ParkinsonCanadaV1, PubMed, Curation, bibRecord, 000E99

Overview of the extranigral aspects of Parkinson disease.

Identifieur interne : 000E99 ( PubMed/Curation ); précédent : 000E98; suivant : 000F00

Overview of the extranigral aspects of Parkinson disease.

Auteurs : Shen-Yang Lim [Canada] ; Susan H. Fox ; Anthony E. Lang

Source :

Archives of neurology [ 1538-3687 ] ; 2009.

RBID : pubmed:19204152

English descriptors

KwdEn :
- Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Autonomic Nervous System Diseases (etiology), Autonomic Nervous System Diseases (pathology), Autonomic Nervous System Diseases (physiopathology), Brain (pathology), Brain (physiopathology), Disease Progression, Humans, Lewy Bodies (metabolism), Lewy Bodies (pathology), Nerve Degeneration (pathology), Nerve Degeneration (physiopathology), Neural Pathways (pathology), Neural Pathways (physiopathology), Neurons (metabolism), Neurons (pathology), Neurotransmitter Agents (metabolism), Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson Disease (physiopathology).
MESH :
- chemical , metabolism : Neurotransmitter Agents.
- chemical , pharmacology : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- complications : Parkinson Disease.
- etiology : Autonomic Nervous System Diseases.
- metabolism : Lewy Bodies, Neurons.
- pathology : Autonomic Nervous System Diseases, Brain, Lewy Bodies, Nerve Degeneration, Neural Pathways, Neurons, Parkinson Disease.
- physiopathology : Autonomic Nervous System Diseases, Brain, Nerve Degeneration, Neural Pathways, Parkinson Disease.
- Disease Progression, Humans.

Abstract

In recent years, there has been increasing recognition of the features of Parkinson disease that are not related to nigrostriatal dopamine deficiency. This review addresses selected clinical, anatomic, pathologic, and biochemical correlates of the early premotor symptoms of Parkinson disease, later nonmotor fluctuations, and advanced dopa-unresponsive motor and nonmotor features. The recognition of early features that predate classic motor symptoms will be important as effective neuroprotective therapy becomes available. Later-stage features often contribute markedly to disability and impaired quality of life and, therefore, represent an important future therapeutic challenge.

DOI: 10.1001/archneurol.2008.561
PubMed: 19204152

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pubmed:19204152

Le document en format XML

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<author><name sortKey="Lim, Shen Yang" sort="Lim, Shen Yang" uniqKey="Lim S" first="Shen-Yang" last="Lim">Shen-Yang Lim</name>
<affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre, Toronto Western Hospital, 399 Bathurst St, Toronto, Ontario M5T 2S8, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
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<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name>
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<term>Antiparkinson Agents (therapeutic use)</term>
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<term>Autonomic Nervous System Diseases (pathology)</term>
<term>Autonomic Nervous System Diseases (physiopathology)</term>
<term>Brain (pathology)</term>
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<term>Lewy Bodies (metabolism)</term>
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<term>Nerve Degeneration (physiopathology)</term>
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<front><div type="abstract" xml:lang="en">In recent years, there has been increasing recognition of the features of Parkinson disease that are not related to nigrostriatal dopamine deficiency. This review addresses selected clinical, anatomic, pathologic, and biochemical correlates of the early premotor symptoms of Parkinson disease, later nonmotor fluctuations, and advanced dopa-unresponsive motor and nonmotor features. The recognition of early features that predate classic motor symptoms will be important as effective neuroprotective therapy becomes available. Later-stage features often contribute markedly to disability and impaired quality of life and, therefore, represent an important future therapeutic challenge.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Overview of the extranigral aspects of Parkinson disease.

Overview of the extranigral aspects of Parkinson disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki