Cortical activity in Parkinson's disease during executive processing depends on striatal involvement.
Identifieur interne : 001100 ( PubMed/Curation ); précédent : 001099; suivant : 001101Cortical activity in Parkinson's disease during executive processing depends on striatal involvement.
Auteurs : Oury Monchi [Canada] ; Michael Petrides ; Beatriz Mejia-Constain ; Antonio P. StrafellaSource :
- Brain : a journal of neurology [ 1460-2156 ] ; 2007.
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Caudate Nucleus (pathology), Caudate Nucleus (physiopathology), Cerebral Cortex (pathology), Cerebral Cortex (physiopathology), Cognition (physiology), Humans, Magnetic Resonance Imaging (methods), Middle Aged, Motor Cortex (pathology), Motor Cortex (physiopathology), Occipital Lobe (pathology), Occipital Lobe (physiopathology), Parietal Lobe (pathology), Parietal Lobe (physiopathology), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Prefrontal Cortex (pathology), Prefrontal Cortex (physiopathology), Psychological Tests, Reaction Time.
- MESH :
- methods : Magnetic Resonance Imaging.
- pathology : Caudate Nucleus, Cerebral Cortex, Motor Cortex, Occipital Lobe, Parietal Lobe, Parkinson Disease, Prefrontal Cortex.
- physiology : Cognition.
- physiopathology : Caudate Nucleus, Cerebral Cortex, Motor Cortex, Occipital Lobe, Parietal Lobe, Parkinson Disease, Prefrontal Cortex.
- Aged, Case-Control Studies, Humans, Middle Aged, Psychological Tests, Reaction Time.
Abstract
Patients with idiopathic Parkinson's disease exhibit impairments in executive processes, including planning and set-shifting, even at the early stages of the disease. We have recently developed a new card-sorting task to study the specific role of the caudate nucleus in such executive processes and have shown, using functional magnetic resonance imaging (fMRI) in young healthy adults, that the caudate nucleus is specifically required when a set-shift must be planned. Here the same fMRI protocol was used to compare the patterns of activation in a group of early-stage Parkinson's disease patients (seven right-handed patients at Hoehn and Yahr stages 1 and 2; mean age 62 years, range 56-70) and matched control subjects. Increased cortical activation was observed in the patients compared with the control group in the condition not specifically requiring the caudate nucleus. On the other hand, decreased cortical activation was observed in the patient group in the condition significantly involving the caudate nucleus. This event-related fMRI study showed a pattern of cortical activation in Parkinson's disease characterized by either reduced or increased activation depending on whether the caudate nucleus was involved or not in the task. This activation pattern included not only the prefrontal regions but also posterior cortical areas in the parietal and prestriate cortex. These findings are not in agreement with the traditional model, which proposes that the nigrostriatal dopamine depletion results in decreased cortical activity. These observations provide further evidence in favour of the hypothesis that not only the nigrostriatal and but also the mesocortical dopaminergic substrate may play a significant role in the cognitive deficits observed in Parkinson's disease.
DOI: 10.1093/brain/awl326
PubMed: 17121746
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Strafella</name></author></analytic><series><title level="j">Brain : a journal of neurology</title><idno type="eISSN">1460-2156</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Caudate Nucleus (pathology)</term><term>Caudate Nucleus (physiopathology)</term><term>Cerebral Cortex (pathology)</term><term>Cerebral Cortex (physiopathology)</term><term>Cognition (physiology)</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Middle Aged</term><term>Motor Cortex (pathology)</term><term>Motor Cortex (physiopathology)</term><term>Occipital Lobe (pathology)</term><term>Occipital Lobe (physiopathology)</term><term>Parietal Lobe (pathology)</term><term>Parietal Lobe (physiopathology)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Prefrontal Cortex (pathology)</term><term>Prefrontal Cortex (physiopathology)</term><term>Psychological Tests</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Caudate Nucleus</term><term>Cerebral Cortex</term><term>Motor Cortex</term><term>Occipital Lobe</term><term>Parietal Lobe</term><term>Parkinson Disease</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Caudate Nucleus</term><term>Cerebral Cortex</term><term>Motor Cortex</term><term>Occipital Lobe</term><term>Parietal Lobe</term><term>Parkinson Disease</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Humans</term><term>Middle Aged</term><term>Psychological Tests</term><term>Reaction Time</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with idiopathic Parkinson's disease exhibit impairments in executive processes, including planning and set-shifting, even at the early stages of the disease. We have recently developed a new card-sorting task to study the specific role of the caudate nucleus in such executive processes and have shown, using functional magnetic resonance imaging (fMRI) in young healthy adults, that the caudate nucleus is specifically required when a set-shift must be planned. Here the same fMRI protocol was used to compare the patterns of activation in a group of early-stage Parkinson's disease patients (seven right-handed patients at Hoehn and Yahr stages 1 and 2; mean age 62 years, range 56-70) and matched control subjects. Increased cortical activation was observed in the patients compared with the control group in the condition not specifically requiring the caudate nucleus. On the other hand, decreased cortical activation was observed in the patient group in the condition significantly involving the caudate nucleus. This event-related fMRI study showed a pattern of cortical activation in Parkinson's disease characterized by either reduced or increased activation depending on whether the caudate nucleus was involved or not in the task. This activation pattern included not only the prefrontal regions but also posterior cortical areas in the parietal and prestriate cortex. These findings are not in agreement with the traditional model, which proposes that the nigrostriatal dopamine depletion results in decreased cortical activity. These observations provide further evidence in favour of the hypothesis that not only the nigrostriatal and but also the mesocortical dopaminergic substrate may play a significant role in the cognitive deficits observed in Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17121746</PMID><DateCreated><Year>2006</Year><Month>12</Month><Day>20</Day></DateCreated><DateCompleted><Year>2007</Year><Month>02</Month><Day>01</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-2156</ISSN><JournalIssue CitedMedium="Internet"><Volume>130</Volume><Issue>Pt 1</Issue><PubDate><Year>2007</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Brain : a journal of neurology</Title><ISOAbbreviation>Brain</ISOAbbreviation></Journal><ArticleTitle>Cortical activity in Parkinson's disease during executive processing depends on striatal involvement.</ArticleTitle><Pagination><MedlinePgn>233-44</MedlinePgn></Pagination><Abstract><AbstractText>Patients with idiopathic Parkinson's disease exhibit impairments in executive processes, including planning and set-shifting, even at the early stages of the disease. We have recently developed a new card-sorting task to study the specific role of the caudate nucleus in such executive processes and have shown, using functional magnetic resonance imaging (fMRI) in young healthy adults, that the caudate nucleus is specifically required when a set-shift must be planned. Here the same fMRI protocol was used to compare the patterns of activation in a group of early-stage Parkinson's disease patients (seven right-handed patients at Hoehn and Yahr stages 1 and 2; mean age 62 years, range 56-70) and matched control subjects. Increased cortical activation was observed in the patients compared with the control group in the condition not specifically requiring the caudate nucleus. On the other hand, decreased cortical activation was observed in the patient group in the condition significantly involving the caudate nucleus. This event-related fMRI study showed a pattern of cortical activation in Parkinson's disease characterized by either reduced or increased activation depending on whether the caudate nucleus was involved or not in the task. This activation pattern included not only the prefrontal regions but also posterior cortical areas in the parietal and prestriate cortex. These findings are not in agreement with the traditional model, which proposes that the nigrostriatal dopamine depletion results in decreased cortical activity. These observations provide further evidence in favour of the hypothesis that not only the nigrostriatal and but also the mesocortical dopaminergic substrate may play a significant role in the cognitive deficits observed in Parkinson's disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Monchi</LastName><ForeName>Oury</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Functional Neuroimaging Unit, Research Centre, Institut Universitaire de Gériatrie de Montréal, Montreal, Quebec, Canada. oury.monchi@umontreal.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petrides</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Mejia-Constain</LastName><ForeName>Beatriz</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Strafella</LastName><ForeName>Antonio P</ForeName><Initials>AP</Initials></Author></AuthorList><Language>eng</Language><GrantList 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