Brain amino acid contents are dissimilar in sporadic and Guamanian amyotrophic lateral sclerosis.
Identifieur interne : 001B60 ( PubMed/Curation ); précédent : 001B59; suivant : 001B61Brain amino acid contents are dissimilar in sporadic and Guamanian amyotrophic lateral sclerosis.
Auteurs : T L Perry [Canada] ; C. Bergeron ; J C Steele ; D R Mclachlan ; S. HansenSource :
- Journal of the neurological sciences [ 0022-510X ] ; 1990.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Amino Acids, Glutamates, Taurine, gamma-Aminobutyric Acid.
- geographic : Guam.
- metabolism : Amyotrophic Lateral Sclerosis, Brain, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Amino acid contents were measured in autopsied brains of five Guamanian patients with amyotrophic lateral sclerosis (ALS) or parkinsonism-dementia. Absence of the glutamate deficiency and taurine excess characteristic of sporadic ALS suggest that, despite clinical similarities, Guamanian ALS is a different disorder from sporadic ALS.
PubMed: 2250169
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Bergeron</name></author><author><name sortKey="Steele, J C" sort="Steele, J C" uniqKey="Steele J" first="J C" last="Steele">J C Steele</name></author><author><name sortKey="Mclachlan, D R" sort="Mclachlan, D R" uniqKey="Mclachlan D" first="D R" last="Mclachlan">D R Mclachlan</name></author><author><name sortKey="Hansen, S" sort="Hansen, S" uniqKey="Hansen S" first="S" last="Hansen">S. Hansen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:2250169</idno><idno type="pmid">2250169</idno><idno type="wicri:Area/PubMed/Corpus">001B60</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B60</idno><idno type="wicri:Area/PubMed/Curation">001B60</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Brain amino acid contents are dissimilar in sporadic and Guamanian amyotrophic lateral sclerosis.</title><author><name sortKey="Perry, T L" sort="Perry, T L" uniqKey="Perry T" first="T L" last="Perry">T L Perry</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver</wicri:regionArea></affiliation></author><author><name sortKey="Bergeron, C" sort="Bergeron, C" uniqKey="Bergeron C" first="C" last="Bergeron">C. Bergeron</name></author><author><name sortKey="Steele, J C" sort="Steele, J C" uniqKey="Steele J" first="J C" last="Steele">J C Steele</name></author><author><name sortKey="Mclachlan, D R" sort="Mclachlan, D R" uniqKey="Mclachlan D" first="D R" last="Mclachlan">D R Mclachlan</name></author><author><name sortKey="Hansen, S" sort="Hansen, S" uniqKey="Hansen S" first="S" last="Hansen">S. Hansen</name></author></analytic><series><title level="j">Journal of the neurological sciences</title><idno type="ISSN">0022-510X</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Amino Acids (metabolism)</term><term>Amyotrophic Lateral Sclerosis (metabolism)</term><term>Brain (metabolism)</term><term>Female</term><term>Glutamates (metabolism)</term><term>Guam</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (metabolism)</term><term>Taurine (metabolism)</term><term>gamma-Aminobutyric Acid (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amino Acids</term><term>Glutamates</term><term>Taurine</term><term>gamma-Aminobutyric Acid</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Guam</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Amyotrophic Lateral Sclerosis</term><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Amino acid contents were measured in autopsied brains of five Guamanian patients with amyotrophic lateral sclerosis (ALS) or parkinsonism-dementia. Absence of the glutamate deficiency and taurine excess characteristic of sporadic ALS suggest that, despite clinical similarities, Guamanian ALS is a different disorder from sporadic ALS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2250169</PMID><DateCreated><Year>1991</Year><Month>01</Month><Day>15</Day></DateCreated><DateCompleted><Year>1991</Year><Month>01</Month><Day>15</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-510X</ISSN><JournalIssue CitedMedium="Print"><Volume>99</Volume><Issue>1</Issue><PubDate><Year>1990</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of the neurological sciences</Title><ISOAbbreviation>J. Neurol. Sci.</ISOAbbreviation></Journal><ArticleTitle>Brain amino acid contents are dissimilar in sporadic and Guamanian amyotrophic lateral sclerosis.</ArticleTitle><Pagination><MedlinePgn>3-8</MedlinePgn></Pagination><Abstract><AbstractText>Amino acid contents were measured in autopsied brains of five Guamanian patients with amyotrophic lateral sclerosis (ALS) or parkinsonism-dementia. Absence of the glutamate deficiency and taurine excess characteristic of sporadic ALS suggest that, despite clinical similarities, Guamanian ALS is a different disorder from sporadic ALS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Perry</LastName><ForeName>T L</ForeName><Initials>TL</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bergeron</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Steele</LastName><ForeName>J C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>McLachlan</LastName><ForeName>D R</ForeName><Initials>DR</Initials></Author><Author ValidYN="Y"><LastName>Hansen</LastName><ForeName>S</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Neurol Sci</MedlineTA><NlmUniqueID>0375403</NlmUniqueID><ISSNLinking>0022-510X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000596">Amino Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005971">Glutamates</NameOfSubstance></Chemical><Chemical><RegistryNumber>1EQV5MLY3D</RegistryNumber><NameOfSubstance UI="D013654">Taurine</NameOfSubstance></Chemical><Chemical><RegistryNumber>56-12-2</RegistryNumber><NameOfSubstance UI="D005680">gamma-Aminobutyric Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000596" MajorTopicYN="N">Amino Acids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000690" MajorTopicYN="N">Amyotrophic Lateral Sclerosis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005971" MajorTopicYN="N">Glutamates</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006141" MajorTopicYN="N" Type="Geographic">Guam</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013654" MajorTopicYN="N">Taurine</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005680" MajorTopicYN="N">gamma-Aminobutyric Acid</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1990</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1990</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1990</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2250169</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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