the use of quetiapine monotherapy and adjunctive therapy for the prevention of manic and depressive events, aripiprazole monotherapy for the prevention of manic events, and risperidone long‐acting injection monotherapy and adjunctive therapy, and adjunctive ziprasidone for the prevention of mood events. Bipolar II disorder is frequently overlooked in treatment guidelines, but has an important clinical impact on patients’ lives. This update provides an expanded look at bipolar II disorder.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>bipolar</term></item><item><term>CANMAT</term></item><item><term>depression</term></item><item><term>guidelines</term></item><item><term>mania</term></item><item><term>treatment</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-05">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/C46746CBD7A9C801528285335F3131C36D3A3BD2/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1399-5618</doi><issn type="print">1398-5647</issn><issn type="electronic">1399-5618</issn><idGroup><id type="product" value="BDI"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="BIPOLAR DISORDERS">Bipolar Disorders</title></titleGroup></publicationMeta><publicationMeta level="part" position="05003"><doi origin="wiley">10.1111/bdi.2009.11.issue-3</doi><numberingGroup><numbering type="journalVolume" number="11">11</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="2009-05">May 2009</coverDate></publicationMeta><publicationMeta level="unit" type="miscellaneous" position="1" status="forIssue"><doi origin="wiley">10.1111/j.1399-5618.2009.00672.x</doi><idGroup><id type="unit" value="BDI672"></id></idGroup><countGroup><count type="pageTotal" number="31"></count></countGroup><titleGroup><title type="tocHeading1">Guidelines Update</title></titleGroup><copyright>© 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard</copyright><eventGroup><event type="firstOnline" date="2009-04-14"></event><event type="publishedOnlineFinalForm" date="2009-04-14"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText" date="2010-05-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-25"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-15"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="225">225</numbering><numbering type="pageLast" number="255">255</numbering></numberingGroup><correspondenceTo>Lakshmi N. Yatham, MBBS, FRCPC, MRCPsych (UK)
Department of Psychiatry
University of British Columbia
2255 Wesbrook Mall
Vancouver, BC, V6T 2A1, Canada
Fax: 604‐822‐7922;
e‐mail: <email>l.yatham@ubc.ca</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:BDI.BDI672.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 17 October 2008, revised and accepted for publication 3 February 2009</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="11"></count></countGroup><titleGroup><title type="main">Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009</title><title type="shortAuthors"><b>Yatham et al.</b></title><title type="short"><b>CANMAT guidelines for bipolar disorder</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>Lakshmi N</givenNames><familyName>Yatham</familyName></personName></creator> a <creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>Sidney H</givenNames><familyName>Kennedy</familyName></personName></creator> b <creator creatorRole="author" xml:id="cr3" affiliationRef="#aff-1-1"><personName><givenNames>Ayal</givenNames><familyName>Schaffer</familyName></personName></creator> b <creator creatorRole="author" xml:id="cr4" affiliationRef="#aff-1-1"><personName><givenNames>Sagar V</givenNames><familyName>Parikh</familyName></personName></creator> b <creator creatorRole="author" xml:id="cr5" affiliationRef="#aff-1-1"><personName><givenNames>Serge</givenNames><familyName>Beaulieu</familyName></personName></creator> c <creator creatorRole="author" xml:id="cr6" affiliationRef="#aff-1-1"><personName><givenNames>Claire</givenNames><familyName>O'Donovan</familyName></personName></creator> d <creator creatorRole="author" xml:id="cr7" affiliationRef="#aff-1-1"><personName><givenNames>Glenda</givenNames><familyName>MacQueen</familyName></personName></creator> e <creator creatorRole="author" xml:id="cr8" affiliationRef="#aff-1-1"><personName><givenNames>Roger S</givenNames><familyName>McIntyre</familyName></personName></creator> b <creator creatorRole="author" xml:id="cr9" affiliationRef="#aff-1-1"><personName><givenNames>Verinder</givenNames><familyName>Sharma</familyName></personName></creator> f <creator creatorRole="author" xml:id="cr10" affiliationRef="#aff-1-1"><personName><givenNames>Arun</givenNames><familyName>Ravindran</familyName></personName></creator> b <creator creatorRole="author" xml:id="cr11" affiliationRef="#aff-1-1"><personName><givenNames>L Trevor</givenNames><familyName>Young</familyName></personName></creator> a <creator creatorRole="author" xml:id="cr12" affiliationRef="#aff-1-1"><personName><givenNames>Allan H</givenNames><familyName>Young</familyName></personName></creator> a <creator creatorRole="author" xml:id="cr13" affiliationRef="#aff-1-1"><personName><givenNames>Martin</givenNames><familyName>Alda</familyName></personName></creator> d <creator creatorRole="author" xml:id="cr14" affiliationRef="#aff-1-1"><personName><givenNames>Roumen</givenNames><familyName>Milev</familyName></personName></creator> g <creator creatorRole="author" xml:id="cr15" affiliationRef="#aff-1-1"><personName><givenNames>Eduard</givenNames><familyName>Vieta</familyName></personName></creator> h <creator creatorRole="author" xml:id="cr16" affiliationRef="#aff-1-1"><personName><givenNames>Joseph R</givenNames><familyName>Calabrese</familyName></personName></creator> i <creator creatorRole="author" xml:id="cr17" affiliationRef="#aff-1-1"><personName><givenNames>Michael</givenNames><familyName>Berk</familyName></personName></creator> j <creator creatorRole="author" xml:id="cr18" affiliationRef="#aff-1-1"><personName><givenNames>Kyooseob</givenNames><familyName>Ha</familyName></personName></creator> k <creator creatorRole="author" xml:id="cr19" affiliationRef="#aff-1-1"><personName><givenNames>Flávio</givenNames><familyName>Kapczinski</familyName></personName></creator> l </creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="KR"><unparsedAffiliation>Affiliations
<sup>a</sup>Department of Psychiatry, University of British Columbia, Vancouver, BC, <sup>b</sup>Department of Psychiatry, University of Toronto, Toronto, ON, <sup>c</sup>Department of Psychiatry, McGill University, Montreal, QC, <sup>d</sup>Department of Psychiatry, Dalhousie University, Halifax, NS, <sup>e</sup>Department of Psychiatry, University of Calgary, Calgary, Alberta, <sup>f</sup>Department of Psychiatry, University of Western Ontario, London, ON, <sup>g</sup>Department of Psychiatry, Queen’s University, Kingston, ON, Canada, <sup>h</sup>Bipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, <sup>i</sup>Mood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, <sup>j</sup>Department of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, <sup>k</sup>Department of Psychiatry, Seoul National University, Seoul, Korea, <sup>l</sup>Bipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">bipolar</keyword><keyword xml:id="k2">CANMAT</keyword><keyword xml:id="k3">depression</keyword><keyword xml:id="k4">guidelines</keyword><keyword xml:id="k5">mania</keyword><keyword xml:id="k6">treatment</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><!-- Yatham LN, Kennedy SH, Schaffer A, Parikh SV, Beaulieu S, O’Donovan C, MacQueen G, McIntyre RS, Sharma V, Ravindran A, Young LT, Young AH, Alda M, Milev R, Vieta E, Calabrese JR, Berk M, Ha K, Kapczinski F. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009.
Bipolar Disord 2009: 11: 225–255. © 2009 The Authors.
Journal compilation © 2009 Blackwell Munksgaard. --><p>The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update. This second update, in conjunction with the International Society for Bipolar Disorders (ISBD), reviews new evidence and is designed to be used in conjunction with the previous publications.</p><p>The recommendations for the management of acute mania remain mostly unchanged. Lithium, valproate, and several atypical antipsychotics continue to be first‐line treatments for acute mania. Tamoxifen is now suggested as a third‐line augmentation option. The combination of olanzapine and carbamazepine is not recommended. For the management of bipolar depression, lithium, lamotrigine, and quetiapine monotherapy, olanzapine plus selective serotonin reuptake inhibitor (SSRI), and lithium or divalproex plus SSRI/bupropion remain first‐line options. New data support the use of adjunctive modafinil as a second‐line option, but also indicate that aripiprazole should not be used as monotherapy for bipolar depression. Lithium, lamotrigine, valproate, and olanzapine continue to be first‐line options for maintenance treatment of bipolar disorder. New data support the use of quetiapine monotherapy and adjunctive therapy for the prevention of manic and depressive events, aripiprazole monotherapy for the prevention of manic events, and risperidone long‐acting injection monotherapy and adjunctive therapy, and adjunctive ziprasidone for the prevention of mood events.</p><p>Bipolar II disorder is frequently overlooked in treatment guidelines, but has an important clinical impact on patients’ lives. This update provides an expanded look at bipolar II disorder.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1" numbered="no"><p>The authors dedicate the CANMAT/ISBD guidelines to Dr. Vivek Kusumakar, who passed away suddenly on January 14, 2009. He was an editor for the first CANMAT Guidelines for bipolar disorder, published in 1997. Dr. Kusumakar’s intellectual curiosity to understand the causes of mental illnesses, scientific ability to lead discovery and development of new treatments, develop and disseminate innovative educational programs to improve outcomes for people with bipolar disorder, and his drive for excellence, along with an ability to inject his vision and enthusiasm to his colleagues will be sorely missed.</p></note><note xml:id="fn2" numbered="no"><p>Affiliations and disclosure information for all authors are listed before the references.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>CANMAT guidelines for bipolar disorder</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009</title></titleInfo><name type="personal"><namePart type="given">Lakshmi N</namePart><namePart type="family">Yatham</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sidney H</namePart><namePart type="family">Kennedy</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ayal</namePart><namePart type="family">Schaffer</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sagar V</namePart><namePart type="family">Parikh</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Serge</namePart><namePart type="family">Beaulieu</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claire</namePart><namePart type="family">O'Donovan</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Glenda</namePart><namePart type="family">MacQueen</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roger S</namePart><namePart type="family">McIntyre</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Verinder</namePart><namePart type="family">Sharma</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arun</namePart><namePart type="family">Ravindran</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L Trevor</namePart><namePart type="family">Young</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Allan H</namePart><namePart type="family">Young</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martin</namePart><namePart type="family">Alda</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roumen</namePart><namePart type="family">Milev</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eduard</namePart><namePart type="family">Vieta</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joseph R</namePart><namePart type="family">Calabrese</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Berk</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kyooseob</namePart><namePart type="family">Ha</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Flávio</namePart><namePart type="family">Kapczinski</namePart><affiliation>AffiliationsaDepartment of Psychiatry, University of British Columbia, Vancouver, BC, bDepartment of Psychiatry, University of Toronto, Toronto, ON, cDepartment of Psychiatry, McGill University, Montreal, QC, dDepartment of Psychiatry, Dalhousie University, Halifax, NS, eDepartment of Psychiatry, University of Calgary, Calgary, Alberta, fDepartment of Psychiatry, University of Western Ontario, London, ON, gDepartment of Psychiatry, Queen’s University, Kingston, ON, Canada, hBipolar Disorder Program, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain, iMood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, jDepartment of Clinical and Biomedical Sciences, University of Melbourne, Parkville, Australia, kDepartment of Psychiatry, Seoul National University, Seoul, Korea, lBipolar Disorders Program, Department of Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="other" displayLabel="miscellaneous"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2009-05</dateIssued><edition>Received 17 October 2008, revised and accepted for publication 3 February 2009</edition><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">11</extent></physicalDescription><abstract lang="en">The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update. This second update, in conjunction with the International Society for Bipolar Disorders (ISBD), reviews new evidence and is designed to be used in conjunction with the previous publications. The recommendations for the management of acute mania remain mostly unchanged. Lithium, valproate, and several atypical antipsychotics continue to be first‐line treatments for acute mania. Tamoxifen is now suggested as a third‐line augmentation option. The combination of olanzapine and carbamazepine is not recommended. For the management of bipolar depression, lithium, lamotrigine, and quetiapine monotherapy, olanzapine plus selective serotonin reuptake inhibitor (SSRI), and lithium or divalproex plus SSRI/bupropion remain first‐line options. New data support the use of adjunctive modafinil as a second‐line option, but also indicate that aripiprazole should not be used as monotherapy for bipolar depression. Lithium, lamotrigine, valproate, and olanzapine continue to be first‐line options for maintenance treatment of bipolar disorder. New data support the use of quetiapine monotherapy and adjunctive therapy for the prevention of manic and depressive events, aripiprazole monotherapy for the prevention of manic events, and risperidone long‐acting injection monotherapy and adjunctive therapy, and adjunctive ziprasidone for the prevention of mood events. Bipolar II disorder is frequently overlooked in treatment guidelines, but has an important clinical impact on patients’ lives. This update provides an expanded look at bipolar II disorder.</abstract><subject lang="en"><genre>keywords</genre><topic>bipolar</topic><topic>CANMAT</topic><topic>depression</topic><topic>guidelines</topic><topic>mania</topic><topic>treatment</topic></subject><relatedItem type="host"><titleInfo><title>Bipolar Disorders</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1398-5647</identifier><identifier type="eISSN">1399-5618</identifier><identifier type="DOI">10.1111/(ISSN)1399-5618</identifier><identifier type="PublisherID">BDI</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>225</start><end>255</end><total>31</total></extent></part></relatedItem><identifier type="istex">C46746CBD7A9C801528285335F3131C36D3A3BD2</identifier><identifier type="DOI">10.1111/j.1399-5618.2009.00672.x</identifier><identifier type="ArticleID">BDI672</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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