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Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden.

Identifieur interne : 000341 ( PubMed/Curation ); précédent : 000340; suivant : 000342

Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden.

Auteurs : Sarah Jane Schwarzenberg [États-Unis] ; Melena Bellin [États-Unis] ; Sohail Z. Husain [États-Unis] ; Monika Ahuja [États-Unis] ; Bradley Barth [États-Unis] ; Heather Davis [États-Unis] ; Peter R. Durie [Canada] ; Douglas S. Fishman [États-Unis] ; Steven D. Freedman [États-Unis] ; Cheryl E. Gariepy [États-Unis] ; Matthew J. Giefer [États-Unis] ; Tanja Gonska [Canada] ; Melvin B. Heyman [États-Unis] ; Ryan Himes [États-Unis] ; Soma Kumar [États-Unis] ; Veronique D. Morinville [Canada] ; Mark E. Lowe [États-Unis] ; Neil E. Nuehring [États-Unis] ; Chee Y. Ooi [Australie] ; John F. Pohl [États-Unis] ; David Troendle [États-Unis] ; Steven L. Werlin [États-Unis] ; Michael Wilschanski [Israël] ; Elizabeth Yen [États-Unis] ; Aliye Uc [États-Unis]

Source :

The Journal of pediatrics [ 1097-6833 ] ; 2015.

RBID : pubmed:25556020

Descripteurs français

KwdFr :
- ADN (génétique), Analyse de mutations d'ADN, Cholangiopancréatographie rétrograde endoscopique, Enfant, Facteurs de risque, Femelle, Humains, Incidence, Mutation, Mâle, Pancréatite chronique (diagnostic), Pancréatite chronique (génétique), Pancréatite chronique (épidémiologie), Protéine CFTR (génétique), Prédisposition génétique à une maladie, Prévalence, États-Unis d'Amérique (épidémiologie), Études transversales.
MESH :
- diagnostic : Pancréatite chronique.
- génétique : ADN, Pancréatite chronique, Protéine CFTR.
- épidémiologie : Pancréatite chronique, États-Unis d'Amérique.
- Analyse de mutations d'ADN, Cholangiopancréatographie rétrograde endoscopique, Enfant, Facteurs de risque, Femelle, Humains, Incidence, Mutation, Mâle, Prédisposition génétique à une maladie, Prévalence, Études transversales.
Wicri :
- geographic : États-Unis.

English descriptors

KwdEn :
- Child, Cholangiopancreatography, Endoscopic Retrograde, Cross-Sectional Studies, Cystic Fibrosis Transmembrane Conductance Regulator (genetics), DNA (genetics), DNA Mutational Analysis, Female, Genetic Predisposition to Disease, Humans, Incidence, Male, Mutation, Pancreatitis, Chronic (diagnosis), Pancreatitis, Chronic (epidemiology), Pancreatitis, Chronic (genetics), Prevalence, Risk Factors, United States (epidemiology).
MESH :
- chemical , genetics : Cystic Fibrosis Transmembrane Conductance Regulator, DNA.
- geographic , epidemiology : United States.
- diagnosis : Pancreatitis, Chronic.
- epidemiology : Pancreatitis, Chronic.
- genetics : Pancreatitis, Chronic.
- Child, Cholangiopancreatography, Endoscopic Retrograde, Cross-Sectional Studies, DNA Mutational Analysis, Female, Genetic Predisposition to Disease, Humans, Incidence, Male, Mutation, Prevalence, Risk Factors.

Abstract

To determine the clinical presentation, diagnostic variables, risk factors, and disease burden in children with chronic pancreatitis.

DOI: 10.1016/j.jpeds.2014.11.019
PubMed: 25556020

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Le document en format XML

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<author><name sortKey="Ahuja, Monika" sort="Ahuja, Monika" uniqKey="Ahuja M" first="Monika" last="Ahuja">Monika Ahuja</name>
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<author><name sortKey="Barth, Bradley" sort="Barth, Bradley" uniqKey="Barth B" first="Bradley" last="Barth">Bradley Barth</name>
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<author><name sortKey="Durie, Peter R" sort="Durie, Peter R" uniqKey="Durie P" first="Peter R" last="Durie">Peter R. Durie</name>
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<author><name sortKey="Fishman, Douglas S" sort="Fishman, Douglas S" uniqKey="Fishman D" first="Douglas S" last="Fishman">Douglas S. Fishman</name>
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<author><name sortKey="Freedman, Steven D" sort="Freedman, Steven D" uniqKey="Freedman S" first="Steven D" last="Freedman">Steven D. Freedman</name>
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<author><name sortKey="Gariepy, Cheryl E" sort="Gariepy, Cheryl E" uniqKey="Gariepy C" first="Cheryl E" last="Gariepy">Cheryl E. Gariepy</name>
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<author><name sortKey="Giefer, Matthew J" sort="Giefer, Matthew J" uniqKey="Giefer M" first="Matthew J" last="Giefer">Matthew J. Giefer</name>
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<author><name sortKey="Gonska, Tanja" sort="Gonska, Tanja" uniqKey="Gonska T" first="Tanja" last="Gonska">Tanja Gonska</name>
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<author><name sortKey="Heyman, Melvin B" sort="Heyman, Melvin B" uniqKey="Heyman M" first="Melvin B" last="Heyman">Melvin B. Heyman</name>
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<author><name sortKey="Himes, Ryan" sort="Himes, Ryan" uniqKey="Himes R" first="Ryan" last="Himes">Ryan Himes</name>
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<author><name sortKey="Kumar, Soma" sort="Kumar, Soma" uniqKey="Kumar S" first="Soma" last="Kumar">Soma Kumar</name>
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<author><name sortKey="Morinville, Veronique D" sort="Morinville, Veronique D" uniqKey="Morinville V" first="Veronique D" last="Morinville">Veronique D. Morinville</name>
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<author><name sortKey="Lowe, Mark E" sort="Lowe, Mark E" uniqKey="Lowe M" first="Mark E" last="Lowe">Mark E. Lowe</name>
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<author><name sortKey="Nuehring, Neil E" sort="Nuehring, Neil E" uniqKey="Nuehring N" first="Neil E" last="Nuehring">Neil E. Nuehring</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Iowa Carver College of Medicine, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa Carver College of Medicine, Iowa City, IA</wicri:regionArea>
</affiliation>
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<author><name sortKey="Ooi, Chee Y" sort="Ooi, Chee Y" uniqKey="Ooi C" first="Chee Y" last="Ooi">Chee Y. Ooi</name>
<affiliation wicri:level="1"><nlm:affiliation>Discipline of Paediatrics, School of Women's and Children's Health, Medicine, University of New South Wales and Sydney Children's Hospital Randwick Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<author><name sortKey="Pohl, John F" sort="Pohl, John F" uniqKey="Pohl J" first="John F" last="Pohl">John F. Pohl</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Utah, Salt Lake City, UT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Utah, Salt Lake City, UT</wicri:regionArea>
</affiliation>
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<author><name sortKey="Troendle, David" sort="Troendle, David" uniqKey="Troendle D" first="David" last="Troendle">David Troendle</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Texas Southwestern Medical School, Dallas, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Texas Southwestern Medical School, Dallas, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Werlin, Steven L" sort="Werlin, Steven L" uniqKey="Werlin S" first="Steven L" last="Werlin">Steven L. Werlin</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical College of Wisconsin, Milwaukee, WI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical College of Wisconsin, Milwaukee, WI</wicri:regionArea>
</affiliation>
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<author><name sortKey="Wilschanski, Michael" sort="Wilschanski, Michael" uniqKey="Wilschanski M" first="Michael" last="Wilschanski">Michael Wilschanski</name>
<affiliation wicri:level="1"><nlm:affiliation>Hadassah Hebrew University Hospital, Jerusalem, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
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</affiliation>
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<author><name sortKey="Yen, Elizabeth" sort="Yen, Elizabeth" uniqKey="Yen E" first="Elizabeth" last="Yen">Elizabeth Yen</name>
<affiliation wicri:level="1"><nlm:affiliation>University of California at San Francisco, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California at San Francisco, San Francisco, CA</wicri:regionArea>
</affiliation>
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<author><name sortKey="Uc, Aliye" sort="Uc, Aliye" uniqKey="Uc A" first="Aliye" last="Uc">Aliye Uc</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Schwarzenberg, Sarah Jane" sort="Schwarzenberg, Sarah Jane" uniqKey="Schwarzenberg S" first="Sarah Jane" last="Schwarzenberg">Sarah Jane Schwarzenberg</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Minnesota Children's Hospital, Minneapolis, Minnesota, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Minnesota Children's Hospital, Minneapolis, Minnesota</wicri:regionArea>
</affiliation>
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<author><name sortKey="Bellin, Melena" sort="Bellin, Melena" uniqKey="Bellin M" first="Melena" last="Bellin">Melena Bellin</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Minnesota Children's Hospital, Minneapolis, Minnesota, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Minnesota Children's Hospital, Minneapolis, Minnesota</wicri:regionArea>
</affiliation>
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<author><name sortKey="Husain, Sohail Z" sort="Husain, Sohail Z" uniqKey="Husain S" first="Sohail Z" last="Husain">Sohail Z. Husain</name>
<affiliation wicri:level="1"><nlm:affiliation>Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Children's Hospital of Pittsburgh, Pittsburgh, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ahuja, Monika" sort="Ahuja, Monika" uniqKey="Ahuja M" first="Monika" last="Ahuja">Monika Ahuja</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Iowa Carver College of Medicine, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa Carver College of Medicine, Iowa City, IA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barth, Bradley" sort="Barth, Bradley" uniqKey="Barth B" first="Bradley" last="Barth">Bradley Barth</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Texas Southwestern Medical School, Dallas, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Texas Southwestern Medical School, Dallas, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Davis, Heather" sort="Davis, Heather" uniqKey="Davis H" first="Heather" last="Davis">Heather Davis</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Iowa Carver College of Medicine, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa Carver College of Medicine, Iowa City, IA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Durie, Peter R" sort="Durie, Peter R" uniqKey="Durie P" first="Peter R" last="Durie">Peter R. Durie</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Hospital for Sick Children, Toronto, ON</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fishman, Douglas S" sort="Fishman, Douglas S" uniqKey="Fishman D" first="Douglas S" last="Fishman">Douglas S. Fishman</name>
<affiliation wicri:level="1"><nlm:affiliation>Baylor College of Medicine, Houston, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Baylor College of Medicine, Houston, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Freedman, Steven D" sort="Freedman, Steven D" uniqKey="Freedman S" first="Steven D" last="Freedman">Steven D. Freedman</name>
<affiliation wicri:level="1"><nlm:affiliation>Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Harvard Medical School, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gariepy, Cheryl E" sort="Gariepy, Cheryl E" uniqKey="Gariepy C" first="Cheryl E" last="Gariepy">Cheryl E. Gariepy</name>
<affiliation wicri:level="1"><nlm:affiliation>Nationwide Children's Hospital, Columbus, OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Nationwide Children's Hospital, Columbus, OH</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giefer, Matthew J" sort="Giefer, Matthew J" uniqKey="Giefer M" first="Matthew J" last="Giefer">Matthew J. Giefer</name>
<affiliation wicri:level="1"><nlm:affiliation>Seattle Children's Hospital, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Seattle Children's Hospital, Seattle, WA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gonska, Tanja" sort="Gonska, Tanja" uniqKey="Gonska T" first="Tanja" last="Gonska">Tanja Gonska</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital for Sick Children, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Hospital for Sick Children, Toronto, ON</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heyman, Melvin B" sort="Heyman, Melvin B" uniqKey="Heyman M" first="Melvin B" last="Heyman">Melvin B. Heyman</name>
<affiliation wicri:level="1"><nlm:affiliation>University of California at San Francisco, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California at San Francisco, San Francisco, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Himes, Ryan" sort="Himes, Ryan" uniqKey="Himes R" first="Ryan" last="Himes">Ryan Himes</name>
<affiliation wicri:level="1"><nlm:affiliation>Baylor College of Medicine, Houston, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Baylor College of Medicine, Houston, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kumar, Soma" sort="Kumar, Soma" uniqKey="Kumar S" first="Soma" last="Kumar">Soma Kumar</name>
<affiliation wicri:level="1"><nlm:affiliation>Nationwide Children's Hospital, Columbus, OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Nationwide Children's Hospital, Columbus, OH</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morinville, Veronique D" sort="Morinville, Veronique D" uniqKey="Morinville V" first="Veronique D" last="Morinville">Veronique D. Morinville</name>
<affiliation wicri:level="1"><nlm:affiliation>Montreal Children's Hospital, McGill University, Montreal, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Montreal Children's Hospital, McGill University, Montreal, QC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lowe, Mark E" sort="Lowe, Mark E" uniqKey="Lowe M" first="Mark E" last="Lowe">Mark E. Lowe</name>
<affiliation wicri:level="1"><nlm:affiliation>Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Children's Hospital of Pittsburgh, Pittsburgh, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nuehring, Neil E" sort="Nuehring, Neil E" uniqKey="Nuehring N" first="Neil E" last="Nuehring">Neil E. Nuehring</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Iowa Carver College of Medicine, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa Carver College of Medicine, Iowa City, IA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ooi, Chee Y" sort="Ooi, Chee Y" uniqKey="Ooi C" first="Chee Y" last="Ooi">Chee Y. Ooi</name>
<affiliation wicri:level="1"><nlm:affiliation>Discipline of Paediatrics, School of Women's and Children's Health, Medicine, University of New South Wales and Sydney Children's Hospital Randwick Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Discipline of Paediatrics, School of Women's and Children's Health, Medicine, University of New South Wales and Sydney Children's Hospital Randwick Sydney</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pohl, John F" sort="Pohl, John F" uniqKey="Pohl J" first="John F" last="Pohl">John F. Pohl</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Utah, Salt Lake City, UT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Utah, Salt Lake City, UT</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Troendle, David" sort="Troendle, David" uniqKey="Troendle D" first="David" last="Troendle">David Troendle</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Texas Southwestern Medical School, Dallas, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Texas Southwestern Medical School, Dallas, TX</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Werlin, Steven L" sort="Werlin, Steven L" uniqKey="Werlin S" first="Steven L" last="Werlin">Steven L. Werlin</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical College of Wisconsin, Milwaukee, WI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical College of Wisconsin, Milwaukee, WI</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wilschanski, Michael" sort="Wilschanski, Michael" uniqKey="Wilschanski M" first="Michael" last="Wilschanski">Michael Wilschanski</name>
<affiliation wicri:level="1"><nlm:affiliation>Hadassah Hebrew University Hospital, Jerusalem, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Hadassah Hebrew University Hospital, Jerusalem</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yen, Elizabeth" sort="Yen, Elizabeth" uniqKey="Yen E" first="Elizabeth" last="Yen">Elizabeth Yen</name>
<affiliation wicri:level="1"><nlm:affiliation>University of California at San Francisco, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California at San Francisco, San Francisco, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Uc, Aliye" sort="Uc, Aliye" uniqKey="Uc A" first="Aliye" last="Uc">Aliye Uc</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Iowa Carver College of Medicine, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa Carver College of Medicine, Iowa City, IA</wicri:regionArea>
</affiliation>
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<series><title level="j">The Journal of pediatrics</title>
<idno type="eISSN">1097-6833</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
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<term>Cholangiopancreatography, Endoscopic Retrograde</term>
<term>Cross-Sectional Studies</term>
<term>Cystic Fibrosis Transmembrane Conductance Regulator (genetics)</term>
<term>DNA (genetics)</term>
<term>DNA Mutational Analysis</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Mutation</term>
<term>Pancreatitis, Chronic (diagnosis)</term>
<term>Pancreatitis, Chronic (epidemiology)</term>
<term>Pancreatitis, Chronic (genetics)</term>
<term>Prevalence</term>
<term>Risk Factors</term>
<term>United States (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN (génétique)</term>
<term>Analyse de mutations d'ADN</term>
<term>Cholangiopancréatographie rétrograde endoscopique</term>
<term>Enfant</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Pancréatite chronique (diagnostic)</term>
<term>Pancréatite chronique (génétique)</term>
<term>Pancréatite chronique (épidémiologie)</term>
<term>Protéine CFTR (génétique)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Prévalence</term>
<term>États-Unis d'Amérique (épidémiologie)</term>
<term>Études transversales</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cystic Fibrosis Transmembrane Conductance Regulator</term>
<term>DNA</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>United States</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Pancreatitis, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Pancréatite chronique</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Pancreatitis, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Pancreatitis, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN</term>
<term>Pancréatite chronique</term>
<term>Protéine CFTR</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Pancréatite chronique</term>
<term>États-Unis d'Amérique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Child</term>
<term>Cholangiopancreatography, Endoscopic Retrograde</term>
<term>Cross-Sectional Studies</term>
<term>DNA Mutational Analysis</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Mutation</term>
<term>Prevalence</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de mutations d'ADN</term>
<term>Cholangiopancréatographie rétrograde endoscopique</term>
<term>Enfant</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Prédisposition génétique à une maladie</term>
<term>Prévalence</term>
<term>Études transversales</term>
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term>
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<front><div type="abstract" xml:lang="en">To determine the clinical presentation, diagnostic variables, risk factors, and disease burden in children with chronic pancreatitis.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25556020</PMID>
<DateCreated><Year>2015</Year>
<Month>03</Month>
<Day>30</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>07</Month>
<Day>02</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>07</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-6833</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>166</Volume>
<Issue>4</Issue>
<PubDate><Year>2015</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of pediatrics</Title>
<ISOAbbreviation>J. Pediatr.</ISOAbbreviation>
</Journal>
<ArticleTitle>Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden.</ArticleTitle>
<Pagination><MedlinePgn>890-896.e1</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jpeds.2014.11.019</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine the clinical presentation, diagnostic variables, risk factors, and disease burden in children with chronic pancreatitis.</AbstractText>
<AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">We performed a cross-sectional study of data from the International Study Group of Pediatric Pancreatitis: In Search for a Cure, a registry of children with acute recurrent pancreatitis and chronic pancreatitis. Between-group differences were compared using Wilcoxon rank-sum test.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Among 170 subjects in the registry, 76 (45%) had chronic pancreatitis; 57% were female, 80% were white; median age at diagnosis was 9.9 years. Pancreatitis-predisposing genetic mutations were identified in 51 (67%) and obstructive risk factors in 25 (33%). Toxic/metabolic and autoimmune factors were uncommon. Imaging demonstrated ductal abnormalities and pancreatic atrophy more commonly than calcifications. Fifty-nine (77%) reported abdominal pain within the past year; pain was reported as constant and receiving narcotics in 28%. Children with chronic pancreatitis reported a median of 3 emergency department visits and 2 hospitalizations in the last year. Forty-seven subjects (70%) missed 1 day of school in the past month as the result of chronic pancreatitis; 26 (34%) missed 3 or more days. Children reporting constant pain were more likely to miss school (P = .002), visit the emergency department (P = .01), and experience hospitalizations (P = .03) compared with children with episodic pain. Thirty-three children (43%) underwent therapeutic endoscopic retrograde pancreatography; one or more pancreatic surgeries were performed in 30 (39%).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Chronic pancreatitis occurs at a young age with distinct clinical features. Genetic and obstructive risk factors are common, and disease burden is substantial.</AbstractText>
<CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Schwarzenberg</LastName>
<ForeName>Sarah Jane</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>University of Minnesota Children's Hospital, Minneapolis, Minnesota, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>Bellin</LastName>
<ForeName>Melena</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>University of Minnesota Children's Hospital, Minneapolis, Minnesota, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>Husain</LastName>
<ForeName>Sohail Z</ForeName>
<Initials>SZ</Initials>
<AffiliationInfo><Affiliation>Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ahuja</LastName>
<ForeName>Monika</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>University of Iowa Carver College of Medicine, Iowa City, IA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barth</LastName>
<ForeName>Bradley</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>University of Texas Southwestern Medical School, Dallas, TX, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Davis</LastName>
<ForeName>Heather</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>University of Iowa Carver College of Medicine, Iowa City, IA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Durie</LastName>
<ForeName>Peter R</ForeName>
<Initials>PR</Initials>
<AffiliationInfo><Affiliation>Hospital for Sick Children, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fishman</LastName>
<ForeName>Douglas S</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Baylor College of Medicine, Houston, TX, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Freedman</LastName>
<ForeName>Steven D</ForeName>
<Initials>SD</Initials>
<AffiliationInfo><Affiliation>Harvard Medical School, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Cheryl E</ForeName>
<Initials>CE</Initials>
<AffiliationInfo><Affiliation>Nationwide Children's Hospital, Columbus, OH, USA.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Matthew J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Seattle Children's Hospital, Seattle, WA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gonska</LastName>
<ForeName>Tanja</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Hospital for Sick Children, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heyman</LastName>
<ForeName>Melvin B</ForeName>
<Initials>MB</Initials>
<AffiliationInfo><Affiliation>University of California at San Francisco, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Himes</LastName>
<ForeName>Ryan</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Baylor College of Medicine, Houston, TX, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kumar</LastName>
<ForeName>Soma</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Nationwide Children's Hospital, Columbus, OH, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morinville</LastName>
<ForeName>Veronique D</ForeName>
<Initials>VD</Initials>
<AffiliationInfo><Affiliation>Montreal Children's Hospital, McGill University, Montreal, QC, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lowe</LastName>
<ForeName>Mark E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nuehring</LastName>
<ForeName>Neil E</ForeName>
<Initials>NE</Initials>
<AffiliationInfo><Affiliation>University of Iowa Carver College of Medicine, Iowa City, IA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ooi</LastName>
<ForeName>Chee Y</ForeName>
<Initials>CY</Initials>
<AffiliationInfo><Affiliation>Discipline of Paediatrics, School of Women's and Children's Health, Medicine, University of New South Wales and Sydney Children's Hospital Randwick Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pohl</LastName>
<ForeName>John F</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>University of Utah, Salt Lake City, UT, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Troendle</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>University of Texas Southwestern Medical School, Dallas, TX, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Werlin</LastName>
<ForeName>Steven L</ForeName>
<Initials>SL</Initials>
<AffiliationInfo><Affiliation>Medical College of Wisconsin, Milwaukee, WI, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wilschanski</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Hadassah Hebrew University Hospital, Jerusalem, Israel.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yen</LastName>
<ForeName>Elizabeth</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>University of California at San Francisco, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Uc</LastName>
<ForeName>Aliye</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>University of Iowa Carver College of Medicine, Iowa City, IA, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>UL1 TR000442</GrantID>
<Acronym>TR</Acronym>
<Agency>NCATS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>DK096327</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P30 DK054759</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R21 DK096327</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 DK097820</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>12</Month>
<Day>30</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Pediatr</MedlineTA>
<NlmUniqueID>0375410</NlmUniqueID>
<ISSNLinking>0022-3476</ISSNLinking>
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</Chemical>
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<NameOfSubstance UI="D019005">Cystic Fibrosis Transmembrane Conductance Regulator</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9007-49-2</RegistryNumber>
<NameOfSubstance UI="D004247">DNA</NameOfSubstance>
</Chemical>
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<CitationSubset>IM</CitationSubset>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002760" MajorTopicYN="N">Cholangiopancreatography, Endoscopic Retrograde</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019005" MajorTopicYN="N">Cystic Fibrosis Transmembrane Conductance Regulator</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004247" MajorTopicYN="N">DNA</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004252" MajorTopicYN="N">DNA Mutational Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020022" MajorTopicYN="Y">Genetic Predisposition to Disease</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050500" MajorTopicYN="N">Pancreatitis, Chronic</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName>
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   |texte=   Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden.
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Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden.

Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden.

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