Brain proteasomal function in sporadic Parkinson's disease and related disorders.
Identifieur interne : 001505 ( PubMed/Curation ); précédent : 001504; suivant : 001506Brain proteasomal function in sporadic Parkinson's disease and related disorders.
Auteurs : Yoshiaki Furukawa [Canada] ; Sophie Vigouroux ; Henry Wong ; Mark Guttman ; Ali H. Rajput ; Lee Ang ; Marièle Briand ; Stephen J. Kish ; Yves BriandSource :
- Annals of neurology [ 0364-5134 ] ; 2002.
English descriptors
- KwdEn :
- Aged, Brain (enzymology), Brain (physiology), Cysteine Endopeptidases (genetics), Cysteine Endopeptidases (metabolism), Humans, Multienzyme Complexes (genetics), Multienzyme Complexes (metabolism), Multiple System Atrophy (enzymology), Multiple System Atrophy (genetics), Parkinson Disease (enzymology), Parkinson Disease (genetics), Peptide Hydrolases (metabolism), Proteasome Endopeptidase Complex, Supranuclear Palsy, Progressive (enzymology), Supranuclear Palsy, Progressive (genetics).
- MESH :
- chemical , genetics : Cysteine Endopeptidases, Multienzyme Complexes.
- enzymology : Brain, Multiple System Atrophy, Parkinson Disease, Supranuclear Palsy, Progressive.
- genetics : Multiple System Atrophy, Parkinson Disease, Supranuclear Palsy, Progressive.
- chemical , metabolism : Cysteine Endopeptidases, Multienzyme Complexes, Peptide Hydrolases.
- physiology : Brain.
- Aged, Humans, Proteasome Endopeptidase Complex.
Abstract
Because genetic defects relating to the ubiquitin-proteasome system were reported in familial parkinsonism, we evaluated proteasomal function in autopsied brains with sporadic Parkinson's disease. We found that proteasome peptidase activities in a fraction specific to the proteasome were preserved in five brain areas (including the striatum) of Parkinson's disease where neuronal loss is not observed. Striatal protein levels of two proteasome subunits were normal in Parkinson's disease but reduced mildly in disease controls (multiple system atrophy). Our brain data suggest that a systemic, global disturbance in the catalytic activity and degradation ability of the proteasome itself is unlikely to explain the cause of Parkinson's disease.
DOI: 10.1002/ana.10207
PubMed: 12112087
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001505
Links to Exploration step
pubmed:12112087Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain proteasomal function in sporadic Parkinson's disease and related disorders.</title><author><name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division, 250 College Street, Toronto, Ontario, Canada M5T 1R8. yoshiaki_furukawa@camh.net</nlm:affiliation><country>Canada</country><wicri:regionArea>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division, 250 College Street, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Vigouroux, Sophie" sort="Vigouroux, Sophie" uniqKey="Vigouroux S" first="Sophie" last="Vigouroux">Sophie Vigouroux</name></author><author><name sortKey="Wong, Henry" sort="Wong, Henry" uniqKey="Wong H" first="Henry" last="Wong">Henry Wong</name></author><author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name></author><author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H" last="Rajput">Ali H. Rajput</name></author><author><name sortKey="Ang, Lee" sort="Ang, Lee" uniqKey="Ang L" first="Lee" last="Ang">Lee Ang</name></author><author><name sortKey="Briand, Mariele" sort="Briand, Mariele" uniqKey="Briand M" first="Marièle" last="Briand">Marièle Briand</name></author><author><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J" last="Kish">Stephen J. Kish</name></author><author><name sortKey="Briand, Yves" sort="Briand, Yves" uniqKey="Briand Y" first="Yves" last="Briand">Yves Briand</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:12112087</idno><idno type="pmid">12112087</idno><idno type="doi">10.1002/ana.10207</idno><idno type="wicri:Area/PubMed/Corpus">001505</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001505</idno><idno type="wicri:Area/PubMed/Curation">001505</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001505</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Brain proteasomal function in sporadic Parkinson's disease and related disorders.</title><author><name sortKey="Furukawa, Yoshiaki" sort="Furukawa, Yoshiaki" uniqKey="Furukawa Y" first="Yoshiaki" last="Furukawa">Yoshiaki Furukawa</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division, 250 College Street, Toronto, Ontario, Canada M5T 1R8. yoshiaki_furukawa@camh.net</nlm:affiliation><country>Canada</country><wicri:regionArea>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division, 250 College Street, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Vigouroux, Sophie" sort="Vigouroux, Sophie" uniqKey="Vigouroux S" first="Sophie" last="Vigouroux">Sophie Vigouroux</name></author><author><name sortKey="Wong, Henry" sort="Wong, Henry" uniqKey="Wong H" first="Henry" last="Wong">Henry Wong</name></author><author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name></author><author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H" last="Rajput">Ali H. Rajput</name></author><author><name sortKey="Ang, Lee" sort="Ang, Lee" uniqKey="Ang L" first="Lee" last="Ang">Lee Ang</name></author><author><name sortKey="Briand, Mariele" sort="Briand, Mariele" uniqKey="Briand M" first="Marièle" last="Briand">Marièle Briand</name></author><author><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J" last="Kish">Stephen J. Kish</name></author><author><name sortKey="Briand, Yves" sort="Briand, Yves" uniqKey="Briand Y" first="Yves" last="Briand">Yves Briand</name></author></analytic><series><title level="j">Annals of neurology</title><idno type="ISSN">0364-5134</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain (enzymology)</term><term>Brain (physiology)</term><term>Cysteine Endopeptidases (genetics)</term><term>Cysteine Endopeptidases (metabolism)</term><term>Humans</term><term>Multienzyme Complexes (genetics)</term><term>Multienzyme Complexes (metabolism)</term><term>Multiple System Atrophy (enzymology)</term><term>Multiple System Atrophy (genetics)</term><term>Parkinson Disease (enzymology)</term><term>Parkinson Disease (genetics)</term><term>Peptide Hydrolases (metabolism)</term><term>Proteasome Endopeptidase Complex</term><term>Supranuclear Palsy, Progressive (enzymology)</term><term>Supranuclear Palsy, Progressive (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cysteine Endopeptidases</term><term>Multienzyme Complexes</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Brain</term><term>Multiple System Atrophy</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cysteine Endopeptidases</term><term>Multienzyme Complexes</term><term>Peptide Hydrolases</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Proteasome Endopeptidase Complex</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Because genetic defects relating to the ubiquitin-proteasome system were reported in familial parkinsonism, we evaluated proteasomal function in autopsied brains with sporadic Parkinson's disease. We found that proteasome peptidase activities in a fraction specific to the proteasome were preserved in five brain areas (including the striatum) of Parkinson's disease where neuronal loss is not observed. Striatal protein levels of two proteasome subunits were normal in Parkinson's disease but reduced mildly in disease controls (multiple system atrophy). Our brain data suggest that a systemic, global disturbance in the catalytic activity and degradation ability of the proteasome itself is unlikely to explain the cause of Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12112087</PMID><DateCreated><Year>2002</Year><Month>07</Month><Day>11</Day></DateCreated><DateCompleted><Year>2002</Year><Month>08</Month><Day>09</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0364-5134</ISSN><JournalIssue CitedMedium="Print"><Volume>51</Volume><Issue>6</Issue><PubDate><Year>2002</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Annals of neurology</Title><ISOAbbreviation>Ann. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Brain proteasomal function in sporadic Parkinson's disease and related disorders.</ArticleTitle><Pagination><MedlinePgn>779-82</MedlinePgn></Pagination><Abstract><AbstractText>Because genetic defects relating to the ubiquitin-proteasome system were reported in familial parkinsonism, we evaluated proteasomal function in autopsied brains with sporadic Parkinson's disease. We found that proteasome peptidase activities in a fraction specific to the proteasome were preserved in five brain areas (including the striatum) of Parkinson's disease where neuronal loss is not observed. Striatal protein levels of two proteasome subunits were normal in Parkinson's disease but reduced mildly in disease controls (multiple system atrophy). Our brain data suggest that a systemic, global disturbance in the catalytic activity and degradation ability of the proteasome itself is unlikely to explain the cause of Parkinson's disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Furukawa</LastName><ForeName>Yoshiaki</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Movement Disorders Research Laboratory, Centre for Addiction and Mental Health-Clarke Division, 250 College Street, Toronto, Ontario, Canada M5T 1R8. yoshiaki_furukawa@camh.net</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vigouroux</LastName><ForeName>Sophie</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Henry</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Guttman</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Rajput</LastName><ForeName>Ali H</ForeName><Initials>AH</Initials></Author><Author ValidYN="Y"><LastName>Ang</LastName><ForeName>Lee</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Briand</LastName><ForeName>Marièle</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kish</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials></Author><Author ValidYN="Y"><LastName>Briand</LastName><ForeName>Yves</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann Neurol</MedlineTA><NlmUniqueID>7707449</NlmUniqueID><ISSNLinking>0364-5134</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009097">Multienzyme Complexes</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.-</RegistryNumber><NameOfSubstance UI="D010447">Peptide Hydrolases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber><NameOfSubstance UI="D003546">Cysteine Endopeptidases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.25.1</RegistryNumber><NameOfSubstance UI="D046988">Proteasome Endopeptidase Complex</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003546" MajorTopicYN="N">Cysteine Endopeptidases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009097" MajorTopicYN="N">Multienzyme Complexes</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019578" MajorTopicYN="N">Multiple System Atrophy</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010447" MajorTopicYN="N">Peptide Hydrolases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D046988" MajorTopicYN="N">Proteasome Endopeptidase Complex</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013494" MajorTopicYN="N">Supranuclear Palsy, Progressive</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>7</Month><Day>12</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>8</Month><Day>10</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>7</Month><Day>12</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12112087</ArticleId><ArticleId IdType="doi">10.1002/ana.10207</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001505 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001505 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:12112087
|texte= Brain proteasomal function in sporadic Parkinson's disease and related disorders.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:12112087" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |