Asymptomatic striatal dopamine depletion: PET scans in unilateral MPTP monkeys.
Identifieur interne : 001C86 ( PubMed/Curation ); précédent : 001C85; suivant : 001C87Asymptomatic striatal dopamine depletion: PET scans in unilateral MPTP monkeys.
Auteurs : M. Guttman [Canada] ; V W Yong ; S U Kim ; D B Calne ; W R Martin ; M J Adam ; T J RuthSource :
- Synapse (New York, N.Y.) [ 0887-4476 ] ; 1988.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Corpus Striatum (drug effects), Corpus Striatum (metabolism), Dopamine (metabolism), Functional Laterality (drug effects), Injections, Intravenous, Macaca fascicularis, Parkinson Disease, Secondary (metabolism), Pyridines (toxicity), Tomography, Emission-Computed.
- MESH :
- chemical , metabolism : Dopamine.
- chemical , toxicity : Pyridines.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- drug effects : Corpus Striatum, Functional Laterality.
- metabolism : Corpus Striatum, Parkinson Disease, Secondary.
- Animals, Injections, Intravenous, Macaca fascicularis, Tomography, Emission-Computed.
Abstract
In cynomolgus monkeys, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces irreversible clinical, chemical, and pathological alterations that are similar to those found in Parkinson's disease. Unilateral carotid injections of this toxin produce ipsilateral nigrostriatal dopamine depletion while sparing the contralateral dopaminergic pathways. In order to study the damage to the nigrostriatal dopamine system in asymptomatic animals after unilateral MPTP administration, positron emission tomography (PET) scans were performed with [18F]fluoro-L-dopa (6-FD). This study demonstrates that clinically asymptomatic MPTP lesions may be assessed in vivo using 6-FD and PET.
DOI: 10.1002/syn.890020502
PubMed: 3263709
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Unilateral carotid injections of this toxin produce ipsilateral nigrostriatal dopamine depletion while sparing the contralateral dopaminergic pathways. In order to study the damage to the nigrostriatal dopamine system in asymptomatic animals after unilateral MPTP administration, positron emission tomography (PET) scans were performed with [18F]fluoro-L-dopa (6-FD). This study demonstrates that clinically asymptomatic MPTP lesions may be assessed in vivo using 6-FD and PET.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3263709</PMID><DateCreated><Year>1988</Year><Month>12</Month><Day>21</Day></DateCreated><DateCompleted><Year>1988</Year><Month>12</Month><Day>21</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0887-4476</ISSN><JournalIssue CitedMedium="Print"><Volume>2</Volume><Issue>5</Issue><PubDate><Year>1988</Year></PubDate></JournalIssue><Title>Synapse (New York, N.Y.)</Title><ISOAbbreviation>Synapse</ISOAbbreviation></Journal><ArticleTitle>Asymptomatic striatal dopamine depletion: PET scans in unilateral MPTP monkeys.</ArticleTitle><Pagination><MedlinePgn>469-73</MedlinePgn></Pagination><Abstract><AbstractText>In cynomolgus monkeys, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces irreversible clinical, chemical, and pathological alterations that are similar to those found in Parkinson's disease. Unilateral carotid injections of this toxin produce ipsilateral nigrostriatal dopamine depletion while sparing the contralateral dopaminergic pathways. In order to study the damage to the nigrostriatal dopamine system in asymptomatic animals after unilateral MPTP administration, positron emission tomography (PET) scans were performed with [18F]fluoro-L-dopa (6-FD). 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