The heterogeneity of cognitive symptoms in Parkinson's disease: a meta-analysis.
Identifieur interne : 000842 ( PubMed/Curation ); précédent : 000841; suivant : 000843The heterogeneity of cognitive symptoms in Parkinson's disease: a meta-analysis.
Auteurs : Christina Tremblay [Canada] ; Amélie M. Achim ; Joël Macoir ; Laura MonettaSource :
- Journal of neurology, neurosurgery, and psychiatry [ 1468-330X ] ; 2013.
English descriptors
- KwdEn :
- Aged, Child, Cognition Disorders (classification), Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Comorbidity, Depressive Disorder (classification), Depressive Disorder (diagnosis), Depressive Disorder (epidemiology), Disability Evaluation, Humans, Infant, Mental Status Schedule (statistics & numerical data), Middle Aged, Neurologic Examination, Parkinson Disease (classification), Parkinson Disease (diagnosis), Parkinson Disease (epidemiology), Psychometrics, Tremor (classification), Tremor (diagnosis), Tremor (epidemiology).
- MESH :
- classification : Cognition Disorders, Depressive Disorder, Parkinson Disease, Tremor.
- diagnosis : Cognition Disorders, Depressive Disorder, Parkinson Disease, Tremor.
- epidemiology : Cognition Disorders, Depressive Disorder, Parkinson Disease, Tremor.
- statistics & numerical data : Mental Status Schedule.
- Aged, Child, Comorbidity, Disability Evaluation, Humans, Infant, Middle Aged, Neurologic Examination, Psychometrics.
Abstract
Several studies have reported heterogeneity in cognitive symptoms associated with specific characteristics of patients with Parkinson's disease (PD). Indeed, researchers have characterised subtypes of patients suffering from PD according to various criteria. Those most frequently used are the type of predominant motor symptoms (tremors or non-tremor symptoms), age at onset and presence of depression. Some characteristics, like the predominant motor subtypes, as well as the presence of depression, are more widely used to categorise cognitive differences between patients. The goal of this study was to analyse the impact of the type of predominant motor symptoms and depression on cognition in PD. A meta-analysis of 27 studies (from 1989 to 2012) was carried out to calculate the average effect size of these factors on the most often used cognitive test during those past years to evaluate cognitive skills, the Mini-Mental State Examination. The studies analysed showed significant mean weighted effect sizes on cognition for the type of motor symptoms (d=0.42; 95% CI 0.30 to 0.54) and for depression (d=0.52; 95% CI 0.38 to 0.66). These results suggested that PD participants with non-tremor predominant motor symptoms or with depression had more or more severe cognitive impairments. Identification of different subtypes in PD is important for a better understanding of the cognitive symptoms associated with this disease. Better knowing the impact of different features of PD subgroups could help to design more appropriate treatments for patients with PD.
DOI: 10.1136/jnnp-2013-305021
PubMed: 23606738
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Achim</name></author><author><name sortKey="Macoir, Joel" sort="Macoir, Joel" uniqKey="Macoir J" first="Joël" last="Macoir">Joël Macoir</name></author><author><name sortKey="Monetta, Laura" sort="Monetta, Laura" uniqKey="Monetta L" first="Laura" last="Monetta">Laura Monetta</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23606738</idno><idno type="pmid">23606738</idno><idno type="doi">10.1136/jnnp-2013-305021</idno><idno type="wicri:Area/PubMed/Corpus">000842</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000842</idno><idno type="wicri:Area/PubMed/Curation">000842</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000842</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The heterogeneity of cognitive symptoms in Parkinson's disease: a meta-analysis.</title><author><name sortKey="Tremblay, Christina" sort="Tremblay, Christina" uniqKey="Tremblay C" first="Christina" last="Tremblay">Christina Tremblay</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation, Faculty of Medicine, Laval University, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Rehabilitation, Faculty of Medicine, Laval University, Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Achim, Amelie M" sort="Achim, Amelie M" uniqKey="Achim A" first="Amélie M" last="Achim">Amélie M. Achim</name></author><author><name sortKey="Macoir, Joel" sort="Macoir, Joel" uniqKey="Macoir J" first="Joël" last="Macoir">Joël Macoir</name></author><author><name sortKey="Monetta, Laura" sort="Monetta, Laura" uniqKey="Monetta L" first="Laura" last="Monetta">Laura Monetta</name></author></analytic><series><title level="j">Journal of neurology, neurosurgery, and psychiatry</title><idno type="eISSN">1468-330X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Child</term><term>Cognition Disorders (classification)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (epidemiology)</term><term>Comorbidity</term><term>Depressive Disorder (classification)</term><term>Depressive Disorder (diagnosis)</term><term>Depressive Disorder (epidemiology)</term><term>Disability Evaluation</term><term>Humans</term><term>Infant</term><term>Mental Status Schedule (statistics & numerical data)</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Parkinson Disease (classification)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (epidemiology)</term><term>Psychometrics</term><term>Tremor (classification)</term><term>Tremor (diagnosis)</term><term>Tremor (epidemiology)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Cognition Disorders</term><term>Depressive Disorder</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term><term>Depressive Disorder</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cognition Disorders</term><term>Depressive Disorder</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Mental Status Schedule</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Child</term><term>Comorbidity</term><term>Disability Evaluation</term><term>Humans</term><term>Infant</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Psychometrics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies have reported heterogeneity in cognitive symptoms associated with specific characteristics of patients with Parkinson's disease (PD). Indeed, researchers have characterised subtypes of patients suffering from PD according to various criteria. Those most frequently used are the type of predominant motor symptoms (tremors or non-tremor symptoms), age at onset and presence of depression. Some characteristics, like the predominant motor subtypes, as well as the presence of depression, are more widely used to categorise cognitive differences between patients. The goal of this study was to analyse the impact of the type of predominant motor symptoms and depression on cognition in PD. A meta-analysis of 27 studies (from 1989 to 2012) was carried out to calculate the average effect size of these factors on the most often used cognitive test during those past years to evaluate cognitive skills, the Mini-Mental State Examination. The studies analysed showed significant mean weighted effect sizes on cognition for the type of motor symptoms (d=0.42; 95% CI 0.30 to 0.54) and for depression (d=0.52; 95% CI 0.38 to 0.66). These results suggested that PD participants with non-tremor predominant motor symptoms or with depression had more or more severe cognitive impairments. Identification of different subtypes in PD is important for a better understanding of the cognitive symptoms associated with this disease. Better knowing the impact of different features of PD subgroups could help to design more appropriate treatments for patients with PD.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23606738</PMID><DateCreated><Year>2013</Year><Month>10</Month><Day>10</Day></DateCreated><DateCompleted><Year>2013</Year><Month>11</Month><Day>25</Day></DateCompleted><DateRevised><Year>2013</Year><Month>10</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-330X</ISSN><JournalIssue CitedMedium="Internet"><Volume>84</Volume><Issue>11</Issue><PubDate><Year>2013</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Journal of neurology, neurosurgery, and psychiatry</Title><ISOAbbreviation>J. Neurol. Neurosurg. Psychiatr.</ISOAbbreviation></Journal><ArticleTitle>The heterogeneity of cognitive symptoms in Parkinson's disease: a meta-analysis.</ArticleTitle><Pagination><MedlinePgn>1265-72</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/jnnp-2013-305021</ELocationID><Abstract><AbstractText>Several studies have reported heterogeneity in cognitive symptoms associated with specific characteristics of patients with Parkinson's disease (PD). Indeed, researchers have characterised subtypes of patients suffering from PD according to various criteria. Those most frequently used are the type of predominant motor symptoms (tremors or non-tremor symptoms), age at onset and presence of depression. Some characteristics, like the predominant motor subtypes, as well as the presence of depression, are more widely used to categorise cognitive differences between patients. The goal of this study was to analyse the impact of the type of predominant motor symptoms and depression on cognition in PD. A meta-analysis of 27 studies (from 1989 to 2012) was carried out to calculate the average effect size of these factors on the most often used cognitive test during those past years to evaluate cognitive skills, the Mini-Mental State Examination. The studies analysed showed significant mean weighted effect sizes on cognition for the type of motor symptoms (d=0.42; 95% CI 0.30 to 0.54) and for depression (d=0.52; 95% CI 0.38 to 0.66). These results suggested that PD participants with non-tremor predominant motor symptoms or with depression had more or more severe cognitive impairments. Identification of different subtypes in PD is important for a better understanding of the cognitive symptoms associated with this disease. 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