Postnatal development of thalamic recipient neurons in the monkey striate cortex: Somatic inhibitory synapse acquisition by spiny stellate neurons of layer 4C
Identifieur interne : 002689 ( Istex/Corpus ); précédent : 002688; suivant : 002690Postnatal development of thalamic recipient neurons in the monkey striate cortex: Somatic inhibitory synapse acquisition by spiny stellate neurons of layer 4C
Auteurs : Jennifer S. Lund ; Thomas R. HarperSource :
- Journal of Comparative Neurology [ 0021-9967 ] ; 1991-07-01.
English descriptors
- KwdEn :
- Alpha, Alpha neurons, Apposition, Beta, Beta neurons, Cell body, Cell diameter, Cell surface, Cerebral cortex, Comp, Dendritic, Dendritic growth, Holbach, Inhibitory, Inhibitory synapses, Laminar boundaries, Lund, Monkey striate cortex, Nemestrina, Neurol, Neuron, Percentage coverage, Perimac, Phosphate buffer, Postnatal, Postnatal development, Postnatal weeks, Same neurons, Similar values, Soma, Somatic, Somatic coverage, Somatic membrane, Spine, Spine acquisition, Spine development, Spine synapse development, Spine synapses, Spiny, Spiny stellate neurons, Stellate, Striate, Striate cortex, Suture, Synapse, Synapse coverage, Synaptic, Synaptic apposition sites, Synaptic appositions, Synaptic contacts, Time course, Type 1and type, Visual cortex, Visual deprivation.
- Teeft :
- Alpha, Alpha neurons, Apposition, Beta, Beta neurons, Cell body, Cell diameter, Cell surface, Cerebral cortex, Comp, Dendritic, Dendritic growth, Holbach, Inhibitory, Inhibitory synapses, Laminar boundaries, Lund, Monkey striate cortex, Nemestrina, Neurol, Neuron, Percentage coverage, Perimac, Phosphate buffer, Postnatal, Postnatal development, Postnatal weeks, Same neurons, Similar values, Soma, Somatic, Somatic coverage, Somatic membrane, Spine, Spine acquisition, Spine development, Spine synapse development, Spine synapses, Spiny, Spiny stellate neurons, Stellate, Striate, Striate cortex, Suture, Synapse, Synapse coverage, Synaptic, Synaptic apposition sites, Synaptic appositions, Synaptic contacts, Time course, Type 1and type, Visual cortex, Visual deprivation.
Abstract
The development of type 2 (Colonnier,1981) synapses on the cell bodies of thalamic recipient spiny stellate neurons in layers 4C alpha and 4C beta of primary visual cortex neurons was examined over the first 36 postnatal weeks and in the adult monkey. The type 2 synapses, known to be GABAergic (Ribak, 1978) and therefore presumed to be inhibitory, developed faster on the alpha neurons than the beta neurons. Both neuron groups show a marked increase and then decline in the percentage of the somatic membrane covered by type 2 synaptic appositions during this 36‐week time period. The time course of the type 2 synapses development is compared to that of the spine synapse development described in previous studies (Lund and Holbach, 1991; Lund et al., 1991), and it is clear that on both neuron groups this inhibitory synapse population is put in place and refined later than the spine synapses. These findings suggest that each cortical neural circuit has a unique time course for its early development within an overall time window (Rakic et al., 1986), or sensitive period (Hubel and Wiesel, 1970). Visual deprivation, although causing the alpha and beta neurons to adopt a more similar temporal and numerical developmental pattern than normal, did not prevent acquisition and loss phases of type 2 synapses or the assumption of a normal numerical loading by 36 weeks of age.
Url:
DOI: 10.1002/cne.903090110
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ISTEX:A51C9636DA78E02053F5D07ACC53BCF1DED17471Le document en format XML
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The type 2 synapses, known to be GABAergic (Ribak, 1978) and therefore presumed to be inhibitory, developed faster on the alpha neurons than the beta neurons. Both neuron groups show a marked increase and then decline in the percentage of the somatic membrane covered by type 2 synaptic appositions during this 36‐week time period. The time course of the type 2 synapses development is compared to that of the spine synapse development described in previous studies (Lund and Holbach, 1991; Lund et al., 1991), and it is clear that on both neuron groups this inhibitory synapse population is put in place and refined later than the spine synapses. These findings suggest that each cortical neural circuit has a unique time course for its early development within an overall time window (Rakic et al., 1986), or sensitive period (Hubel and Wiesel, 1970). Visual deprivation, although causing the alpha and beta neurons to adopt a more similar temporal and numerical developmental pattern than normal, did not prevent acquisition and loss phases of type 2 synapses or the assumption of a normal numerical loading by 36 weeks of age.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>synapse</json:string><json:string>neuron</json:string><json:string>beta neurons</json:string><json:string>synaptic</json:string><json:string>dendritic</json:string><json:string>nemestrina</json:string><json:string>stellate</json:string><json:string>spiny</json:string><json:string>lund</json:string><json:string>beta</json:string><json:string>apposition</json:string><json:string>postnatal</json:string><json:string>spiny stellate neurons</json:string><json:string>suture</json:string><json:string>perimac</json:string><json:string>holbach</json:string><json:string>synapse coverage</json:string><json:string>neurol</json:string><json:string>comp</json:string><json:string>striate</json:string><json:string>cell surface</json:string><json:string>somatic membrane</json:string><json:string>visual cortex</json:string><json:string>cell body</json:string><json:string>alpha neurons</json:string><json:string>visual deprivation</json:string><json:string>cerebral cortex</json:string><json:string>dendritic growth</json:string><json:string>inhibitory synapses</json:string><json:string>somatic</json:string><json:string>soma</json:string><json:string>alpha</json:string><json:string>cell diameter</json:string><json:string>spine</json:string><json:string>inhibitory</json:string><json:string>laminar boundaries</json:string><json:string>spine synapse development</json:string><json:string>type 1and type</json:string><json:string>synaptic apposition sites</json:string><json:string>postnatal development</json:string><json:string>percentage coverage</json:string><json:string>synaptic contacts</json:string><json:string>phosphate buffer</json:string><json:string>time course</json:string><json:string>striate cortex</json:string><json:string>synaptic appositions</json:string><json:string>spine synapses</json:string><json:string>monkey striate cortex</json:string><json:string>similar values</json:string><json:string>somatic coverage</json:string><json:string>same neurons</json:string><json:string>spine acquisition</json:string><json:string>postnatal weeks</json:string><json:string>spine development</json:string></teeft></keywords><author><json:item><name>Jennifer S. 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Harper</name><affiliations><json:string>Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15261</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>vision</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cerebral cortex</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>sensory deprivation inhibition</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>electronmicroscopy</value></json:item></subject><articleId><json:string>CNE903090110</json:string></articleId><arkIstex>ark:/67375/WNG-K62WX763-5</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The development of type 2 (Colonnier,1981) synapses on the cell bodies of thalamic recipient spiny stellate neurons in layers 4C alpha and 4C beta of primary visual cortex neurons was examined over the first 36 postnatal weeks and in the adult monkey. The type 2 synapses, known to be GABAergic (Ribak, 1978) and therefore presumed to be inhibitory, developed faster on the alpha neurons than the beta neurons. Both neuron groups show a marked increase and then decline in the percentage of the somatic membrane covered by type 2 synaptic appositions during this 36‐week time period. The time course of the type 2 synapses development is compared to that of the spine synapse development described in previous studies (Lund and Holbach, 1991; Lund et al., 1991), and it is clear that on both neuron groups this inhibitory synapse population is put in place and refined later than the spine synapses. These findings suggest that each cortical neural circuit has a unique time course for its early development within an overall time window (Rakic et al., 1986), or sensitive period (Hubel and Wiesel, 1970). Visual deprivation, although causing the alpha and beta neurons to adopt a more similar temporal and numerical developmental pattern than normal, did not prevent acquisition and loss phases of type 2 synapses or the assumption of a normal numerical loading by 36 weeks of age.</abstract><qualityIndicators><score>9.18</score><pdfWordCount>4444</pdfWordCount><pdfCharCount>25473</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>792 x 594 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>228</abstractWordCount><abstractCharCount>1382</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Postnatal development of thalamic recipient neurons in the monkey striate cortex: Somatic inhibitory synapse acquisition by spiny stellate neurons of layer 4C</title><pmid><json:string>1894767</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Comparative Neurology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1096-9861</json:string></doi><issn><json:string>0021-9967</json:string></issn><eissn><json:string>1096-9861</json:string></eissn><publisherId><json:string>CNE</json:string></publisherId><volume>309</volume><issue>1</issue><pages><first>141</first><last>149</last><total>9</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Article</value></json:item></subject></host><namedEntities><unitex><date><json:string>1991</json:string></date><geogName></geogName><orgName><json:string>University of Pittsburgh, Pittsburgh</json:string><json:string>National Eye Institute</json:string><json:string>Organization</json:string><json:string>University of Pittsburgh</json:string><json:string>Organization of the Cerebral Cortex</json:string><json:string>Neurosciences Research Program Colloquium</json:string><json:string>LISS, INC.</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Brain Res</json:string><json:string>F.G. Worden</json:string><json:string>F.O. Schmitt</json:string><json:string>Alpha Neurons</json:string><json:string>C.Normal</json:string><json:string>J. Comp</json:string><json:string>S.M. Holbach</json:string><json:string>I. Comparison</json:string><json:string>W. Chung</json:string><json:string>David Lewis</json:string><json:string>S.G. Dennis</json:string><json:string>M.F. Eckenhoff</json:string><json:string>J. Physiol</json:string><json:string>A.A. Peters</json:string><json:string>E.G. Jones</json:string><json:string>J. Neurocytol</json:string><json:string>The</json:string><json:string>W.F. White</json:string><json:string>Deprived</json:string><json:string>G. Adelman</json:string><json:string>A. Peters</json:string><json:string>T.N. Wiesel</json:string><json:string>P. Mac</json:string><json:string>A.C. Towles</json:string><json:string>P. Bourgeois</json:string><json:string>Jonathan Levitt</json:string><json:string>P.S. GoldmanRakic</json:string><json:string>N. Zecevic</json:string></persName><placeName><json:string>LUND</json:string><json:string>Lund</json:string><json:string>Rustad</json:string><json:string>Pittsburgh</json:string><json:string>Saint Marie</json:string><json:string>York</json:string><json:string>Cambridge</json:string><json:string>D.E.</json:string><json:string>PA</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Fitzpatrick et al.</json:string><json:string>Lund et al.</json:string><json:string>Mower et al.</json:string><json:string>Rakic et al.</json:string><json:string>Lund et al</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-K62WX763-5</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - zoology</json:string><json:string>2 - neurosciences</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - neurology & neurosurgery</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Neuroscience</json:string><json:string>3 - General Neuroscience</json:string></scopus></categories><publicationDate>1991</publicationDate><copyrightDate>1991</copyrightDate><doi><json:string>10.1002/cne.903090110</json:string></doi><id>A51C9636DA78E02053F5D07ACC53BCF1DED17471</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/A51C9636DA78E02053F5D07ACC53BCF1DED17471/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/A51C9636DA78E02053F5D07ACC53BCF1DED17471/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A51C9636DA78E02053F5D07ACC53BCF1DED17471/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Postnatal development of thalamic recipient neurons in the monkey striate cortex: Somatic inhibitory synapse acquisition by spiny stellate neurons of layer 4C</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><licence>Copyright © 1991 Wiley‐Liss, Inc.</licence></availability><date type="published" when="1991-07-01"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">Postnatal development of thalamic recipient neurons in the monkey striate cortex: Somatic inhibitory synapse acquisition by spiny stellate neurons of layer 4C</title><title level="a" type="short" xml:lang="en">DEVELOPMENT OF INHIBITORY SYNAPSES IN STRIATE CORTEX</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Jennifer S.</forename><surname>Lund</surname></persName><affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261<address><country key="US"></country></address></affiliation><affiliation>University of Pittsburgh, 336C Scaife Hall, Pittsburgh, PA 15261</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Thomas R.</forename><surname>Harper</surname></persName><affiliation>Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15261<address><country key="US"></country></address></affiliation></author><idno type="istex">A51C9636DA78E02053F5D07ACC53BCF1DED17471</idno><idno type="ark">ark:/67375/WNG-K62WX763-5</idno><idno type="DOI">10.1002/cne.903090110</idno><idno type="unit">CNE903090110</idno><idno type="toTypesetVersion">file:CNE.CNE903090110.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Comparative Neurology</title><idno type="pISSN">0021-9967</idno><idno type="eISSN">1096-9861</idno><idno type="book-DOI">10.1002/(ISSN)1096-9861</idno><idno type="book-part-DOI">10.1002/cne.v309:1</idno><idno type="product">CNE</idno><imprint><biblScope unit="vol">309</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="141">141</biblScope><biblScope unit="page" to="149">149</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1991-07-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="fr" style="main"><head>Abstract</head><p>The development of type 2 (Colonnier,1981) synapses on the cell bodies of thalamic recipient spiny stellate neurons in layers 4C alpha and 4C beta of primary visual cortex neurons was examined over the first 36 postnatal weeks and in the adult monkey. The type 2 synapses, known to be GABAergic (Ribak, 1978) and therefore presumed to be inhibitory, developed faster on the alpha neurons than the beta neurons. Both neuron groups show a marked increase and then decline in the percentage of the somatic membrane covered by type 2 synaptic appositions during this 36‐week time period. The time course of the type 2 synapses development is compared to that of the spine synapse development described in previous studies (Lund and Holbach, 1991; Lund et al., 1991), and it is clear that on both neuron groups this inhibitory synapse population is put in place and refined later than the spine synapses. These findings suggest that each cortical neural circuit has a unique time course for its early development within an overall time window (Rakic et al., 1986), or sensitive period (Hubel and Wiesel, 1970). Visual deprivation, although causing the alpha and beta neurons to adopt a more similar temporal and numerical developmental pattern than normal, did not prevent acquisition and loss phases of type 2 synapses or the assumption of a normal numerical loading by 36 weeks of age.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">vision</term><term xml:id="kwd2">cerebral cortex</term><term xml:id="kwd3">sensory deprivation inhibition</term><term xml:id="kwd4">electronmicroscopy</term></keywords><keywords rend="articleCategory"><term>Article</term></keywords><keywords rend="tocHeading1"><term>Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/A51C9636DA78E02053F5D07ACC53BCF1DED17471/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1096-9861</doi><issn type="print">0021-9967</issn><issn type="electronic">1096-9861</issn><idGroup><id type="product" value="CNE"></id></idGroup><titleGroup><title type="main" xml:lang="en">Journal of Comparative Neurology</title><title type="short">J. Comp. Neurol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/cne.v309:1</doi><numberingGroup><numbering type="journalVolume" number="309">309</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="1991-07-01">1 July 1991</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="10" status="forIssue"><doi origin="wiley" registered="yes">10.1002/cne.903090110</doi><idGroup><id type="unit" value="CNE903090110"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="publisher">Copyright © 1991 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptAccepted" date="1991-04-01"></event><event type="firstOnline" date="2004-10-09"></event><event type="publishedOnlineFinalForm" date="2004-10-09"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-01"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst">141</numbering><numbering type="pageLast">149</numbering></numberingGroup><correspondenceTo>University of Pittsburgh, 336C Scaife Hall, Pittsburgh, PA 15261</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CNE.CNE903090110.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="17"></count></countGroup><titleGroup><title type="main" xml:lang="en">Postnatal development of thalamic recipient neurons in the monkey striate cortex: Somatic inhibitory synapse acquisition by spiny stellate neurons of layer 4C</title><title type="short" xml:lang="en">DEVELOPMENT OF INHIBITORY SYNAPSES IN STRIATE CORTEX</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Jennifer S.</givenNames><familyName>Lund</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Thomas R.</givenNames><familyName>Harper</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15261</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">vision</keyword><keyword xml:id="kwd2">cerebral cortex</keyword><keyword xml:id="kwd3">sensory deprivation inhibition</keyword><keyword xml:id="kwd4">electronmicroscopy</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="fr"><title type="main">Abstract</title><p>The development of type 2 (Colonnier,1981) synapses on the cell bodies of thalamic recipient spiny stellate neurons in layers 4C alpha and 4C beta of primary visual cortex neurons was examined over the first 36 postnatal weeks and in the adult monkey. The type 2 synapses, known to be GABAergic (Ribak, 1978) and therefore presumed to be inhibitory, developed faster on the alpha neurons than the beta neurons. Both neuron groups show a marked increase and then decline in the percentage of the somatic membrane covered by type 2 synaptic appositions during this 36‐week time period. The time course of the type 2 synapses development is compared to that of the spine synapse development described in previous studies (Lund and Holbach, 1991; Lund et al., 1991), and it is clear that on both neuron groups this inhibitory synapse population is put in place and refined later than the spine synapses. These findings suggest that each cortical neural circuit has a unique time course for its early development within an overall time window (Rakic et al., 1986), or sensitive period (Hubel and Wiesel, 1970). Visual deprivation, although causing the alpha and beta neurons to adopt a more similar temporal and numerical developmental pattern than normal, did not prevent acquisition and loss phases of type 2 synapses or the assumption of a normal numerical loading by 36 weeks of age.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Postnatal development of thalamic recipient neurons in the monkey striate cortex: Somatic inhibitory synapse acquisition by spiny stellate neurons of layer 4C</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>DEVELOPMENT OF INHIBITORY SYNAPSES IN STRIATE CORTEX</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Postnatal development of thalamic recipient neurons in the monkey striate cortex: Somatic inhibitory synapse acquisition by spiny stellate neurons of layer 4C</title></titleInfo><name type="personal"><namePart type="given">Jennifer S.</namePart><namePart type="family">Lund</namePart><affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261</affiliation><affiliation>Correspondence address: University of Pittsburgh, 336C Scaife Hall, Pittsburgh, PA 15261</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas R.</namePart><namePart type="family">Harper</namePart><affiliation>Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15261</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1991-07-01</dateIssued><dateValid encoding="w3cdtf">1991-04-01</dateValid><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">5</extent><extent unit="tables">1</extent><extent unit="references">17</extent></physicalDescription><abstract lang="fr">The development of type 2 (Colonnier,1981) synapses on the cell bodies of thalamic recipient spiny stellate neurons in layers 4C alpha and 4C beta of primary visual cortex neurons was examined over the first 36 postnatal weeks and in the adult monkey. The type 2 synapses, known to be GABAergic (Ribak, 1978) and therefore presumed to be inhibitory, developed faster on the alpha neurons than the beta neurons. Both neuron groups show a marked increase and then decline in the percentage of the somatic membrane covered by type 2 synaptic appositions during this 36‐week time period. The time course of the type 2 synapses development is compared to that of the spine synapse development described in previous studies (Lund and Holbach, 1991; Lund et al., 1991), and it is clear that on both neuron groups this inhibitory synapse population is put in place and refined later than the spine synapses. These findings suggest that each cortical neural circuit has a unique time course for its early development within an overall time window (Rakic et al., 1986), or sensitive period (Hubel and Wiesel, 1970). Visual deprivation, although causing the alpha and beta neurons to adopt a more similar temporal and numerical developmental pattern than normal, did not prevent acquisition and loss phases of type 2 synapses or the assumption of a normal numerical loading by 36 weeks of age.</abstract><subject lang="en"><genre>keywords</genre><topic>vision</topic><topic>cerebral cortex</topic><topic>sensory deprivation inhibition</topic><topic>electronmicroscopy</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Comparative Neurology</title></titleInfo><titleInfo type="abbreviated"><title>J. Comp. 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