Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson's patients leukocytes.
Identifieur interne : 000890 ( PubMed/Curation ); précédent : 000889; suivant : 000891Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson's patients leukocytes.
Auteurs : Lilach Soreq [Israël] ; Hagai Bergman ; Zvi Israel ; Hermona SoreqSource :
- BMC genomics [ 1471-2164 ] ; 2013.
English descriptors
- KwdEn :
- Alternative Splicing, Case-Control Studies, Deep Brain Stimulation, Disease Progression, Humans, Leukocytes (metabolism), Male, Models, Molecular, Nonsense Mediated mRNA Decay, Parkinson Disease (blood), Parkinson Disease (genetics), Parkinson Disease (therapy), Protein Conformation, RNA, Messenger (genetics).
- MESH :
- chemical , genetics : RNA, Messenger.
- blood : Parkinson Disease.
- genetics : Parkinson Disease.
- metabolism : Leukocytes.
- therapy : Parkinson Disease.
- Alternative Splicing, Case-Control Studies, Deep Brain Stimulation, Disease Progression, Humans, Male, Models, Molecular, Nonsense Mediated mRNA Decay, Protein Conformation.
Abstract
Nonsense-Mediated decay (NMD) selectively degrades mRNA transcripts that carry premature stop codons. NMD is often triggered by alternative splicing (AS) modifications introducing such codons. NMD plays an important regulatory role in brain neurons, but the in vivo dynamics of AS and NMD changes in neurological diseases and under treatment were scarcely explored.
DOI: 10.1186/1471-2164-14-478
PubMed: 23865419
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pubmed:23865419Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson's patients leukocytes.</title><author><name sortKey="Soreq, Lilach" sort="Soreq, Lilach" uniqKey="Soreq L" first="Lilach" last="Soreq">Lilach Soreq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem</wicri:regionArea></affiliation></author><author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name></author><author><name sortKey="Israel, Zvi" sort="Israel, Zvi" uniqKey="Israel Z" first="Zvi" last="Israel">Zvi Israel</name></author><author><name sortKey="Soreq, Hermona" sort="Soreq, Hermona" uniqKey="Soreq H" first="Hermona" last="Soreq">Hermona Soreq</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23865419</idno><idno type="pmid">23865419</idno><idno type="doi">10.1186/1471-2164-14-478</idno><idno type="wicri:Area/PubMed/Corpus">000890</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000890</idno><idno type="wicri:Area/PubMed/Curation">000890</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000890</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson's patients leukocytes.</title><author><name sortKey="Soreq, Lilach" sort="Soreq, Lilach" uniqKey="Soreq L" first="Lilach" last="Soreq">Lilach Soreq</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem</wicri:regionArea></affiliation></author><author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name></author><author><name sortKey="Israel, Zvi" sort="Israel, Zvi" uniqKey="Israel Z" first="Zvi" last="Israel">Zvi Israel</name></author><author><name sortKey="Soreq, Hermona" sort="Soreq, Hermona" uniqKey="Soreq H" first="Hermona" last="Soreq">Hermona Soreq</name></author></analytic><series><title level="j">BMC genomics</title><idno type="eISSN">1471-2164</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alternative Splicing</term><term>Case-Control Studies</term><term>Deep Brain Stimulation</term><term>Disease Progression</term><term>Humans</term><term>Leukocytes (metabolism)</term><term>Male</term><term>Models, Molecular</term><term>Nonsense Mediated mRNA Decay</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (therapy)</term><term>Protein Conformation</term><term>RNA, Messenger (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alternative Splicing</term><term>Case-Control Studies</term><term>Deep Brain Stimulation</term><term>Disease Progression</term><term>Humans</term><term>Male</term><term>Models, Molecular</term><term>Nonsense Mediated mRNA Decay</term><term>Protein Conformation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nonsense-Mediated decay (NMD) selectively degrades mRNA transcripts that carry premature stop codons. NMD is often triggered by alternative splicing (AS) modifications introducing such codons. NMD plays an important regulatory role in brain neurons, but the in vivo dynamics of AS and NMD changes in neurological diseases and under treatment were scarcely explored.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23865419</PMID><DateCreated><Year>2013</Year><Month>07</Month><Day>26</Day></DateCreated><DateCompleted><Year>2013</Year><Month>10</Month><Day>30</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2164</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><PubDate><Year>2013</Year><Month>Jul</Month><Day>16</Day></PubDate></JournalIssue><Title>BMC genomics</Title><ISOAbbreviation>BMC Genomics</ISOAbbreviation></Journal><ArticleTitle>Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson's patients leukocytes.</ArticleTitle><Pagination><MedlinePgn>478</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1471-2164-14-478</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Nonsense-Mediated decay (NMD) selectively degrades mRNA transcripts that carry premature stop codons. NMD is often triggered by alternative splicing (AS) modifications introducing such codons. NMD plays an important regulatory role in brain neurons, but the in vivo dynamics of AS and NMD changes in neurological diseases and under treatment were scarcely explored.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Here, we report exon arrays analysis of leukocyte mRNA AS events prior to and following Deep Brain Stimulation (DBS) neurosurgery, which efficiently improves the motor symptoms of Parkinson's disease (PD), the leading movement disorder, and is increasingly applied to treat other diseases. We also analyzed publicly available exon array dataset of whole blood cells from mixed early and advanced PD patients. Our in-house exon array dataset of leukocyte transcripts was derived from advanced PD patients' pre- and post-DBS stimulation and matched healthy control volunteers. The mixed cohort exhibited 146 AS changes in 136 transcripts compared to controls, including 9 NMD protein-level assessed events. In comparison, PD patients from our advanced cohort differed from healthy controls by 319 AS events in 280 transcripts, assessed as inducing 27 protein-level NMD events. DBS stimulation induced 254 AS events in 229 genes as compared to the pre-DBS state including 44 NMD inductions. A short, one hour electrical stimulus cessation caused 234 AS changes in 125 genes compared to ON-stimulus state, 22 of these were assessed for NMD. Functional analysis highlighted disease-induced DNA damage and inflammatory control and its reversal under ON and OFF stimulus as well as alternative splicing in all the tested states.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The study findings indicate a potential role for NMD both in PD and following electrical brain stimulation. Furthermore, our current observations entail future implications for developing therapies for PD, and for interfering with the impaired molecular mechanisms that underlie PD and other neurodegenerative and neurological disorders, as well as DBS-treatable conditions in general.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Soreq</LastName><ForeName>Lilach</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bergman</LastName><ForeName>Hagai</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Israel</LastName><ForeName>Zvi</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Soreq</LastName><ForeName>Hermona</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GEO</DataBankName><AccessionNumberList><AccessionNumber>GSE18838</AccessionNumber><AccessionNumber>GSE23676</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>07</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Genomics</MedlineTA><NlmUniqueID>100965258</NlmUniqueID><ISSNLinking>1471-2164</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, 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2008 May;40(5):572-4</RefSource><PMID Version="1">18372902</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D017398" MajorTopicYN="N">Alternative Splicing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046690" MajorTopicYN="Y">Deep Brain Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007962" MajorTopicYN="N">Leukocytes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059365" MajorTopicYN="Y">Nonsense Mediated mRNA Decay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011487" MajorTopicYN="N">Protein Conformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3723527</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>10</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>07</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>7</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>7</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>10</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23865419</ArticleId><ArticleId IdType="pii">1471-2164-14-478</ArticleId><ArticleId IdType="doi">10.1186/1471-2164-14-478</ArticleId><ArticleId IdType="pmc">PMC3723527</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson's patients leukocytes.
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