Comparison of Splicing Factor 3b Inhibitors in Human Cells
Identifieur interne : 001B77 ( Istex/Corpus ); précédent : 001B76; suivant : 001B78Comparison of Splicing Factor 3b Inhibitors in Human Cells
Auteurs : Yang Gao ; Andreas Vogt ; Craig J. Forsyth ; Kazunori KoideSource :
- ChemBioChem [ 1439-4227 ] ; 2013-01-02.
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Abstract
Name your splice: FR901464 analogues and herboxidiene inhibit constitutive splicing, most likely by inhibiting spliceosomal subunit SF3b. A parallel comparison of these compounds in a cell‐based assay system showed meayamycin B as the most potent splicing inhibitor among these small molecules.
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DOI: 10.1002/cbic.201200558
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