Trial designs used to study neuroprotective therapy in Parkinson's disease.
Identifieur interne : 000988 ( PubMed/Curation ); précédent : 000987; suivant : 000989Trial designs used to study neuroprotective therapy in Parkinson's disease.
Auteurs : Anthony E. Lang [Canada] ; Eldad Melamed ; Werner Poewe ; Olivier RascolSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Neuroprotective Agents.
- drug therapy : Parkinson Disease.
- methods : Clinical Trials as Topic.
- Animals, Drug Evaluation, Preclinical, Humans, Research Design.
Abstract
There have been numerous trials conducted to evaluate putative disease-modifying or neuroprotective treatments in Parkinson's disease. These trials have used several different study designs and outcome measures. Each of these has its own strengths and weaknesses. Confounding all studies is the potential symptomatic benefit that the treatment might have on the features of Parkinson's disease. In addition, patient-related factors such as age of onset and the nature of the dominant symptoms may have important impacts that are often not addressed. Here we provide an overview of the various trial designs that have been used and emphasize the challenges faced in attempting to study neuroprotection in Parkinson's disease and the advances needed before this goal can be successfully achieved.
DOI: 10.1002/mds.24997
PubMed: 22927060
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pubmed:22927060Le document en format XML
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<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name>
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<front><div type="abstract" xml:lang="en">There have been numerous trials conducted to evaluate putative disease-modifying or neuroprotective treatments in Parkinson's disease. These trials have used several different study designs and outcome measures. Each of these has its own strengths and weaknesses. Confounding all studies is the potential symptomatic benefit that the treatment might have on the features of Parkinson's disease. In addition, patient-related factors such as age of onset and the nature of the dominant symptoms may have important impacts that are often not addressed. Here we provide an overview of the various trial designs that have been used and emphasize the challenges faced in attempting to study neuroprotection in Parkinson's disease and the advances needed before this goal can be successfully achieved.</div>
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<CopyrightInformation>Copyright © 2013 Movement Disorders Society.</CopyrightInformation>
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