The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite.
Identifieur interne : 000585 ( PubMed/Curation ); précédent : 000584; suivant : 000586The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite.
Auteurs : Johanna Wetzel [Canada] ; Susann Herrmann [Canada] ; Lakshmipuram Seshadri Swapna [Canada] ; Dhaneswar Prusty [Canada] ; Arun T. John Peter [Allemagne] ; Maya Kono ; Sidharth Saini [Canada] ; Srinivas Nellimarla [Canada] ; Tatianna Wai Ying Wong [Canada] ; Louisa Wilcke [Canada] ; Olivia Ramsay [Canada] ; Ana Cabrera [Canada] ; Laura Biller ; Dorothee Heincke [Canada] ; Karen Mossman [Canada] ; Tobias Spielmann ; Christian Ungermann [Allemagne] ; John Parkinson [Canada] ; Tim W. Gilberger [Canada]Source :
- The Journal of biological chemistry [ 1083-351X ] ; 2015.
English descriptors
- KwdEn :
- Actins (chemistry), Acyltransferases (metabolism), Biotin (chemistry), Catalysis, Cell Membrane (metabolism), DNA Mutational Analysis, Green Fluorescent Proteins (metabolism), Humans, Malaria (parasitology), Membrane Proteins (metabolism), Phylogeny, Plasmodium falciparum (metabolism), Protein Structure, Tertiary, Protein Transport, Protozoan Proteins (metabolism).
- MESH :
- chemical , chemistry : Actins, Biotin.
- chemical , metabolism : Acyltransferases, Green Fluorescent Proteins, Membrane Proteins, Protozoan Proteins.
- metabolism : Cell Membrane, Plasmodium falciparum.
- parasitology : Malaria.
- Catalysis, DNA Mutational Analysis, Humans, Phylogeny, Protein Structure, Tertiary, Protein Transport.
Abstract
To survive and persist within its human host, the malaria parasite Plasmodium falciparum utilizes a battery of lineage-specific innovations to invade and multiply in human erythrocytes. With central roles in invasion and cytokinesis, the inner membrane complex, a Golgi-derived double membrane structure underlying the plasma membrane of the parasite, represents a unique and unifying structure characteristic to all organisms belonging to a large phylogenetic group called Alveolata. More than 30 structurally and phylogenetically distinct proteins are embedded in the IMC, where a portion of these proteins displays N-terminal acylation motifs. Although N-terminal myristoylation is catalyzed co-translationally within the cytoplasm of the parasite, palmitoylation takes place at membranes and is mediated by palmitoyl acyltransferases (PATs). Here, we identify a PAT (PfDHHC1) that is exclusively localized to the IMC. Systematic phylogenetic analysis of the alveolate PAT family reveals PfDHHC1 to be a member of a highly conserved, apicomplexan-specific clade of PATs. We show that during schizogony this enzyme has an identical distribution like two dual-acylated, IMC-localized proteins (PfISP1 and PfISP3). We used these proteins to probe into specific sequence requirements for IMC-specific membrane recruitment and their interaction with differentially localized PATs of the parasite.
DOI: 10.1074/jbc.M114.598094
PubMed: 25425642
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Maya Kono<affiliation><nlm:affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><nlm:affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><nlm:affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite.</title><author><name sortKey="Wetzel, Johanna" sort="Wetzel, Johanna" uniqKey="Wetzel J" first="Johanna" last="Wetzel">Johanna Wetzel</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Herrmann, Susann" sort="Herrmann, Susann" uniqKey="Herrmann S" first="Susann" last="Herrmann">Susann Herrmann</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Swapna, Lakshmipuram Seshadri" sort="Swapna, Lakshmipuram Seshadri" uniqKey="Swapna L" first="Lakshmipuram Seshadri" last="Swapna">Lakshmipuram Seshadri Swapna</name><affiliation wicri:level="1"><nlm:affiliation>the Program in Molecular Structure and Function, Hospital for Sick Children, and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>the Program in Molecular Structure and Function, Hospital for Sick Children, and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4</wicri:regionArea></affiliation></author><author><name sortKey="Prusty, Dhaneswar" sort="Prusty, Dhaneswar" uniqKey="Prusty D" first="Dhaneswar" last="Prusty">Dhaneswar Prusty</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="John Peter, Arun T" sort="John Peter, Arun T" uniqKey="John Peter A" first="Arun T" last="John Peter">Arun T. John Peter</name><affiliation wicri:level="1"><nlm:affiliation>the Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück, 49076 Osnabrück, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>the Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück, 49076 Osnabrück</wicri:regionArea></affiliation></author><author><name sortKey="Kono, Maya" sort="Kono, Maya" uniqKey="Kono M" first="Maya" last="Kono">Maya Kono</name><affiliation><nlm:affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Saini, Sidharth" sort="Saini, Sidharth" uniqKey="Saini S" first="Sidharth" last="Saini">Sidharth Saini</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Nellimarla, Srinivas" sort="Nellimarla, Srinivas" uniqKey="Nellimarla S" first="Srinivas" last="Nellimarla">Srinivas Nellimarla</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tatianna Wai Ying" sort="Wong, Tatianna Wai Ying" uniqKey="Wong T" first="Tatianna Wai Ying" last="Wong">Tatianna Wai Ying Wong</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Wilcke, Louisa" sort="Wilcke, Louisa" uniqKey="Wilcke L" first="Louisa" last="Wilcke">Louisa Wilcke</name><affiliation wicri:level="4"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><orgName type="university">Université McMaster</orgName><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ramsay, Olivia" sort="Ramsay, Olivia" uniqKey="Ramsay O" first="Olivia" last="Ramsay">Olivia Ramsay</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Cabrera, Ana" sort="Cabrera, Ana" uniqKey="Cabrera A" first="Ana" last="Cabrera">Ana Cabrera</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Biller, Laura" sort="Biller, Laura" uniqKey="Biller L" first="Laura" last="Biller">Laura Biller</name><affiliation><nlm:affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Heincke, Dorothee" sort="Heincke, Dorothee" uniqKey="Heincke D" first="Dorothee" last="Heincke">Dorothee Heincke</name><affiliation wicri:level="4"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><orgName type="university">Université McMaster</orgName><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mossman, Karen" sort="Mossman, Karen" uniqKey="Mossman K" first="Karen" last="Mossman">Karen Mossman</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Spielmann, Tobias" sort="Spielmann, Tobias" uniqKey="Spielmann T" first="Tobias" last="Spielmann">Tobias Spielmann</name><affiliation><nlm:affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Ungermann, Christian" sort="Ungermann, Christian" uniqKey="Ungermann C" first="Christian" last="Ungermann">Christian Ungermann</name><affiliation wicri:level="1"><nlm:affiliation>the Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück, 49076 Osnabrück, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>the Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück, 49076 Osnabrück</wicri:regionArea></affiliation></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation wicri:level="1"><nlm:affiliation>the Program in Molecular Structure and Function, Hospital for Sick Children, and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>the Program in Molecular Structure and Function, Hospital for Sick Children, and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4</wicri:regionArea></affiliation></author><author><name sortKey="Gilberger, Tim W" sort="Gilberger, Tim W" uniqKey="Gilberger T" first="Tim W" last="Gilberger">Tim W. Gilberger</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and the Center for Structural Systems Biology, 22607 Hamburg, Germany tgilber@mcmaster.ca.</nlm:affiliation><country wicri:rule="url">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and the Center for Structural Systems Biology, 22607 Hamburg</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25425642</idno><idno type="pmid">25425642</idno><idno type="doi">10.1074/jbc.M114.598094</idno><idno type="wicri:Area/PubMed/Corpus">000585</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000585</idno><idno type="wicri:Area/PubMed/Curation">000585</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000585</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite.</title><author><name sortKey="Wetzel, Johanna" sort="Wetzel, Johanna" uniqKey="Wetzel J" first="Johanna" last="Wetzel">Johanna Wetzel</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Herrmann, Susann" sort="Herrmann, Susann" uniqKey="Herrmann S" first="Susann" last="Herrmann">Susann Herrmann</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Swapna, Lakshmipuram Seshadri" sort="Swapna, Lakshmipuram Seshadri" uniqKey="Swapna L" first="Lakshmipuram Seshadri" last="Swapna">Lakshmipuram Seshadri Swapna</name><affiliation wicri:level="1"><nlm:affiliation>the Program in Molecular Structure and Function, Hospital for Sick Children, and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>the Program in Molecular Structure and Function, Hospital for Sick Children, and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4</wicri:regionArea></affiliation></author><author><name sortKey="Prusty, Dhaneswar" sort="Prusty, Dhaneswar" uniqKey="Prusty D" first="Dhaneswar" last="Prusty">Dhaneswar Prusty</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="John Peter, Arun T" sort="John Peter, Arun T" uniqKey="John Peter A" first="Arun T" last="John Peter">Arun T. John Peter</name><affiliation wicri:level="1"><nlm:affiliation>the Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück, 49076 Osnabrück, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>the Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück, 49076 Osnabrück</wicri:regionArea></affiliation></author><author><name sortKey="Kono, Maya" sort="Kono, Maya" uniqKey="Kono M" first="Maya" last="Kono">Maya Kono</name><affiliation><nlm:affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Saini, Sidharth" sort="Saini, Sidharth" uniqKey="Saini S" first="Sidharth" last="Saini">Sidharth Saini</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Nellimarla, Srinivas" sort="Nellimarla, Srinivas" uniqKey="Nellimarla S" first="Srinivas" last="Nellimarla">Srinivas Nellimarla</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tatianna Wai Ying" sort="Wong, Tatianna Wai Ying" uniqKey="Wong T" first="Tatianna Wai Ying" last="Wong">Tatianna Wai Ying Wong</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Wilcke, Louisa" sort="Wilcke, Louisa" uniqKey="Wilcke L" first="Louisa" last="Wilcke">Louisa Wilcke</name><affiliation wicri:level="4"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><orgName type="university">Université McMaster</orgName><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ramsay, Olivia" sort="Ramsay, Olivia" uniqKey="Ramsay O" first="Olivia" last="Ramsay">Olivia Ramsay</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Cabrera, Ana" sort="Cabrera, Ana" uniqKey="Cabrera A" first="Ana" last="Cabrera">Ana Cabrera</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Biller, Laura" sort="Biller, Laura" uniqKey="Biller L" first="Laura" last="Biller">Laura Biller</name><affiliation><nlm:affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Heincke, Dorothee" sort="Heincke, Dorothee" uniqKey="Heincke D" first="Dorothee" last="Heincke">Dorothee Heincke</name><affiliation wicri:level="4"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><orgName type="university">Université McMaster</orgName><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mossman, Karen" sort="Mossman, Karen" uniqKey="Mossman K" first="Karen" last="Mossman">Karen Mossman</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5</wicri:regionArea></affiliation></author><author><name sortKey="Spielmann, Tobias" sort="Spielmann, Tobias" uniqKey="Spielmann T" first="Tobias" last="Spielmann">Tobias Spielmann</name><affiliation><nlm:affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Ungermann, Christian" sort="Ungermann, Christian" uniqKey="Ungermann C" first="Christian" last="Ungermann">Christian Ungermann</name><affiliation wicri:level="1"><nlm:affiliation>the Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück, 49076 Osnabrück, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>the Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück, 49076 Osnabrück</wicri:regionArea></affiliation></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation wicri:level="1"><nlm:affiliation>the Program in Molecular Structure and Function, Hospital for Sick Children, and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>the Program in Molecular Structure and Function, Hospital for Sick Children, and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4</wicri:regionArea></affiliation></author><author><name sortKey="Gilberger, Tim W" sort="Gilberger, Tim W" uniqKey="Gilberger T" first="Tim W" last="Gilberger">Tim W. Gilberger</name><affiliation wicri:level="1"><nlm:affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and the Center for Structural Systems Biology, 22607 Hamburg, Germany tgilber@mcmaster.ca.</nlm:affiliation><country wicri:rule="url">Canada</country><wicri:regionArea>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and the Center for Structural Systems Biology, 22607 Hamburg</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of biological chemistry</title><idno type="eISSN">1083-351X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actins (chemistry)</term><term>Acyltransferases (metabolism)</term><term>Biotin (chemistry)</term><term>Catalysis</term><term>Cell Membrane (metabolism)</term><term>DNA Mutational Analysis</term><term>Green Fluorescent Proteins (metabolism)</term><term>Humans</term><term>Malaria (parasitology)</term><term>Membrane Proteins (metabolism)</term><term>Phylogeny</term><term>Plasmodium falciparum (metabolism)</term><term>Protein Structure, Tertiary</term><term>Protein Transport</term><term>Protozoan Proteins (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Actins</term><term>Biotin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acyltransferases</term><term>Green Fluorescent Proteins</term><term>Membrane Proteins</term><term>Protozoan Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Membrane</term><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Malaria</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Catalysis</term><term>DNA Mutational Analysis</term><term>Humans</term><term>Phylogeny</term><term>Protein Structure, Tertiary</term><term>Protein Transport</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To survive and persist within its human host, the malaria parasite Plasmodium falciparum utilizes a battery of lineage-specific innovations to invade and multiply in human erythrocytes. With central roles in invasion and cytokinesis, the inner membrane complex, a Golgi-derived double membrane structure underlying the plasma membrane of the parasite, represents a unique and unifying structure characteristic to all organisms belonging to a large phylogenetic group called Alveolata. More than 30 structurally and phylogenetically distinct proteins are embedded in the IMC, where a portion of these proteins displays N-terminal acylation motifs. Although N-terminal myristoylation is catalyzed co-translationally within the cytoplasm of the parasite, palmitoylation takes place at membranes and is mediated by palmitoyl acyltransferases (PATs). Here, we identify a PAT (PfDHHC1) that is exclusively localized to the IMC. Systematic phylogenetic analysis of the alveolate PAT family reveals PfDHHC1 to be a member of a highly conserved, apicomplexan-specific clade of PATs. We show that during schizogony this enzyme has an identical distribution like two dual-acylated, IMC-localized proteins (PfISP1 and PfISP3). We used these proteins to probe into specific sequence requirements for IMC-specific membrane recruitment and their interaction with differentially localized PATs of the parasite.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25425642</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>30</Day></DateCreated><DateCompleted><Year>2015</Year><Month>05</Month><Day>04</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1083-351X</ISSN><JournalIssue CitedMedium="Internet"><Volume>290</Volume><Issue>3</Issue><PubDate><Year>2015</Year><Month>Jan</Month><Day>16</Day></PubDate></JournalIssue><Title>The Journal of biological chemistry</Title><ISOAbbreviation>J. Biol. Chem.</ISOAbbreviation></Journal><ArticleTitle>The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite.</ArticleTitle><Pagination><MedlinePgn>1712-28</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1074/jbc.M114.598094</ELocationID><Abstract><AbstractText>To survive and persist within its human host, the malaria parasite Plasmodium falciparum utilizes a battery of lineage-specific innovations to invade and multiply in human erythrocytes. With central roles in invasion and cytokinesis, the inner membrane complex, a Golgi-derived double membrane structure underlying the plasma membrane of the parasite, represents a unique and unifying structure characteristic to all organisms belonging to a large phylogenetic group called Alveolata. More than 30 structurally and phylogenetically distinct proteins are embedded in the IMC, where a portion of these proteins displays N-terminal acylation motifs. Although N-terminal myristoylation is catalyzed co-translationally within the cytoplasm of the parasite, palmitoylation takes place at membranes and is mediated by palmitoyl acyltransferases (PATs). Here, we identify a PAT (PfDHHC1) that is exclusively localized to the IMC. Systematic phylogenetic analysis of the alveolate PAT family reveals PfDHHC1 to be a member of a highly conserved, apicomplexan-specific clade of PATs. We show that during schizogony this enzyme has an identical distribution like two dual-acylated, IMC-localized proteins (PfISP1 and PfISP3). We used these proteins to probe into specific sequence requirements for IMC-specific membrane recruitment and their interaction with differentially localized PATs of the parasite.</AbstractText><CopyrightInformation>© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wetzel</LastName><ForeName>Johanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herrmann</LastName><ForeName>Susann</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Swapna</LastName><ForeName>Lakshmipuram Seshadri</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>the Program in Molecular Structure and Function, Hospital for Sick Children, and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prusty</LastName><ForeName>Dhaneswar</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>John Peter</LastName><ForeName>Arun T</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>the Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück, 49076 Osnabrück, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kono</LastName><ForeName>Maya</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saini</LastName><ForeName>Sidharth</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nellimarla</LastName><ForeName>Srinivas</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Tatianna Wai Ying</ForeName><Initials>TW</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilcke</LastName><ForeName>Louisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramsay</LastName><ForeName>Olivia</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cabrera</LastName><ForeName>Ana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biller</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heincke</LastName><ForeName>Dorothee</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mossman</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spielmann</LastName><ForeName>Tobias</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ungermann</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>the Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück, 49076 Osnabrück, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parkinson</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>the Program in Molecular Structure and Function, Hospital for Sick Children, and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gilberger</LastName><ForeName>Tim W</ForeName><Initials>TW</Initials><AffiliationInfo><Affiliation>From the M. G. DeGroote Institute for Infectious Disease Research, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, the Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany, and the Center for Structural Systems Biology, 22607 Hamburg, Germany tgilber@mcmaster.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MOP111196</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant><Grant><GrantID>MOP84556</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Biol Chem</MedlineTA><NlmUniqueID>2985121R</NlmUniqueID><ISSNLinking>0021-9258</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000199">Actins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015800">Protozoan Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>147336-22-9</RegistryNumber><NameOfSubstance UI="D049452">Green Fluorescent Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>6SO6U10H04</RegistryNumber><NameOfSubstance UI="D001710">Biotin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.-</RegistryNumber><NameOfSubstance 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MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002384" MajorTopicYN="N">Catalysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002462" MajorTopicYN="N">Cell Membrane</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004252" MajorTopicYN="N">DNA Mutational Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049452" MajorTopicYN="N">Green Fluorescent Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008288" MajorTopicYN="N">Malaria</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010963" MajorTopicYN="N">Plasmodium falciparum</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017434" MajorTopicYN="N">Protein Structure, Tertiary</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021381" MajorTopicYN="N">Protein Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015800" MajorTopicYN="N">Protozoan Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4340414</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Inner Membrane Complex</Keyword><Keyword MajorTopicYN="N">Malaria</Keyword><Keyword MajorTopicYN="N">Membrane Trafficking</Keyword><Keyword MajorTopicYN="N">Palmitoyl Acyltransferase</Keyword><Keyword MajorTopicYN="N">Phylogenetics</Keyword><Keyword MajorTopicYN="N">Plasmodium</Keyword><Keyword MajorTopicYN="N">Protein Acylation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>11</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>11</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25425642</ArticleId><ArticleId IdType="pii">M114.598094</ArticleId><ArticleId IdType="doi">10.1074/jbc.M114.598094</ArticleId><ArticleId 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