Small intestinal bacterial overgrowth in Parkinson's disease.
Identifieur interne : 000762 ( PubMed/Curation ); précédent : 000761; suivant : 000763Small intestinal bacterial overgrowth in Parkinson's disease.
Auteurs : Ai Huey Tan [Malaisie] ; Sanjiv Mahadeva [Malaisie] ; Abdul Malik Thalha [Malaisie] ; Peter R. Gibson [Australie] ; Chiun Khang Kiew [Malaisie] ; Chia Ming Yeat [Malaisie] ; Sheang Wen Ng [Malaisie] ; Sheau Phing Ang [Malaisie] ; Siew Kian Chow [Malaisie] ; Chong Tin Tan [Malaisie] ; Hoi Sen Yong [Malaisie] ; Connie Marras [Canada] ; Susan H. Fox [Canada] ; Shen-Yang Lim [Malaisie]Source :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Bacterial Infections (complications), Bacterial Infections (epidemiology), Female, Humans, Hydrogen, Intestinal Diseases (complications), Intestinal Diseases (epidemiology), Lactulose, Male, Middle Aged, Parkinson Disease (epidemiology), Prevalence, Quality of Life (psychology), Regression Analysis, Severity of Illness Index, Surveys and Questionnaires.
- MESH :
- chemical : Hydrogen, Lactulose.
- complications : Bacterial Infections, Intestinal Diseases.
- epidemiology : Bacterial Infections, Intestinal Diseases, Parkinson Disease.
- psychology : Quality of Life.
- Aged, Female, Humans, Male, Middle Aged, Prevalence, Regression Analysis, Severity of Illness Index, Surveys and Questionnaires.
Abstract
Recent studies reported a high prevalence of small intestinal bacterial overgrowth (SIBO) in Parkinson's disease (PD), and a possible association with gastrointestinal symptoms and worse motor function. We aimed to study the prevalence and the potential impact of SIBO on gastrointestinal symptoms, motor function, and quality of life in a large cohort of PD patients.
DOI: 10.1016/j.parkreldis.2014.02.019
PubMed: 24637123
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Safra Program in Parkinson's Disease Research, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital and the Edmond J. Safra Program in Parkinson's Disease Research, University of Toronto, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H" last="Fox">Susan H. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital and the Edmond J. Safra Program in Parkinson's Disease Research, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital and the Edmond J. Safra Program in Parkinson's Disease Research, University of Toronto, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Shen Yang" sort="Lim, Shen Yang" uniqKey="Lim S" first="Shen-Yang" last="Lim">Shen-Yang Lim</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia. Electronic address: limshenyang@ymail.com.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24637123</idno><idno type="pmid">24637123</idno><idno type="doi">10.1016/j.parkreldis.2014.02.019</idno><idno type="wicri:Area/PubMed/Corpus">000762</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000762</idno><idno type="wicri:Area/PubMed/Curation">000762</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000762</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Small intestinal bacterial overgrowth in Parkinson's disease.</title><author><name sortKey="Tan, Ai Huey" sort="Tan, Ai Huey" uniqKey="Tan A" first="Ai Huey" last="Tan">Ai Huey Tan</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Mahadeva, Sanjiv" sort="Mahadeva, Sanjiv" uniqKey="Mahadeva S" first="Sanjiv" last="Mahadeva">Sanjiv Mahadeva</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Thalha, Abdul Malik" sort="Thalha, Abdul Malik" uniqKey="Thalha A" first="Abdul Malik" last="Thalha">Abdul Malik Thalha</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Gibson, Peter R" sort="Gibson, Peter R" uniqKey="Gibson P" first="Peter R" last="Gibson">Peter R. Gibson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Central Clinical School, Monash University and Alfred Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Gastroenterology, Central Clinical School, Monash University and Alfred Hospital, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Kiew, Chiun Khang" sort="Kiew, Chiun Khang" uniqKey="Kiew C" first="Chiun Khang" last="Kiew">Chiun Khang Kiew</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Yeat, Chia Ming" sort="Yeat, Chia Ming" uniqKey="Yeat C" first="Chia Ming" last="Yeat">Chia Ming Yeat</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Ng, Sheang Wen" sort="Ng, Sheang Wen" uniqKey="Ng S" first="Sheang Wen" last="Ng">Sheang Wen Ng</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Ang, Sheau Phing" sort="Ang, Sheau Phing" uniqKey="Ang S" first="Sheau Phing" last="Ang">Sheau Phing Ang</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Chow, Siew Kian" sort="Chow, Siew Kian" uniqKey="Chow S" first="Siew Kian" last="Chow">Siew Kian Chow</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Chong Tin" sort="Tan, Chong Tin" uniqKey="Tan C" first="Chong Tin" last="Tan">Chong Tin Tan</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Yong, Hoi Sen" sort="Yong, Hoi Sen" uniqKey="Yong H" first="Hoi Sen" last="Yong">Hoi Sen Yong</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Biological Sciences, University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital and the Edmond J. Safra Program in Parkinson's Disease Research, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital and the Edmond J. Safra Program in Parkinson's Disease Research, University of Toronto, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H" last="Fox">Susan H. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital and the Edmond J. Safra Program in Parkinson's Disease Research, University of Toronto, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital and the Edmond J. Safra Program in Parkinson's Disease Research, University of Toronto, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Shen Yang" sort="Lim, Shen Yang" uniqKey="Lim S" first="Shen-Yang" last="Lim">Shen-Yang Lim</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia. Electronic address: limshenyang@ymail.com.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Bacterial Infections (complications)</term><term>Bacterial Infections (epidemiology)</term><term>Female</term><term>Humans</term><term>Hydrogen</term><term>Intestinal Diseases (complications)</term><term>Intestinal Diseases (epidemiology)</term><term>Lactulose</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (epidemiology)</term><term>Prevalence</term><term>Quality of Life (psychology)</term><term>Regression Analysis</term><term>Severity of Illness Index</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Hydrogen</term><term>Lactulose</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Bacterial Infections</term><term>Intestinal Diseases</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Bacterial Infections</term><term>Intestinal Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Quality of Life</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Regression Analysis</term><term>Severity of Illness Index</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent studies reported a high prevalence of small intestinal bacterial overgrowth (SIBO) in Parkinson's disease (PD), and a possible association with gastrointestinal symptoms and worse motor function. We aimed to study the prevalence and the potential impact of SIBO on gastrointestinal symptoms, motor function, and quality of life in a large cohort of PD patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24637123</PMID><DateCreated><Year>2014</Year><Month>05</Month><Day>19</Day></DateCreated><DateCompleted><Year>2015</Year><Month>01</Month><Day>07</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>5</Issue><PubDate><Year>2014</Year><Month>May</Month></PubDate></JournalIssue><Title>Parkinsonism & related disorders</Title><ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation></Journal><ArticleTitle>Small intestinal bacterial overgrowth in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>535-40</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2014.02.019</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1353-8020(14)00072-8</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Recent studies reported a high prevalence of small intestinal bacterial overgrowth (SIBO) in Parkinson's disease (PD), and a possible association with gastrointestinal symptoms and worse motor function. We aimed to study the prevalence and the potential impact of SIBO on gastrointestinal symptoms, motor function, and quality of life in a large cohort of PD patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">103 Consecutive PD patients were assessed using the lactulose-hydrogen breath test; questionnaires of gastrointestinal symptoms and quality of life (PDQ-39); the Unified PD Rating Scale (UPDRS) including "on"-medication Part III (motor severity) score; and objective and quantitative measures of bradykinesia (Purdue Pegboard and timed test of gait). Patients and evaluating investigators were blind to SIBO status.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">25.3% of PD patients were SIBO-positive. SIBO-positive patients had a shorter mean duration of PD (5.2 ± 4.1 vs. 8.1 ± 5.5 years, P = 0.007). After adjusting for disease duration, SIBO was significantly associated with lower constipation and tenesmus severity scores, but worse scores across a range of "on"-medication motor assessments (accounting for 4.2-9.0% of the variance in motor scores). There was no association between SIBO and motor fluctuations or PDQ-39 Summary Index scores.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This is the largest study to date on SIBO in PD. SIBO was detected in one quarter of patients, including patients recently diagnosed with the disease. SIBO was not associated with worse gastrointestinal symptoms, but independently predicted worse motor function. Properly designed treatment trials are needed to confirm a causal link between SIBO and worse motor function in PD.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Ai Huey</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahadeva</LastName><ForeName>Sanjiv</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thalha</LastName><ForeName>Abdul Malik</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gibson</LastName><ForeName>Peter R</ForeName><Initials>PR</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Central Clinical School, Monash University and Alfred Hospital, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kiew</LastName><ForeName>Chiun Khang</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeat</LastName><ForeName>Chia Ming</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Sheang Wen</ForeName><Initials>SW</Initials><AffiliationInfo><Affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ang</LastName><ForeName>Sheau Phing</ForeName><Initials>SP</Initials><AffiliationInfo><Affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chow</LastName><ForeName>Siew Kian</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Chong Tin</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yong</LastName><ForeName>Hoi Sen</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marras</LastName><ForeName>Connie</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital and the Edmond J. Safra Program in Parkinson's Disease Research, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fox</LastName><ForeName>Susan H</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital and the Edmond J. Safra Program in Parkinson's Disease Research, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Shen-Yang</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>Faculty of Medicine (Divisions of Neurology and Gastroenterology), University of Malaya, Kuala Lumpur, Malaysia. Electronic address: limshenyang@ymail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>03</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parkinsonism Relat Disord</MedlineTA><NlmUniqueID>9513583</NlmUniqueID><ISSNLinking>1353-8020</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>4618-18-2</RegistryNumber><NameOfSubstance UI="D007792">Lactulose</NameOfSubstance></Chemical><Chemical><RegistryNumber>7YNJ3PO35Z</RegistryNumber><NameOfSubstance UI="D006859">Hydrogen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001424" MajorTopicYN="N">Bacterial Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006859" MajorTopicYN="N">Hydrogen</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007410" MajorTopicYN="N">Intestinal Diseases</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007792" MajorTopicYN="N">Lactulose</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012044" MajorTopicYN="N">Regression Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Gastrointestinal dysfunction</Keyword><Keyword MajorTopicYN="N">Parkinson's disease/Parkinsonism</Keyword><Keyword MajorTopicYN="N">Small intestinal bacterial overgrowth</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>11</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>02</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>02</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>3</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>1</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24637123</ArticleId><ArticleId IdType="pii">S1353-8020(14)00072-8</ArticleId><ArticleId IdType="doi">10.1016/j.parkreldis.2014.02.019</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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