Longitudinal midbrain changes in early Parkinson's disease: iron content estimated from R2*/MRI.
Identifieur interne : 000561 ( PubMed/Curation ); précédent : 000560; suivant : 000562Longitudinal midbrain changes in early Parkinson's disease: iron content estimated from R2*/MRI.
Auteurs : Marguerite Wieler [Canada] ; Myrlene Gee [Canada] ; W R Wayne Martin [Canada]Source :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Basal Ganglia (pathology), Case-Control Studies, Female, Humans, Image Processing, Computer-Assisted, Iron (metabolism), Longitudinal Studies, Magnetic Resonance Imaging, Male, Mesencephalon (pathology), Middle Aged, Parkinson Disease (metabolism), Parkinson Disease (pathology), Severity of Illness Index.
- MESH :
- chemical , metabolism : Iron.
- metabolism : Parkinson Disease.
- pathology : Basal Ganglia, Mesencephalon, Parkinson Disease.
- Aged, Analysis of Variance, Case-Control Studies, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Severity of Illness Index.
Abstract
To determine whether, in patients with early Parkinson's disease (PD), longitudinal changes in midbrain iron content are associated with declining motor function over a period of three years.
DOI: 10.1016/j.parkreldis.2014.11.017
PubMed: 25534153
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pubmed:25534153Le document en format XML
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<author><name sortKey="Wieler, Marguerite" sort="Wieler, Marguerite" uniqKey="Wieler M" first="Marguerite" last="Wieler">Marguerite Wieler</name>
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<author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.</nlm:affiliation>
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<author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name>
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<author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name>
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<series><title level="j">Parkinsonism & related disorders</title>
<idno type="eISSN">1873-5126</idno>
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<term>Analysis of Variance</term>
<term>Basal Ganglia (pathology)</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Iron (metabolism)</term>
<term>Longitudinal Studies</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Mesencephalon (pathology)</term>
<term>Middle Aged</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Severity of Illness Index</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Iron</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Mesencephalon</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Analysis of Variance</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Longitudinal Studies</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
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<front><div type="abstract" xml:lang="en">To determine whether, in patients with early Parkinson's disease (PD), longitudinal changes in midbrain iron content are associated with declining motor function over a period of three years.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25534153</PMID>
<DateCreated><Year>2015</Year>
<Month>02</Month>
<Day>24</Day>
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<DateCompleted><Year>2015</Year>
<Month>11</Month>
<Day>17</Day>
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<Issue>3</Issue>
<PubDate><Year>2015</Year>
<Month>Mar</Month>
</PubDate>
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<Title>Parkinsonism & related disorders</Title>
<ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation>
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<ArticleTitle>Longitudinal midbrain changes in early Parkinson's disease: iron content estimated from R2*/MRI.</ArticleTitle>
<Pagination><MedlinePgn>179-83</MedlinePgn>
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<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine whether, in patients with early Parkinson's disease (PD), longitudinal changes in midbrain iron content are associated with declining motor function over a period of three years.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Nineteen untreated subjects with early PD and 13 age- and sex-matched controls were followed clinically for 36 months. MRI with a 3 T magnet was performed at baseline, 18 months and 36 months with a multiple gradient echo sequence designed for rapid single-scan mapping of the proton transverse relaxation rate R2*. R2* was calculated for midbrain and forebrain basal ganglia regions.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A difference in R2* between patients and controls was observed at baseline (p = 0.035) but not at 18 or 36 months in the lateral substantia nigra pars compacta (SNc). Linear regression indicated significant correlations between the change in R2* in the lateral SNc and the change score in UPDRS III (p = 0.008) and the PDQ-39 -mobility sub-score (p = 0.03) from baseline to 36 months. R2* tended to increase in those with more advanced disease and to decrease in those with milder disease.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">High field MRI demonstrates lateral SNc abnormalities that progress over 3 years in early PD consistent with increased iron content in those with more advanced disease, corresponding to the known distribution of neuronal loss occurring in this disorder, and correlating with motor symptomatology. Larger and longer investigations with more precise mapping of iron-containing midbrain structures are needed to fully evaluate the potential of R2* as a biomarker of disease progression in PD.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
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<ForeName>Marguerite</ForeName>
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<AffiliationInfo><Affiliation>Division of Neurology, University of Alberta, Edmonton, Alberta, Canada.</Affiliation>
</AffiliationInfo>
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<AffiliationInfo><Affiliation>Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.</Affiliation>
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