The rise of Clostridium difficile infection in lung transplant recipients in the modern era
Identifieur interne : 002259 ( Istex/Corpus ); précédent : 002258; suivant : 002260The rise of Clostridium difficile infection in lung transplant recipients in the modern era
Auteurs : Janet T. Lee ; Marshall I. Hertz ; Jordan M. Dunitz ; Rosemary F. Kelly ; Jonathan D'Cunha ; Bryan A. Whitson ; Sara J. ShumwaySource :
- Clinical Transplantation [ 0902-0063 ] ; 2013-03.
English descriptors
- KwdEn :
- Abdominal pain, Additional patients, Antibiotic, Average number, Baseline characteristics, Bilateral surgery, Blood transfusion, Brosis, Brosis copd idiopathic, Brosis patients, Cardiopulmonary, Cardiothoracic surgery, Cephalosporin, Clin microbiol, Clostridium, Clostridium colitis, Clostridium infection, Cohort, Colitis, Control hosp epidemiol, Economic burden, Entire hospital, Fulminant colitis, Hazard ratio, Hazard ratios, Heart transplant recipients, Higher mortality rate, Higher rates, Hospitalization, Hypervirulent strain, Immunosuppression, Immunosuppression diagnosis, Incidence, Incidence analysis, Incidence rate, Incidence rates, Initial hospitalization, Initial hospitalization cardiopulmonary, Inpatient, Lung transplant population, Lung transplant recipients, Lung transplantation, Multivariate analysis, Nationwide inpatient sample, Nationwide inpatient sample database, Overall incidence, Patient population, Potential risk factors, Prevalent cases, Proportional hazard models, Recent years, Recipient, Recipient populations, Recurrence rate, Recurrent episodes, Retrospective chart review, Risk factors, Same hospital, Sequential lung transplant, Solid organ transplant recipients, Study period, Surgery, Survival curves, Total length, Transfusion, Transpl, Transplant, Transplantation, Unadjusted analysis, Women length, Worse outcomes.
- Teeft :
- Abdominal pain, Additional patients, Antibiotic, Average number, Baseline characteristics, Bilateral surgery, Blood transfusion, Brosis, Brosis copd idiopathic, Brosis patients, Cardiopulmonary, Cardiothoracic surgery, Cephalosporin, Clin microbiol, Clostridium, Clostridium colitis, Clostridium infection, Cohort, Colitis, Control hosp epidemiol, Economic burden, Entire hospital, Fulminant colitis, Hazard ratio, Hazard ratios, Heart transplant recipients, Higher mortality rate, Higher rates, Hospitalization, Hypervirulent strain, Immunosuppression, Immunosuppression diagnosis, Incidence, Incidence analysis, Incidence rate, Incidence rates, Initial hospitalization, Initial hospitalization cardiopulmonary, Inpatient, Lung transplant population, Lung transplant recipients, Lung transplantation, Multivariate analysis, Nationwide inpatient sample, Nationwide inpatient sample database, Overall incidence, Patient population, Potential risk factors, Prevalent cases, Proportional hazard models, Recent years, Recipient, Recipient populations, Recurrence rate, Recurrent episodes, Retrospective chart review, Risk factors, Same hospital, Sequential lung transplant, Solid organ transplant recipients, Study period, Surgery, Survival curves, Total length, Transfusion, Transpl, Transplant, Transplantation, Unadjusted analysis, Women length, Worse outcomes.
Abstract
Clostridium difficile infection (CDI) rates have been rising in recent years. We aimed to characterize CDI in lung transplant recipients in the modern era and hypothesized that CDI would increase the mortality risk.
Url:
DOI: 10.1111/ctr.12064
Links to Exploration step
ISTEX:93C4B396FEE7033A9BA248BAECE199C1654E061FLe document en format XML
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Lee</name><affiliation><mods:affiliation>Department of Surgery, University of Minnesota, MN, Minneapolis, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author: Janet T. Lee, Department of Surgery, University of Minnesota, 420 Delaware St SE, MMC 195, Minneapolis, MN 55455, USA.Tel.: +1 612 625 4377; fax: +1 612 625 4406; e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: leex1203@umn.edu</mods:affiliation></affiliation></author><author><name sortKey="Hertz, Marshall I" sort="Hertz, Marshall I" uniqKey="Hertz M" first="Marshall I." last="Hertz">Marshall I. Hertz</name><affiliation><mods:affiliation>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Minnesota, MN, Minneapolis, USA</mods:affiliation></affiliation></author><author><name sortKey="Dunitz, Jordan M" sort="Dunitz, Jordan M" uniqKey="Dunitz J" first="Jordan M." last="Dunitz">Jordan M. 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Kelly</name><affiliation><mods:affiliation>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, MN, Minneapolis, USA</mods:affiliation></affiliation></author><author><name sortKey="D Cunha, Jonathan" sort="D Cunha, Jonathan" uniqKey="D Cunha J" first="Jonathan" last="D'Cunha">Jonathan D'Cunha</name><affiliation><mods:affiliation>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Cardiothoracic Surgery, Department of Surgery, University of Pittsburgh, PA, Pittsburgh, USA</mods:affiliation></affiliation></author><author><name sortKey="Whitson, Bryan A" sort="Whitson, Bryan A" uniqKey="Whitson B" first="Bryan A." last="Whitson">Bryan A. Whitson</name><affiliation><mods:affiliation>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Cardiothoracic Surgery, Department of Surgery, The Ohio State University, OH, Columbus, USA</mods:affiliation></affiliation></author><author><name sortKey="Shumway, Sara J" sort="Shumway, Sara J" uniqKey="Shumway S" first="Sara J." last="Shumway">Sara J. Shumway</name><affiliation><mods:affiliation>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, MN, Minneapolis, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Transplantation</title><title level="j" type="alt">CLINICAL TRANSPLANTATION</title><idno type="ISSN">0902-0063</idno><idno type="eISSN">1399-0012</idno><imprint><biblScope unit="vol">27</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="303">303</biblScope><biblScope unit="page" to="310">310</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2013-03">2013-03</date></imprint><idno type="ISSN">0902-0063</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0902-0063</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abdominal pain</term><term>Additional patients</term><term>Antibiotic</term><term>Average number</term><term>Baseline characteristics</term><term>Bilateral surgery</term><term>Blood transfusion</term><term>Brosis</term><term>Brosis copd idiopathic</term><term>Brosis patients</term><term>Cardiopulmonary</term><term>Cardiothoracic surgery</term><term>Cephalosporin</term><term>Clin microbiol</term><term>Clostridium</term><term>Clostridium colitis</term><term>Clostridium infection</term><term>Cohort</term><term>Colitis</term><term>Control hosp epidemiol</term><term>Economic burden</term><term>Entire hospital</term><term>Fulminant colitis</term><term>Hazard ratio</term><term>Hazard ratios</term><term>Heart transplant recipients</term><term>Higher mortality rate</term><term>Higher rates</term><term>Hospitalization</term><term>Hypervirulent strain</term><term>Immunosuppression</term><term>Immunosuppression diagnosis</term><term>Incidence</term><term>Incidence analysis</term><term>Incidence rate</term><term>Incidence rates</term><term>Initial hospitalization</term><term>Initial hospitalization cardiopulmonary</term><term>Inpatient</term><term>Lung transplant population</term><term>Lung transplant recipients</term><term>Lung transplantation</term><term>Multivariate analysis</term><term>Nationwide inpatient sample</term><term>Nationwide inpatient sample database</term><term>Overall incidence</term><term>Patient population</term><term>Potential risk factors</term><term>Prevalent cases</term><term>Proportional hazard models</term><term>Recent years</term><term>Recipient</term><term>Recipient populations</term><term>Recurrence rate</term><term>Recurrent episodes</term><term>Retrospective chart review</term><term>Risk factors</term><term>Same hospital</term><term>Sequential lung transplant</term><term>Solid organ transplant recipients</term><term>Study period</term><term>Surgery</term><term>Survival curves</term><term>Total length</term><term>Transfusion</term><term>Transpl</term><term>Transplant</term><term>Transplantation</term><term>Unadjusted analysis</term><term>Women length</term><term>Worse outcomes</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abdominal pain</term><term>Additional patients</term><term>Antibiotic</term><term>Average number</term><term>Baseline characteristics</term><term>Bilateral surgery</term><term>Blood transfusion</term><term>Brosis</term><term>Brosis copd idiopathic</term><term>Brosis patients</term><term>Cardiopulmonary</term><term>Cardiothoracic surgery</term><term>Cephalosporin</term><term>Clin microbiol</term><term>Clostridium</term><term>Clostridium colitis</term><term>Clostridium infection</term><term>Cohort</term><term>Colitis</term><term>Control hosp epidemiol</term><term>Economic burden</term><term>Entire hospital</term><term>Fulminant colitis</term><term>Hazard ratio</term><term>Hazard ratios</term><term>Heart transplant recipients</term><term>Higher mortality rate</term><term>Higher rates</term><term>Hospitalization</term><term>Hypervirulent strain</term><term>Immunosuppression</term><term>Immunosuppression diagnosis</term><term>Incidence</term><term>Incidence analysis</term><term>Incidence rate</term><term>Incidence rates</term><term>Initial hospitalization</term><term>Initial hospitalization cardiopulmonary</term><term>Inpatient</term><term>Lung transplant population</term><term>Lung transplant recipients</term><term>Lung transplantation</term><term>Multivariate analysis</term><term>Nationwide inpatient sample</term><term>Nationwide inpatient sample database</term><term>Overall incidence</term><term>Patient population</term><term>Potential risk factors</term><term>Prevalent cases</term><term>Proportional hazard models</term><term>Recent years</term><term>Recipient</term><term>Recipient populations</term><term>Recurrence rate</term><term>Recurrent episodes</term><term>Retrospective chart review</term><term>Risk factors</term><term>Same hospital</term><term>Sequential lung transplant</term><term>Solid organ transplant recipients</term><term>Study period</term><term>Surgery</term><term>Survival curves</term><term>Total length</term><term>Transfusion</term><term>Transpl</term><term>Transplant</term><term>Transplantation</term><term>Unadjusted analysis</term><term>Women length</term><term>Worse outcomes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Clostridium difficile infection (CDI) rates have been rising in recent years. We aimed to characterize CDI in lung transplant recipients in the modern era and hypothesized that CDI would increase the mortality risk.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>lung transplant recipients</json:string><json:string>transplantation</json:string><json:string>transplant</json:string><json:string>clostridium</json:string><json:string>brosis</json:string><json:string>immunosuppression</json:string><json:string>initial hospitalization</json:string><json:string>cardiopulmonary</json:string><json:string>colitis</json:string><json:string>transfusion</json:string><json:string>cohort</json:string><json:string>risk factors</json:string><json:string>clostridium infection</json:string><json:string>clostridium colitis</json:string><json:string>transpl</json:string><json:string>cephalosporin</json:string><json:string>inpatient</json:string><json:string>blood transfusion</json:string><json:string>antibiotic</json:string><json:string>potential risk factors</json:string><json:string>overall incidence</json:string><json:string>multivariate analysis</json:string><json:string>incidence rate</json:string><json:string>economic burden</json:string><json:string>unadjusted analysis</json:string><json:string>solid organ transplant recipients</json:string><json:string>recipient</json:string><json:string>sequential lung transplant</json:string><json:string>hazard ratio</json:string><json:string>fulminant colitis</json:string><json:string>study period</json:string><json:string>lung transplantation</json:string><json:string>survival curves</json:string><json:string>cardiothoracic surgery</json:string><json:string>incidence</json:string><json:string>hospitalization</json:string><json:string>recurrence rate</json:string><json:string>hazard ratios</json:string><json:string>retrospective chart review</json:string><json:string>worse outcomes</json:string><json:string>heart transplant recipients</json:string><json:string>control hosp epidemiol</json:string><json:string>additional patients</json:string><json:string>average number</json:string><json:string>baseline characteristics</json:string><json:string>proportional hazard models</json:string><json:string>abdominal pain</json:string><json:string>bilateral surgery</json:string><json:string>total length</json:string><json:string>same hospital</json:string><json:string>women length</json:string><json:string>immunosuppression diagnosis</json:string><json:string>brosis copd idiopathic</json:string><json:string>initial hospitalization cardiopulmonary</json:string><json:string>entire hospital</json:string><json:string>hypervirulent strain</json:string><json:string>higher rates</json:string><json:string>recipient populations</json:string><json:string>recent years</json:string><json:string>nationwide inpatient sample database</json:string><json:string>higher mortality rate</json:string><json:string>nationwide inpatient sample</json:string><json:string>brosis patients</json:string><json:string>prevalent cases</json:string><json:string>lung transplant population</json:string><json:string>incidence analysis</json:string><json:string>patient population</json:string><json:string>clin microbiol</json:string><json:string>recurrent episodes</json:string><json:string>incidence rates</json:string><json:string>surgery</json:string></teeft></keywords><author><json:item><name>Janet T. Lee</name><affiliations><json:string>Department of Surgery, University of Minnesota, MN, Minneapolis, USA</json:string><json:string>Corresponding author: Janet T. Lee, Department of Surgery, University of Minnesota, 420 Delaware St SE, MMC 195, Minneapolis, MN 55455, USA.Tel.: +1 612 625 4377; fax: +1 612 625 4406; e‐mail:</json:string><json:string>E-mail: leex1203@umn.edu</json:string></affiliations></json:item><json:item><name>Marshall I. Hertz</name><affiliations><json:string>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Minnesota, MN, Minneapolis, USA</json:string></affiliations></json:item><json:item><name>Jordan M. Dunitz</name><affiliations><json:string>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Minnesota, MN, Minneapolis, USA</json:string></affiliations></json:item><json:item><name>Rosemary F. Kelly</name><affiliations><json:string>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, MN, Minneapolis, USA</json:string></affiliations></json:item><json:item><name>Jonathan D'Cunha</name><affiliations><json:string>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN, USA</json:string><json:string>Division of Cardiothoracic Surgery, Department of Surgery, University of Pittsburgh, PA, Pittsburgh, USA</json:string></affiliations></json:item><json:item><name>Bryan A. Whitson</name><affiliations><json:string>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN, USA</json:string><json:string>Division of Cardiothoracic Surgery, Department of Surgery, The Ohio State University, OH, Columbus, USA</json:string></affiliations></json:item><json:item><name>Sara J. Shumway</name><affiliations><json:string>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, MN, Minneapolis, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Clostridium difficile</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>infection</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>lung transplantation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>thoracic surgery</value></json:item></subject><articleId><json:string>CTR12064</json:string></articleId><arkIstex>ark:/67375/WNG-LWX0R9LR-M</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Clostridium difficile infection (CDI) rates have been rising in recent years. We aimed to characterize CDI in lung transplant recipients in the modern era and hypothesized that CDI would increase the mortality risk.</abstract><qualityIndicators><score>6.567</score><pdfWordCount>4171</pdfWordCount><pdfCharCount>28248</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>33</abstractWordCount><abstractCharCount>215</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>The rise of Clostridium difficile infection in lung transplant recipients in the modern era</title><pmid><json:string>23316931</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Clinical Transplantation</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1399-0012</json:string></doi><issn><json:string>0902-0063</json:string></issn><eissn><json:string>1399-0012</json:string></eissn><publisherId><json:string>CTR</json:string></publisherId><volume>27</volume><issue>2</issue><pages><first>303</first><last>310</last><total>8</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item></subject></host><namedEntities><unitex><date><json:string>2009</json:string><json:string>2011</json:string><json:string>2005</json:string><json:string>2006 to 2011</json:string><json:string>2006</json:string><json:string>2006 to 7/2011</json:string><json:string>1999</json:string><json:string>1331</json:string><json:string>2010</json:string><json:string>1996</json:string><json:string>2012-12-03</json:string></date><geogName></geogName><orgName><json:string>Department of Surgery, University of Pittsburgh, Pittsburgh, PA</json:string><json:string>United States, Canada, and Europe</json:string><json:string>Department of Surgery, The Ohio State University, Columbus, OH, USA Key</json:string><json:string>University of Minnesota</json:string><json:string>Department of Surgery, University of Minnesota</json:string><json:string>University of Minnesota Medical Center</json:string><json:string>University of Minnesota Lung Transplant</json:string><json:string>Healthcare Research and Quality</json:string><json:string>Austria Pittsburgh, PA, USA Brussels, Belgium US</json:string><json:string>Department of Medicine, University of Minnesota, Minneapolis, MN</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Age</json:string><json:string>Jordan M. 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Whitsonc</json:string></persName><placeName><json:string>United States</json:string><json:string>Innsbruck</json:string><json:string>LA</json:string><json:string>New Orleans</json:string><json:string>USA</json:string><json:string>MN</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Boutros et al.</json:string><json:string>Pant et al.</json:string><json:string>Ali et al.</json:string><json:string>Theunissen et al.</json:string><json:string>Dallal et al.</json:string><json:string>Stelzmueller et al.</json:string><json:string>Gunderson et al.</json:string><json:string>Lee et al.</json:string><json:string>Ghantoji et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-LWX0R9LR-M</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - transplantation</json:string><json:string>2 - surgery</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - surgery</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Transplantation</json:string></scopus></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1111/ctr.12064</json:string></doi><id>93C4B396FEE7033A9BA248BAECE199C1654E061F</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/93C4B396FEE7033A9BA248BAECE199C1654E061F/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/93C4B396FEE7033A9BA248BAECE199C1654E061F/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/93C4B396FEE7033A9BA248BAECE199C1654E061F/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">The rise of <hi rend="italic"><hi rend="fc">C</hi>lostridium difficile</hi> infection in lung transplant recipients in the modern era</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Publishing Ltd</publisher><availability><licence>© 2013 John Wiley & Sons A/S.</licence></availability><date type="published" when="2013-03"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">The rise of <hi rend="italic"><hi rend="fc">C</hi>lostridium difficile</hi> infection in lung transplant recipients in the modern era</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Janet T.</forename><surname>Lee</surname></persName><affiliation><orgName>Department of Surgery</orgName><orgName>University of Minnesota</orgName><address><settlement type="city">Minneapolis</settlement><region>MN</region><country key="US">USA</country></address></affiliation><affiliation>Corresponding author: Janet T. Lee, Department of Surgery, University of Minnesota, 420 Delaware St SE, MMC 195, Minneapolis, MN 55455, USA. Tel.: +1 612 625 4377; fax: +1 612 625 4406; e‐mail: leex1203@umn.edu</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Marshall I.</forename><surname>Hertz</surname></persName><affiliation><orgName>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine</orgName><orgName>Department of Medicine</orgName><orgName>University of Minnesota</orgName><address><settlement type="city">Minneapolis</settlement><region>MN</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Jordan M.</forename><surname>Dunitz</surname></persName><affiliation><orgName>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine</orgName><orgName>Department of Medicine</orgName><orgName>University of Minnesota</orgName><address><settlement type="city">Minneapolis</settlement><region>MN</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Rosemary F.</forename><surname>Kelly</surname></persName><affiliation><orgName>Division of Cardiothoracic Surgery</orgName><orgName>Department of Surgery</orgName><orgName>University of Minnesota</orgName><address><settlement type="city">Minneapolis</settlement><region>MN</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Jonathan</forename><surname>D'Cunha</surname></persName><affiliation><orgName>Division of Cardiothoracic Surgery</orgName><orgName>Department of Surgery</orgName><orgName>University of Minnesota</orgName><address><settlement type="city">Minneapolis</settlement><region>MN</region><country key="US">USA</country></address></affiliation><affiliation><orgName>Division of Cardiothoracic Surgery</orgName><orgName>Department of Surgery</orgName><orgName>University of Pittsburgh</orgName><address><settlement type="city">Pittsburgh</settlement><region>PA</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Bryan A.</forename><surname>Whitson</surname></persName><affiliation><orgName>Division of Cardiothoracic Surgery</orgName><orgName>Department of Surgery</orgName><orgName>University of Minnesota</orgName><address><settlement type="city">Minneapolis</settlement><region>MN</region><country key="US">USA</country></address></affiliation><affiliation><orgName>Division of Cardiothoracic Surgery</orgName><orgName>Department of Surgery</orgName><orgName>The Ohio State University</orgName><address><settlement type="city">Columbus</settlement><region>OH</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Sara J.</forename><surname>Shumway</surname></persName><affiliation><orgName>Division of Cardiothoracic Surgery</orgName><orgName>Department of Surgery</orgName><orgName>University of Minnesota</orgName><address><settlement type="city">Minneapolis</settlement><region>MN</region><country key="US">USA</country></address></affiliation></author><idno type="istex">93C4B396FEE7033A9BA248BAECE199C1654E061F</idno><idno type="ark">ark:/67375/WNG-LWX0R9LR-M</idno><idno type="DOI">10.1111/ctr.12064</idno><idno type="unit">CTR12064</idno><idno type="toTypesetVersion">file:CTR.CTR12064.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Transplantation</title><title level="j" type="alt">CLINICAL TRANSPLANTATION</title><idno type="pISSN">0902-0063</idno><idno type="eISSN">1399-0012</idno><idno type="book-DOI">10.1111/(ISSN)1399-0012</idno><idno type="book-part-DOI">10.1111/ctr.2013.27.issue-2</idno><idno type="product">CTR</idno><imprint><biblScope unit="vol">27</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="303">303</biblScope><biblScope unit="page" to="310">310</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2013-03"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="ctr12064-abs-0001"><head>Abstract</head>
Purpose
<p><hi rend="italic">Clostridium difficile</hi> infection (<hi rend="fc">CDI</hi>) rates have been rising in recent years. We aimed to characterize <hi rend="fc">CDI</hi> in lung transplant recipients in the modern era and hypothesized that <hi rend="fc">CDI</hi> would increase the mortality risk.</p>
Methods
<p>We performed a retrospective chart review of patients undergoing transplantation at our center from 1/2006 to 7/2011. Attributes of <hi rend="fc">CDI</hi>+ and <hi rend="fc">CDI</hi>− groups were compared using Student's <hi rend="italic">t</hi>‐ and chi‐square tests (α = 0.05). Multivariate <hi rend="fc">C</hi>ox proportional hazard models were used to control for confounding factors.</p>
Results
<p>Overall <hi rend="fc">CDI</hi> incidence was 22.5%. Seven of 151 patients (4.6%) developed <hi rend="fc">CDI</hi> during the initial hospitalization after transplantation (mean time 10.6 ± 6 d) while 27 patients (19.7%) developed <hi rend="fc">CDI</hi> after discharge (mean time 467 ± 471 d). Incidence rate was 224.6 cases/100 000 patient‐days compared to 110 cases/100 000 patient‐days (rate for entire hospital). <hi rend="fc">CDI</hi> was not predictive of mortality (<hi rend="fc">HR</hi> 2.06, 95% <hi rend="fc">CI</hi> 0.94–4.52).</p>
Conclusion
<p><hi rend="fc">CDI</hi> rates in lung transplant recipients are high in the modern era. No risk factors for <hi rend="fc">CDI</hi> were identified. Although not statistically significant, <hi rend="fc">CDI</hi>+ patients had a higher risk of death. The economic burden of <hi rend="fc">CDI</hi> and trend toward worse outcomes for <hi rend="fc">CDI</hi> patients have important implications for post‐operative surveillance of <hi rend="fc">CDI</hi>‐related complications and need for <hi rend="fc">CDI</hi> prophylaxis.</p></abstract><textClass><keywords><term xml:id="ctr12064-kwd-0001"><hi rend="italic"><hi rend="fc">C</hi>lostridium difficile</hi></term><term xml:id="ctr12064-kwd-0002">infection</term><term xml:id="ctr12064-kwd-0003">lung transplantation</term><term xml:id="ctr12064-kwd-0004">thoracic surgery</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/93C4B396FEE7033A9BA248BAECE199C1654E061F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="ctr12064" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1399-0012</doi><issn type="print">0902-0063</issn><issn type="electronic">1399-0012</issn><idGroup><id type="product" value="CTR"></id></idGroup><titleGroup><title sort="CLINICAL TRANSPLANTATION" type="main">Clinical Transplantation</title><title type="short">Clin Transplant</title></titleGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley">10.1111/ctr.2013.27.issue-2</doi><copyright ownership="publisher">© 2013 John Wiley & Sons A/S.</copyright><numberingGroup><numbering type="journalVolume" number="27">27</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2013-03">March–April 2013</coverDate></publicationMeta><publicationMeta level="unit" position="190" status="forIssue" type="article"><doi>10.1111/ctr.12064</doi><idGroup><id type="unit" value="CTR12064"></id></idGroup><countGroup><count number="8" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">© 2013 John Wiley & Sons A/S.</copyright><eventGroup><event date="2012-11-07" type="manuscriptAccepted"></event><event agent="SPS" date="2012-12-03" type="xmlCreated"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-01-14"></event><event type="publishedOnlineFinalForm" date="2013-04-09"></event><event type="firstOnline" date="2013-01-14"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-16"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-01"></event></eventGroup><numberingGroup><numbering type="pageFirst">303</numbering><numbering type="pageLast">310</numbering></numberingGroup><correspondenceTo><lineatedText><line>Corresponding author: Janet T. Lee, Department of Surgery, University of Minnesota, 420 Delaware St SE, MMC 195, Minneapolis, MN 55455, USA.</line><line>Tel.: +1 612 625 4377; fax: +1 612 625 4406; e‐mail: <email>leex1203@umn.edu</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="ctr12064-cit-1001"><author><familyName>Lee</familyName> <givenNames>JT</givenNames></author>, <author><familyName>Hertz</familyName> <givenNames>MI</givenNames></author>, <author><familyName>Dunitz</familyName> <givenNames>JM</givenNames></author>, <author><familyName>Kelly</familyName> <givenNames>RF</givenNames></author>, <author><familyName>D'Cunha</familyName> <givenNames>J</givenNames></author>, <author><familyName>Whitson</familyName> <givenNames>BA</givenNames></author>, <author><familyName>Shumway</familyName> <givenNames>SJ</givenNames></author>. <articleTitle>The rise of <i>Clostridium difficile</i> infection in lung transplant recipients in the modern era</articleTitle>.</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:CTR.CTR12064.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">The rise of <i><fc>C</fc>lostridium difficile</i> infection in lung transplant recipients in the modern era</title><title type="shortAuthors">Lee et al.</title></titleGroup><creators><creator affiliationRef="#ctr12064-aff-0001" corresponding="yes" creatorRole="author" xml:id="ctr12064-cr-0001"><personName><givenNames>Janet T.</givenNames> <familyName>Lee</familyName></personName></creator><creator affiliationRef="#ctr12064-aff-0002" creatorRole="author" xml:id="ctr12064-cr-0002"><personName><givenNames>Marshall I.</givenNames> <familyName>Hertz</familyName></personName></creator><creator affiliationRef="#ctr12064-aff-0002" creatorRole="author" xml:id="ctr12064-cr-0003"><personName><givenNames>Jordan M.</givenNames> <familyName>Dunitz</familyName></personName></creator><creator affiliationRef="#ctr12064-aff-0003" creatorRole="author" xml:id="ctr12064-cr-0004"><personName><givenNames>Rosemary F.</givenNames> <familyName>Kelly</familyName></personName></creator><creator affiliationRef="#ctr12064-aff-0003 #ctr12064-aff-0004" creatorRole="author" xml:id="ctr12064-cr-0005"><personName><givenNames>Jonathan</givenNames> <familyName>D'Cunha</familyName></personName></creator><creator affiliationRef="#ctr12064-aff-0003 #ctr12064-aff-0005" creatorRole="author" xml:id="ctr12064-cr-0006"><personName><givenNames>Bryan A.</givenNames> <familyName>Whitson</familyName></personName></creator><creator affiliationRef="#ctr12064-aff-0003" creatorRole="author" xml:id="ctr12064-cr-0007"><personName><givenNames>Sara J.</givenNames> <familyName>Shumway</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="US" type="organization" xml:id="ctr12064-aff-0001"><orgDiv>Department of Surgery</orgDiv> <orgName>University of Minnesota</orgName> <address><city>Minneapolis</city> <countryPart>MN</countryPart><country>USA</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="ctr12064-aff-0002"><orgDiv>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine</orgDiv> <orgDiv>Department of Medicine</orgDiv> <orgName>University of Minnesota</orgName> <address><city>Minneapolis</city> <countryPart>MN</countryPart><country>USA</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="ctr12064-aff-0003"><orgDiv>Division of Cardiothoracic Surgery</orgDiv> <orgDiv>Department of Surgery</orgDiv> <orgName>University of Minnesota</orgName> <address><city>Minneapolis</city> <countryPart>MN</countryPart><country>USA</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="ctr12064-aff-0004"><orgDiv>Division of Cardiothoracic Surgery</orgDiv> <orgDiv>Department of Surgery</orgDiv> <orgName>University of Pittsburgh</orgName> <address><city>Pittsburgh</city> <countryPart>PA</countryPart><country>USA</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="ctr12064-aff-0005"><orgDiv>Division of Cardiothoracic Surgery</orgDiv> <orgDiv>Department of Surgery</orgDiv> <orgName>The Ohio State University</orgName> <address><city>Columbus</city> <countryPart>OH</countryPart> <country>USA</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="ctr12064-kwd-0001"><i><fc>C</fc>lostridium difficile</i></keyword><keyword xml:id="ctr12064-kwd-0002">infection</keyword><keyword xml:id="ctr12064-kwd-0003">lung transplantation</keyword><keyword xml:id="ctr12064-kwd-0004">thoracic surgery</keyword></keywordGroup><abstractGroup><abstract type="main" xml:id="ctr12064-abs-0001"><title type="main">Abstract</title><section xml:id="ctr12064-sec-0001"><title type="main">Purpose</title><p><i>Clostridium difficile</i> infection (<fc>CDI</fc>) rates have been rising in recent years. We aimed to characterize <fc>CDI</fc> in lung transplant recipients in the modern era and hypothesized that <fc>CDI</fc> would increase the mortality risk.</p></section><section xml:id="ctr12064-sec-0002"><title type="main">Methods</title><p>We performed a retrospective chart review of patients undergoing transplantation at our center from 1/2006 to 7/2011. Attributes of <fc>CDI</fc>+ and <fc>CDI</fc>− groups were compared using Student's <i>t</i>‐ and chi‐square tests (α = 0.05). Multivariate <fc>C</fc>ox proportional hazard models were used to control for confounding factors.</p></section><section xml:id="ctr12064-sec-0003"><title type="main">Results</title><p>Overall <fc>CDI</fc> incidence was 22.5%. Seven of 151 patients (4.6%) developed <fc>CDI</fc> during the initial hospitalization after transplantation (mean time 10.6 ± 6 d) while 27 patients (19.7%) developed <fc>CDI</fc> after discharge (mean time 467 ± 471 d). Incidence rate was 224.6 cases/100 000 patient‐days compared to 110 cases/100 000 patient‐days (rate for entire hospital). <fc>CDI</fc> was not predictive of mortality (<fc>HR</fc> 2.06, 95% <fc>CI</fc> 0.94–4.52).</p></section><section xml:id="ctr12064-sec-0004"><title type="main">Conclusion</title><p><fc>CDI</fc> rates in lung transplant recipients are high in the modern era. No risk factors for <fc>CDI</fc> were identified. Although not statistically significant, <fc>CDI</fc>+ patients had a higher risk of death. The economic burden of <fc>CDI</fc> and trend toward worse outcomes for <fc>CDI</fc> patients have important implications for post‐operative surveillance of <fc>CDI</fc>‐related complications and need for <fc>CDI</fc> prophylaxis.</p></section></abstract></abstractGroup></contentMeta><noteGroup xml:id="ctr12064-ntgp-0001"><note numbered="no" xml:id="ctr12064-note-0001">Conflict of interest: This study was not funded. The authors have no conflicts of interest to disclose.</note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The rise of Clostridium difficile infection in lung transplant recipients in the modern era</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The rise of Clostridium difficile infection in lung transplant recipients in the modern era</title></titleInfo><name type="personal"><namePart type="given">Janet T.</namePart><namePart type="family">Lee</namePart><affiliation>Department of Surgery, University of Minnesota, MN, Minneapolis, USA</affiliation><affiliation>Corresponding author: Janet T. Lee, Department of Surgery, University of Minnesota, 420 Delaware St SE, MMC 195, Minneapolis, MN 55455, USA.Tel.: +1 612 625 4377; fax: +1 612 625 4406; e‐mail:</affiliation><affiliation>E-mail: leex1203@umn.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marshall I.</namePart><namePart type="family">Hertz</namePart><affiliation>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Minnesota, MN, Minneapolis, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jordan M.</namePart><namePart type="family">Dunitz</namePart><affiliation>Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Minnesota, MN, Minneapolis, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rosemary F.</namePart><namePart type="family">Kelly</namePart><affiliation>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, MN, Minneapolis, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jonathan</namePart><namePart type="family">D'Cunha</namePart><affiliation>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN, USA</affiliation><affiliation>Division of Cardiothoracic Surgery, Department of Surgery, University of Pittsburgh, PA, Pittsburgh, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bryan A.</namePart><namePart type="family">Whitson</namePart><affiliation>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN, USA</affiliation><affiliation>Division of Cardiothoracic Surgery, Department of Surgery, The Ohio State University, OH, Columbus, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sara J.</namePart><namePart type="family">Shumway</namePart><affiliation>Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, MN, Minneapolis, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-03</dateIssued><dateCreated encoding="w3cdtf">2012-12-03</dateCreated><dateValid encoding="w3cdtf">2012-11-07</dateValid><edition>Lee JT, Hertz MI, Dunitz JM, Kelly RF, D'Cunha J, Whitson BA, Shumway SJ. The rise of Clostridium difficile infection in lung transplant recipients in the modern era.</edition><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Clostridium difficile infection (CDI) rates have been rising in recent years. We aimed to characterize CDI in lung transplant recipients in the modern era and hypothesized that CDI would increase the mortality risk.</abstract><abstract>We performed a retrospective chart review of patients undergoing transplantation at our center from 1/2006 to 7/2011. Attributes of CDI+ and CDI− groups were compared using Student's t‐ and chi‐square tests (α = 0.05). Multivariate Cox proportional hazard models were used to control for confounding factors.</abstract><abstract>Overall CDI incidence was 22.5%. Seven of 151 patients (4.6%) developed CDI during the initial hospitalization after transplantation (mean time 10.6 ± 6 d) while 27 patients (19.7%) developed CDI after discharge (mean time 467 ± 471 d). Incidence rate was 224.6 cases/100 000 patient‐days compared to 110 cases/100 000 patient‐days (rate for entire hospital). CDI was not predictive of mortality (HR 2.06, 95% CI 0.94–4.52).</abstract><abstract>CDI rates in lung transplant recipients are high in the modern era. No risk factors for CDI were identified. Although not statistically significant, CDI+ patients had a higher risk of death. The economic burden of CDI and trend toward worse outcomes for CDI patients have important implications for post‐operative surveillance of CDI‐related complications and need for CDI prophylaxis.</abstract><subject><genre>keywords</genre><topic>Clostridium difficile</topic><topic>infection</topic><topic>lung transplantation</topic><topic>thoracic surgery</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Transplantation</title></titleInfo><titleInfo type="abbreviated"><title>Clin Transplant</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0902-0063</identifier><identifier type="eISSN">1399-0012</identifier><identifier type="DOI">10.1111/(ISSN)1399-0012</identifier><identifier type="PublisherID">CTR</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>303</start><end>310</end><total>8</total></extent></part></relatedItem><identifier type="istex">93C4B396FEE7033A9BA248BAECE199C1654E061F</identifier><identifier type="ark">ark:/67375/WNG-LWX0R9LR-M</identifier><identifier type="DOI">10.1111/ctr.12064</identifier><identifier type="ArticleID">CTR12064</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2013 John Wiley & Sons A/S.© 2013 John Wiley & Sons A/S.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/93C4B396FEE7033A9BA248BAECE199C1654E061F/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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