Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.
Identifieur interne : 000850 ( PubMed/Curation ); précédent : 000849; suivant : 000851Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.
Auteurs : Hongliu Ding [Canada] ; Kaltra Dhima ; Kaitlin C. Lockhart ; Joseph J. Locascio ; Ashley N. Hoesing ; Karen Duong ; Ana Trisini-Lipsanopoulos ; Michael T. Hayes ; U Shivraj Sohur ; Anne-Marie Wills ; Brit Mollenhauer ; Alice W. Flaherty ; Albert Y. Hung ; Nicte Mejia ; Vikram Khurana ; Stephen N. Gomperts ; Dennis J. Selkoe ; Michael A. Schwarzschild ; Michael G. Schlossmacher ; Bradley T. Hyman ; Lewis R. Sudarsky ; John H. Growdon ; Clemens R. ScherzerSource :
- Neurology [ 1526-632X ] ; 2013.
English descriptors
- KwdEn :
- Aged, Biomarkers (metabolism), Case-Control Studies, Cholecalciferol (deficiency), Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson Disease (etiology), Parkinson Disease (metabolism), Prevalence, Severity of Illness Index, Vitamin D Deficiency (complications), Vitamin D Deficiency (diagnosis).
- MESH :
- chemical , deficiency : Cholecalciferol.
- chemical , metabolism : Biomarkers.
- complications : Vitamin D Deficiency.
- diagnosis : Vitamin D Deficiency.
- etiology : Parkinson Disease.
- metabolism : Parkinson Disease.
- Aged, Case-Control Studies, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Prevalence, Severity of Illness Index.
Abstract
To conclusively test for a specific association between the biological marker 25-hydroxy-vitamin D3, a transcriptionally active hormone produced in human skin and liver, and the prevalence and severity of Parkinson disease (PD).
DOI: 10.1212/WNL.0b013e3182a95818
PubMed: 24068787
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<author><name sortKey="Ding, Hongliu" sort="Ding, Hongliu" uniqKey="Ding H" first="Hongliu" last="Ding">Hongliu Ding</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Neurogenomics Laboratory (H.D., K.D., K.C.L., A.N.H., K.D., A.T.-L., C.R.S.), Harvard Medical School and Brigham & Women's Hospital, Cambridge; Biomarkers Program (K.D., K.C.L., A.N.H., K.D., A.T.-L., M.T.H., U.S.S., B.M., N.M., V.K., S.N.G., D.J.S., M.A.S., M.G.S., B.T.H., J.H.G., C.R.S.), Harvard NeuroDiscovery Center, Boston; Department of Neurology (J.J.L., U.S.S., A.-M.W., A.W.F., A.Y.H., N.M., V.K., S.N.G., M.A.S., B.T.H., J.H.G., C.R.S.), Massachusetts General Hospital, Boston; Department of Neurology (M.T.H., A.Y.H., D.J.S., L.R.S., C.R.S.), Brigham and Women's Hospital, Boston, MA; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; and Division of Neurology, the Ottawa Hospital, University of Ottawa (M.G.S.), Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>From the Neurogenomics Laboratory (H.D., K.D., K.C.L., A.N.H., K.D., A.T.-L., C.R.S.), Harvard Medical School and Brigham & Women's Hospital, Cambridge; Biomarkers Program (K.D., K.C.L., A.N.H., K.D., A.T.-L., M.T.H., U.S.S., B.M., N.M., V.K., S.N.G., D.J.S., M.A.S., M.G.S., B.T.H., J.H.G., C.R.S.), Harvard NeuroDiscovery Center, Boston; Department of Neurology (J.J.L., U.S.S., A.-M.W., A.W.F., A.Y.H., N.M., V.K., S.N.G., M.A.S., B.T.H., J.H.G., C.R.S.), Massachusetts General Hospital, Boston; Department of Neurology (M.T.H., A.Y.H., D.J.S., L.R.S., C.R.S.), Brigham and Women's Hospital, Boston, MA; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; and Division of Neurology, the Ottawa Hospital, University of Ottawa (M.G.S.)</wicri:regionArea>
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<author><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name>
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<author><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.</title>
<author><name sortKey="Ding, Hongliu" sort="Ding, Hongliu" uniqKey="Ding H" first="Hongliu" last="Ding">Hongliu Ding</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Neurogenomics Laboratory (H.D., K.D., K.C.L., A.N.H., K.D., A.T.-L., C.R.S.), Harvard Medical School and Brigham & Women's Hospital, Cambridge; Biomarkers Program (K.D., K.C.L., A.N.H., K.D., A.T.-L., M.T.H., U.S.S., B.M., N.M., V.K., S.N.G., D.J.S., M.A.S., M.G.S., B.T.H., J.H.G., C.R.S.), Harvard NeuroDiscovery Center, Boston; Department of Neurology (J.J.L., U.S.S., A.-M.W., A.W.F., A.Y.H., N.M., V.K., S.N.G., M.A.S., B.T.H., J.H.G., C.R.S.), Massachusetts General Hospital, Boston; Department of Neurology (M.T.H., A.Y.H., D.J.S., L.R.S., C.R.S.), Brigham and Women's Hospital, Boston, MA; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; and Division of Neurology, the Ottawa Hospital, University of Ottawa (M.G.S.), Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>From the Neurogenomics Laboratory (H.D., K.D., K.C.L., A.N.H., K.D., A.T.-L., C.R.S.), Harvard Medical School and Brigham & Women's Hospital, Cambridge; Biomarkers Program (K.D., K.C.L., A.N.H., K.D., A.T.-L., M.T.H., U.S.S., B.M., N.M., V.K., S.N.G., D.J.S., M.A.S., M.G.S., B.T.H., J.H.G., C.R.S.), Harvard NeuroDiscovery Center, Boston; Department of Neurology (J.J.L., U.S.S., A.-M.W., A.W.F., A.Y.H., N.M., V.K., S.N.G., M.A.S., B.T.H., J.H.G., C.R.S.), Massachusetts General Hospital, Boston; Department of Neurology (M.T.H., A.Y.H., D.J.S., L.R.S., C.R.S.), Brigham and Women's Hospital, Boston, MA; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; and Division of Neurology, the Ottawa Hospital, University of Ottawa (M.G.S.)</wicri:regionArea>
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<author><name sortKey="Lockhart, Kaitlin C" sort="Lockhart, Kaitlin C" uniqKey="Lockhart K" first="Kaitlin C" last="Lockhart">Kaitlin C. Lockhart</name>
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<author><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J" last="Locascio">Joseph J. Locascio</name>
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<author><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N" last="Hoesing">Ashley N. Hoesing</name>
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<author><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name>
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<author><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name>
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<author><name sortKey="Hayes, Michael T" sort="Hayes, Michael T" uniqKey="Hayes M" first="Michael T" last="Hayes">Michael T. Hayes</name>
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<author><name sortKey="Sohur, U Shivraj" sort="Sohur, U Shivraj" uniqKey="Sohur U" first="U Shivraj" last="Sohur">U Shivraj Sohur</name>
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<author><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name>
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<author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name>
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<author><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W" last="Flaherty">Alice W. Flaherty</name>
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<author><name sortKey="Hung, Albert Y" sort="Hung, Albert Y" uniqKey="Hung A" first="Albert Y" last="Hung">Albert Y. Hung</name>
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<author><name sortKey="Mejia, Nicte" sort="Mejia, Nicte" uniqKey="Mejia N" first="Nicte" last="Mejia">Nicte Mejia</name>
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<author><name sortKey="Khurana, Vikram" sort="Khurana, Vikram" uniqKey="Khurana V" first="Vikram" last="Khurana">Vikram Khurana</name>
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<author><name sortKey="Gomperts, Stephen N" sort="Gomperts, Stephen N" uniqKey="Gomperts S" first="Stephen N" last="Gomperts">Stephen N. Gomperts</name>
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<author><name sortKey="Selkoe, Dennis J" sort="Selkoe, Dennis J" uniqKey="Selkoe D" first="Dennis J" last="Selkoe">Dennis J. Selkoe</name>
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<author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A" last="Schwarzschild">Michael A. Schwarzschild</name>
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<author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G" last="Schlossmacher">Michael G. Schlossmacher</name>
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<author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T" last="Hyman">Bradley T. Hyman</name>
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<author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R" last="Sudarsky">Lewis R. Sudarsky</name>
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<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H" last="Growdon">John H. Growdon</name>
</author>
<author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R" last="Scherzer">Clemens R. Scherzer</name>
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<series><title level="j">Neurology</title>
<idno type="eISSN">1526-632X</idno>
<imprint><date when="2013" type="published">2013</date>
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<term>Biomarkers (metabolism)</term>
<term>Case-Control Studies</term>
<term>Cholecalciferol (deficiency)</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (etiology)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Prevalence</term>
<term>Severity of Illness Index</term>
<term>Vitamin D Deficiency (complications)</term>
<term>Vitamin D Deficiency (diagnosis)</term>
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<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Cholecalciferol</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Vitamin D Deficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Vitamin D Deficiency</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
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<term>Case-Control Studies</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">To conclusively test for a specific association between the biological marker 25-hydroxy-vitamin D3, a transcriptionally active hormone produced in human skin and liver, and the prevalence and severity of Parkinson disease (PD).</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24068787</PMID>
<DateCreated><Year>2013</Year>
<Month>10</Month>
<Day>22</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>12</Month>
<Day>11</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>81</Volume>
<Issue>17</Issue>
<PubDate><Year>2013</Year>
<Month>Oct</Month>
<Day>22</Day>
</PubDate>
</JournalIssue>
<Title>Neurology</Title>
<ISOAbbreviation>Neurology</ISOAbbreviation>
</Journal>
<ArticleTitle>Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.</ArticleTitle>
<Pagination><MedlinePgn>1531-7</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1212/WNL.0b013e3182a95818</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To conclusively test for a specific association between the biological marker 25-hydroxy-vitamin D3, a transcriptionally active hormone produced in human skin and liver, and the prevalence and severity of Parkinson disease (PD).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We used liquid chromatography/tandem mass spectrometry to establish an association specifically between deficiency of 25-hydroxy-vitamin D3 and PD in a cross-sectional and longitudinal case-control study of 388 patients (mean Hoehn and Yahr stage of 2.1 ± 0.6) and 283 control subjects free of neurologic disease nested in the Harvard Biomarker Study.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Plasma levels of 25-hydroxy-vitamin D3 were associated with PD in both univariate and multivariate analyses with p values = 0.0034 and 0.047, respectively. Total 25-hydroxy-vitamin D levels, the traditional composite measure of endogenous and exogenous vitamin D, were deficient in 17.6% of patients with PD compared with 9.3% of controls. Low 25-hydroxy-vitamin D3 as well as total 25-hydroxy-vitamin D levels were correlated with higher total Unified Parkinson's Disease Rating Scale scores at baseline and during follow-up.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our study reveals an association between 25-hydroxy-vitamin D3 and PD and suggests that thousands of patients with PD in North America alone may be vitamin D-deficient. This finding has immediate relevance for individual patients at risk of falls as well as public health, and warrants further investigation into the mechanism underlying this association.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ding</LastName>
<ForeName>Hongliu</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>From the Neurogenomics Laboratory (H.D., K.D., K.C.L., A.N.H., K.D., A.T.-L., C.R.S.), Harvard Medical School and Brigham & Women's Hospital, Cambridge; Biomarkers Program (K.D., K.C.L., A.N.H., K.D., A.T.-L., M.T.H., U.S.S., B.M., N.M., V.K., S.N.G., D.J.S., M.A.S., M.G.S., B.T.H., J.H.G., C.R.S.), Harvard NeuroDiscovery Center, Boston; Department of Neurology (J.J.L., U.S.S., A.-M.W., A.W.F., A.Y.H., N.M., V.K., S.N.G., M.A.S., B.T.H., J.H.G., C.R.S.), Massachusetts General Hospital, Boston; Department of Neurology (M.T.H., A.Y.H., D.J.S., L.R.S., C.R.S.), Brigham and Women's Hospital, Boston, MA; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; and Division of Neurology, the Ottawa Hospital, University of Ottawa (M.G.S.), Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dhima</LastName>
<ForeName>Kaltra</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lockhart</LastName>
<ForeName>Kaitlin C</ForeName>
<Initials>KC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Locascio</LastName>
<ForeName>Joseph J</ForeName>
<Initials>JJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hoesing</LastName>
<ForeName>Ashley N</ForeName>
<Initials>AN</Initials>
</Author>
<Author ValidYN="Y"><LastName>Duong</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Trisini-Lipsanopoulos</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hayes</LastName>
<ForeName>Michael T</ForeName>
<Initials>MT</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sohur</LastName>
<ForeName>U Shivraj</ForeName>
<Initials>US</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wills</LastName>
<ForeName>Anne-Marie</ForeName>
<Initials>AM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mollenhauer</LastName>
<ForeName>Brit</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Flaherty</LastName>
<ForeName>Alice W</ForeName>
<Initials>AW</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hung</LastName>
<ForeName>Albert Y</ForeName>
<Initials>AY</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mejia</LastName>
<ForeName>Nicte</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Khurana</LastName>
<ForeName>Vikram</ForeName>
<Initials>V</Initials>
</Author>
<Author ValidYN="Y"><LastName>Gomperts</LastName>
<ForeName>Stephen N</ForeName>
<Initials>SN</Initials>
</Author>
<Author ValidYN="Y"><LastName>Selkoe</LastName>
<ForeName>Dennis J</ForeName>
<Initials>DJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schwarzschild</LastName>
<ForeName>Michael A</ForeName>
<Initials>MA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schlossmacher</LastName>
<ForeName>Michael G</ForeName>
<Initials>MG</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hyman</LastName>
<ForeName>Bradley T</ForeName>
<Initials>BT</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sudarsky</LastName>
<ForeName>Lewis R</ForeName>
<Initials>LR</Initials>
</Author>
<Author ValidYN="Y"><LastName>Growdon</LastName>
<ForeName>John H</ForeName>
<Initials>JH</Initials>
</Author>
<Author ValidYN="Y"><LastName>Scherzer</LastName>
<ForeName>Clemens R</ForeName>
<Initials>CR</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>K24 NS060991</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
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