ParkinsonCanadaV1, PubMed, Curation, bibRecord, 000418

Network structure of brain atrophy in de novo Parkinson's disease.

Identifieur interne : 000418 ( PubMed/Curation ); précédent : 000417; suivant : 000419

Network structure of brain atrophy in de novo Parkinson's disease.

Auteurs : Yashar Zeighami [Canada] ; Miguel Ulla [Canada] ; Yasser Iturria-Medina [Canada] ; Mahsa Dadar [Canada] ; Yu Zhang [Canada] ; Kevin Michel-Herve Larcher [Canada] ; Vladimir Fonov [Canada] ; Alan C. Evans [Canada] ; D Louis Collins [Canada] ; Alain Dagher [Canada]

Source :

eLife [ 2050-084X ] ; 2015.

RBID : pubmed:26344547

English descriptors

KwdEn :
- Adolescent, Adult, Atrophy (pathology), Biometry, Brain (diagnostic imaging), Brain (pathology), Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease (pathology), Radiography, Young Adult.
MESH :
- diagnostic imaging : Brain.
- pathology : Atrophy, Brain, Parkinson Disease.
- Adolescent, Adult, Biometry, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Radiography, Young Adult.

Abstract

We mapped the distribution of atrophy in Parkinson's disease (PD) using magnetic resonance imaging (MRI) and clinical data from 232 PD patients and 117 controls from the Parkinson's Progression Markers Initiative. Deformation-based morphometry and independent component analysis identified PD-specific atrophy in the midbrain, basal ganglia, basal forebrain, medial temporal lobe, and discrete cortical regions. The degree of atrophy reflected clinical measures of disease severity. The spatial pattern of atrophy demonstrated overlap with intrinsic networks present in healthy brain, as derived from functional MRI. Moreover, the degree of atrophy in each brain region reflected its functional and anatomical proximity to a presumed disease epicenter in the substantia nigra, compatible with a trans-neuronal spread of the disease. These results support a network-spread mechanism in PD. Finally, the atrophy pattern in PD was also seen in healthy aging, where it also correlated with the loss of striatal dopaminergic innervation.

DOI: 10.7554/eLife.08440
PubMed: 26344547

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Le document en format XML

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<front><div type="abstract" xml:lang="en">We mapped the distribution of atrophy in Parkinson's disease (PD) using magnetic resonance imaging (MRI) and clinical data from 232 PD patients and 117 controls from the Parkinson's Progression Markers Initiative. Deformation-based morphometry and independent component analysis identified PD-specific atrophy in the midbrain, basal ganglia, basal forebrain, medial temporal lobe, and discrete cortical regions. The degree of atrophy reflected clinical measures of disease severity. The spatial pattern of atrophy demonstrated overlap with intrinsic networks present in healthy brain, as derived from functional MRI. Moreover, the degree of atrophy in each brain region reflected its functional and anatomical proximity to a presumed disease epicenter in the substantia nigra, compatible with a trans-neuronal spread of the disease. These results support a network-spread mechanism in PD. Finally, the atrophy pattern in PD was also seen in healthy aging, where it also correlated with the loss of striatal dopaminergic innervation.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Network structure of brain atrophy in de novo Parkinson's disease.

Network structure of brain atrophy in de novo Parkinson's disease.

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